Planck 2013 results. I. Overview of products and scientific results

Peer reviewe

Towards an Ideation Process applied to the Automotive Supplier Industry

International audienc

The Need for a Structured Approach towards Production Technology Roadmaps in Innovation-Driven Industries

International audienc

their cardiorespiratory effects in rabbits

Origanum onites L. and Thymbra spicata L. were collected in June-July 2004 in Denizli, Western Turkey. Essential oils from the leaves of these plants were extracted using either Soxhlet or steam distillation. The components of essential oils were removed from the steam distillate by C18 solid phase extraction. Chemical compositions of the essential oils were determined using two-dimensional gas chromatography (GC-TOF/MS). Portions (1 mL) of aqueous extracts (differing between groups in types of plants and extraction methods) were given orally to twenty-eight anesthetized rabbits using feeding tubes, and their electro-cardiography (ECG) and spirometric data recorded. The possible effects of these extracts obtained by using two different methods were evaluated by statistical analyses. According to the data obtained from the animal experiments, administration of these plant extracts caused a decrease in ventilation and heart rate. The common usage of thyme water in public, and the purposes of consumption were discussed in terms of public health

Original scientific paper

The possibilities of the application of some species of sage (Salvia L.) as auxiliaries in the treatment of some disease

Effect of dynamic high pressure on functional and structural properties of bovine serum albumin

Dynamic high pressure (DHP) has been investigated as an innovative suitable method to induce protein modifications. This work evaluated the effect of DHP (up to three passes at 100, 150 and 200 MPa, with an inlet temperature of 20 °C) on functional and structural properties of bovine serum albumin (BSA). Results indicated that DHP process applied up to an energy limit of 100 MPa increased the protein foaming capacity (FC) (p < 0.05 - increase up to 63% after 1 pass at 100 MPa) and the utilization of multiple passes at high pressure promoted a reduction in this property (p < 0.05 - reduction up to 31.6% after 3 passes at 200 MPa). Similar results were observed for sulfhydryl group, indicating an influence of free thiol groups on FC. Complementarily, DHP process promoted an increase of proteins particles size, suggesting a new rearrangement of their conformational structure. DHP did not affect tryptophan microenvironment in BSA; however, this process induced the rearrangement of secondary structure elements. In the first cycle, the pressure increase resulted in a loss of secondary structure, while in the second and third cycles the DHP process resulted in the gain of secondary structure elements. These results indicated that the second and third passes triggered a molecular rearrangement of the protein structure, giving rise to a novel and more stable conformational state. This conclusion was also supported by thermal unfolding studies (melting temperature reduction from 67.5 to 54.6 °C after 1 pass at 200 MPa), in which the additional cycles of DHP caused the occurrence of an initial denaturation at high temperatures, compared to the first cycle