European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.The EU-ROS consortium (COST Action BM1203) was supported by the European Cooperation in Science and Technology (COST). The present overview represents the final Action dissemination summarizing the major achievements of COST Action BM1203 (EU-ROS) as well as research news and personal views of its members. Some authors were also supported by COST Actions BM1005 (ENOG) and BM1307 (PROTEOSTASIS), as well as funding from the European Commission FP7 and H2020 programmes, and several national funding agencies

Uloha oxidu dusnateho v patogenezi plicni hypertenze

One of the most important differences between the pulmonary and systemic circulation is a considerably lower blood pressure and hemodynamic resistance in the lesser circulation. After the discovery of the endogenous vasocilator, nitric oxide , it had been assumed that pulmonary vasculature is characterized by a high tonic NO production, which might contribute to the low basal tone of these vessels. Inability to maintain this high NO production would then lead to the development of pulmonary hypertension. However, numerous studies summarized in the review gradually proved that, in reality, this simple scheme does not apply. Healthy pulmonary vessels usually produce only relatively small amounts of NO. In pulmonary hypertension, NO synthesis increases. The rise in pulmonary artery pressure is partly blunted by this protective mechanism, at least until the pulmonary endothelium is damaged by the permanent and severe elevation of intravascular pressure. However, it is also possible that the increased NO production, contribute to the development of pulmonary hypertension by interacting with superoxide and yielding peroxynitrite. The highly reactive and cytotoxic peroxynitrite, contribute to the pulmonary vascular wall injury, which underlies the development of pulmonary hypertensionAvailable from STL Prague, CZ / NTK - National Technical LibrarySIGLECZCzech Republi

A partir de l'Europe centrale, analyser un monde qui change: colloque organisé à l'occasion du 20e anniversaire du Centre français de recherche en sciences sociales

À l'occasion de son vingtième anniversaire, le CEFRES a invité des chercheurs et des responsables de la recherche et de la coopération internationale à participer à huit tables rondes. Il s'agissait d'abord de réfléchir aux transformations du contexte dans lequel s'inscrit dorénavant le développement de la recherche, et aux défis que doivent relever les chercheurs et leurs réseaux ici, en France, et en Europe centrale depuis l'élargissement européen. Lors d'une seconde journée, de jeunes chercheurs formés partiellement par les institutions comme le CEFRES encadraient des tables rondes interdisciplinaires sur des thèmes d'actualité: Penser la violence et Culture et politique

A partir de l'Europe centrale, analyser un monde qui change: colloque organisé à l'occasion du 20e anniversaire du Centre français de recherche en sciences sociales

À l'occasion de son vingtième anniversaire, le CEFRES a invité des chercheurs et des responsables de la recherche et de la coopération internationale à participer à huit tables rondes. Il s'agissait d'abord de réfléchir aux transformations du contexte dans lequel s'inscrit dorénavant le développement de la recherche, et aux défis que doivent relever les chercheurs et leurs réseaux ici, en France, et en Europe centrale depuis l'élargissement européen. Lors d'une seconde journée, de jeunes chercheurs formés partiellement par les institutions comme le CEFRES encadraient des tables rondes interdisciplinaires sur des thèmes d'actualité: Penser la violence et Culture et politique

European contribution to the study of ROS:a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Abstract The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed