191 research outputs found
A Man-Made ATP-Binding Protein Evolved Independent of Nature Causes Abnormal Growth in Bacterial Cells
- Author
- A Filipovska
- A McBroom
- A Schmid
- AA Henry
- AD Keefe
- AM Sismour
- B Kuhlman
- B Pruss
- C Lartigue
- C Walsh
- D Endy
- D Huang
- D-J Scheffers
- DG Gibson
- E Harry
- E Leonard
- FK Balagadde
- GZ Chen
- HJ Chung
- IR Vetter
- James W. Wilson
- JC Chaput
- JC Chaput
- JC Delaney
- JL Watkins
- John C. Chaput
- Joshua M. Stomel
- JW Szostak
- K Suefuji
- L Yim
- LM Guzman
- M Isalan
- M Schena
- Mark Isalan
- MB Elowitz
- MD Smith
- Megan A. León
- MM Hanczyc
- NW Goehring
- Phillip Stafford
- PK Dhar
- PM Pryciak
- RL Lock
- RM MacNab
- S Brakmann
- SA Benner
- SA Benner
- SJR Arends
- SS Justice
- SS Mansy
- T Elbeik
- T Elbeik
- TS Gardner
- YN Wei
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
Recent advances in de novo protein evolution have made it possible to create synthetic proteins from unbiased libraries that fold into stable tertiary structures with predefined functions. However, it is not known whether such proteins will be functional when expressed inside living cells or how a host organism would respond to an encounter with a non-biological protein. Here, we examine the physiology and morphology of Escherichia coli cells engineered to express a synthetic ATP-binding protein evolved entirely from non-biological origins. We show that this man-made protein disrupts the normal energetic balance of the cell by altering the levels of intracellular ATP. This disruption cascades into a series of events that ultimately limit reproductive competency by inhibiting cell division. We now describe a detailed investigation into the synthetic biology of this man-made protein in a living bacterial organism, and the effect that this protein has on normal cell physiology
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- Alcázar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- Alegría L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- Antón DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
- Ataman S
- Atchade E
- Atchade E
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- Avilés-Jurado FX
- Avramidis V
- Ayala LY
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- Azevedo JC
- Azevedo JR
- Aznar GP
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- CAPCRI Study
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- Carpio D
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- Carrero-Gómez F
- Carreño ER
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- Carvalho JP
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- Casals XN
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- Cassina T
- Castañeda DP
- Castellana D
- Castellanos A
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- Castillo-Lorente E
- Castillo-Lorente E
- Catalan M
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- Cavalcanti D
- Cavalheiro AM
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- Champigneulle B
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- Charitidou E
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- Charron C
- Chatelon J
- Chaudhari HK
- Chaussard M
- Chavanon O
- Chaves S
- Chelly J
- Chemam S
- Chen CM
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- Chen CW
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- Chen GQ
- Chen L
- Chen YS
- Chen YS
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- Cheng CC
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng KC
- Cheng YJ
- Chernyshuk S
- Chevret S
- Chhor V
- Chiang CC
- Chiang CH
- Chiang CH
- Chiang CH
- Chiappa C
- Chiou KR
- Chiou KR
- Chiou KR
- Chiu LC
- Chiumello D
- Chiurazzi C
- Chiurazzi C
- Cho Y
- Cho YJ
- Cho YJ
- Choi JY
- Choi JY
- Choi KS
- Choi S
- Choi YJ
- Choi YY
- Chok L
- Cholkraisuwat J
- Cholley B
- Chondropoulos S
- Chou W
- Chouris I
- Chouvarda I
- Christopher KB
- Chrétien JM
- Chrétien JM
- Chrétien JM
- Chumaev A
- Chung CR
- Churchill K
- Chytas A
- Cinel I
- Cinnella G
- Citerio G
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- Clavel M
- Clemente EA
- Clermont G
- Cleyet M
- Cohen Y
- Colaprico A
- Colino L
- Collange O
- Colombo A
- Colombo A
- Colson P
- Combes A
- Concha P
- Connolly B
- Constan A
- Constan A
- Constan A
- Conte V
- Conti G
- Conti G
- Contreras KM
- Contreras MR
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- Coombs M
- Cordeiro CP
- Cordero M
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- Cordovilla-Guardia S
- Cordón J
- Corona A
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- Dalhuisen A
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- Das Neves A
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- de Abreu MG
- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
- De La Fuente-Martos C
- De La Rica AS
- De la Torre MA
- De Maglie M
- De Maglie M
- de Molina FJ
- De Morton N
- de Oca Sandoval MA
- De Pascale G
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- de Vera AP
- de Wilde W
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- Deblier I
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- Del Arco A
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- Delgado-Amaya M
- Demirkiran O
- Demoule A
- Denehy L
- Der Kinderen EP
- Descotte E
- Deshpande K
- Desmard M
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- Di Gravio V
- Di Gregorio A
- Di Mussi R
- Di Rosso R
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- Dilek M
- Dilly MP
- Dima E
- Dimitroulakis K
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- Dimopoulou IK
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- Divatia JV
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- Dos Santos HP
- Dougall PC
- Doyle J
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- Dubrawski A
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- Durand M
- Durovray JD
- Durrant J
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- Echeverría JG
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- El-Keraie A
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- Elbers PW
- Elgendy M
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- Endacott R
- Endacott R
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- ENVIN-HELICS Study Group
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- Erdogan M
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- Escalada SH
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- Estella A
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- Feijoo AM
- Feliot E
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- Fernandez-Zamora MD
- Fernández IF
- Fernández L
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- Fernández-Barat L
- Fernández-Mondéjar E
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- Ferrón FR
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- Filipe E
- FINNRESUSCI Study Group
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- Flowers E
- Follin A
- Follin A
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- Fontaiña LP
- Fontana V
- Fontenot T
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- FROG ICU Investigators
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- IPREA Study Group
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- Itenov TS
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Javadpour S
- Jayasinghe S
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- Jiménez GJ
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- Joachim J
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- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
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- Kalenka A
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- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
- Kang PL
- Kang PL
- Kang PL
- Kang PL
- Kang Y
- Kao KC
- Kappler F
- Kara A
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- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
- Katabami K
- Katabami K
- Katabami K
- Katira BH
- Kavanagh BP
- Kawamura N
- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
- Ke MW
- Ke MW
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- Keep J
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- Kellner F
- Kelly JM
- Kenardy J
- Keough E
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- Kerr C
- Kezyte G
- Khadjibaev A
- Khaliq W
- Khine H
- Kim DJ
- Kim HJ
- Kim JM
- Kim JM
- Kim JW
- Kim KS
- Kim KS
- Kim KS
- Kim KS
- Kim MH
- Kim MH
- Kim W
- Kimmoun A
- King HS
- Kinnear J
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- Kirakli C
- Kirca H
- Kirman M
- Kirwan CJ
- Kittnar O
- Klapsing P
- Klaus DA
- Kleinpell R
- Kluge S
- Knafelj R
- Knight LD
- Ko JI
- Ko SB
- Kobayashi A
- Koco E
- Kodate A
- Kodate A
- Kodate A
- Kokkini S
- Kolnikova I
- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
- Kotsopoulos A
- Kou PS
- Kouatchet A
- Kovacikova L
- Kox M
- Kraegpoeth A
- Krenn CG
- Krishna B
- Kristof J
- Kruger A
- Kruger A
- Krüger A
- Ku NS
- Ku NS
- Kubik M
- Kubota K
- Kuebler WM
- Kulaga EV
- Kulkarni AP
- Kumari BK
- Kumbamu A
- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
- Kurtz P
- Kurtz P
- Kwon HM
- Kwon HM
- Kwon WY
- Kwon WY
- Kwon WY
- Kye YC
- Kyle UG
- Kyle UG
- Labaune MA
- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
- Lafuente E
- Lagonidis D
- Lagos R
- Lahmer T
- Lai CC
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- Lake K
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- Latini R
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- Latini R
- Latorre J
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- Laurent A
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- Legrand M
- Legrand M
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- Leitao AL
- Leite RT
- Leonard H
- Leone M
- Leone M
- Lerma FA
- Lesmes SP
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- Letizia T
- Levrat Q
- Levy B
- León JL
- León JP
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- Lheureux O
- Lheureux O
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- Lheureux O
- Li R
- Li SH
- Liao X
- Lichtenstein D
- Lim TH
- Limuti R
- Lin KC
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- Lin WC
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- Lipcsey M
- Lischinsky A
- Lissonde F
- Lissonde F
- Litchfield K
- Liu CP
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- Liu D
- Llaurado-Serra M
- Llorente B
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- Lobato MS
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- Loizou C
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- Longani N
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- Lopez-Caler C
- Lopez-Gude MJ
- Lorini L
- Lortat-Jacob B
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- Lotay R
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- Louis B
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- Lukaszewicz AC
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- López MA
- Macfarlane B
- MacKay A
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- Mackey G
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- MacPhee I
- Macrì M
- Madueño VP
- Maekawa K
- Maekawa K
- Maekawa K
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- Maertens B
- Maggiorini M
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- Magnanimi E
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- Maistry N
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- Mezidi M
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- Mistry M
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- Moraes RB
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- Moro F
- Morán I
- Motos A
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- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
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- PICS- HCPA: Programa Intrahospitalar de Combate à Sepse do Hospital de Clínicas de Porto Alegre
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- Revel N
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- Stamm J
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- Stretti F
- Struijs A
- Stubbs C
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- Suh GJ
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- Tabatabaei HR
- Tabei SH
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- Tokyo Womens Medical University
- Tomas E
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- Winder-Rhodes S
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- Yılmaz G
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- Yoshitake E
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- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Search for strongly interacting massive particles generating trackless jets in proton-proton collisions at s = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
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- Chawla R
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- Álvarez Fernández A
- Österberg K
- Özçelik Ö
- Široký J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
A search for dark matter in the form of strongly interacting massive particles (SIMPs) using the CMS detector at the LHC is presented. The SIMPs would be produced in pairs that manifest themselves as pairs of jets without tracks. The energy fraction of jets carried by charged particles is used as a key discriminator to suppress efficiently the large multijet background, and the remaining background is estimated directly from data. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 16.1 fb - 1 , collected with the CMS detector in 2016. No significant excess of events is observed above the expected background. For the simplified dark matter model under consideration, SIMPs with masses up to 100 GeV are excluded and further sensitivity is explored towards higher masses
Measurement of the inclusive and differential Higgs boson production cross sections in the decay mode to a pair of τ Leptons in pp collisions at sqrt[s]=13 TeV
- Author
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- Yao Y
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- Yusli MN
- Zabi A
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- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli AG
- Zeinali M
- Zeuner WD
- Zghiche A
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- Ziemons T
- Zoi I
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- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zotz A
- Zou D
- Zou R
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2022
- Field of study
Measurements of the inclusive and differential fiducial cross sections of the Higgs boson are presented, using the τ lepton decay channel. The differential cross sections are measured as functions of the Higgs boson transverse momentum, jet multiplicity, and transverse momentum of the leading jet in the event, if any. The analysis is performed using proton-proton collision data collected with the CMS detector at the LHC at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138 fb^{-1}. These are the first differential measurements of the Higgs boson cross section in the final state of two τ leptons. In final states with a large jet multiplicity or with a Lorentz-boosted Higgs boson, these measurements constitute a significant improvement over measurements performed in other final states
Observation of the B-s(0) -> X(3872)phi Decay
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
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- Consuegra Rodríguez S
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- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Using a data sample of proton-proton collisions at root s = 13 TeV, corresponding to an integrated luminosity of 140 fb(-1) collected by the CMS experiment in 2016-2018, the B-s(0) -> X(3872)phi decay is observed. Decays into J/psi pi(+)pi(-) and K+K- are used to reconstruct, respectively, the X(3872) and phi. The ratio of the product of branching fractions B[B-s(0) -> X(3872)phi]B[X(3872) -> J/psi pi(+)pi(-)] to the product B[B-s(0) ->psi(2S)phi]B[psi(2S) -> J/psi pi(+)pi(-)] is measured to be [2.21 +/- 0.29(stat) +/- 0.17(syst)]%. The ratio B[B-s(0) -> X(3872)phi]/B[B-0 -> X(3872)K-0] is found to be consistent with one, while the ratio B[B-s(0) -> X(3872)phi]/B[B+-> X(3872)K+] is two times smaller. This suggests a difference in the production dynamics of the X(3872) in B-0 and B(0)s meson decays compared to B+. The reported observation may shed new light on the nature of the X(3872) particle.Peer reviewe
Observation of a New Excited Beauty Strange Baryon Decaying to Ξb- π+π-
- Author
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- Aarup Petersen H
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- Turkcapar S
- Turkot O
- Tuuva T
- Tuve C
- Tytgat M
- Tyurin N
- Tziaferi E
- Uchida K
- Ujvari B
- Ulmer KA
- Ulrich R
- Undleeb S
- Uniyal R
- Uplegger L
- Urda Gómez L
- Uribe Estrada C
- Usai E
- Uvarov L
- Uzunian A
- Vaandering EW
- Vagnerini A
- Vai I
- Vaitkevicius A
- Valencia Palomo L
- Valsecchi D
- Valuev V
- Van De Klundert M
- Van Der Linden J
- Van Doninck W
- Van Hove P
- Van Mechelen P
- Van Mulders P
- Van Onsem GP
- Van Putte S
- Van Remortel N
- Vanden Bemden M
- Vander Donckt M
- Vander Velde C
- Vanegas Arbelaez N
- Vanlaer P
- Vannerom D
- Varela J
- Varelas N
- Vargas Hernandez AM
- Vartak A
- Vazquez Valencia F
- Vazzoler F
- Veckalns V
- Veelken C
- Velasco M
- Velkovska J
- Vellidis K
- Venditti R
- Venturi A
- Verbeke W
- Verdini PG
- Veres GI
- Vermassen B
- Verwilligen P
- Verzetti M
- Veszpremi V
- Vesztergombi G
- Vetens W
- Viinikainen J
- Vila I
- Vilela Pereira A
- Viliani L
- Virdee T
- Virdi AK
- Viret S
- Vischia P
- Vit M
- Vitulo P
- Vizan Garcia JM
- Vlasov E
- Vlimant JR
- Volkov A
- Volkov S
- Volobouev I
- Von Cube RF
- Vormwald B
- Vorobiev I
- Vorobyev A
- Vourliotis E
- Voutilainen M
- Voytishin N
- Vámi TÁ
- Wadud MA
- Wagner SR
- Walczak M
- Wallny R
- Walsh R
- Waltenberger W
- Walter D
- Wamorkar T
- Wan Abdullah WAT
- Wanczyk J
- Wang B
- Wang C
- Wang D
- Wang F
- Wang H
- Wang H
- Wang J
- Wang J
- Wang J
- Wang L
- Wang Q
- Wang Q
- Wang S
- Wang X
- Wang Y
- Wang Z
- Wang Z
- Waqas M
- Wardle N
- Wassmer M
- Watson IJ
- Wayne M
- Webb SN
- Weber HA
- Weber M
- Wei K
- Wen Y
- Wertz S
- West C
- Wetzel J
- Wezenbeek L
- Whitbeck A
- White R
- Wichmann K
- Wickramage N
- Wickramarathna DDC
- Wiedenbeck S
- Wieland S
- Wightman A
- Williams A
- Williams J
- Williams T
- Willmott C
- Wilson G
- Wilson J
- Wimpenny S
- Winer BL
- Winterbottom D
- Wisecarver A
- Wissing C
- Wittich P
- Wolf M
- Wolf R
- Wolfe E
- Wong K
- Wong WY
- Wood D
- Woodard A
- Wozniak KA
- Wozniewski S
- Wright D
- Wu Z
- Wuchterl S
- Wulz C-E
- Wunsch S
- Wuyckens S
- Wyslouch B
- Würthwein F
- Xiang Y
- Xiao J
- Xiao M
- Xiao R
- Xie S
- Xie W
- Yagil A
- Yalvac M
- Yan F
- Yan X
- Yang UK
- Yang YC
- Yao Y
- Yarar H
- Yates BR
- Yazgan E
- Ye Z
- Yetkin EA
- Yi K
- Yigitbasi E
- Yohay R
- Yoo HD
- Yoo J
- Yoon I
- You Z
- Yu D
- Yu GB
- Yu I
- Yu PR
- Yu SS
- Yuan L
- Yuan S
- Yumiceva F
- Yusli MN
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli AG
- Zeinali M
- Zeuner WD
- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhang S
- Zhang W
- Zhang Y
- Zhang Z
- Zhao J
- Zhizhin I
- Zhokin A
- Zhu DH
- Zhu RY
- Ziemons T
- Zientek M
- Zlebcik R
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- American Physical Society
- Publication date
- 01/01/2021
- Field of study
The Ξb-π+π- invariant mass spectrum is investigated with an event sample of proton-proton collisions at s=13 TeV, collected by the CMS experiment at the LHC in 2016-2018 and corresponding to an integrated luminosity of 140 fb-1. The ground state Ξb- is reconstructed via its decays to J/ψΞ- and J/ψΛK-. A narrow resonance, labeled Ξb(6100)-, is observed at a Ξb-π+π- invariant mass of 6100.3±0.2(stat)±0.1(syst)±0.6(Ξb-) MeV, where the last uncertainty reflects the precision of the Ξb- baryon mass. The upper limit on the Ξb(6100)- natural width is determined to be 1.9 MeV at 95% confidence level. The low Ξb(6100)- signal yield observed in data does not allow a measurement of the quantum numbers of the new state. However, following analogies with the established excited Ξc baryon states, the new Ξb(6100)- resonance and its decay sequence are consistent with the orbitally excited Ξb- baryon, with spin and parity quantum numbers JP=3/2-
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Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies
- Author
- Alonso SM
- Arriortua AB
- Ayestarán OS
- Barba ÁF
- Barral-Arca R
- Bergara EO
- Caballero Macarrón CP
- Calle IR
- Cancela MS
- Carracedo A
- Carrol ED
- Cebey M
- Currás-Tuala MJ
- Davila S
- De Aguilar PAG
- De La Cruz Moreno J
- Doce AH
- Dominguez SR
- Fachal L
- Fernández MS
- García Rodríguez JL
- García MDMB
- García SR
- Garzón MGR
- Grande AJ
- Gómez-Carballa A
- Hibberd ML
- Inwald D
- Khor CC
- Levin M
- León León MC
- López-Bayón J
- Martinón-Sánchez JM
- Martinón-Torres F
- Martinón-Torres N
- Martínez XA
- Martínez-Padilla MDC
- Menchón NM
- Millán Miralles ML
- Monge CC
- Morteruel E
- Muñoz Bonet JI
- Nadel S
- Navarro Gómez ML
- Ortega ÁC
- Palazón SC
- Pallares MO
- Pardo-Seco J
- Payo R
- Pischedda S
- Png E
- Redondo-Collazo L
- Rodriguez-Tenreiro C
- Romero AR
- Rosso SP
- Salas A
- Sim KS
- Sánchez Granados JM
- Sánchez FG
- Sánchez FP
- Sánchez NG
- Torné EE
- Torre AC
- Vega A
- Wright VJ
- Publication venue
- Scientific Reports
- Publication date
- 02/11/2016
- Field of study
Meningococcal disease (MD) remains an important infectious cause of life threatening infection in both industrialized and resource poor countries. Genetic factors influence both occurrence and severity of presentation, but the genes responsible are largely unknown. We performed a genome-wide association study (GWAS) examining 5,440,063 SNPs in 422 Spanish MD patients and 910 controls. We then performed a meta-analysis of the Spanish GWAS with GWAS data from the United Kingdom (combined cohorts: 897 cases and 5,613 controls; 4,898,259 SNPs). The meta-analysis identified strong evidence of association (P-value≤5×10−8) in 20 variants located at the CFH gene. SNP rs193053835 showed the most significant protective effect (Odds Ratio (OR)=0.62, 95% confidence interval (C.I.)=0.52–0.73; P-value=9.62×10−9). Five other variants had been previously reported to be associated with susceptibility to MD, including the missense SNP rs1065489 (OR=0.64, 95% C.I.)=0.55–0.76, P-value=3.25×10−8). Theoretical predictions point to a functional effect of rs1065489, which may be directly responsible for protection against MD. Our study confirms the association of CFH with susceptibility to MD and strengthens the importance of this link in understanding pathogenesis of the disease.This study received support from the Instituto de Salud Carlos III (Proyecto de Investigación en Salud, Acción Estratégica en Salud: proyecto GePEM PI16/01478) (A.S.); Instituto Carlos III (Intensificación de la actividad investigadora) (A.V.); Consellería de Sanidade, Xunta de Galicia (RHI07/2-intensificación actividad investigadora, PS09749 and 10PXIB918184PR), Instituto de Salud Carlos III (Intensificación de la actividad investigadora 2007–2012, PI16/01569), Convenio de colaboración de investigación (Wyeth España-Fundación IDICHUS 2007–2011), Convenio de colaboración de investigación (Novartis España-Fundación IDICHUS 2010–2011), Fondo de Investigación Sanitaria (FIS; PI070069/PI1000540) del plan nacional de I+ D+ I and ‘fondos FEDER’ (F.M.T.). More information at: www. esigem.org. The UK cohort was established with support of the Meningitis Research Foundation (UK), who provide ongoing support, and the European Society for Paediatric Infectious Diseases supported the establishment of the international collaboration. This study makes use of data generated by the Wellcome Trust Case-Control Consortium 2. A full list of the investigators who contributed to the generation of the data is available from www. wtccc.org.uk. Funding for the project was provided by the Wellcome Trust under award 085475. The research leading to these results has received funding from the European Union’s Seventh Framework Programme under EC-GA No. 279185 (EUCLIDS)
In vivo synthesis of nanomaterials in plants: location of silver nanoparticles and plant metabolism
- Author
- A Manceau
- AI Lukman
- Alessandro Mattiello
- AT Harris
- AT Marshall
- Cristiana Giordano
- D Marinova
- D Starnes
- DA Klein
- DC Adriano
- E Corredor
- E Rodríguez-León
- E Weier
- Filip Pošćić
- HCW Skinner
- HU Bergmeyer
- HV Koontz
- IC Smith
- IR Beattie
- JA Hernandez-Viezcas
- JL Gardea-Torresdey
- JL Gardea-Torresdey
- K Quester
- Luca Marchiol
- M Kowshik
- NC Sharma
- OV Kharissova
- P Mohanpuria
- PP Gan
- RG Haverkamp
- RG Haverkamp
- RG Haverkamp
- Rita Musetti
- S Dagley
- S Iravani
- SJ Klaine
- T Aubert
- T Keller
- VL Singleton
- WN Brown
- Y Kawazoe
- Y Park
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Vibrational spectroscopy for the triage of traumatic brain injury computed tomography priority and hospital admissions
- Author
- Amra Čović A
- Amrein K
- Andelic N
- Andreassen L
- Anke A
- Antoni A
- Ao BT
- Ashton K
- Audibert G
- Azouvi P
- Azzolini ML
- Baker MJ
- Bartels R
- Barzó P
- Beauvais R
- Beer R
- Bellander B-M
- Belli A
- Benali H
- Berardino M
- Beretta L
- Blaabjerg M
- Boogert HD
- Bragge P
- Brazinova A
- Brennan PM
- Brinck V
- Brooker J
- Brorsson C
- Buki A
- Bullinger M
- Cabeleira M
- Caccioppola A
- Calappi E
- Calvi MR
- Cameron P
- Carbonara M
- Castaño-León AM
- Cavallo S
- Chevallard G
- Chieregato A
- Citerio G
- Clusmann H
- Coburn M
- Coles J
- Cooper JD
- Correia M
- Corte FD
- Curry N
- Czeiter E
- Czosnyka M
- Dahyot-Fizelier C
- Dark P
- Dawes H
- Degos V
- Depreitere B
- Dixit A
- Donoghue E
- Dreier J
- Dulière G-L
- Ercole A
- Esser P
- Ezer E
- Fabricius M
- Feigin VL
- Foks K
- Frisvold S
- Furmanov A
- Gagliardo P
- Galanaud D
- Gantner D
- Gao G
- George P
- Ghuysen A
- Giga L
- Glocker B
- Golubovic J
- Gomez PA
- Gratz J
- Gravesteijn B
- Grossi F
- Gruen RL
- Gupta D
- Haagsma JA
- Haitsma I
- Helbok R
- Helmrich IR
- Helseth E
- Horton L
- Huijben J
- Hutchinson PJ
- Jacobs B
- Jagt MVD
- Jankowski S
- Jarrett M
- Jenkinson MD
- Jiang J-Y
- Johnson F
- Jones K
- Karan M
- Keyser VD
- Kolias AG
- Kompanje E
- Kondziella D
- Kornaropoulos E
- Koskinen L-O
- Kovács N
- Kowark A
- Lagares A
- Lanyon L
- Laureys S
- Lecky F
- Ledoux D
- Lefering R
- Legrand V
- Lejeune A
- Levi L
- Lightfoot R
- Lingsma H
- Lozano GC
- Maas AIR
- Maegele M
- Majdan M
- Manara A
- Manley G
- Martino C
- Maréchal H
- Mattern J
- McMahon C
- Melegh B
- Menon D
- Menovsky T
- Mikolic A
- Misset B
- Muraleedharan V
- Murray L
- Naalt JVD
- Negru A
- Nelson D
- Newcombe V
- Nieboer D
- Nyirádi J
- Olubukola O
- Oresic M
- Ortolano F
- Palotie A
- Parizel PM
- Payen J-F
- Perera N
- Perlbarg V
- Persona P
- Peul W
- Piippo-Karjalainen A
- Pirinen M
- Pisica D
- Ples H
- Polinder S
- Pomposo I
- Posti JP
- Puybasset L
- Radoi A
- Ragauskas A
- Raj R
- Rambadagalla M
- Reed MJ
- Rhodes J
- Richardson S
- Richter S
- Ripatti S
- Rocka S
- Roe C
- Roise O
- Rosand J
- Rosenfeld JV
- Rosenlund C
- Rosenthal G
- Rossaint R
- Rossi S
- Rueckert D
- Rusnák M
- Sahuquillo J
- Sakowitz O
- Sanchez-Porras R
- Sandor J
- Schmidt S
- Schoechl H
- Schoonman G
- Schou RF
- Schwendenwein E
- Schäfer N
- Sewalt C
- Singh RD
- Skandsen T
- Smielewski P
- Sorinola A
- Stamatakis E
- Stanworth S
- Steen GVD
- Steinbüchel NV
- Stevens R
- Stewart W
- Steyerberg EW
- Stocchetti N
- Sundström N
- Syed K
- Takala R
- Tamosuitis T
- Tamás V
- Taylor MS
- Tenovuo O
- Theadom A
- Theakstone AG
- Thomas M
- Tibboel D
- Timmers M
- Tolias C
- Trapani T
- Tudora CM
- Unterberg A
- Vajkoczy P
- Valeinis E
- Vallance S
- van Dijck JTJM
- van Erp IA
- van Essen TA
- Van Hecke W
- van Heugten C
- Van Praag D
- van Veen E
- van Wijk RPJ
- Vargiolu A
- Vega E
- Velt K
- Verheyden J
- Vespa PM
- Vik A
- Vilcinis R
- Volovici V
- Voormolen D
- Vulekovic P
- Vyvere TV
- Vámos Z
- Wang KKW
- Whitehouse D
- Wiegers E
- Williams G
- Wilson L
- Winzeck S
- Wolf S
- Yang Z
- Ylén P
- Younsi A
- Zeiler FA
- Zelinkova V
- Ziverte A
- Zoerle T
- Åkerlund C
- Đilvesi Đ
- Publication venue
- 'Mary Ann Liebert Inc'
- Publication date
- 03/06/2022
- Field of study
Computed tomography (CT) brain imaging is routinely used to support clinical decision-making in patients with traumatic brain injury (TBI). Only 7% of scans, however, demonstrate evidence of TBI. The other 93% of scans contribute a significant cost to the healthcare system and a radiation risk to patients. There may be better strategies to identify which patients, particularly those with mild TBI, are at risk of deterioration and require hospital admission. We introduce a blood serum liquid biopsy that utilizes attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) spectroscopy with machine learning algorithms as a decision-making tool to identify which patients with mild TBI will most likely present with a positive CT scan. Serum samples were obtained from patients (n = 298) patients who had acquired a TBI and were enrolled in CENTER-TBI and from asymptomatic control patients (n = 87). Injury patients (all severities) were stratified against non-injury controls. The cohort with mild TBI was further examined by stratifying those who had at least one CT abnormality against those who had no CT abnormalities. The test performed exceptionally well in classifications of patients with mild injury versus non-injury controls (sensitivity = 96.4% and specificity = 98.0%) and also provided a sensitivity of 80.2% when stratifying mild patients with at least one CT abnormality against those without. The results provided illustrate the test ability to identify four of every five CT abnormalities and show great promise to be introduced as a triage tool for CT priority in patients with mild TBI
A century of trends in adult human height
- Author
- Abdeen ZA
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adams R
- Aekplakorn W
- Aguilar-Salinas CA
- Agyemang C
- Ahmadvand A
- Ahrens W
- Al-Hazzaa HM
- Al-Othman AR
- Ali MM
- Alkerwi A
- Alvarez-Pedrerol M
- Aly E
- Amouyel P
- Amuzu A
- Andersen LB
- Anderssen SA
- Anjana RM
- Ano DJ
- Aounallah-Skhiri H
- Ariansen I
- Aris T
- Arlappa N
- Arveiler D
- Assah FK
- Ati JE
- Avdicová M
- Azizi F
- Babu BV
- Backer GD
- Bacquer DD
- Bahijri S
- Balakrishna N
- Bandosz P
- Banegas JR
- Bao Kle N
- Bao TQ
- Barbagallo CM
- Barceló A
- Barkat A
- Barros MV
- Bata I
- Batieha AM
- Batista RL
- Baur LA
- Beaglehole R
- Benet M
- Bennett JE
- Bentham J
- Bernabe-Ortiz A
- Bernotiene G
- Bettiol H
- Bhagyalaxmi A
- Bharadwaj S
- Bhargava SK
- Bhatti Z
- Bhutta ZA
- Bi H
- Bi Y
- Bixby H
- Bjerregaard P
- Bjertness E
- Bjertness MB
- Björkelund C
- Blokstra A
- Bo S
- Bobak M
- Boddy LM
- Boehm BO
- Boeing H
- Boissonnet CP
- Boker LK
- Bongard V
- Bovet P
- Braeckman L
- Bragt MC
- Brajkovich I
- Branca F
- Breckenkamp J
- Brenner H
- Brewster LM
- Brian GR
- Bruno G
- Bueno-de-Mesquita HA
- Bugge A
- Burns C
- Cacciottolo J
- Cadena LH
- Cama T
- Cameron C
- Camolas J
- Can G
- Capuano V
- Cardoso VC
- Carlsson AC
- Carvalho MJ
- Casanueva FF
- Casas JP
- Caserta CA
- Castelnuovo AF
- Cesare MD
- Chamukuttan S
- Chan AW
- Chan Q
- Chaturvedi HK
- Chaturvedi N
- Chen CJ
- Chen F
- Chen H
- Chen S
- Chen Z
- Cheng CY
- Chetrit A
- Chiolero A
- Chiou ST
- Chirita-Emandi A
- Cho B
- Cho Y
- Christensen K
- Chudek J
- Cifkova R
- Cisneros JZ
- Claessens F
- Clays E
- Concin H
- Cooper C
- Cooper R
- Coppinger TC
- Costanzo S
- Cottel D
- Cowan M
- Cowell C
- Craig CL
- Crujeiras AB
- Cândido AP
- D'Arrigo G
- d'Orsi E
- Dallongeville J
- Damasceno A
- Damsgaard CT
- Danaei G
- Dankner R
- Dauchet L
- Deepa M
- Deev AD
- Dehghan A
- Delisle H
- Delpeuch F
- Deschamps V
- Dhana K
- Dias-da-Costa JS
- Diaz A
- Djalalinia S
- Do HT
- Dobson AJ
- Donfrancesco C
- Donoso SP
- Doua K
- Drygas W
- Dzerve V
- Döring A
- Egbagbe E
- Eggertsen R
- Ekelund U
- Elliott P
- Engle-Stone R
- Erasmus RT
- Erem C
- Eriksen L
- Evans A
- Ezzati M
- Faeh D
- Fall CH
- Farzadfar F
- Felix-Redondo FJ
- Ferguson TS
- Fernández-Bergés D
- Ferrante D
- Ferrari M
- Ferreccio C
- Ferrieres J
- Finn JD
- Fischer K
- Flores EM
- Foo LH
- Forslund AS
- Forsner M
- Fortmann SP
- Fortunato L
- Fouad HM
- Francis DK
- Franco Mdo C
- Franco OH
- Frontera G
- Fuchs FD
- Fuchs SC
- Fujita Y
- Furusawa T
- Föger B
- Gaciong Z
- Gaetano Gd
- Gafencu M
- Gareta D
- Garnett SP
- Gaspoz JM
- Gasull M
- Gates L
- Geleijnse JM
- Ghasemian A
- Giampaoli S
- Gianfagna F
- Giovannelli J
- Giwercman A
- Goldsmith RA
- Gonçalves H
- Gorbea MB
- Gottrand F
- Graff-Iversen S
- Grafnetter D
- Grajda A
- Grammatikopoulou MG
- Gregor RD
- Grodzicki T
- Gross MG
- Gruden G
- Grujic V
- Grøntved A
- Gu D
- Gualdi-Russo E
- Guan OP
- Gudnason V
- Guerrero R
- Guessous I
- Guimaraes AL
- Gulliford MC
- Gunnlaugsdottir J
- Gunter M
- Guo X
- Guo Y
- Gupta PC
- Gureje O
- Gurzkowska B
- Gutierrez L
- Gutzwiller F
- Hajifathalian K
- Halkjær J
- Hambleton IR
- Hamid ZA
- Hardy R
- Hata J
- Hayes AJ
- He J
- Henauw SD
- Hendriks ME
- Herck KV
- Herrala S
- Heshmat R
- Hihtaniemi IT
- Ho SC
- Ho SY
- Hobbs M
- Hofman A
- Horimoto AR
- Hormiga CM
- Horta BL
- Houti L
- Howitt C
- Htay TT
- Htet AS
- Htike MM
- Hu Y
- Husseini A
- Huu CN
- Huybrechts I
- Hwalla N
- Iacoviello L
- Iannone AG
- Ibrahim MM
- Ikeda N
- Ikram MA
- Irazola VE
- Islam M
- Ivkovic V
- Iwasaki M
- Jackson RT
- Jacobs JM
- Jafar T
- Jamil KM
- Jamrozik K
- Jana N
- Janszky I
- Jasienska G
- Jelakovic B
- Jiang CQ
- Joffres M
- Johansson M
- Jonas JB
- Joshi P
- Juolevi A
- Jurak G
- Jureša V
- Jérome CS
- Jørgensen T
- Kaaks R
- Kafatos A
- Kalter-Leibovici O
- Kapantais E
- Kasaeian A
- Katz J
- Kaur P
- Kavousi M
- Keil U
- Keinänen-Kiukaanniemi S
- Kelishadi R
- Kemper HC
- Kengne AP
- Kersting M
- Key T
- Khader YS
- Khalili D
- Khang YH
- Khaw KT
- Khouw IM
- Kiechl S
- Killewo J
- Kim J
- Klimont J
- Klumbiene J
- Koirala B
- Kolle E
- Kolsteren P
- Kontis V
- Korrovits P
- Koskinen S
- Kouda K
- Koziel S
- Kratzer W
- Krokstad S
- Kromhout D
- Kruger HS
- Kubinova R
- Kujala UM
- Kula K
- Kulaga Z
- Kumar RH
- Kumar RK
- Kurjata P
- Kusuma YS
- Kuulasmaa K
- Kyobutungi C
- Laamiri FZ
- Laatikainen T
- Lachat C
- Laid Y
- Lam TH
- Landrove O
- Lanska V
- Lappas G
- Larijani B
- Laugsand LE
- Laxmaiah A
- Le TD
- Leclercq C
- Lee J
- Lehtimäki T
- Lekhraj R
- León AC
- León-Muñoz LM
- Li Y
- Lilly CL
- Lim WY
- Lima-Costa MF
- Lin HH
- Lin X
- Linneberg A
- Lissner L
- Litwin M
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- Zimmermann E
- Publication venue
- 'eLife Sciences Publications, Ltd'
- Publication date
- 28/10/2022
- Field of study
- …