3. Informationsveranstaltung des Open Access Network Austria (OANA) (Wien, 1. Juni 2016)

Dieser Beitrag fasst die Ergebnisse der 3. OANA-Veranstaltung, die am 01.06.2016 im Palais Harrach in Wien stattfand, zusammen. Das „Open Access Network Austria“ (OANA) ist eine „joint activity“ unter dem organisatorischen Dach des Fonds zur Förderung der wissenschaftlichen Forschung (FWF) und der Österreichischen Universitätenkonferenz (UNIKO) mit dem Ziel Open Access Aktivitäten in der österreichischen Forschungslandschaft zu koordinieren. Die fünf Arbeitsgruppen, die im Jänner 2015 gebildet wurden, präsentierten bei der Informationsveranstaltung die Ergebnisse und Fortschritte aus eineinhalb Jahren Arbeit. Ab Herbst 2016 werden sich vier neue Arbeitsgruppen mit den Themenschwerpunkten „Strategische Positionierung & Administration der Open-Access-Transition“, „Open Access & die Zukunft von Scholarly Communication“, „Open Access & Open Research Data“ und „Open Access & Open Educational Resources“ beschäftigen

3. Informationsveranstaltung des Open Access Network Austria (OANA) (Wien, 1. Juni 2016)

This article provides an overview of the activities at the third OANA Meeting at the Palais Harrach in Vienna on the 1st of June, 2016. OANA is a joint activity initiated and organized by the Austrian Science Fund (FWF) and the Universities Austria (UNIKO) that aims to coordinate Open Access activities in the Austrian research landscape. At the information event, the five OANA working groups that were established in January 2015 presented their results and developments of one and a half years of work. From fall 2016 onwards, four new working groups will concentrate on the following topics: “Strategic Positioning & Administration of the Open-Access-Transition“, „Open Access & the future of Scholarly Communication“, „Open Access & Open Research Data“ und „Open Access & Open Educational Resources“

3. Informationsveranstaltung des Open Access Network Austria (OANA) (Wien, 1. Juni 2016)

This article provides an overview of the activities at the third OANA Meeting at the Palais Harrach in Vienna on the 1st of June, 2016. OANA is a joint activity initiated and organized by the Austrian Science Fund (FWF) and the Universities Austria (UNIKO) that aims to coordinate Open Access activities in the Austrian research landscape. At the information event, the five OANA working groups that were established in January 2015 presented their results and developments of one and a half years of work. From fall 2016 onwards, four new working groups will concentrate on the following topics: “Strategic Positioning & Administration of the Open-Access-Transition“, „Open Access & the future of Scholarly Communication“, „Open Access & Open Research Data“ und „Open Access & Open Educational Resources“

Konzept OER-Zertifizierung an österreichischen Hochschulen

Das Ergebnis der Arbeitsgruppe „Open Educational Resources“ ist ein Konzept zur OER-Zertifizierung an österreichischen Hochschulen. Dazu wird unterschieden in eine zweistufige Zertifizierung für Hochschullehrende und eine dreistufige Zertifizierung für Hochschulen. Der Umsetzungsvorschlag sieht dafür digitale Open Badges vor, die von einer zentralen Stelle bereits in der nächsten Leistungsvereinbarungsperiode (2019–2021) vergeben werden sollen

Satellites reveal Earth's seasonally shifting dust emission sources

Establishing mineral dust impacts on Earth's systems requires numerical models of the dust cycle. Differences between dust optical depth (DOD) measurements and modelling the cycle of dust emission, atmospheric transport, and deposition of dust indicate large model uncertainty due partially to unrealistic model assumptions about dust emission frequency. Calibrating dust cycle models to DOD measurements typically in North Africa, are routinely used to reduce dust model magnitude. This calibration forces modelled dust emissions to match atmospheric DOD but may hide the correct magnitude and frequency of dust emission events at source, compensating biases in other modelled processes of the dust cycle. Therefore, it is essential to improve physically based dust emission modules. Here we use a global collation of satellite observations from previous studies of dust emission point source (DPS) dichotomous frequency data. We show that these DPS data have little-to-no relation with MODIS DOD frequency. We calibrate the albedo-based dust emission model using the frequency distribution of those DPS data. The global dust emission uncertainty constrained by DPS data (±3.8 kg m−2 y−1) provides a benchmark for dust emission model development. Our calibrated model results reveal much less global dust emission (29.1 ± 14.9 Tg y−1) than previous estimates, and show seasonally shifting dust emission predominance within and between hemispheres, as opposed to a persistent North African dust emission primacy widely interpreted from DOD measurements. Earth's largest dust emissions, proceed seasonally from East Asian deserts in boreal spring, to Middle Eastern and North African deserts in boreal summer and then Australian shrublands in boreal autumn-winter. This new analysis of dust emissions, from global sources of varying geochemical properties, have far-reaching implications for current and future dust-climate effects. For more reliable coupled representation of dust-climate projections, our findings suggest the need to re-evaluate dust cycle modelling and benefit from the albedo-based parameterisation

Learning together for and with the Martuwarra Fitzroy River

Co-production across scientific and Indigenous knowledge systems has become a cornerstone of research to enhance knowledge, practice, ethics, and foster sustainability transformations. However, the profound differences in world views and the complex and contested histories of nation-state colonisation on Indigenous territories, highlight both opportunities and risks for Indigenous people when engaging with knowledge co-production. This paper investigates the conditions under which knowledge co-production can lead to improved Indigenous adaptive environmental planning and management among remote land-attached Indigenous peoples through a case study with ten Traditional Owner groups in the Martuwarra (Fitzroy River) Catchment in Western Australia’s Kimberley region. The research team built a 3D map of the river and used it, together with an interactive table-top projector, to bring together both scientific and Indigenous spatial knowledge. Participatory influence mapping, aligned with Traditional Owner priorities to achieve cultural governance and management planning goals set out in the Fitzroy River Declaration, investigated power relations. An analytical framework, examining underlying mechanisms of social learning, knowledge promotion and enhancing influence, based on different theories of change, was applied to unpack the immediate outcomes from these activities. The analysis identified that knowledge co-production activities improved the accessibility of the knowledge, the experiences of the knowledge users, strengthened collective identity and partnerships, and strengthened Indigenous-led institutions. The focus on cultural governance and management planning goals in the Fitzroy River Declaration enabled the activities to directly affect key drivers of Indigenous adaptive environmental planning and management—the Indigenous-led institutions. The nation-state arrangements also gave some support to local learning and decision-making through a key Indigenous institution, Martuwarra Fitzroy River Council. Knowledge co-production with remote land-attached Indigenous peoples can improve adaptive environmental planning and management where it fosters learning together, is grounded in the Indigenous-led institutions and addresses their priorities

Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium : an application of Item Response Theory

Peer reviewe

Comprehensive genomic profiles of small cell lung cancer

We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimes by complex genomic rearrangements. Two tumours with wild-type RB1 had evidence of chromothripsis leading to overexpression of cyclin D1 (encoded by the CCND1 gene), revealing an alternative mechanism of Rb1 deregulation. Thus, loss of the tumour suppressors TP53 and RB1 is obligatory in SCLC. We discovered somatic genomic rearrangements of TP73 that create an oncogenic version of this gene, TP73Dex2/3. In rare cases, SCLC tumours exhibited kinase gene mutations, providing a possible therapeutic opportunity for individual patients. Finally, we observed inactivating mutations in NOTCH family genes in 25% of human SCLC. Accordingly, activation of Notch signalling in a pre-clinical SCLC mouse model strikingly reduced the number of tumours and extended the survival of the mutant mice. Furthermore, neuroendocrine gene expression was abrogated by Notch activity in SCLC cells. This first comprehensive study of somatic genome alterations in SCLC uncovers several key biological processes and identifies candidate therapeutic targets in this highly lethal form of cancer

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts

Peer reviewe

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion