176 research outputs found
Bulk Higgs Boson Decays in Brane Localized Gravity
We embed the Standard Model in the Randall-Sundrum model of 5 dimensional
brane localized gravity. The SM gauge and chiral fermion fields are restricted
on the 4D visible brane whereas the Higgs and the right-handed neutrino are
assumed to be 5D bulk fields. We calculate the effective couplings of the
lowest mass Higgs field to the SM fermions and to the gauge bosons and find
that the couplings are enhanced. Furthermore, the invisible decay width of a
bulk Higgs of mass 150 GeV is shown to be large.Comment: 14 pages, 2 postscript figures, minor typos corrected, two references
added, to appear in Physics Letters
Non-standard Hamiltonian effects on neutrino oscillations
We investigate non-standard Hamiltonian effects on neutrino oscillations,
which are effective additional contributions to the vacuum or matter
Hamiltonian. Since these effects can enter in either flavor or mass basis, we
develop an understanding of the difference between these bases representing the
underlying theoretical model. In particular, the simplest of these effects are
classified as ``pure'' flavor or mass effects, where the appearance of such a
``pure'' effect can be quite plausible as a leading non-standard contribution
from theoretical models. Compared to earlier studies investigating particular
effects, we aim for a top-down classification of a possible ``new physics''
signature at future long-baseline neutrino oscillation precision experiments.
We develop a general framework for such effects with two neutrino flavors and
discuss the extension to three neutrino flavors, as well as we demonstrate the
challenges for a neutrino factory to distinguish the theoretical origin of
these effects with a numerical example. We find how the precision measurement
of neutrino oscillation parameters can be altered by non-standard effects alone
(not including non-standard interactions in the creation and detection
processes) and that the non-standard effects on Hamiltonian level can be
distinguished from other non-standard effects (such as neutrino decoherence and
decay) if we consider specific imprint of the effects on the energy spectra of
several different oscillation channels at a neutrino factory.Comment: 30 pages, 6 figures, LaTeX, final version, published in Eur.Phys.J.
D* Production in Deep Inelastic Scattering at HERA
This paper presents measurements of D^{*\pm} production in deep inelastic
scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The
data have been taken with the ZEUS detector at HERA. The decay channel
(+ c.c.) has been used in the study. The
cross section for inclusive D^{*\pm} production with
and is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region
{ GeV and }. Differential cross
sections as functions of p_T(D^{*\pm}), and are
compared with next-to-leading order QCD calculations based on the photon-gluon
fusion production mechanism. After an extrapolation of the cross section to the
full kinematic region in p_T(D^{*\pm}) and (D^{*\pm}), the charm
contribution to the proton structure function is
determined for Bjorken between 2 10 and 5 10.Comment: 17 pages including 4 figure
Observation of hard scattering in photoproduction events with a large rapidity gap at HERA
Events with a large rapidity gap and total transverse energy greater than 5
GeV have been observed in quasi-real photoproduction at HERA with the ZEUS
detector. The distribution of these events as a function of the
centre of mass energy is consistent with diffractive scattering. For total
transverse energies above 12 GeV, the hadronic final states show predominantly
a two-jet structure with each jet having a transverse energy greater than 4
GeV. For the two-jet events, little energy flow is found outside the jets. This
observation is consistent with the hard scattering of a quasi-real photon with
a colourless object in the proton.Comment: 19 pages, latex, 4 figures appended as uuencoded fil
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Measurements of the qsq dependence of the D0 to K mu nu and D0 to pi mu nu form factors
Using a large sample of D0 to K mu nu and pi mu nu decays collected by the
FOCUS photoproduction experiment at Fermilab, we present new measurements of
the q^2 dependence for the f+(q^2) form factor. These measured f+(q^2) form
factors are fit to common parameterizations such as the pole dominance form and
compared to recent unquenched Lattice QCD calculations. We find m_pole =
1.93+-0.05+-0.03 GeV/c^2 for D0 to K mu nu and m_pole = 1.91+0.30-0.15+-0.07
GeV/c^2 for D0 to pi mu nu and f-^{K}(0)/f+^{K}(0) = -1.7+1.5-1.4+-0.3.Comment: 14 pages, 6 figure
Observation of Events with an Energetic Forward Neutron in Deep Inelastic Scattering at HERA
In deep inelastic neutral current scattering of positrons and protons at the center of mass energy of 300 GeV, we observe, with the ZEUS detector, events with a high energy neutron produced at very small scattering angles with respect to the proton direction. The events constitute a fixed fraction of the deep inelastic, neutral current event sample independent of Bjorken x and Q2 in the range 3 · 10-4 \u3c xBJ \u3c 6 · 10-3 and 10 \u3c Q2 \u3c 100 GeV2
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy
Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group
BACKGROUND: Only a handful of genetic discovery efforts in apparent treatment-resistant hypertension (aTRH) have been described. METHODS: We conducted a case-control genome-wide association study of aTRH among persons treated for hypertension, using data from 10 cohorts of European ancestry (EA) and 5 cohorts of African ancestry (AA). Cases were treated with 3 different antihypertensive medication classes and had blood pressure (BP) above goal (systolic BP â„ 140 mm Hg and/or diastolic BP â„ 90 mm Hg) or 4 or more medication classes regardless of BP control (nEA = 931, nAA = 228). Both a normotensive control group and a treatment-responsive control group were considered in separate analyses. Normotensive controls were untreated (nEA = 14,210, nAA = 2,480) and had systolic BP/diastolic BP < 140/90 mm Hg. Treatment-responsive controls (nEA = 5,266, nAA = 1,817) had BP at goal (<140/90 mm Hg), while treated with one antihypertensive medication class. Individual cohorts used logistic regression with adjustment for age, sex, study site, and principal components for ancestry to examine the association of single-nucleotide polymorphisms with case-control status. Inverse variance-weighted fixed-effects meta-analyses were carried out using METAL. RESULTS: The known hypertension locus, CASZ1, was a top finding among EAs (P = 1.1 Ă 10-8) and in the race-combined analysis (P = 1.5 Ă 10-9) using the normotensive control group (rs12046278, odds ratio = 0.71 (95% confidence interval: 0.6-0.8)). Single-nucleotide polymorphisms in this locus were robustly replicated in the Million Veterans Program (MVP) study in consideration of a treatment-responsive control group. There were no statistically significant findings for the discovery analyses including treatment-responsive controls. CONCLUSION: This genomic discovery effort for aTRH identified CASZ1 as an aTRH risk locus
Measurement of the azimuthal anisotropy of Y(1S) and Y(2S) mesons in PbPb collisions at âNN = 5.02 TeV
The second-order Fourier coefficients (Ï
) characterizing the azimuthal distributions of ΄(1S) and ΄(2S) mesons produced in PbPb collisions at = 5.02 TeV are studied. The ΄mesons are reconstructed in their dimuon decay channel, as measured by the CMS detector. The collected data set corresponds to an integrated luminosity of 1.7 nb. The scalar product method is used to extract the Ï
coefficients of the azimuthal distributions. Results are reported for the rapidity range |y| < 2.4, in the transverse momentum interval 0 < p < 50 GeV/c, and in three centrality ranges of 10â30%, 30â50% and 50â90%. In contrast to the J/Ï mesons, the measured Ï
values for the ΄ mesons are found to be consistent with zero
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