“Confining the Enemy”—Halford Mackinder’s Theory of Containment and the Conflict in Ukraine

Before George Kennan outlined his vision of containment, Halford Mackinder articulated a vision of maritime geostrategic logic that prioritized some geographic locations over others. Because Mackinder’s writings have been marshaled to assess the ongoing U.S. commitment to Ukraine, it is important to appreciate how his theory applies to the current crisis

Blockading The American Confederacy, 1861-1865:a Geo-strategic Analysis

A paper to be included in a volume devoted to the comparison to the comparative history of blockages, edited by Professor Jean-David Avenal. INTRODUCTION Blockade, as a formal and systematic weapon in modern naval warfare, distinct from battle and maneuver, developed during the Napoleonic wars and was further refined by the Royal Navy in its decades-long campaign after 1815 to suppress the African slave trade (1). In spite of this extensive history, it was not until the Treaty of Paris ending the Crimean War that a Declaration Respecting Maritime Law, dated April 16, 1856, formally established the general principles of international law that would define blockade and abolish privateering, blockade\u27s traditional response. Blockades were described in four short articles..

The Visualization Of Cartographic Information: A Review Essay Of Six Civil War Atlases

The Visualization of Cartographic Information: A Review Essay of Six Civil War Atlasesby Hardy, Jr. James D. and Hochberg, Leonard J. Issue: Winter 2006Acknowledgement: This essay would not have been possible had the authors not worked with Professor Edward Whiting Fox, historian, c...

Community Psychology Coverage in Introduction to Psychology Textbooks

The field of Community Psychology is approximately 50 years old, and it has become an active and invigorating source of ideas (e.g., prevention, ecological theory, sense of community, empowerment, participatory-based research, providing care to marginalized populations, etc.) for the overall field of Psychology. However, many undergraduates have never heard of this discipline in part because introductory Psychology textbooks are not providing adequate coverage of this field. The current study examined 53 introductory Psychology textbooks, published between 2010 and 2016, for their coverage of the field of Community Psychology. Findings indicated that only 17% of these textbooks contained an adequate representation of the discipline of Community Psychology. The lack of adequate coverage of this field in most introductory Psychology textbooks has significant implications for attracting undergraduates to this content area. Fifty percent of the textbook authors responded to an email that provided them information regarding the current study, and many indicated that new versions of their textbooks could include information from the field of Community Psychology.  This positive response suggests that many authors are willing to better represent the field of Community Psychology in their introductory Psychology textbooks.&nbsp

Community Psychology Coverage in Introduction to Psychology Textbooks

The field of Community Psychology is approximately 50 years old, and it has become an active and invigorating source of ideas (e.g., prevention, ecological theory, sense of community, empowerment, participatory-based research, providing care to marginalized populations, etc.) for the overall field of Psychology. However, many undergraduates have never heard of this discipline in part because introductory Psychology textbooks are not providing adequate coverage of this field. The current study examined 53 introductory Psychology textbooks, published between 2010 and 2016, for their coverage of the field of Community Psychology. Findings indicated that only 17% of these textbooks contained an adequate representation of the discipline of Community Psychology. The lack of adequate coverage of this field in most introductory Psychology textbooks has significant implications for attracting undergraduates to this content area. Fifty percent of the textbook authors responded to an email that provided them information regarding the current study, and many indicated that new versions of their textbooks could include information from the field of Community Psychology.  This positive response suggests that many authors are willing to better represent the field of Community Psychology in their introductory Psychology textbooks.&nbsp

Tolerability and safety of fluvoxamine and other antidepressants

Selective serotonin [5-hydroxytryptamine (5-HT)] reuptake inhibitors (SSRIs) and the 5-HT noradrenaline reuptake inhibitor, venlafaxine, are mainstays in treatment for depression. The highly specific actions of SSRIs of enhancing serotonergic neurotransmission appears to explain their benefit, while lack of direct actions on other neurotransmitter systems is responsible for their superior safety profile compared with tricyclic antidepressants. Although SSRIs (and venlafaxine) have similar adverse effects, certain differences are emerging. Fluvoxamine may have fewer effects on sexual dysfunction and sleep pattern. SSRIs have a cardiovascular safety profile superior to that of tricyclic antidepressants for patients with cardiovascular disease; fluvoxamine is safe in patients with cardiovascular disease and in the elderly. A discontinuation syndrome may develop upon abrupt SSRI cessation. SSRIs are more tolerable than tricyclic antidepressants in overdose, and there is no conclusive evidence to suggest that they are associated with an increased risk of suicide. Although the literature suggests that there are no clinically significant differences in efficacy amongst SSRIs, treatment decisions need to be based on considerations such as patient acceptability, response history and toxicity

Basis for the gain and subsequent dilution of epidermal pigmentation during human evolution: The barrier and metabolic conservation hypotheses revisited

The evolution of human skin pigmentation must address both the initial evolution of intense epidermal pigmentation in hominins, and its subsequent dilution in modern humans. While many authorities believe that epidermal pigmentation evolved to protect against either ultraviolet B (UV-B) irradiation-induced mutagenesis or folic acid photolysis, we hypothesize that pigmentation augmented the epidermal barriers by shifting the UV-B dose-response curve from toxic to beneficial. Whereas erythemogenic UV-B doses produce apoptosis and cell death, suberythemogenic doses benefit permeability and antimicrobial function. Heavily melanized melanocytes acidify the outer epidermis and emit paracrine signals that augment barrier competence. Modern humans, residing in the cooler, wetter climes of south-central Europe and Asia, initially retained substantial pigmentation. While their outdoor lifestyles still permitted sufficient cutaneous vitamin D3 (VD3) synthesis, their marginal nutritional status, coupled with cold-induced caloric needs, selected for moderate pigment reductions that diverted limited nutritional resources towards more urgent priorities (=metabolic conservation). The further pigment-dilution that evolved as humans reached north-central Europe (i.e., northern France, Germany), likely facilitated cutaneous VD3 synthesis, while also supporting ongoing, nutritional requirements. But at still higher European latitudes where little UV-B breaches the atmosphere (i.e., present-day UK, Scandinavia, Baltic States), pigment dilution alone could not suffice. There, other nonpigment-related mutations evolved to facilitate VD3 production; for example, in the epidermal protein, filaggrin, resulting in reduced levels of its distal metabolite, trans-urocanic acid, a potent UV-B chromophore. Thus, changes in human pigmentation reflect a complex interplay between latitude, climate, diet, lifestyle, and shifting metabolic priorities

Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c.

Racial differences in the pathophysiology of atherothrombosis are poorly understood. We explored the function and transcriptome of platelets in healthy black (n = 70) and white (n = 84) subjects. Platelet aggregation and calcium mobilization induced by the PAR4 thrombin receptor were significantly greater in black subjects. Numerous differentially expressed RNAs were associated with both race and PAR4 reactivity, including PCTP (encoding phosphatidylcholine transfer protein), and platelets from black subjects expressed higher levels of PC-TP protein. PC-TP inhibition or depletion blocked PAR4- but not PAR1-mediated activation of platelets and megakaryocytic cell lines. miR-376c levels were differentially expressed by race and PAR4 reactivity and were inversely correlated with PCTP mRNA levels, PC-TP protein levels and PAR4 reactivity. miR-376c regulated the expression of PC-TP in human megakaryocytes. A disproportionately high number of microRNAs that were differentially expressed by race and PAR4 reactivity, including miR-376c, are encoded in the DLK1-DIO3 locus and were expressed at lower levels in platelets from black subjects. These results suggest that PC-TP contributes to the racial difference in PAR4-mediated platelet activation, indicate a genomic contribution to platelet function that differs by race and emphasize a need to consider the effects of race when developing anti-thrombotic drugs

So You Want to Study Geopolitics?: A Guide to Classes, Curriculum & Resources

This work is a collaborative venture between Bert Chapman, Leonard Hochberg, and other members of the Mackinder Forum on studying geopolitics. It contains information on relevant courses, degrees, and scholars in this field, guidance on how to find appropriate coursework in this field from the perspective of classical geopolitics, links to U.S. and global research center websites, and relevant U.S. and foreign government information resources. Extreme caution in using Chinese and Russian government resources is also stressed