Measurement of dijet photoproduction for events with a leading neutron at HERA

Differential cross sections for dijet photoproduction and this process in association with a leading neutron, e+ + p -> e+ + jet + jet + X (+ n), have been measured with the ZEUS detector at HERA using an integrated luminosity of 40 pb-1. The fraction of dijet events with a leading neutron was studied as a function of different jet and event variables. Single- and double-differential cross sections are presented as a function of the longitudinal fraction of the proton momentum carried by the leading neutron, xL, and of its transverse momentum squared, pT^2. The dijet data are compared to inclusive DIS and photoproduction results; they are all consistent with a simple pion-exchange model. The neutron yield as a function of xL was found to depend only on the fraction of the proton beam energy going into the forward region, independent of the hard process. No firm conclusion can be drawn on the presence of rescattering effects.Comment: 40 pages, 18 figure

Erratum: Measurement of D^{∗±} production in deep inelastic scattering at HERA

The ZEUS collaborationIn the analysis for our paper on D* production, the beauty contribution was erroneously subtracted twice in the extraction of the reduced cross sections. This affected tables 9 and 10 as well as figures 9 and 10 that are reproduced here in a corrected version. The kinematical acceptances shown in the last colum of table 10 have been also corrected since they were calculated with a different value for the charm fragmentation fraction than what was used in the rest of the analysis and reported in the text. A misprint was found in table 7: the value in the third column at four rows from the bottom should read 49.8, not 59.8. Finally, one of the authors was missing from the author list: C. Uribe-Estrada (Department of Physics, University of Oxford, United Kingdom).Article funded by SCOAP

Total synthesis of reblastatin

info:eu-repo/semantics/publishe

Metal-Catalyzed Synthesis of Hetero-Substituted Alkenes and Alkynes

SCOPUS: ar.jSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Virtue ethics and social psychology

Virtue ethics has emerged as an alternative to deontological and utilitarian theory in recent moral philosophy. The basic notion of virtue ethics is to reassert the importance of virtuous character in ethical judgement in contrast to the emphasis on principles and consequences. Since questions of virtue have been largely neglected in modern moral theory, there has been a return to Aristotle’s account of virtue as character. This in turn has been questioned as the basis of virtue ethics and there has been a search for alternative accounts of moral agency. One aspect of this critical reflection on virtue ethics is an engagement with social psychology as a source of criticism of the Aristotelian conception of character and as a more plausible alternative foundation for a theory of moral character with contemporary relevance. This paper aims to introduce this area of moral theory to a psychological audience and reflect on the interpretation of social psychological theory and evidence in criticisms of virtuous character, focusing on the use of Milgram’s (1974) experiments on obedience to authority as an argument for situationism. A number of questions emerge concerning the interpretation and use of social psychological theory and evidence in debates within moral philosophy

Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90

The benzoquinone ansamycin geldanamycin and its derivatives are inhibitors of heat shock protein Hsp90, an emerging target for novel therapeutic agents both in cancer and in neurodegeneration. However, the toxicity of these compounds to normal cells has been ascribed to reaction with thiol nucleophiles at the quinone 19-position. We reasoned that blocking this position would ameliorate toxicity, and that it might also enforce a favourable conformational switch of the trans-amide group into the cis-form required for protein binding. Here, we report an efficient synthesis of such 19-substituted compounds and realization of our hypotheses. Protein crystallography established that the new compounds bind to Hsp90 with, as expected, a cis-amide conformation. Studies on Hsp90 inhibition in cells demonstrated the molecular signature of Hsp90 inhibitors: decreases in client proteins with compensatory increases in other heat shock proteins in both human breast cancer and dopaminergic neural cells, demonstrating their potential for use in the therapy of cancer or neurodegenerative diseases

Production of Z⁰ bosons in elastic and quasi-elastic <i>ep</i> collisions at HERA

The production of Z&lt;sup&gt;0&lt;/sup&gt; bosons in the reaction ep→eZ&lt;sup&gt;0&lt;/sup&gt;p&lt;sup&gt;(⁎)&lt;/sup&gt;, where p&lt;sup&gt;(⁎)&lt;/sup&gt; stands for a proton or a low-mass nucleon resonance, has been studied in &lt;i&gt;ep&lt;/i&gt; collisions at HERA using the ZEUS detector. The analysis is based on a data sample collected between 1996 and 2007, amounting to 496 pb&lt;sup&gt;−1&lt;/sup&gt; of integrated luminosity. The Z&lt;sup&gt;0&lt;/sup&gt; was measured in the hadronic decay mode. The elasticity of the events was ensured by a cut on ηmax&lt;3.0, where η&lt;sub&gt;max&lt;/sub&gt; is the maximum pseudorapidity of energy deposits in the calorimeter defined with respect to the proton beam direction. A signal was observed at the Z&lt;sup&gt;0&lt;/sup&gt; mass. The cross section of the reaction ep→ eZ&lt;sup&gt;0&lt;/sup&gt;p&lt;sup&gt;(⁎)&lt;/sup&gt; was measured to be σ(ep→ eZ&lt;sup&gt;0&lt;/sup&gt;p&lt;sup&gt;(⁎)&lt;/sup&gt;)=0.13±0.06(stat.)±0.01(syst.) pb, in agreement with the Standard Model prediction of 0.16 pb. This is the first measurement of Z&lt;sup&gt;0&lt;/sup&gt; production in &lt;i&gt;ep&lt;/i&gt; collisions