A Black Hole Kicked At Birth: MAXI J1305-704

When a compact object is formed in a binary, any mass lost during core collapse will impart a kick on the binary's center of mass. Asymmetries in this mass loss would impart an additional natal kick on the remnant black hole or neutron star, whether it was formed in a binary or in isolation. While it is well established that neutron stars receive natal kicks upon formation, it is unclear whether black holes do as well. Here, we consider the low-mass X-ray binary MAXI J1305-704, which has been reported to have a space velocity $\gtrsim$ 200 km/s. In addition to integrating its trajectory to infer its velocity upon formation of its black hole, we reconstruct its evolutionary history, accounting for recent estimates of its period, black hole mass, mass ratio, and donor effective temperature from photometric and spectroscopic observations. We find that if MAXI J1305-704 formed via isolated binary evolution in the thick Galactic disk, then its black hole received a natal kick of at least 70 km/s with 95\% confidence.Comment: To be submitted; 9 pages, 5 figure

Falciparum malaria and HIV-1 in hospitalized adults in Maputo, Mozambique: does HIV-infection obscure the malaria diagnosis?

<p>Abstract</p> <p>Background</p> <p>The potential impact of HIV-1 on falciparum malaria has been difficult to determine because of diagnostic problems and insufficient epidemiological data.</p> <p>Methods</p> <p>In a prospective, cross-sectional study, clinical and laboratory data was registered consecutively for all adults admitted to a medical ward in the Central Hospital of Maputo, Mozambique, during two months from 28^thOctober 2006. Risk factors for fatal outcome were analysed. The impact of HIV on the accuracy of malaria diagnosis was assessed, comparing "Presumptive malaria", a diagnosis assigned by the ward clinicians based on fever and symptoms suggestive of malaria in the absence of signs of other infections, and "Verified malaria", a malaria diagnosis that was not rejected during retrospective review of all available data.</p> <p>Results</p> <p>Among 333 included patients, fifteen percent (51/333) had "presumptive malaria", ten percent (28 of 285 tested persons) had positive malaria blood slides, while 69.1% (188/272) were HIV positive. Seven percent (n = 23) had "verified malaria", after the diagnosis was rejected in patients with neck stiffness or symptom duration longer than 2 weeks (n = 5) and persons with negative (n = 19) or unknown malaria blood slide (n = 4). Clinical stage of HIV infection (CDC), hypotension and hypoglycaemia was associated with fatal outcome. The "presumptive malaria" diagnosis was rejected more frequently in HIV positive (20/31) than in HIV negative patients (2/10, p = 0.023).</p> <p>Conclusion</p> <p>The study suggests that the fraction of febrile illness attributable to malaria is lower in HIV positive adults. HIV testing should be considered early in evaluation of patients with suspected malaria.</p

A new route towards more harmonious intergroup relationships in England? Majority members’ proximal-acculturation

Although the ways that immigrants relate to UK culture has been a hot topic since the EU-referendum, little attention has been given to how majority group members such as Host Country Nationals (HCNs) relate to immigrants’ culture. Thus, we explored English HCNs’ globalisation-based proximal-acculturation – the extent to which they prefer to adopt aspects of immigrants’ cultures and/or maintain their national culture. Using two-step cluster analysis, a pilot study (N = 63) revealed a separated, integrated, and undifferentiated cluster, with separated HCNs perceiving cultural diversity more as a threat and less as an enrichment. Using latent profile analysis in a second study (N = 220) also revealed a three strategy-solution, identifying assimilated, integrated and separated profiles. Again we examined how these strategies differed across perceptions of cultural threat and enrichment as well as other psychosocial characteristics: identifying with fellow English citizens, recognizing cultural differences whilst not being culturally embedded (constructive marginalization), and various forms of intergroup contact. Separated HCNs identified more with fellow English citizens, endorsed less constructive marginalization, perceived less cultural enrichment yet more cultural threat than HCNs following some of the other strategies. These results stress that the onus of cultural adoption lies with both groups – minorities and majority members – with English HCNs showing distinct proximal-acculturation strategies. Lastly, when exploring a variable-centred approach, proximal-acculturation orientations (cultural maintenance/adoption) mediated the relationship between cultural threat, cultural enrichment, and intergroup contact on positive feelings towards immigrants. Thus, the ways that HCNs acculturate may provide a new route towards harmonious intergroup relations

Subtype-specific regulatory network rewiring in acute myeloid leukemia

Acute myeloid leukemia (AML) is a heterogeneous disease caused by a variety of alterations in transcription factors, epigenetic regulators and signaling molecules. To determine how different mutant regulators establish AML subtype–specific transcriptional networks, we performed a comprehensive global analysis of cis-regulatory element activity and interaction, transcription factor occupancy and gene expression patterns in purified leukemic blast cells. Here, we focused on specific subgroups of subjects carrying mutations in genes encoding transcription factors (RUNX1, CEBPα), signaling molecules (FTL3-ITD, RAS) and the nuclear protein NPM1). Integrated analysis of these data demonstrates that each mutant regulator establishes a specific transcriptional and signaling network unrelated to that seen in normal cells, sustaining the expression of unique sets of genes required for AML growth and maintenance