Karakteristik Penderita Glaukoma di Klinik Mata Rumah Sakit Muhammadiyah Palembang Tahun 2011

Glaukoma adalah suatu keadaan dimana terjadi peningkatan tekanan intraokuler didalam bola mata sehinggamenyebabkan penyempitan lapang pandang dan kerusakan saraf optik ataupun buta meskipun juga ditemuipenderita yang tidak mengalami peningkatan tekanan intraokuler. Untuk mengetahui distribusi karakteristikpenderita glaukoma dilakukan penelitian di Rumah Sakit Muhammadiyah Palembang tahun 2011, dilakukanpenelitian deskriptif dengan desain cross sectional. Sampel pada penelitian ini adalah 53 orang. Dari hasilpenelitian didapatkan insidensi glaukoma 6,17%, distribusi karakteristik penderita glaukoma terbanyak adalahkelompok umur 40 - 65 tahun (64,2%), jenis kelamin perempuan (62,3%), suku tidak tercatat (100%), Pekerjaantidak bekerja (34%), keluhan kerusakan lapang pandang (34%), jenis glaukoma sudut terbuka (50,9%), riwayatterdapat riwayat penyakit (71,7%), riwayat penyakit hipertensi (52,7%), penatalaksanaan medis operasi(50,9%), nilai rata-rata pemeriksaan tekanan intraokuler pada mata kanan yang pertama 28,443 mmHg, kedua22,647 mmHg, ketiga 19,572 mmHg, sedangkan yang pada mata kiri yang pertama 25,349 mmHg, kedua 22,111dan yang ketiga 18,151 mmHg. Dengan diketahuinya karakteristik dari penderita glaukoma, diharapkan untukpihak Rumah Sakit Muhammadiyah Palembang untuk melakukan penyuluhan terutama kepada pasien yangmenderita hipertensi karena riwayat penyakit hipertensi cukup tinggi memberikan distribusi karakteristikpenderita glaukoma dan untuk mengisi rekam medik pasien secara lengkap

Tetrabutylammonium methacrylate as a novel receptor for selective extraction of sulphonylurea drugs from biological fluids using molecular imprinting

Tetrabutylammonium methacrylate introduced as functional monomer for the stoichiometric imprinting of sulfonylurea drug glibenclamide.</p

Trends in bone metastasis modeling

Bone is one of the most common sites for cancer metastasis. Bone tissue is composed by different kinds of cells that coexist in a coordinated balance. Due to the complexity of bone, it is impossible to capture the intricate interactions between cells under either physiological or pathological conditions. Hence, a variety of in vivo and in vitro approaches have been developed. Various models of tumor\u2013bone diseases are routinely used to provide valuable information on the relationship between metastatic cancer cells and the bone tissue. Ideally, when modeling the metastasis of human cancers to bone, models would replicate the intra-tumor heterogeneity, as well as the genetic and phenotypic changes that occur with human cancers; such models would be scalable and reproducible to allow high-throughput investigation. Despite the continuous progress, there is still a lack of solid, amenable, and affordable models that are able to fully recapitulate the biological processes happening in vivo, permitting a correct interpretation of results. In the last decades, researchers have demonstrated that three-dimensional (3D) methods could be an innovative approach that lies between bi-dimensional (2D) models and animal models. Scientific evidence supports that the tumor microenvironment can be better reproduced in a 3D system than a 2D cell culture, and the 3D systems can be scaled up for drug screening in the same way as the 2D systems thanks to the current technologies developed. However, 3D models cannot completely recapitulate the inter-and intra-tumor heterogeneity found in patients. In contrast, ex vivo cultures of fragments of bone preserve key cell\u2013cell and cell\u2013matrix interactions and allow the study of bone cells in their natural 3D environment. Moreover, ex vivo bone organ cultures could be a better model to resemble the human pathogenic metastasis condition and useful tools to predict in vivo response to therapies. The aim of our review is to provide an overview of the current trends in bone metastasis modeling. By showing the existing in vitro and ex vivo systems, we aspire to contribute to broaden the knowledge on bone metastasis models and make these tools more appealing for further translational studies

Antimicrobial and Free Radical Scavenging Potentials of N-Hexane and Ethyl Acetate Fractions of Phyllanthus Fraternus

The genus Phyllanthus (Phyllantaceae) is widely used in the african system of traditional medicine and is reported to have various biological activities. In this study, antimicrobial and antioxidant activities of n-hexane and ethyl acetate fractions of Phyllanthus fraternus leaves were investigated. The antimicrobial screening was carried out against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruguinosa, Salmonella typhi and Klebsiella pneumoniae, using Agar-well diffusion method. The antioxidant activity was carried out using DPPH free radical scavenging capacity. The results show that fractions of Phyllanthus fraternus leaves have DPPH radical scavenging activities with IC50 value of 263.53 mg/mL and 143.56 mg/mL for n-hexane and ethyl acetate fractions respectively. For n-hexane fraction, the MICs of the extract were; 80 mg/mL against K. pneumoniae and S. aureus,120 mg/mL against P. aeruginosa and S. typhi, and 160 mg/mL against E. Coli. However, ethyl acetate fraction had MICs of 80 mg/mL against all test organisms except S. aureus (40 mg/mL). The n-hexane and ethyl acetate fractions of Phyllanthus fraternus leaves exhibited considerable antioxidant and antimicrobial properties, with ethyl acetate fraction been the most potent. This plant extract can be regarded as promising resource for antimicrobial and antioxidant drugs.Keywords: Antioxidant; Antimicrobial; Phyllanthus fraternus; n-hexane, ethyl acetate fractions

Estimation method for determining surface film conductance during cooling of fish packages.

This paper presents an alternative method for determining the surface film conductance of an infinite fish slab subjected to the cooling process. Many methods have been published, but their solutions have inherent appreciable inaccuracy and limitations. The present authors used the temperature histories of five locations within a slab sample of fish, obtained by the experimental investigation part of this work, along with the inverse heat conduction problem (IHCP) technique to develop a correlation for variable surface film conductance. When the above correlation was used for temperature predictions, the predicted and experimentally measured temperature distribution profiles were compared numerically. Better agreement than that implemented by other investigators was achieved. This revealed the accuracy and superiority of the present method, and the limitations of other methods are overcome in this method

Public awareness of the coronary artery disease and its risk factors in the population of Hail region, Saudi Arabia: a cross-sectional study

Background: Coronary Artery Disease (CAD) is a severe cardiovascular complication prevalent in the Kingdom of Saudi Arabia. The risk factors of this disease are so high that it became one of the major causes of mortality among middle-aged individuals. This study aimed to investigate the degree of awareness about risk factors for CAD among the Hail region population.  Methods: The study was carried out in the Hail region, Saudi Arabia, from April 2020 to May 2020. Data collected from five hundred and thirty-seven participants participated through an online survey. The process of selection of participants was through volunteer testing and an online review poll that was disseminated to them to complete. No limitations on age or sex were applied to the surveys.Results: Awareness of TV watching (88.5%), smoking (87.9%), lack of physical activities (78.4%) and family history of CAD (74.7%) as the leading cause of CAD has a notable higher percentage among the studied population whereas the family history of diabetes mellitus (51.6%), having diabetes mellitus (57.7%), family history of hypertension (65.7%) and family history of hyperlipidemia (69.1%) have the lowest percentages. Regarding the gender, the male participants have the poorest awareness degrees about risk factors for the CAD.Conclusion: The study revealed that the family history of hyperlipidemia, Family history of DM, having DM and family history of hypertension have the poorest degrees of awareness of the risk factors for CAD among the studied population.Keywords: Coronary artery disease; Risk factors; Awareness; Hail regio

Removal of Copper Ions from Aqueous Solution Using Waste Mill Scales

The optimization of the Copper ions (Cu ions) adsorption from aqueous solution for inclusion in prolonged the milling time of the extracted iron oxides from waste mill scales has been investigated. Different milling times were used to reduce the size of the raw mill scale which are 24, 48 and 72 h. The three adsorbents were characterized using XRD, FESEM and VSM. Adsorbents that milled for 72 hours gave pure magnetite from the XRD results. FESEM images revealed that prolonged the milling time might reduced the particle sizes. Magnetic hysteresis revealed that all the samples having ferromagnetic behavior. Batch adsorption experiment had been carried out with the three adsorbents and as the results, adsorbents that milled with 72 hours shown highest removal of Cu ions with 95% removal efficiency

Measurement of (anti)deuteron and (anti)proton production in DIS at HERA

The first observation of (anti)deuterons in deep inelastic scattering at HERA has been made with the ZEUS detector at a centre-of-mass energy of 300--318 GeV using an integrated luminosity of 120 pb-1. The measurement was performed in the central rapidity region for transverse momentum per unit of mass in the range 0.3<p_T/M<0.7. The particle rates have been extracted and interpreted in terms of the coalescence model. The (anti)deuteron production yield is smaller than the (anti)proton yield by approximately three orders of magnitude, consistent with the world measurements.Comment: 26 pages, 9 figures, 5 tables, submitted to Nucl. Phys.

Yes, size does matter (for cycling safety)! Comparing behavioral and safety outcomes in S, M, L, and XL cities from 18 countries

Although most actions aimed at promoting the use of active transport means have been conducted in ‘large’ cities, recent studies suggest that their cycling dynamics could hinder the efforts put into infrastructural, modal share, and cycling culture improvements. Aim The present study aimed to assess the role of city sizes on riding behavioral and crash-related cycling outcomes in an extensive sample of urban bicycle users. Methods For this purpose, a full sample of 5705 cyclists from >300 cities in 18 countries responded to the Cycling Behavior Questionnaire (CBQ), one of the most widely used behavioral questionnaires to assess risky and positive riding behaviors. Following objective criteria, data were grouped according to small cities (S; population of 50,000 or fewer), medium cities (M; population between 50,000 and 200,000), large cities (L; population between 200,000 and one million), and megacities (XL; population larger than one million). Results Descriptive analyses endorsed the associations between city size, cycling behavioral patterns, and mid-term self-reported crash outcomes. Also, it was observed a significant effect of the city size on cyclists' traffic violations and errors (all p < .001). However, no significant effects of the city size on positive behaviors were found. Also, it stands out that cyclists from megacities self-reported significantly more violations and errors than any of the other groups. Further, the outcomes of this study suggest that city sizes account for cycling safety outcomes through statistical associations, differences, and confirmatory predictive relationships through the mediation of risky cycling behavioral patterns. Conclusion The results of the present study highlight the need for authorities to promote road safety education and awareness plans aimed at cyclists in larger cities. Furthermore, path analysis suggests that “size does matter”, and it statistically accounts for cycling crashes, but only through the mediation of riders' risky behaviors

Detecção de Brucella abortus em tecidos bovinos utilizando ensaios de PCR e qPCR¹

Objetivou-se no presente estudo avaliar as técnicas reação em cadeia da polimerase (PCR) e PCR em Tempo Real (qPCR) para detectar Brucella abortus, a partir de tecidos bovinos com lesões sugestivas de brucelose. Para isto, 21 fragmentos de tecidos bovinos coletados em abatedouros de Mato Grosso do Sul foram processados e submetidos ao cultivo microbiológico e extração do DNA genômico para realização das reações de PCR e qPCR. No cultivo microbiológico, oito amostras apresentaram crescimento bacteriano e cinco foram confirmadas como B. abortus por PCR. Diretamente das amostras de tecido, DNA do gênero Brucella (oligonucleotídeos IS711) foi detectado em 13 (61,9%) amostras de tecido e 17 (81%) amostras de homogeneizado. Já com os oligonucleotídeos espécie-específicos BruAb2_0168F e BruAb2_0168R, 14 (66%) amostras de tecido e 18 (85,7%) amostras de homogeneizado foram amplificadas. Seis amostras positivas na PCR espécie-específica foram sequenciadas e o best hit na análise BLASTn foi B. abortus. Na qPCR, 21 (100%) amostras de tecidos e 19 (90,5%) amostras de homogeneizado foram positivas para B. abortus. Dez amostras de DNA de sangue bovino de rebanho certificado livre foram utilizadas como controle negativo nas análises de PCR e qPCR utilizando-se os oligonucleotídeos BruAb2_0168F e BruAb2_0168R. Na PCR nenhuma amostra amplificou, enquanto que na qPCR 2 (20%) amplificaram. Conclui-se que as duas técnicas detectam a presença de B. abortus diretamente de tecidos e homogeneizados, porém a qPCR apresentou maior sensibilidade. Os resultados obtidos indicam que a qPCR pode representar uma alternativa rápida e precisa para a detecção de B. abortus diretamente de tecidos, e ser utilizada em programas de vigilância sanitária, por apresentar sensibilidade e especificidade satisfatórias