Primary health service use by mothers and children from London-Middlesex, Ontario

Primary health service use (P-HSU) may be influenced by predisposing and enabling factors measured at individual- and contextual-levels but is equitable when driven by need factors. Objectives: 1) Estimate the effect of residential location on maternal and child P-HSU; 2) Assess P-HSU inequity by determining whether the effects of need factors on P-HSU are dependent on predisposing and enabling factors; 3) Describe perceived unmet healthcare needs in the maternal-child population observed to have inequitable P-HSU. Methodology: The sample of 1451 mother-child pairs was from a prenatal cohort recruited from London, Ontario between 2002 and 2004, with follow-up until children were toddler/preschooler-aged. Individual-level data were linked by residential address to contextual-level data sourced from Statistics Canada. Two multilevel logistic regression models were built to assess the multilevel characteristics associated with P-HSU by mothers and children, and interactions of need factors with covariates were tested to assess P-HSU inequity. The prevalence of perceived unmet healthcare need was described, and a discussion on limitations of its measurement in the literature was performed. Results: P-HSU varied between neighbourhoods but only for mothers (p=0.02). Maternal obesity’s effect on P-HSU was different for rural mothers living in low-income households (OR=0.26, pConclusion:Results indicate that differences in maternal P-HSU exist between neighbourhoods, partially explained by urban/rural residence. Several enabling factors modified the effect of need factors on both maternal and child P-HSU, providing evidence for inequitable P-HSU. This research has the potential to inform Canadian healthcare policy with regards to contextual effects, P-HSU inequity, and perceived unmet healthcare needs in mothers and children

Melting processes and mantle sources of lavas on Mercury

peer reviewe

Assessment of Geological Storage Capacity of the Southeastern U.S. for CO2 in Brines and Economic Use for EOR

Bureau of Economic Geolog

Scaling up local energy infrastructure; An agent-based model of the emergence of district heating networks

The potential contribution of local energy infrastructure – such as heat networks – to the transition to a low carbon economy is increasingly recognised in international, national and municipal policy. Creating the policy environment to foster the scaling up of local energy infrastructure is, however, still challenging; despite national policy action and local authority interest the growth of heat networks in UK cities remains slow. Technoeconomic energy system models commonly used to inform policy are not designed to address institutional and governance barriers. We present an agent-based model of heat network development in UK cities in which policy interventions aimed at the institutional and governance barriers faced by diverse actors can be explored. Three types of project instigators are included – municipal, commercial and community – which have distinct decision heuristics and capabilities and follow a multi-stage development process. Scenarios of policy interventions developed in a companion modelling approach indicate that the effect of interventions differs between actors depending on their capabilities. Successful interventions account for the specific motivations and capabilities of different actors, provide a portfolio of support along the development process and recognise the important strategic role of local authorities in supporting low carbon energy infrastructure

De novo variants in ATXN7L3 lead to developmental delay, hypotonia and distinctive facial features

Deubiquitination is critical for the proper functioning of numerous biological pathways such as DNA repair, cell cycle progression, transcription, signal transduction, and autophagy. Accordingly, pathogenic variants in deubiquitinating enzymes (DUBs) have been implicated in neurodevelopmental disorders (ND) and congenital abnormalities. ATXN7L3 is a component of the DUB module of the SAGA complex, and two other related DUB modules, and serves as an obligate adaptor protein of 3 ubiquitin-specific proteases (USP22, USP27X or USP51). Through exome sequencing and GeneMatching, we identified nine individuals with heterozygous variants in ATXN7L3. The core phenotype included global motor and language developmental delay, hypotonia, and distinctive facial characteristics including hypertelorism, epicanthal folds, blepharoptosis, a small nose and mouth, and low-set posteriorly rotated ears. In order to assess pathogenicity, we investigated the effects of a recurrent nonsense variant [c.340C>T; p.(Arg114Ter)] in fibroblasts of an affected individual. ATXN7L3 protein levels were reduced, and deubiquitylation was impaired, as indicated by an increase in histone H2Bub1 levels. This is consistent with the previous observation of increased H2Bub1 levels in Atxn7l3-null mouse embryos, which have developmental delay and embryonic lethality. In conclusion, we present clinical information and biochemical characterization supporting ATXN7L3 variants in the pathogenesis of a rare syndromic ND

A complexity approach to defining urban energy systems

Urban energy systems have been commonly considered to be socio-technical systems within the boundaries of an urban area. However, recent literature challenges this notion in that it urges researchers to look at the wider interactions and influences of urban energy systems wherein the socio-technical sphere is expanded to political, environmental and economic realms as well. In addition to the inter-sectoral linkages, the diverse agents and multilevel governance trends of energy sustainability in the dynamic environment of cities make the urban energy landscape a complex one. There is a strong case then for establishing a new conceptualisation of urban energy systems that builds upon these contemporary understandings of such systems. We argue that the complex systems approach can be suitable for this. In this paper, we propose a pilot framework for understanding urban energy systems using complex systems theory as an integrating plane. We review the multiple streams of urban energy literature to identify the contemporary discussions and construct this framework that can serve as a common ontological understanding for the different scholarships studying urban energy systems. We conclude the paper by highlighting the ways in which the framework can serve some of the relevant communities

Mass transfer in the lower crust: Evidence for incipient melt assisted flow along grain boundaries in the deep arc granulites of Fiordland, New Zealand

Knowledge of mass transfer is critical in improving our understanding of crustal evolution, however mass transfer mechanisms are debated, especially in arc environments. The Pembroke Granulite is a gabbroic gneiss, passively exhumed from depths of >45 km from the arc root of Fiordland, New Zealand. Here, enstatite and diopside grains are replaced by coronas of pargasite and quartz, which may be asymmetric, recording hydration of the gabbroic gneiss. The coronas contain microstructures indicative of the former presence of melt, supported by pseudosection modeling consistent with the reaction having occurred near the solidus of the rock (630–710°C, 8.8–12.4 kbar). Homogeneous mineral chemistry in reaction products indicates an open system, despite limited metasomatism at the hand sample scale. We propose the partial replacement microstructures are a result of a reaction involving an externally derived hydrous, silicate melt and the relatively anhydrous, high-grade assemblage. Trace element mapping reveals a correlation between reaction microstructure development and bands of high-Sr plagioclase, recording pathways of the reactant melt along grain boundaries. Replacement microstructures record pathways of diffuse porous melt flow at a kilometer scale within the lower crust, which was assisted by small proportions of incipient melt providing a permeable network. This work recognizes melt flux through the lower crust in the absence of significant metasomatism, which may be more common than is currently recognized. As similar microstructures are found elsewhere within the exposed Fiordland lower crustal arc rocks, mass transfer of melt by diffuse porous flow may have fluxed an area >10,000 km2