362 research outputs found
Effects of intradermal injection of atrial natriuretic peptide.
Abstract
Atrial natriuretic peptide (ANP) causes mast cell degranulation in rats in vivo and in vitro but is bronchodilator in humans. The aim of this study was to investigate the wheal and flare dose-response to intradermal injection of alpha-human ANP in normal humans. Eight normal subjects received five 30 microliters injections containing 1, 10, 39, 78, 117 pmol ANP and one each of normal saline, histamine 675 pmol and substance P 30 pmol. Maximum ANP flare response was greater but not significantly than that to saline at 1.55 +/- 0.6 (mean +/- s.e. mean) compared with 0.42 +/- 0.17 cm2, but much less than to histamine 9.86 +/- 0.97 or to substance P 12.5 +/- 1.2. Maximum ANP wheal response was significantly greater than that to saline at 0.38 +/- 0.08 compared with 0.18 +/- 0.05 cm2 (difference between means 0.20, 95% CI 0.05, 0.35), but much less than to histamine 0.75 +/- 0.06 or to substance P 1.05 +/- 0.08 cm2. No dose-response to ANP was demonstrated, though responses to the highest dose differed significantly from those to the lowest dose studied. We conclude that human cutaneous responses to ANP differ from those of animals and that the skin is less responsive than other tissues in humans
UK COVID-19 lockdown: 100 days of air pollution reduction?
On the 23 March 2020, a country-wide COVID-19 lockdown was imposed on the UK. The following 100 days saw anthropogenic movements quickly halt, before slowly easing back to a “new” normality. In this short communication, we use data from official UK air-quality sensors (DEFRA AURN) and the UK Met Office stations to show how lockdown measures affected air quality in the UK. We compare the 100 days post-lockdown (23 March to 30 June 2020) with the same period from the previous 7 years. We find, as shown in numerous studies of other countries, the nitrogen oxides levels across the country dropped substantially (∼ 50%). However, we also find the ozone levels increased (∼ 10%), and the levels of sulphur dioxide more than doubled across the country. These changes, driven by a complex balance in the air chemistry near the surface, may reflect the influence of low humidity as suggested by Met Office data, and potentially, the reduction of nitrogen oxides and their interactions with multiple pollutants
Extinction and recurrence of multi-group SEIR epidemic
In this paper, we consider a class of multi-group SEIR epidemic models with stochastic perturbations. By the method of stochastic Lyapunov functions, we study their asymptotic behavior in terms of the intensity of the stochastic perturbations and the reproductive number R0R0. When the perturbations are sufficiently large, the exposed and infective components decay exponentially to zero whilst the susceptible components converge weakly to a class of explicit stationary distributions regardless of the magnitude of R0R0. An interesting result is that, if the perturbations are sufficiently small and R0≤1R0≤1, then the exposed, infective and susceptible components have similar behaviors, respectively, as in the case of large perturbations. When the perturbations are small and R0>1R0>1, we construct a new class of stochastic Lyapunov functions to show the ergodic property and the positive recurrence, and our results reveal some cycling phenomena of recurrent diseases. Computer simulations are carried out to illustrate our analytical results
4-tert-Butyl-2-[2-(1,3,3-trimethylindolin-2-ylidene)ethylidene]cyclohexanone
The title molecule, C23H31NO, has two alternative cyclohexanone configurations at the 4-position in a ratio of 0.663 (3):0.337 (3). The plane of the five-membered planar ring in the indolin-2-ylidene subtends an angle of 2.19 (7)° with its fused aromatic ring, an angle of 16.24 (8)° with the plane of the major cyclohexanone configuration and an angle of 8.54 (15)° with the bridging planar ethylidene C atoms. These last atoms subtend an angle of 8.37 (16)° with the mean plane through the major cyclohexanone configuration. The molecules pack approximately parallel to the (01) plane via C—H⋯π and C—H⋯O interactions
On the well-posedness of the stochastic Allen-Cahn equation in two dimensions
White noise-driven nonlinear stochastic partial differential equations
(SPDEs) of parabolic type are frequently used to model physical and biological
systems in space dimensions d = 1,2,3. Whereas existence and uniqueness of weak
solutions to these equations are well established in one dimension, the
situation is different for d \geq 2. Despite their popularity in the applied
sciences, higher dimensional versions of these SPDE models are generally
assumed to be ill-posed by the mathematics community. We study this discrepancy
on the specific example of the two dimensional Allen-Cahn equation driven by
additive white noise. Since it is unclear how to define the notion of a weak
solution to this equation, we regularize the noise and introduce a family of
approximations. Based on heuristic arguments and numerical experiments, we
conjecture that these approximations exhibit divergent behavior in the
continuum limit. The results strongly suggest that a series of published
numerical studies are problematic: shrinking the mesh size in these simulations
does not lead to the recovery of a physically meaningful limit.Comment: 21 pages, 4 figures; accepted by Journal of Computational Physics
(Dec 2011
Geckos decouple fore- and hind limb kinematics in response to changes in incline
This work is supported by an NSF grant (NSF IOS-1147043) to TE
Evolutionary distances in the twilight zone -- a rational kernel approach
Phylogenetic tree reconstruction is traditionally based on multiple sequence
alignments (MSAs) and heavily depends on the validity of this information
bottleneck. With increasing sequence divergence, the quality of MSAs decays
quickly. Alignment-free methods, on the other hand, are based on abstract
string comparisons and avoid potential alignment problems. However, in general
they are not biologically motivated and ignore our knowledge about the
evolution of sequences. Thus, it is still a major open question how to define
an evolutionary distance metric between divergent sequences that makes use of
indel information and known substitution models without the need for a multiple
alignment. Here we propose a new evolutionary distance metric to close this
gap. It uses finite-state transducers to create a biologically motivated
similarity score which models substitutions and indels, and does not depend on
a multiple sequence alignment. The sequence similarity score is defined in
analogy to pairwise alignments and additionally has the positive semi-definite
property. We describe its derivation and show in simulation studies and
real-world examples that it is more accurate in reconstructing phylogenies than
competing methods. The result is a new and accurate way of determining
evolutionary distances in and beyond the twilight zone of sequence alignments
that is suitable for large datasets.Comment: to appear in PLoS ON
A model of feedback control for the charge-balanced suppression of epileptic seizures
Here we present several refinements to a model of feedback control for the suppression of epileptic seizures. We utilize a stochastic partial differential equation (SPDE) model of the human cortex. First, we verify the strong convergence of numerical solutions to this model, paying special attention to the sharp spatial changes that occur at electrode edges. This allows us to choose appropriate step sizes for our simulations; because the spatial step size must be small relative to the size of an electrode in order to resolve its electrical behavior, we are able to include a more detailed electrode profile in the simulation. Then, based on evidence that the mean soma potential is not the variable most closely related to the measurement of a cortical surface electrode, we develop a new model for this. The model is based on the currents flowing in the cortex and is used for a simulation of feedback control. The simulation utilizes a new control algorithm incorporating the total integral of the applied electrical potential. Not only does this succeed in suppressing the seizure-like oscillations, but it guarantees that the applied signal will be charge-balanced and therefore unlikely to cause cortical damage
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