Measurement of dijet photoproduction for events with a leading neutron at HERA

Differential cross sections for dijet photoproduction and this process in association with a leading neutron, e+ + p -> e+ + jet + jet + X (+ n), have been measured with the ZEUS detector at HERA using an integrated luminosity of 40 pb-1. The fraction of dijet events with a leading neutron was studied as a function of different jet and event variables. Single- and double-differential cross sections are presented as a function of the longitudinal fraction of the proton momentum carried by the leading neutron, xL, and of its transverse momentum squared, pT^2. The dijet data are compared to inclusive DIS and photoproduction results; they are all consistent with a simple pion-exchange model. The neutron yield as a function of xL was found to depend only on the fraction of the proton beam energy going into the forward region, independent of the hard process. No firm conclusion can be drawn on the presence of rescattering effects.Comment: 40 pages, 18 figure

Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts

Background: Patients with COVID-19-related acute respiratory distress syndrome (ARDS) have been postulated to present with distinct respiratory subphenotypes. However, most phenotyping schema have been limited by sample size, disregard for temporal dynamics, and insufficient validation. We aimed to identify respiratory subphenotypes of COVID-19-related ARDS using unbiased data-driven approaches. Methods: PRoVENT–COVID was an investigator-initiated, national, multicentre, prospective, observational cohort study at 22 intensive care units (ICUs) in the Netherlands. Consecutive patients who had received invasive mechanical ventilation for COVID-19 (aged 18 years or older) served as the derivation cohort, and similar patients from two ICUs in the USA served as the replication cohorts. COVID-19 was confirmed by positive RT-PCR. We used latent class analysis to identify subphenotypes using clinically available respiratory data cross-sectionally at baseline, and longitudinally using 8-hourly data from the first 4 days of invasive ventilation. We used group-based trajectory modelling to evaluate trajectories of individual variables and to facilitate potential clinical translation. The PRoVENT-COVID study is registered with ClinicalTrials.gov, NCT04346342. Findings: Between March 1, 2020, and May 15, 2020, 1007 patients were admitted to participating ICUs in the Netherlands, and included in the derivation cohort. Data for 288 patients were included in replication cohort 1 and 326 in replication cohort 2. Cross-sectional latent class analysis did not identify any underlying subphenotypes. Longitudinal latent class analysis identified two distinct subphenotypes. Subphenotype 2 was characterised by higher mechanical power, minute ventilation, and ventilatory ratio over the first 4 days of invasive mechanical ventilation than subphenotype 1, but PaO2/FiO2, pH, and compliance of the respiratory system did not differ between the two subphenotypes. 185 (28%) of 671 patients with subphenotype 1 and 109 (32%) of 336 patients with subphenotype 2 had died at day 28 (p=0·10). However, patients with subphenotype 2 had fewer ventilator-free days at day 28 (median 0, IQR 0–15 vs 5, 0–17; p=0·016) and more frequent venous thrombotic events (109 [32%] of 336 patients vs 176 [26%] of 671 patients; p=0·048) compared with subphenotype 1. Group-based trajectory modelling revealed trajectories of ventilatory ratio and mechanical power with similar dynamics to those observed in latent class analysis-derived trajectory subphenotypes. The two trajectories were: a stable value for ventilatory ratio or mechanical power over the first 4 days of invasive mechanical ventilation (trajectory A) or an upward trajectory (trajectory B). However, upward trajectories were better independent prognosticators for 28-day mortality (OR 1·64, 95% CI 1·17–2·29 for ventilatory ratio; 1·82, 1·24–2·66 for mechanical power). The association between upward ventilatory ratio trajectories (trajectory B) and 28-day mortality was confirmed in the replication cohorts (OR 4·65, 95% CI 1·87–11·6 for ventilatory ratio in replication cohort 1; 1·89, 1·05–3·37 for ventilatory ratio in replication cohort 2). Interpretation: At baseline, COVID-19-related ARDS has no consistent respiratory subphenotype. Patients diverged from a fairly homogenous to a more heterogeneous population, with trajectories of ventilatory ratio and mechanical power being the most discriminatory. Modelling these parameters alone provided prognostic value for duration of mechanical ventilation and mortality. Funding: Amsterdam UMC

Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study

Background: Little is known about the practice of ventilation management in patients with COVID-19. We aimed to describe the practice of ventilation management and to establish outcomes in invasively ventilated patients with COVID-19 in a single country during the first month of the outbreak. Methods: PRoVENT-COVID is a national, multicentre, retrospective observational study done at 18 intensive care units (ICUs) in the Netherlands. Consecutive patients aged at least 18 years were eligible for participation if they had received invasive ventilation for COVID-19 at a participating ICU during the first month of the national outbreak in the Netherlands. The primary outcome was a combination of ventilator variables and parameters over the first 4 calendar days of ventilation: tidal volume, positive end-expiratory pressure (PEEP), respiratory system compliance, and driving pressure. Secondary outcomes included the use of adjunctive treatments for refractory hypoxaemia and ICU complications. Patient-centred outcomes were ventilator-free days at day 28, duration of ventilation, duration of ICU and hospital stay, and mortality. PRoVENT-COVID is registered at ClinicalTrials.gov (NCT04346342). Findings: Between March 1 and April 1, 2020, 553 patients were included in the study. Median tidal volume was 6·3 mL/kg predicted bodyweight (IQR 5·7–7·1), PEEP was 14·0 cm H2O (IQR 11·0–15·0), and driving pressure was 14·0 cm H2O (11·2–16·0). Median respiratory system compliance was 31·9 mL/cm H2O (26·0–39·9). Of the adjunctive treatments for refractory hypoxaemia, prone positioning was most often used in the first 4 days of ventilation (283 [53%] of 530 patients). The median number of ventilator-free days at day 28 was 0 (IQR 0–15); 186 (35%) of 530 patients had died by day 28. Predictors of 28-day mortality were gender, age, tidal volume, respiratory system compliance, arterial pH, and heart rate on the first day of invasive ventilation. Interpretation: In patients with COVID-19 who were invasively ventilated during the first month of the outbreak in the Netherlands, lung-protective ventilation with low tidal volume and low driving pressure was broadly applied and prone positioning was often used. The applied PEEP varied widely, despite an invariably low respiratory system compliance. The findings of this national study provide a basis for new hypotheses and sample size calculations for future trials of invasive ventilation for COVID-19. These data could also help in the interpretation of findings from other studies of ventilation practice and outcomes in invasively ventilated patients with COVID-19. Funding: Amsterdam University Medical Centers, location Academic Medical Center

Inclusive dijet cross sections in neutral current deep inelastic scattering at HERA

Single- and double-differential inclusive dijet cross sections in neutral current deep inelastic ep scattering have been measured with the ZEUS detector using an integrated luminosity of 374 pb(-1). The measurement was performed at large values of the photon virtuality, Q (2), between 125 and 20 000 GeV2. The jets were reconstructed with the k (T) cluster algorithm in the Breit reference frame and selected by requiring their transverse energies in the Breit frame, E-jet (T,B), to be larger than 8 GeV. In addition, the invariant mass of the dijet system, M-jj,M- was required to be greater than 20 GeV. The cross sections are described by the predictions of next-to-leading-order QCD

A QCD analysis of ZEUS diffractive data

ZEUS inclusive diffractive-cross-section measurements have been used in a DGLAP next-to-leading-order QCD analysis to extract the diffractive parton distribution functions. Data on diffractive dijet production in deep inelastic scattering have also been included to constrain the gluon density. Predictions based on the extracted parton densities are compared to diffractive charm and dijet photoproduction data. (C) 2010 Elsevier B.V. All rights reserved

Production of Z⁰ bosons in elastic and quasi-elastic <i>ep</i> collisions at HERA

The production of Z&lt;sup&gt;0&lt;/sup&gt; bosons in the reaction ep→eZ&lt;sup&gt;0&lt;/sup&gt;p&lt;sup&gt;(⁎)&lt;/sup&gt;, where p&lt;sup&gt;(⁎)&lt;/sup&gt; stands for a proton or a low-mass nucleon resonance, has been studied in &lt;i&gt;ep&lt;/i&gt; collisions at HERA using the ZEUS detector. The analysis is based on a data sample collected between 1996 and 2007, amounting to 496 pb&lt;sup&gt;−1&lt;/sup&gt; of integrated luminosity. The Z&lt;sup&gt;0&lt;/sup&gt; was measured in the hadronic decay mode. The elasticity of the events was ensured by a cut on ηmax&lt;3.0, where η&lt;sub&gt;max&lt;/sub&gt; is the maximum pseudorapidity of energy deposits in the calorimeter defined with respect to the proton beam direction. A signal was observed at the Z&lt;sup&gt;0&lt;/sup&gt; mass. The cross section of the reaction ep→ eZ&lt;sup&gt;0&lt;/sup&gt;p&lt;sup&gt;(⁎)&lt;/sup&gt; was measured to be σ(ep→ eZ&lt;sup&gt;0&lt;/sup&gt;p&lt;sup&gt;(⁎)&lt;/sup&gt;)=0.13±0.06(stat.)±0.01(syst.) pb, in agreement with the Standard Model prediction of 0.16 pb. This is the first measurement of Z&lt;sup&gt;0&lt;/sup&gt; production in &lt;i&gt;ep&lt;/i&gt; collisions

Measurement of the t dependence in exclusive photoproduction of Υ\Upsilon(1S) mesons at HERA

The exclusive photoproduction reaction gamma p -> Upsilon(1S) p has been studied with the ZEUS detector in ep collisions at HERA using an integrated luminosity of 468 pb^-1. The measurement covers the kinematic range 60<W<220 GeV and Q^2<1 GeV^2, where W is the photon-proton centre-of-mass energy and Q^2 is the photon virtuality. The exponential slope, b, of the t dependence of the cross section, where t is the squared four-momentum transfer at the proton vertex, has been measured, yielding b = 4.3 +2.0 -1.3 (stat.) +0.5 -0.6 (syst.) GeV^-2. This constitutes the first measurement of the t dependence of the gamma p -> Upsilon(1S) p cross section.Comment: 15 pages, 4 figures; http://dx.doi.org/10.1016/j.physletb.2012.01.00

Measurement of the Energy Dependence of the Total Photon-Proton Cross Section at HERA

The energy dependence of the photon-proton total cross section, σtotγp, was determined from e+p scattering data collected with the ZEUS detector at HERA at three values of the center-of-mass energy, W, of the γp system in the range 19

Measurement of isolated photon production in deep inelastic epep scattering

Isolated photon production in deep inelastic ep scattering has been measured with the ZEUS detector at HERA using an integrated luminosity of 320 pb - 1. Measurements were made in the isolated-photon transverse-energy and pseudorapidity ranges 4 &lt; E Tγ &lt; 15 GeV and - 0.7 &lt; η γ &lt; 0.9 for exchanged photon virtualities, Q 2, in the range 10 &lt; Q 2 &lt; 350 GeV 2 and for invariant masses of the hadronic system W X &gt; 5 GeV. Differential cross sections are presented for inclusive isolated photon production as functions of Q 2, x, E Tγ and η γ. Leading-logarithm parton-shower Monte Carlo simulations and perturbative QCD predictions give a reasonable description of the data over most of the kinematic range. © 2010 Elsevier B.V