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813. Ecdysone Receptor-Based Inducible Gene Regulation System for Simultaneous Regulation of Multiple Genes
- Publication venue
- Elsevier Limited
- Publication date
- 01/05/2004
- Field of study
An ecdysone receptor (EcR)-based inducible gene regulation system that functions in mammalian cells in a tightly regulated fashion is described. This gene switch functions efficiently in a two-hybrid format in which heterologous DNA binding and transcription activation domains are fused to the two heterodimeric receptor partners EcR and RXR. Extensive mutagenesis of the ecdysone receptor along with the development and screening of a large number of non-steroid ligands has resulted in the discovery of several orthogonal ligand-receptor pairs. Receptor mutants were obtained that are activated at low nanomolar concentrations of the ligand. The different components of the gene switch were assembled into a two-vector format or into a single cassette all-in-one vector for expression of genes of interest. Different ecdysone receptor mutants were fused to different DNA binding domains to create several independently acting gene switch combinations (multiplex). The orthogonal nature of the ligand-receptor pairs was demonstrated in reporter assays of two-channel gene switch combinations. Experiments will be presented to demonstrate that the multiplex gene switch system works independently in single cells in response to different ligands. The utility of this system in gene therapy applications will be discussed
Klinik der Kardiomyopathien
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- A Askanas
- A Fleckenstein
- A Johansen
- A Lockhart
- A Rees
- A Saint-Pierre
- A Senning
- A Senning
- A Tilkian
- A Watt
- A Windorfer
- AA Schmaltz
- AD Pichard
- AG Adelman
- AG Adelman
- AG Morrow
- AG Morrow
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- AJ Beuren
- AJ Linzbach
- AJ Linzbach
- AJ Linzbach
- AJ Linzbach
- AJ Tajik
- AL Simon
- AM Lerner
- AN Maria De
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- Publication date
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- Neuere Erfahrungen mit der antibiotischen Behandlung der Hautkrankheiten (Aureomycin Chloromycetin, Terramycin)
- Neuzeitliche Behandlung der Dermatomykosen unter besonderer Berücksichtigung der Mikrosporie
- Neuzeitliche Behandlung mit Antibiotica und Sulfonamiden
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- The action of antibiotic combinations on pathogenic staphylococci in vitro
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- The mechanism of action of penicillin
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- W Krause
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- W Lutz
- W Mcdermott
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- Zur Beurteilung der Wirkungsweise von Antibiotica
- Zusammenfassung
- Zusammenhang zwischen Dermatitis und Paraxininjektion
- Über allergische Erscheinungen beim Gebrauch von Antibiotika
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- Über die Wirksamkeit der Antibiotica Streptomycin und Tetracyclin bei der Behandlung der Acrodermatitis atrophicans Herxheimer
- Über Penicillinase und ihre Inhibitoren
- Über Penicillingewinnung und Penicillinwertbestimmung
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1961
- Field of study
Assessing written work by determining competence to achieve the module-specific learning outcomes.
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- Publication venue
- Publication date
- 01/01/2012
- Field of study
This chapter describes lasers and other sources of coherent light that operate in a wide wavelength range. First, the general principles for the generation of coherent continuous-wave and pulsed radiation are treated including the interaction of radiation with matter, the properties of optical resonators and their modes as well as such processes as Q-switching and mode-locking. The general introduction is followed by sections on numerous types of lasers, the emphasis being on todayʼs most important sources of coherent light, in particular on solid-state lasers and several types of gas lasers. An important part of the chapter is devoted to the generation of coherent radiation by nonlinear processes with optical parametric oscillators, difference- and sum-frequency generation, and high-order harmonics. Radiation in the extended ultraviolet (EUV) and x-ray ranges can be generated by free electron lasers (FEL) and advanced x-ray sources. Ultrahigh light intensities up to 1021 W/cm2 open the door to studies of relativistic laser–matter interaction and laser particle acceleration. The chapter closes with a section on laser stabilization
Description and performance of track and primary-vertex reconstruction with the CMS tracker
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdelalim Ahmed Ali
- Abdullin Salavat
- Abdulsalam Abdulla
- Acosta Darin
- Acosta John Gabriel
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- Adam Wolfgang
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- Adams Todd
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- Adler Volker
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- Ahmad Muhammad
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- Polatoz Ayse
- Polese Giovanni
- Polic Dunja
- Poll Anthony
- Pollack Brian
- Pompili Alexis
- Pooth Oliver
- Popov Andrey
- Popov Vladimir
- Postema Hans
- Potenza Alberto
- Potenza Renato
- Pozdnyakov Andrey
- Pozzobon Nicola
- Prado Da Silva Wanda Lucia
- Preuten Marius
- Primavera Federica
- Printz Martin
- Prokofyev Oleg
- Prosper Harrison
- Prosser Alan
- Psallidas Andreas
- Ptochos Fotios
- Puerta Pelayo Jesus
- Pugliese Gabriella
- Puigh Darren
- Puljak Ivica
- Python Quentin
- Pérez Calero Yzquierdo Antonio María
- Pöhlsen Thomas
- Qazi Shamona
- Qian Si-Jin
- Quan Xiaohang
- Quast Gunter
- Quertenmont Loic
- Quintario Olmeda Adrián
- Quittnat Milena
- Rabady Dinyar
- Rabbertz Klaus
- Racz Attila
- Radburn-Smith Benjamin Charles
- Radi Amr
- Radogna Raffaella
- Raffaelli Fabrizio
- Ragazzi Stefano
- Rahatlou Shahram
- Rahbaran Babak
- Rahmat Rahmat
- Raics Peter
- Raidal Martti
- Rakness Gregory
- Ralph Duncan
- Ramirez Vargas Juan Eduardo
- Rander John
- Ranjan Kirti
- Rappoccio Salvatore
- Raspereza Alexei
- Rathjens Denis
- Ratnikov Fedor
- Ratnikova Natalia
- Ratti Lodovico
- Ratti Sergio P.
- Raupach Frank Arthur
- Raval Amita
- Raymond David Mark
- Razis Panos A.
- Re Valerio
- Rebane Liis
- Rebassoo Finn
- Redaelli Nicola
- Redjimi Radia
- Redondo Ignacio
- Reece William
- Reid Ivan
- Reis Thomas
- Reithler Hans
- Rekovic Vladimir
- Renker Dieter
- Reucroft Steve
- Ribeiro Cipriano Pedro M.
- Riccardi Cristina
- Ricci-Tam Francesca
- Richardson Clint
- Richman Jeffrey
- Riedl Caroline
- Rinkevicius Aurelijus
- Rivera Ryan
- Rivetti Angelo
- Rizzi Andrea
- Roberts Jay
- Robles Jorge
- Robmann Peter
- Robutti Enrico
- Rodenburg Marissa
- Rodozov Mircho
- Rodrigo Teresa
- Rodrigues Antunes Joao
- Rodriguez Jorge Luis
- Rodríguez-Marrero Ana Yaiza
- Roe Jeffrey
- Rogan Christopher
- Rogerson Samuel
- Roh Youn
- Rohe Tilman
- Rohlf James
- Rohringer Herbert
- Roland Benoit
- Roland Christof
- Roland Gunther
- Rolandi Gigi
- Romanowska-Rybinska Katarzyna
- Romeo Francesco
- Romero Alessandra
- Romero Luciano
- Ron Elias
- Ronchese Paolo
- Ronga Frederic Jean
- Rose Andrew
- Rose Keith
- Rosowsky André
- Ross Ian
- Rossi Antonio
- Rossin Roberto
- Rossini Marco
- Rougny Romain
- Rovelli Chiara
- Rovelli Tiziano
- Rovere Marco
- Roy Debarati
- Ruchti Randy
- Ruiz Alvarez José David
- Ruiz-Jimeno Alberto
- Rumerio Paolo
- Rusack Roger
- Rusakov Sergey V.
- Ruspa Marta
- Russ James
- Rutherford Britney
- Ryckbosch Dirk
- Ryd Anders
- Ryu Geonmo
- Ryutin Roman
- Rzonca Marcin
- Röcker Steffen
- Röser Ulf
- Sabes David
- Sacchi Roberto
- Safarzadeh Batool
- Safonov Alexei
- Safronov Grigory
- Saha Anirban
- Sahin Mehmet Özgür
- Saini Lovedeep Kaur
- Saizu Mirela Angela
- Saka Halil
- Sakharov Alexandre
- Sakulin Hannes
- Sakuma Tai
- Sala Giuliano
- Salazar Ibarguen Humberto Antonio
- Salerno Roberto
- Salfeld-Nebgen Jakob
- Salur Sevil
- Salva Diblen Sinem
- Salvati Emmanuele
- Salvatore Michele
- Salvini Paola
- Sammet Jan
- Sanabria Juan Carlos
- Sander Christian
- Sanders David A.
- Sanders Stephen
- Sandoval Gonzalez Irving Daniel
- Sani Matteo
- Santanastasio Francesco
- Santaolalla Javier
- Santocchia Attilio
- Santoro Alberto
- Saoulidou Niki
- Sarangi Tapas
- Sarkar Subir
- Sauvan Jean-Baptiste
- Savin Alexander
- Savoy-Navarro Aurore
- Savrin Viktor
- Saxena Pooja
- Scarborough Tara
- Scarlini Enrico
- Schael Stefan
- Schettler Hannes
- Schilling Frank-Peter
- Schizzi Andrea
- Schlein Peter
- Schleper Peter
- Schlieckau Eike
- Schmidt Alexander
- Schmidt Ringo
- Schmitt Michael Henry
- Schmitz Stefan Antonius
- Schnetzer Steve
- Schoerner-Sadenius Thomas
- Schott Gregory
- Schröder Matthias
- Schulte Jan-Frederik
- Schwering Georg
- Schwick Christoph
- Schäfer Christoph
- Schöfbeck Robert
- Scinta Manuel
- Scodellaro Luca
- Searle Matthew
- Seez Christopher
- Segala Michael
- Seidel Markus
- Seitz Claudia
- Seixas Joao
- Sekaric Jadranka
- Sekmen Sezen
- Selvaggi Giovanna
- Selvaggi Michele
- Semenov Sergey
- Sen Sercan
- Senghi Soares Mara
- Senkin Sergey
- Seo Hyunkwan
- Serban Alin Titus
- Serin Meltem
- Servoli Leonello
- Seva Tomislav
- Sever Ramazan
- Sevova Stanislava
- Sexton-Kennedy Elizabeth
- Sgandurra Louis
- Sguazzoni Giacomo
- Shah Mehar Ali
- Shalhout Shalhout
- Sharan Manoj
- Sharma Archana
- Sharma Archana
- Sharma Monika
- Sharma Seema
- Sharma Varun
- Sharma Vivek
- Sharp Peter
- Shchutska Lesya
- Sheldon Paul
- Shepherd-Themistocleous Claire H.
- Shi Xin
- Shipsey Ian
- Shiu Jing-Ge
- Shivpuri Ram Krishen
- Shmatov Sergey
- Shoaib Muhammad
- Shrestha Shruti
- Shrinivas Amithabh
- Shukla Prashant
- Shumeiko Nikolai
- Siegrist Patrice
- Sigamani Michael
- Sikler Ferenc
- Silkworth Christopher
- Silva Pedro
- Silvers David
- Silvestris Lucia
- Simon Michal
- Simon Sean
- Simonetto Franco
- Simonis Hans-Jürgen
- Singh Anil
- Singh Gurpreet
- Singh Jasbir
- Singovsky Alexander
- Sinthuprasith Tutanon
- Sirois Yves
- Siroli Gian Piero
- Sirunyan Albert M.
- Skatchkov Nikolai
- Skhirtladze Nikoloz
- Skuja Andris
- Slaunwhite Jason
- Smirnov Igor
- Smirnov Vitaly
- Smith Geoffrey
- Smith James
- Smith John
- Smith Vincent J.
- Smith Wesley H.
- Snoek Hella
- Snook Benjamin
- Snow Gregory R.
- Snowball Matthew
- Sobol Andrei
- Soffi Livia
- Sogut Kenan
- Sola Valentina
- Solano Ada
- Somalwar Sunil
- Son Dong-Chul
- Song Sanghyeon
- Sonnenschein Lars
- Sordini Viola
- Sorokin Pavel
- Spagnolo Paolo
- Spalding William J.
- Spanier Stefan
- Spannagel Simon
- Sparrow Alex
- Speer Thomas
- Sperka David
- Sphicas Paraskevas
- Spiegel Leonard
- Spiezia Aniello
- Spiga Daniele
- Spiridonov Alexander
- Spiropulu Maria
- Sprenger Daniel
- Squillacioti Paola
- Squires Michael
- St John Jason
- Stadie Hartmut
- Stahl Achim
- Staiano Amedeo
- Starodumov Andrei
- Steck Pia
- Steggemann Jan
- Stein Matthias
- Steinbrück Georg
- Stenson Kevin
- Stephans George
- Stickland David
- Stieger Benjamin
- Stiliaris Efstathios
- Stober Fred-Markus Helmut
- Stolin Viatcheslav
- Stone Robert
- Stoye Markus
- Stoynev Stoyan
- Strauss Josef
- Streuli Silvan
- Stringer Robert
- Strobbe Nadja
- Strom Derek
- Stuart David
- Stupak John
- Sturdy Jared
- Stöckli Fabian
- Suarez Gonzalez Juan
- Suarez Indara
- Sudano Elizabeth
- Sudhakar Katta
- Sudic Lucija
- Sulak Lawrence
- Sulimov Valentin
- Sultanov Georgi
- Summers Don
- Sumorok Konstanty
- Sumowidagdo Suharyo
- Sun Werner
- Sunar Cerci Deniz
- Sung Kevin
- Surat Ugur Emrah
- Suwonjandee Narumon
- Svintradze Irakli
- Svyatkovskiy Alexey
- Swain Sanjay Kumar
- Swanson Joshua
- Swartz Morris
- Symonds Philip
- Szillasi Zoltan
- Szleper Michal
- Sznajder Andre
- Szwarc Tomasz
- Sánchez Hernández Alberto
- Tabarelli de Fatis Tommaso
- Tadel Matevz
- Takahashi Maiko
- Takasugi Eric
- Tali Bayram
- Tambe Norbert
- Tamponi Umberto
- Tan Ping
- Tao Junquan
- Tapper Alexander
- Taroni Silvia
- Tatarinov Aysen
- Taurok Anton
- Tauscher Ludwig
- Tavernier Stefaan
- Taylor Lucas
- Taylor Russell
- Temple Jeffrey
- Tenchini Roberto
- Teo Wee Don
- Teodorescu Liliana
- Teyssier Daniel
- Thea Alessandro
- Theofilatos Konstantinos
- Thom Julia
- Thomas Laurent
- Thomas Scott
- Thomassen Peter
- Thompson Joshua
- Thomson John
- Thyssen Filip
- Thüer Sebastian
- Tiko Andres
- Timciuc Vladlen
- Tinti Gemma
- Tiras Emrah
- Titov Maksym
- Tkaczyk Slawek
- Tlisov Danila
- To Wing
- Toback David
- Toda Sachiko
- Tomalin Ian R.
- Tomei Thiago
- Tonelli Manganote Edmilson José
- Tonelli Guido
- Tonjes Marguerite
- Tonwar Suresh C.
- Topakli Huseyin
- Topkar Anita
- Topsis-Giotis Iasonas
- Torassa Ezio
- Toropin Alexander
- Tosi Mia
- Tosi Nicolò
- Tosi Silvano
- Tourtchanovitch Leonid
- Traczyk Piotr
- Tran Nhan Viet
- Trapani Pier Paolo
- Travaglini Riccardo
- Traversi Gianluca
- Treberer-Treberspurg Wolfgang
- Treille Daniel
- Tricomi Alessia
- Trimpl Marcel
- Tripathi Mani
- Trocino Daniele
- Trocsanyi Zoltan Laszlo
- Troendle Daniel
- Tropea Paola
- Tropiano Antonio
- Troshin Sergey
- Troska Jan
- Trovato Marco
- Tsamalaidze Zviad
- Tsirou Andromachi
- Tu Yanjun
- Tucker Jordan
- Tully Christopher
- Tumasyan Armen
- Tuo Shengquan
- Tuominen Eija
- Tuominiemi Jorma
- Tuovinen Esa
- Turkewitz Jared
- Turner Mark
- Turner Paul
- Tuuva Tuure
- Tuve Cristina
- Tytgat Michael
- Tyurin Nikolay
- Tzeng Yeng-Ming
- Ujvari Balazs
- Ulmer Keith
- Ulrich Ralf
- Umer Tomo
- Uplegger Lorenzo
- Usai Emanuele
- Uvarov Lev
- Uzunian Andrey
- Vaandering Eric Wayne
- Valls Nil
- Valuev Vyacheslav
- Van Doninck Walter
- Van Haevermaet Hans
- Van Hove Pierre
- Van Lancker Luc
- Van Mechelen Pierre
- Van Mulders Petra
- Van Onsem Gerrit Patrick
- Van Remortel Nick
- Van Spilbeeck Alex
- Vander Donckt Muriel
- Vander Velde Catherine
- Vanelderen Lukas
- Vanlaer Pascal
- Vardarli Fuat Ilkehan
- Varela Joao
- Varelas Nikos
- Vartak Adish
- Vasey François
- Vavilov Sergey
- Vazquez Acosta Monica
- Vazquez Valencia Fabiola
- Veelken Christian
- Veeraraghavan Venkatesh
- Velasco Mayda
- Velicanu Dragos
- Velkovska Julia
- Venditti Rosamaria
- Venturi Andrea
- Verdier Patrice
- Verdini Piero Giorgio
- Veres Gabor Istvan
- Vergili Mehmet
- Verlaat Bart
- Verlage Tobias Anton
- Vernieri Caterina
- Verwilligen Piet
- Verzetti Mauro
- Veszpremi Viktor
- Vesztergombi Gyorgy
- Veverka Jan
- Vichoudis Paschalis
- Vidal Marono Miguel
- Vidal Richard
- Vila Ivan
- Vilar Cortabitarte Rocio
- Vilela Pereira Antonio
- Villasenor-Cendejas Luis Manuel
- Villella Ilaria
- Vinogradov Alexey
- Virdee Tejinder
- Viret Sébastien
- Vischia Pietro
- Vishnevskiy Dmitry
- Vitulo Paolo
- Vizan Garcia Jesus Manuel
- Vlasov Evgueni
- Vlimant Jean-Roch
- Vogel Helmut
- Voirin Erik
- Volkov Alexey
- Volobouev Igor
- Volpe Roberta
- von Gunten Hans Peter
- Vorobiev Igor
- Vorobyev Alexey
- Vorobyev Andrey
- Voutilainen Mikko
- Vuosalo Carl
- Vutova Mariana
- Wagner Stephen Robert
- Wagner-Kuhr Jeannine
- Wakefield Stuart
- Walker Matthew
- Wallny Rainer
- Walsh Roberval
- Walsh Sinead
- Waltenberger Wolfgang
- Wang Dayong
- Wang Fuqiang
- Wang Jian
- Wang Minzu
- Wang Quan
- Wang Xianyou
- Wang Zheng
- Wardle Nicholas
- Wasserbaech Steven
- Wayand Stefan
- Wayne Mitchell
- Weber Hannsjoerg Artur
- Weber Hendrik
- Weber Martin
- Weber Matthias
- Weiler Thomas
- Weinberg Marc
- Wendland Lauri
- Weng Yao
- Werner Jeremy Scott
- West Christopher
- Wetzel James
- Whitbeck Andrew
- White Dean
- Whitmore Juliana
- Wickramage Nadeesha
- Wilbur Scott
- Wilken Rachel
- Wilkinson Richard
- Williams Thomas
- Willmott Carlos
- Wimpenny Stephen
- Winer Brian L.
- Winn Dave
- Winstrom Lucas
- Wissing Christoph
- Wittich Peter
- Wittmer Bruno
- Wlochal Michael
- Wolf Matthias
- Wolf Roger
- Wolfe Homer
- Wolszczak Weronika
- Womersley William John
- Won Steven
- Wood Darien
- Wood Jeffrey Scott
- Wood John
- Woodard Anna
- Woods Nathaniel
- Worm Steven
- Wright Douglas
- Wrochna Grzegorz
- Wu Weimin
- Wulsin Howard Wells
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Würthwein Frank
- Xiao Hong
- Xiao Meng
- Xie Si
- Xie Wei
- Xu Lingshan
- Yagil Avraham
- Yalvac Metin
- Yang Fan
- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Yücel Mete
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zeise Manuel
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zheng Yu
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zielinski Marek
- Zito Giuseppe
- Zoccarato Yannick
- Zotto Pierluigi
- Zou Wei
- Zsigmond Anna Julia
- Zuber Adam
- Zucca Stefano
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Zwalinski Lukasz
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Mapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M
- Abdullah T
- Abe R
- Abe S
- Abecasis GR
- Abel L
- Abernathy C
- Abraheem A
- Abul-Husn NS
- Acosta-Herrera M
- Acquilini D
- Acquilini D
- Adachi T
- Adachi Y
- Adams C
- Adams K
- Adanini O
- Adeleye O
- Adeniji K
- Adra D
- Afifi N
- Afilalo J
- Afilalo M
- Afolabi D
- Afrasiabi Z
- Afset JE
- Agasou A
- Aghemo A
- Agranoff D
- Agrawal S
- Aguirre LA
- Agwuh K
- Ahmad HF
- Ahmad N
- Ahmed A
- Ahmed C
- Ahmed KA
- Ai M
- Ail D
- Akeroyd L
- Akhtar MN
- Akhtar S
- Akinkugbe O
- Aksentijevich A
- Al Thani A
- Al-Muftah W
- Al-Sarraj Y
- Alarcon C
- Alarcon-Riquelme ME
- Alasdair F
- Alaverdian D
- Alavere H
- Albertos R
- Albillos A
- Albrecht W
- Albrich W
- Albrich WC
- Aldera EL
- Aldridge J
- Alegria A
- Alex B
- Alexander P
- Alfonso J
- Algera AG
- Ali A
- Ali IMA
- Ali S
- Aliberti S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen S
- Allibone S
- Allison KS
- Allos R
- Ally SM
- Almaden-Boyle C
- Altabaibeh A
- Altmueller J
- Alvaro A
- Amar D
- Amin V
- Amitrano S
- Amiya S
- Ampuero J
- Anan R
- Anania S
- Anastasescu E
- Anderson F
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Ando A
- Andolfo I
- Andrade V
- Andretta F
- Andreucci E
- Andreucci E
- Andrew A
- Andrew B
- Andrew G
- Andrews E
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrews SJ
- Andrikopoulos P
- Anedda F
- Aneli S
- Anemoli V
- Angelini C
- Angus B
- Annis A
- Antcliffe D
- Antinori A
- Antoni MD
- Anumakonda V
- Anwar M
- Anzai T
- Apetri E
- Arai D
- Arana E
- Arbane G
- Archer K
- Arciero E
- Arden T
- Arias SS
- Arif S
- Arimura K
- Armstrong J
- Armstrong JA
- Armstrong L
- Armstrong R
- Arning N
- Arnold S
- Arora J
- Artuso R
- Arumugam P
- Asakura T
- Asano K
- Aschard H
- Ascolillo S
- Ashish A
- Ashley E
- Ashraf S
- Ashraf S
- Ashton L
- Ashworth M
- Asiimwe IG
- Aslibekyan S
- Asselta R
- Atanasovska B
- Atkinson D
- Atkinson EG
- Attwood B
- Aucella F
- Augustin M
- Auld D
- Auld F
- Austin K
- Austin P
- Auton A
- Auton A
- Avendano-Ortiz J
- Awano N
- Ayers A
- Azarzar S
- Aziz F
- Azuma M
- Azuure C
- Azzolini E
- Baba R
- Baba T
- Bach B
- Bacher P
- Bachetti T
- Badalamenti S
- Badia JR
- Badji RM
- Bahmer T
- Baikady RR
- Baillie JK
- Baillie JK
- Baillie JK
- Baillie JK
- Baines B
- Baines D
- Baines K
- Baird T
- Baird Y
- Bakshi S
- Bakthavatsalam D
- Balaconis MK
- Baldassarri M
- Baldini M
- Ball CA
- Bals R
- Baltzell AH
- Bamford A
- Bamford P
- Banach D
- Banagan J
- Banales JM
- Bancroft H
- Band G
- Bandera A
- Bandini M
- Bandla N
- Bano S
- Baptista D
- Barada O
- Baras A
- Baratti S
- Barber R
- Barbieri C
- Barbieri C
- Barbour A
- Barclay L
- Barclay WS
- Barda B
- Bargagli E
- Bari S
- Barker J
- Barlow G
- Barlow SL
- Barnass S
- Barnes KC
- Baroni S
- Baroni S
- Barreira A
- Barrett F
- Barrett KMS
- Barrett N
- Barron A
- Barry P
- Bartels M
- Bartley S
- Baruah R
- Baselli G
- Bashyal A
- Basikolo C
- Bassetti M
- Bassford C
- Basso MEF
- Bastion V
- Basude S
- Bates H
- Bates M
- Battle C
- Bauchmuller K
- Bax D
- Baxter D
- Baxter N
- Baya N
- Bayo L-A
- Beadle J
- Beadsworth M
- Beale R
- Bean S
- Beaumont K
- Beavis S
- Beck A
- Beckmann ND
- Beech E
- Beech V
- Beekes M
- Beesley K
- Begg C
- Beguin Y
- Behan T
- Beith CM
- Belagodu Z
- Belbin GM
- Belfield H
- Belhaj Y
- Beligni G
- Belisle A
- Bell D
- Bell G
- Bell M
- Bellamy M
- Belli MA
- Bellinghausen C
- Bellini A
- Bellwood R
- Below JE
- Bemand T
- Benetti E
- Benham L
- Bennet D
- Bennett S
- Bentley M
- Benyon S
- Beppu S
- Beranova E
- Bercades G
- Bergan J
- Bergantini L
- Berger MM
- Bergomi M
- Bergomi P
- Berkowitz N
- Bernardo D
- Bernasconi A
- Bernatoniene J
- Berridge J
- Bertrand A
- Best N
- Bettini LR
- Beudel M
- Bevan E
- Bewley J
- Bhardwaj N
- Bhatia N
- Bhatterjee R
- Bhuie P
- Bi R
- Bianchi F
- Bianco C
- Bibert S
- Bibert S
- Bibi F
- Biddle J
- Biesecker L
- Biggs H
- Biondi A
- Birch J
- Birch J
- Birch S
- Birchall K
- Birchall K
- Bird S
- Birkinshaw I
- Birney E
- Birt M
- Biscarini F
- Black E
- Black K
- Blackledge B
- Blackledge B
- Blackman H
- Blakemore H
- Blanco-Grau A
- Blasi F
- Blay N
- Blay N
- Blow S
- Blunt M
- Boada M
- Board S
- Bocciardi R
- Bocciolone M
- Bochud M
- Bochud P-Y
- Bochud PY
- Bochud PY
- Bochud PY
- Bociek A
- Boer C
- Boezen M
- Bogaard HJ
- Bogaert D
- Boillat N
- Boillat-Blanco N
- Bokhari M
- Bolton M
- Bolton R
- Bolze A
- Bombace S
- Bomers M
- Bonfanti P
- Bonner S
- Bonta PI
- Booker L
- Booth L
- Booth S
- Borislavova B
- Borra C
- Bos L
- Bosari S
- Bosio G
- Bosse Y
- Botello A
- Bothma P
- Botta G
- Botta M
- Boua PR
- Bouab M
- Bough L
- Boughton AP
- Boujemla B
- Bouras K
- Boutros P
- Bouysran Y
- Bowes A
- Bowles R
- Boyle P
- Boyle R
- Boz C
- Bradford Y
- Bradley C
- Bradley P
- Bradley-Potts J
- Bradshaw Z
- Brady A
- Brady M
- Brady R
- Brahier T
- Brandwood C
- Branney D
- Brantwood C
- Brassard N
- Braun A
- Braun N
- Brayne A
- Brealey D
- Brealey D
- Breen G
- Bremmer P
- Brennan B
- Brenner B
- Brenner T
- Bretherick AD
- Brett M
- Brett S
- Brickell K
- Bridgett V
- Brimfield L
- Brinkworth E
- Briton K
- Brittain-Long R
- Britvan B
- Bromley M
- Brooke H
- Brooks S
- Brouwer MC
- Brown A
- Brown A
- Brown A
- Brown CW
- Brown E
- Brown J
- Bruce M
- Brunak S
- Bruno R
- Brunton M
- Brusco A
- Bruttini M
- Bryant J
- Bryant S
- Bryant S
- Buckley C
- Buckley S
- Bugiani M
- Bujanda L
- Bulik CM
- Bulle E
- Bullock K
- Bulteel N
- Bunni L
- Burda D
- Burden T
- Burn I
- Burnett C
- Burns K
- Burt K
- Burtenshaw A
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- zu Bentrup FM
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- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
Orbital electron capture by the nucleus
- Author
- Abers E. S.
- Adam I.
- Adam N.
- Adamovicz B.
- Albrecht G.
- Alburger D. E.
- Alburger D. E.
- Allen R. A.
- Alvarez L. W.
- Alvarez L. W.
- Alvarez L. W.
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- Anderson C. E.
- Andersson G.
- Arbman E.
- Armstrong L.
- Asai J.
- Aston G. H.
- Auble R. L.
- Auble R. L.
- Avignon P.
- Avignon P.
- Avignon P.
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- Bahcall J. N.
- Bahcall J. N.
- Bahcall J. N.
- Bakhru H.
- Bambynek W.
- Bambynek W.
- Bambynek W.
- Bambynek W.
- Bambynek W.
- Bambynek W.
- Bambynek W.
- Bambynek W.
- Band I. M.
- Band I. M.
- Baskova K. A.
- Baskova K. A.
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- Bayer G.
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- Field of study