The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity

The unfolded protein response (UPR) and activation of XBP1 is necessary for high secretory efficiency and functional differentiation of antibody secreting cells (ASCs). The UPR additionally includes a branch in which membrane-bound transcription factors, exemplified by ATF6, undergo intramembrane-proteolysis by the sequential action of site-1 (MBTPS1/S1P) and site-2 proteases (MBTPS2/S2P) and release of the cytoplasmic domain as an active transcription factor. Such regulation is shared with a family of CREB3-related transcription factors and sterol regulatory element-binding proteins (SREBPs). Of these, we identify that the CREB3 family member CREB3L2 is strongly induced and activated during the transition from B-cell to plasma cell state. Inhibition of site-1 protease leads to a profound reduction in plasmablast number linked to induction of autophagy. Plasmablasts generated in the presence of site-1 protease inhibitor segregated into CD38high and CD38low populations, the latter characterized by a marked reduction in the capacity to secrete IgG. Site-1 protease inhibition is accompanied by a distinctive change in gene expression associated with amino acid, steroid and fatty acid synthesis pathways. These results demonstrate that transcriptional control of metabolic programs necessary for secretory activity can be targeted via site-1 protease inhibition during ASC differentiation

Noverint universi, q[uod] nos Petrus dei gratia rex Aragon[um] ... [Manuscrito] : [confirmación de los Fueros de Cetina y privilegios otorgados a sus habitantes por Pedro IV de Aragón]

Copia de documentos reales realizada por Miguel Beltrán, notario público y escribanoDigitalizad

[Fueros, 1626]

Copia digital : Google BooksSign.: [parágrafo]4, A-C8, D6, E4.Texto a dos columnas y con apostillas marginales.Portada con grabado xilográfico con el escudo llamado de Íñigo Arista y el de Alcoraz protegidos por ángeles tenantes que sostienen el Señal Real timbrado con cimera del rey de Aragón.Escudo real xilográfico en p. [4]Iniciales grabadas xilográficas

[Ordenanzas, 1354]

Sign. : A-E\p4\s, F\p2\s, A-T\p4\s, a-h\p4\s, C\p2\

[Mandato de Pedro IV a Pedro Jordan de Urries, Baile General del Reino de Aragón y Justicia y Receptor de las aldeas de Daroca, sobre la reedificación de las defensas de la frontera con Castilla y demás obras, a arbitrio de dicho noble señor] [Manuscrito]

Restos de sello de cera de Pedro IV en el v. (11 cm de diám.)Filigrana: capullo de flor (Briquet, C.M. Papiers et filigranes des archives de Genes 1154 à 1700; 57