Überarbeitung ausgewählter Monographien des österreichischen Arzneibuchs

In dieser Diplomarbeit wurden die Monograhien „Folium Vitis-idaeae“ und „Tinctura Valerianae aetherea“ des Österreichischen Arzneibuchs (ÖAB) überarbeitet. Dabei wurden sie hinsichtlich der Aktualisierung der Analysenmethoden, der ausschließlichen Verwendung des europäischen Reagenziensatzes und der Harmonisierung in Stil und Inhalt an den Standard des Europäischen Arzneibuchs (Ph. Eur.) angepasst. Der Nomenklatur des Ph. Eur. entsprechend sind diese Monographien jetzt unter dem Namen „Baldriantinktur, etherische / Valeriana tinctura aetherea“ und „Preiselbeerblatt / Vitis-idaeae folium“ zu finden. Die wichtigsten Neuerungen der Analysenmethoden werden im Folgenden kurz geschildert: beiden Monographien wurden Vorschriften zur Identitätsprüfung mittels Dünnschicht-chromatographie (DC) sowie eine Gehaltsbestimmung spezifischer Hauptinhaltsstoffe mittels High Performance Liquid Chromatography (HPLC) hinzugefügt. Für die zu quantifzierenden Verbindungen wurde ein vorgeschriebener Mindestgehalt festgelegt. DC- und HPLC- Vorschriften konnten dabei weitgehend unverändert von den Monographien „Baldriantinktur / Valerianae tinctura“ und „Bärentraubenblätter / Uvae ursi folium“ des Ph. Eur. 6.0 übernommen werden. Es ergab sich lediglich eine geringfügige Modifikation des zweiten Sprühreagens in der DC-Vorschrift von Vitis-idaeae folium. Die Monographie „Vitis-idaeae folium“ enthält von nun an schematische Darstellungen der wichtigsten mikroskopischen Drogenmerkmale sowie eine mikroskopische Charakterisierung der Pulverdroge. Die bereits in der Monographie des ÖAB beschriebenen Charakteristika wurden anhand einiger Stichproben überprüft. Dabei wurden Änderungen der morphologischen Beschreibung des Blattrands und der Nervatur vorgenommen. Ebenfalls wurde die Beschreibung einiger mikroskopischer Merkmale wie Drüsenzotten, Kutikula und Stomatatyp sowie Calciumoxalatkristalle bzw. Drusen geändert. Der Abschnitt PRÜFUNG AUF REINHEIT wurde um die Bestimmung des Trocknungsverlustes erweitert und ein dafür gültiger Grenzwert festgelegt. In der Monographie „Valerianae tinctura aetherea“ wurden Änderungen betreffend der Grenzwerte der Dichte und des Trockenrückstands vorgenommen. Abschließend wurde eine Anpassung des Erscheinungsbildes entsprechend dem Stil des Ph. Eur. durchgeführt, um die Revision dieser Monographien als vollständig betrachten zu können.In this diploma thesis the monographs „Folium Vitis-idaeae“ and „Tinctura Valerianae aetherea“ of the Austrian Pharmacopoeia (Österreichisches Arzneibuch, ÖAB) were updated. The monographs were adapted to the European Pharmacopoeia (Ph. Eur.) monograph structure concerning the actualisation of the methods of analysis, the exclusive use of the Ph. Eur. reagent set and the harmonisation in style and contents. According to the nomenclature of the Ph. Eur. these monographs can be found under the names „Baldriantinktur, etherische / Valerianae tinctura aetherea“ and "Preiselbeerblatt / Vitis-idaeae folium". In the following paragraphs the most important modifications of the analysis methods are briefly described: to both monographs thin layer chromatography (TLC) as means of identification as well as High Performance Liquid Chromatography (HPLC) methods for quantification of lead compounds were added. A prescribed minimum content of the main components was determined. For both monographs existing TLC and HPLC systems were adopted from the monographs „Baldriantinktur / Valerianae tinctura“ und „Bärentraubenblätter / Uvae ursi folium“ of the Ph. Eur. 6.0. Regarding the monograph Vitis-ideae folium there was only a slight modification of the second spraying reagent used for TLC analysis. From now on the monograph Vitis-ideae folium contains schematic pictures of the most important microscopic drug features as well as a microscopic characterisation of the powdered drug. The characteristic features, already described in the existing monograph, were verified using random samples. Hence changes in the morphologic description of leaf edge and venation were established. Also the description of some microscopic features like gland villi, cuticle and stomata type as well as calcium oxalate crystals respectively druses was changed. “Loss on drying” was added to the TESTS section, including the introduction of a proper limit value. In the monograph “Valerianae tinctura aetherea” new limits were set for density and dry matter. Finally the general appearance of both monographs was adapted to the style of the Ph.Eur. to complete the revision

Die Register Innocenz’ III. 13. Jahrgang (1210/1211). Texte und Indices

The volume is containing the critical edition of 207 letters of pope Innocent III’ addressed to recipients all over Europe and in the Middle East which were entered into the chancery registers of the 13th year of pontificate (1210/1211). It is the first of four volumes transmitted not as original but as a copy written at the Curia in mid-14th century and as print published in the 17th century.Der Band beinhaltet die kritische Edition von 207 Schreiben Papst Innocenz’ III. an unterschiedliche Empfänger in Europa und im Nahen Osten aus dem 13. Pontifikatsjahr (1210/1211), die in das Kanzleiregister aufgenommen wurden. Er ist der erste von vier Bänden, die nicht als Originalregister, sondern in einer an der Kurie gefertigten Abschrift aus der Mitte des 14. und als Druck aus dem 17. Jahrhundert überliefert sind

Plasmonic Hepatitis B Biosensor for the Analysis of Clinical Saliva

A biosensor for the detection of hepatitis B antibodies in clinical saliva was developed. Compared to conventional analysis of blood serum, it offers the advantage of noninvasive collection of samples. Detection of biomarkers in saliva imposes two major challenges associated with the low analyte concentration and increased surface fouling. The detection of minute amounts of hepatitis B antibodies was performed by plasmonically amplified fluorescence sandwich immunoassay. To have access to specific detection, we prevented the nonspecific adsorption of biomolecules present in saliva by brushes of poly[(N-(2-hydroxypropyl) methacrylamide)-co-(carboxybetaine methacrylamide)] grafted from the gold sensor surface and post modified with hepatitis B surface antigen. Obtained results were validated against the response measured with ELISA at a certified laboratory using serum from the same patients. © 201

Plasmonic Hepatitis B Biosensor for the Analysis of Clinical Saliva

A biosensor for the detection of hepatitis B antibodies in clinical saliva was developed. Compared to conventional analysis of blood serum, it offers the advantage of noninvasive collection of samples. Detection of biomarkers in saliva imposes two major challenges associated with the low analyte concentration and increased surface fouling. The detection of minute amounts of hepatitis B antibodies was performed by plasmonically amplified fluorescence sandwich immunoassay. To have access to specific detection, we prevented the nonspecific adsorption of biomolecules present in saliva by brushes of poly[(N-(2-hydroxypropyl) methacrylamide)-co-(carboxybetaine methacrylamide)] grafted from the gold sensor surface and post modified with hepatitis B surface antigen. Obtained results were validated against the response measured with ELISA at a certified laboratory using serum from the same patients. © 201

Die Register Innocenz’ III. 15. Jahrgang (1212/1213). Texte und Indices

The fifteenth volume of the critical edition of pope Innocent III’s chancery-registers is containing 242 letters addressed to recipients all over Europe and in the Middle East. In this year of the pontificate, the organization of the Church in The Latin Empire, the war against muslims in Spain and in the East and against heretics in Southern France are main topics constantly recurring in the Pope’s letters. The register of Innocent’s fifteenth year of pontificate is one of the four volumes transmitted not as original but as a copy written at the Curia in mid-14th century and as print published in the 17th century.Das Register des 15. Pontifikatsjahrs Innocenz’ III. enthält die kritische Edition von 242 Briefen aus der päpstlichen Kanzlei, die sich an unterschiedliche Empfänger in ganz Europa wie im Nahen Osten richten. Leitthemen des Jahrgangs sind die Kirchenorganisation im Lateinischen Kaiserreich, der Sarazenenkrieg in Spanien, die Bemühungen um einen neuen Kreuzzug ins Heilige Land und die Bekämpfung der Häresie in Südfrankreich. Auch der 15. Jahrgang gehört zu den vier Bänden der Register Innocenz’ III., die nicht als Originalregister, sondern in einer an der Kurie gefertigten Abschrift aus der Mitte des 14. und in einem gelehrten Druck aus dem 17. Jahrhundert überliefert sind

Die Register Innocenz’ III. 13. Jahrgang (1210/1211). Texte und Indices

The volume is containing the critical edition of 207 letters of pope Innocent III’ addressed to recipients all over Europe and in the Middle East which were entered into the chancery registers of the 13th year of pontificate (1210/1211). It is the first of four volumes transmitted not as original but as a copy written at the Curia in mid-14th century and as print published in the 17th century

Morgawr: an experimental Bronze Age-type sewn-plank craft based on the Ferriby boats

Photographs and a link to a video showing the construction and launch of "Morgawr" can also be found in ORE: http://hdl.handle.net/10871/14703This paper reports on the construction of a full-scale Bronze Age-type sewn-plank boat based on the Ferriby boats. The boat, which was named Morgawr, was constructed in the National Maritime Museum Cornwall in Falmouth, England, during 2012 and the first months of 2013, as part of a larger exhibition in the museum. This paper provides the background and context of the project, describes the process of building the craft, and reflects in particular on differences between Morgawr and the ‘hypothetical reconstruction of a complete sewn-plank boat’ published in 1990 by Ted Wright and John Coates which formed the basis for this project.Arts and Humanities Research Council (AHRC

Capitalist Formations of Enclosure: Space and the Extinction of the Commons

Despite their theoretical and political potential, recent debates on enclosure usually lack an effective consideration of how space is mobilized in the process of dispossession. This article connects the analysis of enclosure's general spatial rationality to a range of illustrations of its particular formations and procedures. Enclosure is understood as one of capitalism's “universal territorial equivalents”, a polymorphous technique with variegated expressions in time but also with a consistent logic that uses the spatial erosion of the commons to subsume non-commodified, self-managed social spaces. In response to the ever-changing nature of commoning, successive regimes of enclosure reshape the morphologies of deprivation and their articulation to other state and market apparatuses in order to meet shifting strategies of capital accumulation and social reproduction. Through a spatially nuanced account of these phenomena, I outline a tentative genealogy of enclosure formations that allows tracking diverse geographies of dispossession across different scales and regulatory contexts in various historical stages of capitalist development