1,898 research outputs found
The POINT-AGAPE Survey: Comparing Automated Searches of Microlensing Events toward M31
Searching for microlensing in M31 using automated superpixel surveys raises a
number of difficulties which are not present in more conventional techniques.
Here we focus on the problem that the list of microlensing candidates is
sensitive to the selection criteria or "cuts" imposed and some subjectivity is
involved in this. Weakening the cuts will generate a longer list of
microlensing candidates but with a greater fraction of spurious ones;
strengthening the cuts will produce a shorter list but may exclude some genuine
events. We illustrate this by comparing three analyses of the same data-set
obtained from a 3-year observing run on the INT in La Palma. The results of two
of these analyses have been already reported: Belokurov et al. (2005) obtained
between 3 and 22 candidates, depending on the strength of their cuts, while
Calchi Novati et al. (2005) obtained 6 candidates. The third analysis is
presented here for the first time and reports 10 microlensing candidates, 7 of
which are new. Only two of the candidates are common to all three analyses. In
order to understand why these analyses produce different candidate lists, a
comparison is made of the cuts used by the three groups...Comment: 28 pages, 24 figures, 9 table
The POINT-AGAPE survey II: An Unrestricted Search for Microlensing Events towards M31
An automated search is carried out for microlensing events using a catalogue
of 44554 variable superpixel lightcurves derived from our three-year monitoring
program of M31. Each step of our candidate selection is objective and
reproducible by a computer. Our search is unrestricted, in the sense that it
has no explicit timescale cut. So, it must overcome the awkward problem of
distinguishing long-timescale microlensing events from long-period stellar
variables. The basis of the selection algorithm is the fitting of the
superpixel lightcurves to two different theoretical models, using variable star
and blended microlensing templates. Only if microlensing is preferred is an
event retained as a possible candidate. Further cuts are made with regard to
(i) sampling, (ii) goodness of fit of the peak to a Paczynski curve, (iii)
consistency of the microlensing hypothesis with the absence of a resolved
source, (iv) achromaticity, (v) position in the colour-magnitude diagram and
(vi) signal-to-noise ratio. Our results are reported in terms of first-level
candidates, which are the most trustworthy, and second-level candidates, which
are possible microlensing but have lower signal-to-noise and are more
questionable. The pipeline leaves just 3 first-level candidates, all of which
have very short full-width half-maximum timescale (<5 days) and 3 second-level
candidates, which have timescales of 31, 36 and 51 days respectively. We also
show 16 third-level lightcurves, as an illustration of the events that just
fail the threshold for designation as microlensing candidates. They are almost
certainly mainly variable stars. Two of the 3 first-level candidates correspond
to known events (PA 00-S3 and PA 00-S4) already reported by the POINT-AGAPE
project. The remaining first-level candidate is new.Comment: 22 pages, 18 figures, MNRAS, to appea
Recommended from our members
Early symptoms and sensations as predictors of lung cancer: a machine learning multivariate model.
The aim of this study was to identify a combination of early predictive symptoms/sensations attributable to primary lung cancer (LC). An interactive e-questionnaire comprised of pre-diagnostic descriptors of first symptoms/sensations was administered to patients referred for suspected LC. Respondents were included in the present analysis only if they later received a primary LC diagnosis or had no cancer; and inclusion of each descriptor required ≥4 observations. Fully-completed data from 506/670 individuals later diagnosed with primary LC (n = 311) or no cancer (n = 195) were modelled with orthogonal projections to latent structures (OPLS). After analysing 145/285 descriptors, meeting inclusion criteria, through randomised seven-fold cross-validation (six-fold training set: n = 433; test set: n = 73), 63 provided best LC prediction. The most-significant LC-positive descriptors included a cough that varied over the day, back pain/aches/discomfort, early satiety, appetite loss, and having less strength. Upon combining the descriptors with the background variables current smoking, a cold/flu or pneumonia within the past two years, female sex, older age, a history of COPD (positive LC-association); antibiotics within the past two years, and a history of pneumonia (negative LC-association); the resulting 70-variable model had accurate cross-validated test set performance: area under the ROC curve = 0.767 (descriptors only: 0.736/background predictors only: 0.652), sensitivity = 84.8% (73.9/76.1%, respectively), specificity = 55.6% (66.7/51.9%, respectively). In conclusion, accurate prediction of LC was found through 63 early symptoms/sensations and seven background factors. Further research and precision in this model may lead to a tool for referral and LC diagnostic decision-making
Associations of sleep-related outcomes with behavioral and emotional functioning in children with overweight/obesity
Objective To evaluate the associations of parent-reported sleep-disordered breathing (SDB) and deviceassessed sleep behaviors with behavioral and emotional functioning in pediatric patients with overweight/ obesity. Study design A total of 109 children with overweight/obesity (mean age, 10.0 (±) 1.1 years) were included in this cross-sectional study. We used the Spanish version of the Pediatric Sleep Questionnaire (PSQ) to assess SDB and its subscales (ie, snoring, daytime sleepiness, and inattention/hyperactivity). Device-assessed sleep behaviors (ie, wake time, sleep onset time, total time in bed, total sleep time, and waking after sleep onset) were estimated using wrist-worn accelerometers. We used the Behavior Assessment System for Children, second edition to assess behavioral and emotional functioning (ie, clinical scale: aggressiveness, hyperactivity, behavior problems, attention problems, atypicality, depression, anxiety, retreat, and somatization; adaptive scale: adaptability, social skills, and leadership). Results SDB was positively associated with all clinical scale variables (all b > 0.197, P ≤ .041) and with lower adaptability and leadership (all b 0.196, P ≤ .045) and lower adaptability (b = 0.246, P = .011). The inattention/hyperactivity subscale was significantly associated with the entire clinical and adaptive scales (all b > |0.192|, P ≤ .046) except for somatization. The snoring subscale and device-assessed sleep behaviors were not related to any behavioral or emotional functioning variables. Conclusions Our study suggests that SDB symptoms, but not deviceassessed sleep behaviors, are associated with behavioral and emotional functioning in children with overweight/obesity. Specifically, daytime sleepiness, a potential SDB symptom, was related to higher attention problems, depression, anxiety, and retreat and lower adaptability. (J Pediatr 2022;246:170-8).The ActiveBrains project was funded by the Spanish Ministry of Economy and Competitiveness and the Fondo Europeo de Desarrollo Regional (DEP2013-47540, DEP2016-79512-R, DEP2017-91544-EXP, and RYC-2011-09011). L.V.T.-L. is supported by a grant from the Spanish Ministry of Science, Innovation and Universities (FPU17/04802). C.C.-S. is supported by the Spanish Ministry of Science and Innovation (FJC2018-037925-I). J.H.M. is supported by a grant from the Spanish Ministry of Education, Culture, and Sport (FPU15/02645). Additional support was provided by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence, Scientific Excellence Unit on Exercise and Health, by the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, and European Regional Development Fund (SOMM17/6107/UGR). Funding was also provided by the SAMID III network, RETICS , funded by the PNI + D + I 2017-2021 (Spain), ISCIII Sub-Directorate General for Research Assessment and Promotion, the European Regional Development Fund (RD16/0022 ), the EXERNET Research Network on Exercise and Health ( DEP2005-00046/ACTI ; 09/UPB/19; 45/UPB/20; 27/UPB/21), the European Union's 2020 Research and Innovation Program under Grant Agreement 667302, and the HL-PIVOT network Healthy Living for Pandemic Event Protection . Additional funding was obtained from the Andalusian Operational Programme supported with European Regional Development Fund (project B-CTS-355-UGR18)
Cosmic shear requirements on the wavelength-dependence of telescope point spread functions
Cosmic shear requires high precision measurement of galaxy shapes in the
presence of the observational Point Spread Function (PSF) that smears out the
image. The PSF must therefore be known for each galaxy to a high accuracy.
However, for several reasons, the PSF is usually wavelength dependent,
therefore the differences between the spectral energy distribution of the
observed objects introduces further complexity. In this paper we investigate
the effect of the wavelength-dependence of the PSF, focusing on instruments in
which the PSF size is dominated by the diffraction-limit of the telescope and
which use broad-band filters for shape measurement.
We first calculate biases on cosmological parameter estimation from cosmic
shear when the stellar PSF is used uncorrected. Using realistic galaxy and star
spectral energy distributions and populations and a simple three-component
circular PSF we find that the colour-dependence must be taken into account for
the next generation of telescopes. We then consider two different methods for
removing the effect (i) the use of stars of the same colour as the galaxies and
(ii) estimation of the galaxy spectral energy distribution using multiple
colours and using a telescope model for the PSF. We find that both of these
methods correct the effect to levels below the tolerances required for per-cent
level measurements of dark energy parameters. Comparison of the two methods
favours the template-fitting method because its efficiency is less dependent on
galaxy redshift than the broad-band colour method and takes full advantage of
deeper photometry.Comment: 10 pages, 8 figures, version accepted for publication in MNRA
Cosmological Systematics Beyond Nuisance Parameters : Form Filling Functions
In the absence of any compelling physical model, cosmological systematics are
often misrepresented as statistical effects and the approach of marginalising
over extra nuisance systematic parameters is used to gauge the effect of the
systematic. In this article we argue that such an approach is risky at best
since the key choice of function can have a large effect on the resultant
cosmological errors. As an alternative we present a functional form filling
technique in which an unknown, residual, systematic is treated as such. Since
the underlying function is unknown we evaluate the effect of every functional
form allowed by the information available (either a hard boundary or some
data). Using a simple toy model we introduce the formalism of functional form
filling. We show that parameter errors can be dramatically affected by the
choice of function in the case of marginalising over a systematic, but that in
contrast the functional form filling approach is independent of the choice of
basis set. We then apply the technique to cosmic shear shape measurement
systematics and show that a shear calibration bias of |m(z)|< 0.001(1+z)^0.7 is
required for a future all-sky photometric survey to yield unbiased cosmological
parameter constraints to percent accuracy. A module associated with the work in
this paper is available through the open source iCosmo code available at
http://www.icosmo.org .Comment: 24 pages, 18 figures, accepted to MNRA
Proinsulin C-peptide elicits disaggregation of insulin resulting in enhanced physiological insulin effects
Using surface plasmon resonance (SPR) and electrospray mass spectrometry (ESI-MS), proinsulin C-peptide was found to influence insulin-insulin interactions. In SPR with chip-bound insulin, C-peptide mixed with analyte insulin increased the binding, while alone C-peptide did not. A control peptide with the same residues in random sequence had little effect. In ESI-MS, C-peptide lowered the presence of insulin hexamer. The data suggest that C-peptide promotes insulin disaggregation. Insulin/insulin oligomer μM dissociation constants were determined. Compatible with these findings, type 1 diabetic patients receiving insulin and C-peptide developed 66% more stimulation of glucose metabolism than when given insulin alone. A role of C-peptide in promoting insulin disaggregation may be important physiologically during exocytosis of pancreatic β-cell secretory granulae and pharmacologically at insulin injection sites. It is compatible with the normal co-release of C-peptide and insulin and may contribute to the beneficial effect of C-peptide and insulin replacement in type 1 diabetics
The Angstrom Project: a microlensing survey of the structure and composition of the bulge of the Andromeda galaxy
The Andromeda Galaxy Stellar Robotic Microlensing Project (The Angstrom
Project) aims to use stellar microlensing events to trace the structure and
composition of the inner regions of the Andromeda Galaxy (M31). We present
microlensing rate and timescale predictions and spatial distributions for
stellar and sub-stellar lens populations in combined disk and barred bulge
models of M31. We show that at least half of the stellar microlenses in and
around the bulge are expected to have characteristic durations between 1 and 10
days, rising to as much as 80% for brown-dwarf dominated mass functions. These
short-duration events are mostly missed by current microlensing surveys that
are looking for Macho candidates in the M31 dark matter halo. Our models
predict that an intensive monitoring survey programme such as Angstrom, which
will be able to detect events of durations upwards of a day, could detect
around 30 events per season within ~5 arcminutes of the M31 centre, due to
ordinary low-mass stars and remnants. This yield increases to more than 60
events for brown-dwarf dominated mass functions. The overall number of events
and their average duration are sensitive diagnostics of the bulge mass, in
particular the contribution of low-mass stars and brown dwarfs. The combination
of an inclined disk, an offset bar-like bulge, and differences in the bulge and
disk luminosity functions results in a four-way asymmetry in the number of
events expected in each quadrant defined by the M31 disk axes. The asymmetry is
sensitive to the bar prolongation, orientation and mass.Comment: 9 pages, submitted to MNRA
- …