785 research outputs found

    A framework of firms' business sustainability endeavours with internal and external stakeholders through time across oriental and occidental business contexts

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    Purpose The purpose of the paper is to test and compare a framework of firms' business sustainability endeavours with internal and external stakeholders in an oriental business context and to verify the validity and reliability of a stakeholder framework through time and across oriental and occidental business contexts. Design/methodology/approach Quantitative approach based on a questionnaire survey in corporate Taiwan with a response rate of 68.5%. Multivariate analysis is undertaken to uncover the measurement properties of a stakeholder framework. Findings A framework of firms' business sustainability endeavours with internal and external stakeholders appears valid and reliable through time and across occidental and oriental business contexts. Research limitations/implications This study verifies and fortifies a stakeholder framework through time and across business contexts consisting of five stakeholder groups: upstream, the focal firm, downstream, market and societal. Practical implications The framework of firms' business sustainability endeavours provides guidance to firms in their endeavours of business sustainability with internal and external stakeholders. Originality/value This study contributes to existing theory and previous studies by validating a stakeholder framework of business sustainability with internal and external stakeholders beyond occidental business context to be also valid and reliable in oriental ones

    TBL dominant logic for sustainability in oriental businesses

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    Purpose This paper aims to examine the common denominators of measurement properties of a Triple Bottom Line (TBL) dominant logic for business sustainability through time and across business contexts. Design/methodology/approach The method was based on a quantitative approach and a questionnaire survey in corporate Taiwan with a response rate of 68.5%. Findings This article uncovers and fortifies common denominators through time between oriental and occidental business contexts. Practical implications The framework of TBL dominant logic for business sustainability establishes a toolbox for practitioners to examine economic, social and environmental elements as the marketing strategy in connection with business sustainability. Social implications This enables to validate the framework of TBL dominant logic for business sustainability in previous research. Multiple dimensions are validated through time and across business contexts. Originality/value This study contributes to existing theory and previous research by fortifying the framework of TBL-dominant logic for business sustainability. The twenty-dimensional framework demonstrates universal measurement properties through time and across oriental and occidental business contexts

    A self-consistent hybrid Comptonization model for broad-band spectra of accreting supermassive black holes

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    The nature of the broad-band spectra of supermassive accreting black holes in active galactic nuclei (AGNs) is still unknown. The hard X-ray spectra of Seyferts as well as of Galactic stellar-mass black holes (GBHs) are well represented by thermal Comptonization, but the origin of the seed photons is less certain. The MeV tails observed in GBHs provide evidence in favour of non-thermal electron tails and it is possible that such electrons are also present in the X-ray emitting regions of AGNs. Using simulations with the kinetic code that self-consistently models electron and photon distributions, we find that the power-law-like X-ray spectra in AGNs can be explained in terms of the synchrotron self-Compton radiation of hybrid thermal/non-thermal electrons, similarly to the hard/low state of GBHs. Under a very broad range of parameters the model predicts a rather narrow distribution of photon spectral slopes consistent with that observed from LINERs and Seyferts at luminosities less than 3 per cent of the Eddington luminosity. The entire infrared to X-ray spectrum of these objects can be described in terms of our model, suggesting a tight correlation between the two energy bands. We show that the recently found correlation between slope and the Eddington ratio at higher luminosities can be described by the increasing fraction of disc photons in the emitting region, which may be associated with the decreasing inner radius of the optically thick accretion disc. The increasing flux of soft photons is also responsible for the transformation of the electron distribution from nearly thermal to almost completely non-thermal. The softer X-ray spectra observed in narrow-line Seyfert galaxies may correspond to non-thermal Comptonization of the disc photons, predicting that no cutoff should be observed up to MeV energies in these sources, similarly to the soft-state GBHs.Comment: MNRAS publishe

    A celestial gamma-ray foreground due to the albedo of small solar system bodies and a remote probe of the interstellar cosmic ray spectrum

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    We calculate the gamma-ray albedo flux from cosmic-ray (CR) interactions with the solid rock and ice in Main Belt asteroids (MBAs), Jovian and Neptunian Trojan asteroids, and Kuiper Belt objects (KBOs) using the Moon as a template. We show that the gamma-ray albedo for the Main Belt, Trojans, and Kuiper Belt strongly depends on the small-body size distribution of each system. Based on an analysis of the Energetic Gamma Ray Experiment Telescope (EGRET) data we infer that the diffuse emission from the MBAs, Trojans, and KBOs has an integrated flux of less than ~6x10^{-6} cm^{-2} s^{-1} (100-500 MeV), which corresponds to ~12 times the Lunar albedo, and may be detectable by the forthcoming Gamma Ray Large Area Space Telescope (GLAST). If detected by GLAST, it can provide unique direct information about the number of small bodies in each system that is difficult to assess by any other method. Additionally, the KBO albedo flux can be used to probe the spectrum of CR nuclei at close-to-interstellar conditions. The orbits of MBAs, Trojans, and KBOs are distributed near the ecliptic, which passes through the Galactic center and high Galactic latitudes. Therefore, the asteroid gamma-ray albedo has to be taken into account when analyzing weak gamma-ray sources close to the ecliptic, especially near the Galactic center and for signals at high Galactic latitudes, such as the extragalactic gamma-ray emission. The asteroid albedo spectrum also exhibits a 511 keV line due to secondary positrons annihilating in the rock. This may be an important and previously unrecognized celestial foreground for the INTErnational Gamma-Ray Astrophysics Laboratory (INTEGRAL) observations of the Galactic 511 keV line emission including the direction of the Galactic center.Comment: 10 pages, 5 figures, 1 table, emulateapj.cls; ApJ in press. Calculations extended to include Jovian and Neptunian Trojan groups, and Centaurs, in addition to Main Belt Asteroids and Kuiper Belt Objects. Many other considerable change

    Elevated intracellular cAMP concentration mediates growth suppression in glioma cells.

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    Supressed levels of intracellular cAMP have been associated with malignancy. Thus, elevating cAMP through activation of adenylyl cyclase (AC) or by inhibition of phosphodiesterase (PDE) may be therapeutically beneficial. Here, we demonstrate that elevated cAMP levels suppress growth in C6 cells (a model of glioma) through treatment with forskolin, an AC activator, or a range of small molecule PDE inhibitors with differing selectivity profiles. Forskolin suppressed cell growth in a PKA-dependent manner by inducing a G2/M phase cell cycle arrest. In contrast, trequinsin (a non-selective PDE2/3/7 inhibitor), not only inhibited cell growth via PKA, but also stimulated (independent of PKA) caspase-3/-7 and induced an aneuploidy phenotype. Interestingly, a cocktail of individual PDE 2,3,7 inhibitors suppressed cell growth in a manner analogous to forskolin but not trequinsin. Finally, we demonstrate that concomitant targeting of both AC and PDEs synergistically elevated intracellular cAMP levels thereby potentiating their antiproliferative actions

    Soft X-ray spectral variations of the narrow line Seyfert l galaxy Markarian 766

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    The X-ray variability of the narrow-line Seyfert 1 galaxy Markarian 766 is studied using nine ROSAT PSPC data sets. The spectrum is well described by a power law combined with a blackbody (kT ∼ 70 eV) soft excess. Examination of flux ratio changes and variability amplitude in three X-ray bands shows that the power-law component varies continuously on time-scales of ∼ 5000 s and is steeper when it is brighter. In contrast, variability of the soft excess is not detected. Spectral modelling of 31 spectra from different observations and at a range of count rates is also consistent with a picture in which the power law is steeper when it is brighter, and in which the soft-excess component does not vary. The power-law variability can be explained if the power law is produced by variable thermal or non-thermal Comptonization of soft photons. This behaviour is similar to that of Galactic black hole candidates in the low state. The X-ray and multiwavelength properties of Markarian 766 are shown to be very similar to those of other narrow-line Seyfert 1s. This may mean that the rapid X-ray variability seen in other narrow-line Seyfert 1s may also not originate in their strong soft-excess components

    Determinants of medication adherence to antihypertensive medications among a Chinese population using Morisky medication adherence scale

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    <b>Background and objectives</b> Poor adherence to medications is one of the major public health challenges. Only one-third of the population reported successful control of blood pressure, mostly caused by poor drug adherence. However, there are relatively few reports studying the adherence levels and their associated factors among Chinese patients. This study aimed to study the adherence profiles and the factors associated with antihypertensive drug adherence among Chinese patients.<p></p> <b>Methods</b> A cross-sectional study was conducted in an outpatient clinic located in the New Territories Region of Hong Kong. Adult patients who were currently taking at least one antihypertensive drug were invited to complete a self-administered questionnaire, consisting of basic socio-demographic profile, self-perceived health status, and self-reported medication adherence. The outcome measure was the Morisky Medication Adherence Scale (MMAS-8). Good adherence was defined as MMAS scores greater than 6 points (out of a total score of 8 points).<p></p> <b>Results</b> From 1114 patients, 725 (65.1%) had good adherence to antihypertensive agents. Binary logistic regression analysis was conducted. Younger age, shorter duration of antihypertensive agents used, job status being employed, and poor or very poor self-perceived health status were negatively associated with drug adherence.<p></p> <b>Conclusion</b> This study reported a high proportion of poor medication adherence among hypertensive subjects. Patients with factors associated with poor adherence should be more closely monitored to optimize their drug taking behavior

    Interrogation of modern and ancient genomes reveals the complex domestic history of cattle

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    The analysis of mitochondrial and nuclear DNA sequence polymorphisms from modern cattle populations has had a profound impact on our understanding of the events surrounding the domestication of cattle. From these studies, it has been possible to distinguish between pre- and post-domestic genetic differentiation, supporting previous assertions from archaeological studies and, in some cases, revealing novel aspects of the demographic history of cattle. Analyses of genetic material retrieved from the remains of extinct ancestral wild cattle have also added valuable layers of information pertaining to cattle domestic origins; however, information from these investigations have, in general, been limited to small, variable portions of the mitochondrial genome owing to technical challenges associated with the retrieval and amplification of ancient DNA. In recent years, however, new high-throughput, massively parallel genomics technology platforms, such as single-nucleotide polymorphism (SNP) genotyping arrays and next-generation sequencing (NGS), have provided a new impetus to the studies of genetic variation in extant and ancient cattle. Arrays of SNP have facilitated high-resolution genetic surveys of global cattle populations and detection of ancient and recent genomic selective sweeps. Next-generation sequencing analyses of modern and ancient cattle hold great promise for identifying and cataloging of pre- and post-domestication patterns of genomic variation and correlating this with natural and artificial selection processes
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