Cardiovascular risk assessment using carotid ultrasonography: The Rotterdam Study

Atherosclerosis is the main cause of coronary heart disease, stroke and peripheral arterial disease. These cardiovascular diseases are the most important cause of morbidity and responsible for 50% of all mortality in the United States, Europe and much of Asia. l Since atherosclerosis and cardiovascular diseases are most prominently present in the elderly and the number of elderly people will increase in the coming decades, atherosclerosis-related diseases will put a heavy burden on our health care systems

Assessment the SlidingWear Behavior of Laser Microtexturing Ti6Al4V under Wet Conditions

Laser micro-texturing processes, compared to untreated surfaces, can improve the friction, wear and wettability behavior of sliding parts. This improvement is related to the micro-geometry and the dimensions of the texture which is also dependent on the processing parameters. This research studied the effect of laser textured surfaces on the tribological behavior of titanium alloy Ti6Al4V. The influence of processing parameters was analyzed by changing the scanning speed of the beam and the energy density of pulse. First, the characterization of dimensional and geometrical features of the texturized tracks was carried out. Later, their influence on the wetting behavior was also evaluated through contact angle measurements using water as a contact fluid. Then, the tribological performance of these surfaces was analyzed using a ball-on-flat reciprocating tribometer under wet and dry conditions. Finally, wear mechanisms were identified employing electronic and optical microscopy techniques capable to evaluate the wear tracks on Ti surfaces and WC–Co spheres. These analyses had determined a strong dependence between the wear behavior and the laser patterning parameters. Wear friction effects were reduced by up to a 70% replacing conventional untreated surfaces of Ti6Al4V alloy with laser textured surfaces

New age constraints for the Salamanca Formation and lower Río Chico Group in the western San Jorge Basin, Patagonia, Argentina: Implications for Cretaceous-Paleogene extinction recovery and land mammal age correlations

The Salamanca Formation of the San Jorge Basin (Patagonia, Argentina) preserves critical records of Southern Hemisphere Paleocene biotas, but its age remains poorly resolved, with estimates ranging from Late Cretaceous to middle Paleocene. We report a multi-disciplinary geochronologic study of the Salamanca Formation and overlying Rio Chico Group in the western part of the basin. New constraints include (1) an 40Ar/39Ar age determination of 67.31 ± 0.55 Ma from a basalt flow underlying the Salamanca Formation, (2) micropaleontological results indicating an early Danian age for the base of the Salamanca Formation, (3) laser ablation HR-MC-ICP-MS (high resolution-multi collector-inductively coupled plasma-mass spectrometry) U-Pb ages and a high-resolution TIMS (thermal ionization mass spectrometry) age of 61.984 ± 0.041(0.074)[0.100] Ma for zircons from volcanic ash beds in the Penas Coloradas Formation (Rio Chico Group), and (4) paleomagnetic results indicating that the Salamanca Formation in this area is entirely of normal polarity, with reversals occurring in the Rio Chico Group. Placing these new age constraints in the context of a sequence stratigraphic model for the basin, we correlate the Salamanca Formation in the study area to Chrons C29n and C28n, with the Banco Negro Inferior (BNI), a mature widespread fossiliferous paleosol unit at the top of the Salamanca Formation, corresponding to the top of Chron C28n. The diverse paleobotanical assemblages from this area are here assigned to C28n (64.67–63.49 Ma), ∼2–3 million years older than previously thought, adding to growing evidence for rapid Southern Hemisphere floral recovery after the Cretaceous-Paleogene extinction. Important Peligran and “Carodnia” zone vertebrate fossil assemblages from coastal BNI and Penas Coloradas exposures are likely older than previously thought and correlate to the early Torrejonian and early Tiffanian North American Land Mammal Ages, respectively.Centro de Investigaciones Geográfica

Salud mental y derecho. Derechos Sociales e Intersectorialidad.

Contenido Nos volvemos a encontrar. Un poco de historia............................... 5 PRIMERA PARTE: LÍNEAS GENERALES Capítulo 1. Los derechos sociales como derechos fundamentales. Reflexiones introductorias en un libro sobre derecho a la salud (mental) Andrés Rosetti.............................................................................................. 17 Capítulo 2. Los modelos de la discapacidad y la Convención sobre los Derechos de las Personas con Discapacidad Mariana Gandolfo y Martín Passini....31 SEGUNDA PARTE: Capítulo 3 Derecho a la tierra y vivienda: una mirada crítica a las políticas públicas en la provincia de Córdoba (2001-2015) Ana Laura Elorza y Mariana Gamboa.......................................................................................55 Capítulo 4. Casa de convivencia autogestionada en Córdoba: Una experiencia de externación. Roxana Serafín, Alejandra Arizó y Mirna Ramos............. 73 TERCERA PARTE: TRABAJO Capítulo 5. La Salud Mental en el Derecho del Trabajo. Silvia Díaz ................. 87 Capítulo 6. Una experiencia de inclusión laboral en salud mental. Adriana Vitelli y Eugenia Fruttero............................................................................. 113 CUARTA PARTE: EDUCACIÓN Capítulo 7. ¿Qué significa tener “derecho a la educación”? Horacio Etchichury 123 Capítulo 8. Educación, niñez y salud mental: El Forum Infancias y la salud mental. Analía Giannone y Marta Moreno........................................ 137 QUINTA PARTE: JUSTICIA Capítulo 9. Proceso de limitación de capacidad: Rol del Ministerio Público. Eloisa del Valle Sacco...................................................................... 153 Capítulo 10. Salud Mental Forense: Superación del esquema biologicista por el enfoque psicosocial. Alfonsina Gabriela Muñiz............................... 169 Capítulo 11. Medidas de seguridad respecto de inimputables adultos por incapacidad mental: principios generales y garantías. José Daniel Cesano ........................................................................................... 179 Capítulo 12. Nadie muere porque sí: Suicidio, libertad y control. Natalia Monasterolo.................................................................................... 193 SEXTA PARTE: INTERSECTORIALIDAD Capítulo 13. Políticas intersectoriales para el abordaje integral en salud mental: La complejidad de la acción conjunta. Jacinta Burijovich................ 221 Capítulo 14. Cobertura Universal en Salud: entre los derechos y el mercado. Iván Ase ................................................................................................ 235 Capítulo 15 Derechos Sociales y Salud Mental: De la vulneración de derechos y la exclusión social a políticas públicas integrales. Solana María Yoma.259 SÉPTIMA PARTE: PRODUCCIONES y RECORRIDOS ESPECÍFICOS EN EL TERRENO DE LA SALUD MENTAL Capítulo 16. La atención en salud mental en Hospitales Generales. María Paz Caminada Rossetti, Sol Victoria del Carpio y Ana Heredia................. 275 Capítulo 17. Resolución de las situaciones de crisis y urgencia en salud mental desde el enfoque de Derechos Humanos. Soledad Buhlman, Jéssica Ferreyra y Ana Heredia.................................................................... 295 OCTAVA PARTE: INTERVENCIONES ORALES Registro auditivo: Presentación del libro Cruzar el muro: desafíos y propuestas para la externación del manicomio (Centro de Estudios Legales y Sociales- CELS) Macarena Sabin Paz y Víctor Rodríguez.. 313 Registro auditivo: El Órgano de Revisión de la Ley Nacional de Salud Mental................................................................................. 325 Datxs de los autorxs ..................................................................... 337Después de "Salud mental y derecho. Reflexiones en torno a un nuevo paradigma", sociabilizado durante el año 2016, nos volvemos a encontrar en este texto correlato literario del Seminario de Salud mental y Derechos Humanos, ese espacio de poli-formación que comenzamos a construir durante un cálido septiembre del año 2014 y que aún hoy continúa marchando. Dos año pasaron desde la primera poligrafía, suficientes para acumular experiencias e intercambios, mas para volver a asomarnos desde la escritura a una coyuntura ciertamente distinta. En la ocasión, producto de algunos cruces efectuados durante el año 2015 y de las intensas jornadas que dieron cuerpo al Seminario del año 2016, nos colocamos en clave de Derechos Económicos, Sociales y Culturales (injustamente designados como derechos de segunda y acertadamente nominados como derechos sociales), para abrir la puerta a la intersectorialidad. A lo largo de este texto, construído colectivamente a partir de diferentes posiciones epistémicas, el lector podrá reflexionar en clave de salud mental desde diversos derechos y circulaciones (trabajo, vivienda, educación, justicia, etc.) para preguntar y responder(se) al mismo tiempo de qué hablamos cuando hablamos de salud. Esperamos que la inquietud resulte lo suficientemente intolerable para voltear esta contratapa y auspiciar una zambullida en las páginas que se le anteponen (Extraído de la contratapa).Universidad Nacional de Córdob

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics

Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.

Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics

Plasma lipid profiles discriminate bacterial from viral infection in febrile children

Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection ar