Design and manufacture of a customised temporomandibular prosthesis

In this work, design, manufacture and surgical success of a personalised temporomandibular prosthesis is featured. A fused deposition modelling technique and Die forging process constitute the methodology used in a patient who had an amputation in the upper third branch of the mandible, without considering the joint capsule. The implant was designed using a processed resection image of a computational tomography and using the methodology of Özkaya and Nordin. The jaw operating conditions were simulated by the finite element method (FEM). The main considered factors were the morphological geometry of the patient, implant fixation in the first third of the branch, implant fixation on the chin, dental post for placement of the teeth, and the form of the sub-lingual fossa weight optimisation. Special consideration was to preserve the patients facial aesthetics.Peer Reviewe

Paleoseismic analysis of the San Vicente segment of the El Salvador Fault Zone, El Salvador, Central America

The El Salvador earthquake of February 13th 2001 (Mw 6.6) was associated with the tectonic rupture of the El Salvador Fault Zone. Paleoseismic studies of the El Salvador Fault Zone undertaken after this earthquake provide a basis for examining the longer history of surface rupturing earthquakes on the fault. Trenching at five sites along the San Vicente segment, a 21km-long and up to 2km-wide central section of the El Salvador Fault Zone, shows that surface fault rupture has occurred at least seven times during the past 8ka. Single-event displacements identified at each trench vary from several decimetres to at least 3.7m. Fault trace mapping, geomorphic analysis, and paleoseismic studies indicate a maximum magnitude for the El Salvador Fault Zone is c. Mw 7.6, with a recurrence interval of around 800yr. Earthquakes of Mw 6.6 or smaller, such as the February 2001 event are unlikely to be identified in the paleoseismic trenches, so our observations represent the minimum number of moderate to large earthquakes that have occurred on this part of the El Salvador Fault Zone. We observe significant variability in single-event displacement in the trenches, which we interpret as possible cascade rupture of several segments of the El Salvador Fault Zone. Combining displacements of river courses and the timing of events revealed in the trenches, we calculate a slip rate of c. 4mm/yr for El Salvador Fault Zone, identifying the fault zone as a major tectonic feature of the region, and a major source of seismic hazard and risk in El Salvador

Neutrino oscillation physics with a higher γ\gamma β\beta-beam

The precision measurement and discovery potential of a neutrino factory based on a storage ring of boosted radioactive ions ($\beta$-beam) is re-examined. In contrast with past designs, which assume ion $\gamma$ factors of $\sim 100$ and baselines of L=130 km, we emphasize the advantages of boosting the ions to higher $\gamma$ and increasing the baseline proportionally. In particular, we consider a medium-$\gamma$ scenario ($\gamma \sim 500$, L=730 km) and a high-$\gamma$ scenario ($\gamma \sim 2000$, L = 3000 km).The increase in statistics, which grow linearly with the average beam energy, the ability to exploit the energy dependence of the signal and the sizable matter effects at this longer baseline all increase the discovery potential of such a machine very significantly.Comment: An error corrected, conclusions unchanged. Revised version to appear in Nuclear Physics

A Pilot Point Guided Pattern Matching Approach to Integrate Dynamic Data into Geological Modeling

Methods based on multiple-point statistics (MPS) have been routinely used to characterize complex geological formations in the last decade. These methods use the available static data (for example, measured conductivities) for conditioning. Integrating dynamic data (for example, measured transient piezometric head data) into the same framework is challenging because of the complex non-linear relationship between the dynamic response and geology. The Ensemble PATtern (EnPAT) search method was recently developed as a promising technique to handle this problem. In this approach, a pattern is postulated to be composed of both parameter and state variables, and then, parameter values are sequentially (point-wise) simulated by directly sampling the matched pattern from an ensemble of training images of both geologic parameters and state variables. As a consequence, the updated ensemble of realizations of the geological parameters preserve curvilinear structures (i.e., non-multiGaussanity) as well as the complex relationship between static and dynamic data. Moreover, the uncertainty of flow and transport predictions can be assessed using the updated ensemble of geological models. In this work, we further modify the EnPAT method by introducing the pilot-point concept into the algorithm. More specifically, the parameter values at a set of randomly selected pilot point locations are simulated by the pattern searching procedure, and then a faster MPS method is used to complete the simulation by conditioning to the previously simulated pilot point values. This pilot point guided MPS implementation results in lower computational cost and more accurate inference of the parameter field. In addition, in some situations where there is sparsity of measured geologic static data, the EnPAT algorithm is extended to work only with the dynamic data. We employed a synthetic example to demonstrate the effectiveness of pilot points in the implementation of EnPAT, and also the capability of dynamic data to identify complex geologic structures when measured conductivity data are not available.The first three authors gratefully acknowledge the financial support by DOE through project DE-FE0004962. The fourth author acknowledges the financial support by the Spanish Ministry of Science and Innovation through project CGL2011-23295. The authors also wish to thank Wolfgang Nowak as well as two anonymous reviewers for their comments, which helped improving the final version of the manuscript.Li, L.; Srinivasan, S.; Zhou, H.; Gómez-Hernández, JJ. (2013). A Pilot Point Guided Pattern Matching Approach to Integrate Dynamic Data into Geological Modeling. Advances in Water Resources. 62(Part A):125-138. https://doi.org/10.1016/j.advwatres.2013.10.008S12513862Part

Optimal β\beta-beam at the CERN-SPS

A $\beta$-beam with maximum $\gamma=150$ (for \helio ions) or $\gamma=250$ (for \neon) could be achieved at the CERN-SPS. We study the sensitivity to $\theta_{13}$ and $\delta$ of such a beam as function of $\gamma$, optimizing with the baseline constrained to CERN-Frejus (130 km), and also with simultaneous variation of the baseline. These results are compared to the {\it standard} scenario previously considered, with lower $\gamma=60/100$, and also with a higher $\gamma\sim 350$ option that requires a more powerful accelerator. Although higher $\gamma$ is better, loss of sensitivity to $\theta _{13}$ and $\delta$ is most pronounced for $\gamma$ below 100.Comment: 22 page

Evaluación urodinámica y comparativa de la calidad de vida en pacientes con trastorno de vaciamiento vesical sometidos a terapia InterStim, Medtronic®

ResumenAntecedentesDesde 1980 la terapia de neuroestimulación sacra ha demostrado ser una terapia válida y alternativa en el manejo de los trastornos miccionales por patología del tracto urinario bajo, siendo sus principales indicaciones la retención urinaria idiopática, la incontinencia de urgencia y la incontinencia fecal. En nuestro país sigue siendo una terapia novedosa y no se cuenta aún con estudios que evalúen esta eficacia en términos de calidad de vida o con parámetros cuantitativos.Objetivo del estudioEstablecer la eficacia de la terapia de neuroestimulación sacra tipo InterStim, Medtronic®, en el manejo de los pacientes con trastornos de vaciamiento vesical, efectuando un análisis urodinámico y de la calidad de vida comparativo previo y posterior al tratamiento, determinando los volúmenes miccionales, los períodos de incontinencia, la satisfacción del paciente y la calidad de vida.Material y métodosDesde enero de 2010 hasta junio de 2013, en el Hospital Central Militar se realizó evaluación urodinámica y comparativa de la calidad de vida mediante el empleo del instrumento SF-36 v2 (versión mexicana) e ICIQSF, en los pacientes que presentaron trastorno de vaciamiento vesical de etiología no obstructiva y que fueron refractarios a tratamiento médico.ResultadosSe incluyeron 10 pacientes en el estudio, bajo los siguientes diagnósticos: disinergia detrusor-esfínter, vejiga hiperactiva y retención urinaria no obstructiva, ubicados por género (2 masculinos y 8 femeninos). En la totalidad de los pacientes se presentó mejoría del 50% o superior durante la fase de prueba de la terapia de neuroestimulación, y se colocó fase definitiva con los siguientes resultados: se obtuvieron resultados equivalentes al 50-65% de mejoría en los parámetros cualitativos de función física, función social y rol emocional, así como en las variables cuantitativas de volumen de vaciamiento, eficacia de vaciamiento y disminución de los períodos de incontinencia.DiscusiónComo se ha establecido a nivel de la literatura mundial, nuestros resultados fueron similares en el efecto benéfico y la eficacia en la calidad de vida e incontinencia urinaria, respectivamente, y se reportan porcentajes de éxito mayores al 50% en el cese total de los episodios de incontinencia.ConclusionesLa neuromodulación mediante la estimulación del nervio sacro es una forma exitosa de tratamiento en los trastornos de vaciamiento vesical de etiología no obstructiva y refractaria al tratamiento médico, es segura, mínimamente invasiva y de fácil aplicación, y mejora la calidad de vida de los pacientes. Sin embargo, es necesario realizar estudios aleatorizados y que consideren parámetros objetivos (urodinámicos), así como las complicaciones posibles a mediano y largo plazo en este tipo de terapia.AbstractBackgroundSince 1980, sacral neuromodulation therapy has been shown to be a valid alternative therapy in the management of urinary disorders due to lower urinary tract pathology, and its primary indications are: idiopathic urinary retention, urge incontinence, and fecal incontinence. It is still considered a novel therapy in Mexico and there are no studies using quantitative parameters that evaluate its efficacy in terms of quality of life.AimsTo establish the efficacy of the Medtronic InterStim® sacral neuromodulation therapy in the management of patients with bladder voiding disorders through urodynamic and quality of life analyses before and after treatment. Urine volume, periods of incontinence, patient satisfaction, and quality of life were determined.MethodsA comparative urodynamic and quality of life evaluation was carried out using the SF-36 v2 (Mexican version) and the ICIQSF instruments on patients presenting with nonobstructive bladder voiding disorders that were refractory to medical treatment.ResultsTen patients with the following diagnoses were included in the study: detrusor sphincter dyssynergia, overactive bladder, and nonobstructive urinary retention. Two of the patients were men and 8 were women. There was a 50% or greater improvement in all 10 patients during the test phase of the neuromodulation therapy and the definitive placement phase produced the following results: a 50-65% improvement in the qualitative parameters of physical function, social function, and emotional role, as well as in the quantitative variables of voiding volume, voiding efficacy, and reduced periods of incontinence.DiscussionOur results were similar to those established in the international literature in relation to the beneficial effect on quality of life and efficacy in urinary incontinence management; the literature reports success percentages in the complete cessation of incontinence episodes at above 50%.ConclusionsNeuromodulation through sacral nerve stimulation is a successful form of treatment of nonobstructive and medical treatment-refractory bladder voiding disorders. It is safe, minimally invasive, and easy to apply and it improves patient quality of life. Nevertheless, further randomized studies on this type of therapy need to be conducted that take into account objective parameters (urodynamics) and possible medium and long-term complications

On the measurement of leptonic CP violation

We show that the simultaneous determination of the leptonic CP-odd phase $\delta$ and the angle $\theta_{13}$ from the subleading transitions $\nu_e\to\nu_\mu$ and ${\bar\nu}_e\to{\bar\nu}_\mu$ results generically, at fixed neutrino energy and baseline, in two degenerate solutions. In light of this, we refine a previous analysis of the sensitivity to leptonic CP violation at a neutrino factory, in the LMA-MSW scenario, by exploring the full range of $\delta$ and $\theta_{13}$. Furthermore, we take into account the expected uncertainties on the solar and atmospheric oscillation parameters and in the average Earth matter density along the neutrino path. An intermediate baseline of O(3000) km is still the best option to tackle CP violation, although a combination of two baselines turns out to be very important in resolving degeneracies.Comment: 19 pages, 14 figures, uses epsfi

Superbeams plus Neutrino Factory: the golden path to leptonic CP violation

Superbeams (SB) and neutrino factories (NF) are not alternative facilities for exploring neutrino oscillation physics, but successive steps. The correct strategy is to contemplate the combination of their expected physics results. We show its important potential on the disappearance of fake degenerate solutions in the simultaneous measurement Of theta(13) and leptonic CP violation. Intrinsic, sign (Deltam(13)(2)) and theta(23) degeneracies are shown to be extensively eliminated when the results from one NF baseline and a SB facility are combined. A key point is the different average neutrino energy and baseline of the facilities. For values of theta(13) near its present limit, the short NF baseline, e.g., L = 732 km, becomes, after such a combination, a very interesting distance. For smaller theta(13), an intermediate NF baseline of O (3000 km) is still required

Feeding programmes based on highly-digestible fibre weaning diets: effects on health, growth performance and carcass and meat quality in rabbits

The effect of three different dietary programmes on health, growth performance and carcass and meat quality in young rabbits weaned at 28 d was studied using a diet (F) rich in highly-digestible fibre, from 17 to 63 d of age (group FF); using diet F from 17 to 42 d followed by a diet poor in highly-digestible fibre and rich in starch and fat (S) until 63 d (group FS); and using a standard diet C with intermediate highly-digestible fibre and starch content, containing 100 ppm of zinc-bacitracin, from 17 to 63 d (group CC). A highly-digestible fibre diet could be useful to reduce the incidence of digestive disorders. However, it decreased slaughter weight (2294 g in FF vs. 2406 g in CC; P<0.05) and carcass and meat traits, e.g. dressing out percentage (55.4% in FF vs. 56.7% in CC; P<0.05), meat to bone ratio (5.73 in FF vs. 5.94 in CC; P<0.05) and hind leg fat content (3.81% in FF vs. 4.71% in CC; P<0.05) at 63 d of age. Switching to a high starch and fat diet at late fattening improved chilled carcass weight at 63 d of age (1339 g in FS vs. 1263 g in FF; P<0.05) mainly through the promotion of liver development (7.53% in group FS vs. 6.47% in group FF; P<0.05) and fat deposition (3.89% in FS vs. 2.63% in FF; P<0.05), and increased hind leg fat content (+1.2 points of fat percentage; P<0.05). However, this switch increased health risk (35.1% in FS vs. 17.6% in FF; P<0.05).This study was supported by the Interministerial Commission for Science and Technology (CICYT) from the Spanish Government Grant number AGL2011-30170-C02-01 is gratefully acknowledged. Funding from the Spanish Ministry of Economy and Competitiveness for Madam Pascual's contract (PTA2011-5888-T) is also gratefully acknowledged.Pascual Amorós, MDLD.; Soler Sanchis, MD.; Cervera Fras, MC.; Pla Torres, M.; Pascual Amorós, JJ.; Blas Ferrer, E. (2014). Feeding programmes based on highly-digestible fibre weaning diets: effects on health, growth performance and carcass and meat quality in rabbits. Livestock Science. 169:88-95. https://doi.org/10.1016/j.livsci.2014.07.007S889516

The molecular basis and biologic significance of the β-dystroglycan-emerin interaction

β-dystroglycan (β-DG) assembles with lamins A/C and B1 and emerin at the nuclear envelope (NE) to maintain proper nuclear architecture and function. To provide insight into the nuclear function of β-DG, we characterized the interaction between β-DG and emerin at the molecular level. Emerin is a major NE protein that regulates multiple nuclear processes and whose deficiency results in Emery–Dreifuss muscular dystrophy (EDMD). Using truncated variants of β-DG and emerin, via a series of in vitro and in vivo binding experiments and a tailored computational analysis, we determined that the β-DG–emerin interaction is mediated at least in part by their respective transmembrane domains (TM). Using surface plasmon resonance assays we showed that emerin binds to β-DG with high affinity (KD in the nanomolar range). Remarkably, the analysis of cells in which DG was knocked out demonstrated that loss of β-DG resulted in a decreased emerin stability and impairment of emerin-mediated processes. β-DG and emerin are reciprocally required for their optimal targeting within the NE, as shown by immunofluorescence, western blotting and immunoprecipitation assays using emerin variants with mutations in the TM domain and B-lymphocytes of a patient with EDMD. In summary, we demonstrated that β-DG plays a role as an emerin interacting partner modulating its stability and function