A review of the literature on the characteristics and current status of "modern type depression" and perspectives for future research.

“Modern-type depression” is the syndrome with symptoms of depression, has different characteristic from traditional depression. These characteristics are pointed out that younger, feeling for stress to social rules, being depressive only situation that being at workplace, feeling better when they away from work, and blaming others of their bad conditions. Previous studies have focused exclusively on the individual's internal factors for the causes of modern type depression. “modern type depressive” people are susceptible to misunderstandings due to the variability of symptoms and behavior outside the workplace. In addition, they are more prone to interpersonal problems. It has been suggested that these behaviors and problems are due to their blaming others. In this paper we suggested that the "blaming others" nature of modern type depressive people may function as stress coping for them. As a means of modifying such coping, we discussed the necessity of devising an intervention approach to promote the acquisition of the other's viewpoint

Relationship of Physical Activity to Self-Care Agency and Physical Condition Among Older Adults in a Rural Area

[Background] Maintaining physical activity is important for older adults. “Self-care agency” is the ability to perform self-care, which is defined as people following their own will, managing themselves, and maintaining activities. We investigated the relationship among physical activity and self-care agency, demographic factors and physical condition in older adults. [Methods] Self-care agency was assessed by using the Self-Care Agency Questionnaire developed for Japanese patients with chronic diseases. Among 175 older adults aged 65 years or older living in a rural area, responses from 83 who performed physical activities were analyzed. Correspondence analysis was conducted to characterize demographic factors and self-care agency. [Results] A higher proportion of women than men were engaged in physical activity. Irrespective of age and sex, many of the participants performed stretching exercises, walking, radio exercises, TV exercises, and participated in community circles. Participants who engaged in physical activities had significantly higher self-care agency scores than inactive participants. Among the active participants, the self-care agency score was significantly higher for women than men (P = .04) and was also significantly higher for participants aged ≥ 75 years compared to those aged < 75 years. Individuals with a high self-care agency tended to participate in local programs and perform brief physical activities at home. [Conclusion] Physically active older adults demonstrated high self-care agency. Their activities were easily carried out in their daily lives, with activities varying by age and sex. Support from community health experts is needed to promote suitable physical activity among older adults tailored for age and sex, especially among older adults who have low self-care agency

Effect of CO2 laser cutting process parameters on edge quality and operating cost of AISI316L

Laser cutting is a popular manufacturing process utilized to cut various types of materials economically. The width of laser cut or kerf, quality of the cut edges and the operating cost are affected by laser power, cutting speed, assist gas pressure, nozzle diameter and focus point position as well as the work-piece material. In this paper CO2 laser cutting of stainless steel of medical grade AISI316L has been investigated. Design of experiment (DOE) was implemented by applying Box-Behnken design to develop the experiment lay-out. The aim of this work is to relate the cutting edge quality parameters namely: upper kerf, lower kerf, the ratio between them, cut section roughness and operating cost to the process parameters mentioned above. Then, an overall optimization routine was applied to find out the optimal cutting setting that would enhance the quality or minimize the operating cost. Mathematical models were developed to determine the relationship between the process parameters and the edge quality features. Also, process parameters effects on the quality features have been defined. Finally, the optimal laser cutting conditions have been found at which the highest quality or minimum cost can be achieved

Kinematical and nonlocality effects on the nonmesonic weak hypernuclear decay

We derive in detail the transition potential for nonmesonic lambda-hypernuclear decay in a one-meson-exchange model involving the full pseudoscalar and vector meson octets and including two effects that have been systematically omitted in the literature. These are the kinematical effects due to the difference between the lambda and nucleon masses and the first-order nonlocality corrections. Numerical results for $^{12}_\Lambda$C and $^5_\Lambda$He are presented and they show that the combined kinematical plus nonlocal corrections have an appreciable influence on the partial decay rates. However, this is somewhat diminished in the main decay observables: the total nonmesonic rate, the neutron-to-proton branching ratio, and the asymmetry parameter. The latter two still cannot be reconciled with the available experimental data. The existing theoretical predictions for the sign of the asymmetry parameter in $^5_\Lambda$He are confirmed.Comment: 36 pages; LaTeX2e; 1 eps figure. Changes: 2 more tables and 14 new references added; effects on asymmetry parameter calculated; discussions expanded; more definite conclusions reache

Final State Interactions in Hypernuclear Decay

We present an update of the One-Meson-Exchange (OME) results for the weak decay of s- and p-shell hypernuclei (Ref. Phys. Rev. C {\bf 56}, 339 (1997)), paying special attention to the role played by final state interactions between the emitted nucleons. The present study also corrects for a mistake in the inclusion of the $K$ and $K^*$ exchange mechanisms, which substantially increases the ratio of neutron-induced to proton-induced transitions, $\Gamma_n/\Gamma_p$. With the most up-to-date model ingredients, we find that the OME approach is able to describe very satisfactorily most of the measured observables, including the ratio $\Gamma_n/\Gamma_p$.Comment: 20 pages, 2 eps figure

Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation

Members of the leucine-rich repeat-containing 8 (LRRC8) protein family, composed of the five LRRC8A-E isoforms, are pore-forming components of the volume-regulated anion channel (VRAC). LRRC8A and at least one of the other LRRC8 isoforms assemble into heteromers to generate VRAC transport activities. Despite the availability of the LRRC8A structures, the structural basis of how LRRC8 isoforms other than LRRC8A contribute to the functional diversity of VRAC has remained elusive. Here, we present the structure of the human LRRC8D isoform, which enables the permeation of organic substrates through VRAC. The LRRC8D homo-hexamer structure displays a two-fold symmetric arrangement, and together with a structure-based electrophysiological analysis, revealed two key features. The pore constriction on the extracellular side is wider than that in the LRRC8A structures, which may explain the increased permeability of organic substrates. Furthermore, an N-terminal helix protrudes into the pore from the intracellular side and may be critical for gating

Clinical efficacy and safety of monthly oral ibandronate 100 mg versus monthly intravenous ibandronate 1 mg in Japanese patients with primary osteoporosis

Summary: The MOVEST study evaluated the efficacy and safety of monthly oral ibandronate versus licensed monthly IV ibandronate in Japanese osteoporotic patients. Relative BMD gains after 12 months were 5.22 % oral and 5.34 % IV, showing non-inferiority of oral to IV ibandronate (primary endpoint). No new safety concerns were identified. Introduction: The randomized, phase 3, double-blind MOVEST (Monthly Oral VErsus intravenouS ibandronaTe) study evaluated the efficacy and safety of monthly oral ibandronate versus the licensed monthly intravenous (IV) ibandronate regimen in Japanese patients with osteoporosis. Methods: Ambulatory patients aged ?55 years with primary osteoporosis were randomized to receive oral ibandronate 100 mg/month plus monthly IV placebo, or IV ibandronate 1 mg/month plus monthly oral placebo. The primary endpoint was non-inferiority of oral versus IV ibandronate with respect to bone mineral density (BMD) gains at the lumbar spine after 12 months of treatment. Results: Four hundred twenty-two patients were enrolled with 372 patients in the per-protocol set (183 and 189 in the oral and IV ibandronate groups, respectively). The relative change from baseline in lumbar spine BMD values for the oral and IV ibandronate groups, respectively, was 5.22 % (95 % confidence interval [CI] 4.65, 5.80) and 5.34 % (95 % CI 4.78, 5.90). The least squares mean difference between the two groups was ?0.23 % (95 % CI ?0.97, 0.51), showing non-inferiority of oral ibandronate to IV ibandronate (non-inferiority limit = ?1.60). Changes in BMD values at other sites, and bone turnover marker levels in the oral ibandronate group, were comparable with those of the IV group. The safety profile was similar to that previously demonstrated; no new safety concerns were identified. Conclusions: This study demonstrated the non-inferiority of oral ibandronate 100 mg/month to IV ibandronate 1 mg/month (licensed dose in Japan) in increasing lumbar spine BMD in Japanese patients with primary osteoporosis

Weak Decay of Lambda Hypernuclei

In this review we discuss the present status of strange nuclear physics, with special attention to the weak decay of Lambda hypernuclei. The models proposed for the evaluation of the Lambda decay widths are summarized and their results are compared with the data. Despite the recent intensive investigations, the main open problem remains a sound theoretical interpretation of the large experimental values of the ratio G_n/G_p. Although recent works offer a step forward in the solution of the puzzle, further efforts must be invested in order to understand the detailed dynamics of the non-mesonic decay. Even if, by means of single nucleon spectra measurements, the error bars on G_n/G_p have been considerably reduced very recently at KEK, a clean extraction of G_n/G_p is needed. What is missing at present, but planned for the next future, are measurements of 1) nucleon energy spectra in double coincidence and 2) nucleon angular correlations: such observations allow to disentangle the nucleons produced in one- and two-body induced decays and lead to a direct determination of G_n/G_p. For the asymmetric non-mesonic decay of polarized hypernuclei the situation is even more puzzling. Indeed, strong inconsistencies appear already among data. A recent experiment obtained a positive intrinsic Lambda asymmetry parameter, a_{Lambda}, for 5_{Lambda}He. This is in complete disagreement with a previous measurement, which obtained a large and negative a_{Lambda} for p-shell hypernuclei, and with theory, which predicts a negative value moderately dependent on nuclear structure effects. Also in this case, improved experiments establishing with certainty the sign and magnitude of a_{Lambda} for s- and p-shell hypernuclei will provide a guidance for a deeper understanding of hypernuclear dynamics and decay mechanisms.Comment: 129 pages, 21 figures, Submitted to Phys. Rep

The Quiescent Intracluster Medium in the Core of the Perseus Cluster

Clusters of galaxies are the most massive gravitationally-bound objects in the Universe and are still forming. They are thus important probes of cosmological parameters and a host of astrophysical processes. Knowledge of the dynamics of the pervasive hot gas, which dominates in mass over stars in a cluster, is a crucial missing ingredient. It can enable new insights into mechanical energy injection by the central supermassive black hole and the use of hydrostatic equilibrium for the determination of cluster masses. X-rays from the core of the Perseus cluster are emitted by the 50 million K diffuse hot plasma filling its gravitational potential well. The Active Galactic Nucleus of the central galaxy NGC1275 is pumping jetted energy into the surrounding intracluster medium, creating buoyant bubbles filled with relativistic plasma. These likely induce motions in the intracluster medium and heat the inner gas preventing runaway radiative cooling; a process known as Active Galactic Nucleus Feedback. Here we report on Hitomi X-ray observations of the Perseus cluster core, which reveal a remarkably quiescent atmosphere where the gas has a line-of-sight velocity dispersion of 164+/-10 km/s in a region 30-60 kpc from the central nucleus. A gradient in the line-of-sight velocity of 150+/-70 km/s is found across the 60 kpc image of the cluster core. Turbulent pressure support in the gas is 4% or less of the thermodynamic pressure, with large scale shear at most doubling that estimate. We infer that total cluster masses determined from hydrostatic equilibrium in the central regions need little correction for turbulent pressure.Comment: 31 pages, 11 Figs, published in Nature July