FORMULATION AND OPTIMIZATION OF FAST DISSOLVING TABLETS OF PROMETHAZINE THEOCLATE USING 32 FACTORIAL DESIGN

The fast dissolving tablets of Promethazine Theoclate were prepared by sublimation technique, using 32 full factorial design. This research work aimed to study and to develop a unique drug delivery system for immediate release of drugs which can dissolve readily when placed in the oral cavity. The different subliming agents (Camphor, Urea and Menthol) in varying concentration (5-15% w/w) were used to develop the tablets. Total 12 formulations were prepared and evaluated for pre-compression and post compression characteristics. The optimization of the batches was carried out using 32 full factorial design and results of polynomial equation were analyzed using ANOVA and regression analysis. By the use of desirability approach final optimized formulation was prepared

IN VITRO AND IN VIVO EVALUATION OF MUCOADHESIVE MICROSPHERES FOR TREATMENT OF HELICOBACTER PYLORI USING FACTORIAL DESIGN

The research involves characterization of in vitro and in vivo activity of mucoadhesive microspheres for Helicobacter pylori eradication. Amoxicillin and Famotidine were used as model drugs so that the dual therapy gives better H. pylori eradication. Preparation was carried by an emulsion-solvent evaporation method and 27 batches were prepared individually using 33 factorial designs to study the effect of independent variables on dependent variables. The in vitro mucoadhesion test and in vivo studies (Bacterial clearance study, in vivo mucoadhesion and in vivo ulcer index studies) were performed. A27 batch showed 66% mucoadhesion after 10 h and F24 showed 74% of mucoadhesion after 10 h. In the bacterial clearance studies, the mean bacterial count (log colony forming units) after oral administration of drug-loaded microspheres was found to be 3.72 ± 0.58. The drug-loaded microspheres formulation exhibited better clearance from infection than plain drugs solution at the same doses. Drug microspheres formulation was found to be effective in the treatment of H. pylori infections effectively, and in in vivo mucoadhesion studies, the developed system was well taken up and processed by the cells of gastric mucosa of the stomach

A study to assess major indications and outcome of lower segment cesarean section in hospital setting

The caesarean rate is substantially greater in India as compared to other regions of the world. The rising caesarean rate has contributed in greater socioeconomic strain on health care and also increased maternal morbidity. Jammu & Kashmir, Punjab, Haryana, Rajasthan, Orissa, Madhya Pradesh, Andhra Pradesh and Tamil nadu have been enjoying tremendous growth in institutional delivery between 1992-93 and 2007-08. Except Rajasthan and Madhya Pradesh, all these states provide the evidence of significant rise in caesarean section births. In 2008, the Maternal mortality (MMR) and the infant mortality rate (IMR/9 in these states were likewise highly high (Register General, India, 2011 and office of the Registrar General, India, 2016). (Register General, India, 2011 and office of the Registrar General, India, 2016). So, it can be stated that these states suffer from lack of health facilities to address surgical obstetric needs which totally explains increased mortality and ill health of mothers and their newborns in these states. The present study sought to find the significant indications and outcome of lower segment caesarean section. The present study sought to find out significant indications and outcome of lower segment caesarean section