149 research outputs found
Comparison of long-term mortality risk following normal exercise vs adenosine myocardial perfusion SPECT
- Author
- A Abidov
- A Abidov
- A Aiden
- Alan Rozanski
- AM Amanullah
- AS Iskandrian
- AS Leon
- D Rothembacher
- DA Calnon
- Daniel S. Berman
- DS Berman
- DS Berman
- FJ Klocke
- GV Heller
- Heidi Gransar
- HG Stratmann
- JA Leppo
- John D. Friedman
- L Ulrich
- LD Metz
- LJ Shaw
- MG Levine
- NC Gupta
- R Hachamovitch
- R Ross
- R Taillefer
- RH Fagard
- Rory Hachamovitch
- Sean W. Hayes
- SK Varma
- SM Navare
- SM Navare
- SO Becker
- SU Chang
- SW Hayes
- T Sharir
- WC Knowler
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2010
- Field of study
A higher frequency of clinical events has been observed in patients undergoing pharmacological vs exercise myocardial perfusion single-photon emission computed tomography (SPECT). While this difference is attributed to greater age and co-morbidities, it is not known whether these tests also differ in prognostic ability among patients with similar clinical profiles.
We assessed all-cause mortality rates in 6,069 patients, followed for 10.2 ± 1.7 years after undergoing exercise or adenosine SPECT. We employed propensity analysis to match exercise and adenosine subgroups by age, gender, symptoms, and coronary risk factors. Within our propensity-matched cohorts, adenosine patients had an annualized mortality rate event rates that was more than twice that of exercise patients (3.9% vs 1.6%, P < .0001). Differences in mortality persisted among age groups, including those <55 years old. In the exercise cohort, mortality was inversely related to exercise duration, with comparable mortality noted for patients exercising <3 min and those undergoing adenosine testing.
Among patients with normal stress SPECT tests, those undergoing adenosine testing manifest a mortality rate that is substantially higher than that observed among adequately exercising patients, but comparable to that observed among very poorly exercising patients. This elevated risk underscores an important challenge for managing patients undergoing pharmacological stress testing
NT-proBNP and Circulating Inflammation Markers in Prediction of a Normal Myocardial Scintigraphy in Patients with Symptoms of Coronary Artery Disease
- Author
- A Elhendy
- A Peer
- AN Clark
- B Zeng
- B Zerahn
- B Zethelius
- Bo Zerahn
- C Heeschen
- C Kragelund
- C Nojgaard
- Camilla Noelle Rathcke
- CN Rathcke
- CN Rathcke
- CN Rathcke
- D Kroll
- DL Wingard
- DS Berman
- Erik Kjøller
- G Mowatt
- GJ Blake
- Henrik Vestergaard
- HG Stratmann
- J Danesh
- J Danesh
- J Kastrup
- JA de Lemos
- JA de Lemos
- JP Goetze
- JS Johansen
- M Kaushik
- M Kucur
- M Weber
- MA Hlatky
- ND Mercaldo
- Niels Fogh-Andersen
- NR de
- P Ferroni
- P Libby
- Pedro Antonio Valdes-Sosa
- R Sukhija
- SK James
- SP D'Souza
- SR Underwood
- T Sharir
- TJ Wang
- V Majstorov
- Y Wang
- ZS Galis
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Myocardial perfusion imaging (MPI) can detect myocardial perfusion abnormalities but many examinations are without pathological findings. This study examines whether circulating biomarkers can be used as screening modality prior to MPI.243 patients with an intermediate risk of CAD or with known CAD with renewed suspicion of ischemia were referred to MPI. Blood samples were analyzed for N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP), YKL-40, IL-6, matrix metalloproteinase 9 (MMP-9) and high sensitive C-reactive protein (hsCRP). Patients with myocardial perfusion defects had elevated levels of NT-proBNP (p<0.0001), YKL-40 (p = 0.03) and IL-6 (p = 0.03) but not of hsCRP (p = 0.58) nor of MMP-9 (p = 0.14). The NT-proBNP increase was observed in both genders (p<0.0001), whereas YKL-40 (p = 0.005) and IL-6 (p = 0.02) were elevated only in men. A NT-proBNP cut off-concentration at 25 ng/l predicted a normal MPI with a negative predictive value >95% regardless of existing CAD.20-25% of patients suspected of CAD could have been spared a MPI by using a NT-proBNP cut-off concentration at 25 ng/l with a negative predictive value >95%. NT-proBNP has the potential use of being a screening marker of CAD before referral of the patient to MPI
Selective inhibition of the human tie-1 promoter with triplex-forming oligonucleotides targeted to ets binding sites
- Author
- A Dube
- A Dube
- A Hart
- A Kaipainen
- A Ray
- A Stratmann
- AM Stutz
- Asif Ahmed
- B Scaggiante
- BD Perkins
- BJ Graves
- C Giovannangeli
- CA Stein
- CD Kontos
- Charles A. Laughton
- D Ahe von der
- D Praseuth
- E Hatva
- E Lelievre
- EM McGuffie
- Emma L. Daft
- F McLaughlin
- F Rininsland
- H Kampfer
- H-G Kim
- HB Gamper Jr.
- HE Moser
- HG Kim
- J Korhonen
- J Korhonen
- J Lauren
- J Liu
- J. Clifford Murray
- JL Schwachtgen
- JM Dagle
- K Iljin
- K Kuroda
- K Wakiya
- KG Peters
- KL Talks
- KM Vasquez
- KM Vasquez
- LC Wang
- M Faria
- MB Marron
- MF Neurath
- N Wernert
- N Wernert
- N Wernert
- P Lin
- P Lin
- P Saharinen
- P Salven
- PA Beal
- Peter W. Hewett
- PP Chan
- PW Hewett
- S Cogoi
- S Gory
- S White
- Shakil Ahmad
- SW Blume
- T Doan Le
- T Uchida
- T Veikkola
- TN Sato
- V Laudet
- Publication venue
- 'The Feinstein Institute for Medical Research (North Shore LIJ Research Institute)'
- Publication date
- 01/01/2006
- Field of study
The Tie receptors (Tie-1 and Tie-2/Tek) are essential for angiogenesis and vascular remodeling/integrity. Tie receptors are up-regulated in tumor-associated endothelium, and their inhibition disrupts angiogenesis and can prevent tumor growth as a consequence. To investigate the potential of anti-gene approaches to inhibit tie gene expression for anti-angiogenic therapy, we have examined triple-helical (triplex) DNA formation at 2 tandem Ets transcription factor binding motifs (designated E-1 and E-2) in the human tie-1 promoter. Various tie-1 promoter deletion/mutation luciferase reporter constructs were generated and transfected into endothelial cells to examine the relative activities of E-1 and E-2. The binding of antiparallel and parallel (control) purine motif oligonucleotides (21-22 bp) targeted to E-1 and E-2 was assessed by plasmid DNA fragment binding and electrophoretic mobility shift assays. Triplex-forming oligonucleotides were incubated with tie-1 reporter constructs and transfected into endothelial cells to determine their activity. The Ets binding motifs in the E-1 sequence were essential for human tie-1 promoter activity in endothelial cells, whereas the deletion of E-2 had no effect. Antiparallel purine motif oligonucleotides targeted at E-1 or E-2 selectively formed strong triplex DNA (K(d) approximately 10(-7) M) at 37 degrees C. Transfection of tie-1 reporter constructs with triplex DNA at E-1, but not E-2, specifically inhibited tie-1 promoter activity by up to 75% compared with control oligonucleotides in endothelial cells. As similar multiple Ets binding sites are important for the regulation of several endothelial-restricted genes, this approach may have broad therapeutic potential for cancer and other pathologies involving endothelial proliferation/dysfunction
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
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- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
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- Burtt D
- Busak L
- Busic N
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- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
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- Carrillo J
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- Casala J
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- Casoinic F
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- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
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- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
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- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
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- Clocotan M
- Cmrecnjak J
- Colfer H
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- Collier D
- Collins R
- Coloma G
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- Coman S
- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
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- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
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- Crocamo A
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- Cuentas I
- Cuervo A
- Curiac D
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- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
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- Dahlen G
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- Danik J
- Davalos C
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- Dawkins-Hughes S
- Dawood Sy
- Dayer M
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- De Caterina R
- De Jong C
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- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
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- Decsi K
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- Dedek V
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- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
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- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
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- Devasia T
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- Dhanak R
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- Di Biase M
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- Dickstein K
- Diederich C
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- Diller P
- Dimattia M
- Dimitrov G
- Diodati J
- Dobariya H
- Dobilas V
- Dodds G
- Doesborg L
- Doggett J
- Dognini Gp
- Doi M
- Dokupilova A
- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
- Dudhatra N
- Duff J
- Duhan S
- Dunhurst F
- Dussan Ma
- Dutka C
- Dwenger E
- Dzupina A
- Dékány Jn
- E Eleuteri
- E Englmann
- Earl J
- East C
- Eaton C
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- Ebeling K
- Ebrahim I
- Eccleston D
- Echeverria L
- Eder F
- Edgerton L
- Edillo C
- Edwards J
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- Eichinger G
- Einhorn D
- Eki Y
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- Ellenbroek D
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- Emil B
- Endo T
- Engelen W
- Erhard M
- Erickson B
- Ervin W
- Eskridge L
- Espinosa V
- Everett Bm
- F Fedele
- F Fonseca
- F Fucci
- Facello A
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- Falcon D
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- Farias E
- Fattal P
- Fawson A
- Feitosa G
- Felario Junior Ga
- Felix L
- Feng Y
- Feng Z
- Ferdinand K
- Ferkl R
- Fernandez Aa
- Ferrari V
- Ferrario M
- Ferraz R
- Ferreira Dos Santos T
- Ferreira-Jardim A
- Fien E
- Filardi Pp
- Filho P
- Fintel D
- Firek C
- Fischer Sm
- Fisher J
- Fitilev S
- Fitz-Patrick D
- Fitzpatrick L
- Flaksa I
- Flather M
- Flezar M
- Fliesser-Goerzer E
- Flores E
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- Floro T
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- Fonseca A
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- Forgon T
- Forgosh L
- Forker A
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- Foster M
- Foucauld J
- Fowler V
- Fox B
- Franco M
- Francoeur L
- Frandsen B
- Frandsen B
- Frankenstein L
- Fratczak M
- Freitas E
- French J
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- Fruchter G
- Fu G
- Fucak E
- Fuchs R
- Fucili A
- Fukuike C
- Fullerton D
- Fulop P
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- Fulwani M
- Furch G
- Furuseth B
- G Gacioch
- G Gosselin
- Gabito A
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- Gabriel J
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- Gazizianova V
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- Genest J
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- Gilley J
- Gits F
- Glancy R
- Glenny J
- Glover J
- Glynn Rj
- Godoy Sanchez M
- Goette A
- Goff R
- Goffinet C
- Gohel P
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- Gordeev I
- Gorges R
- Gospodinov K
- Gotcheva N
- Goudev A
- Gould R
- Govindaraj D
- Goyal B
- Goyal S
- Grabeau R
- Grable M
- Graham J
- Graham Ja
- Graif J
- Gralow J
- Gravellone M
- Gravenhorst-Muenter U
- Green E
- Greener R
- Greenway F
- Grieshaber V
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- Grigaraviciene I
- Grigorova V
- Gros C
- Grosse A
- Grover A
- Grundtvig M
- Gudipati Rvc
- Guerrero A
- Guillinta P
- Gundala Ak
- Gupta A
- Gupta A
- Gupta M
- Gupta V
- Gutmann J
- Guzman I
- Guzman P
- Gwyn M
- Gyorgyova E
- H Haldane
- H Hansen
- H Haught
- H Hill
- Haase F
- Haege R
- Haenel T
- Hage F
- Hageman T
- Hagemann D
- Hagenow A
- Hagiwara Y
- Haidar A
- Haider K
- Hakas J
- Haldis T
- Hall C
- Hall L
- Hall S
- Halliwell Tc
- Halpern S
- Hamer Bjb
- Hamud-Socoro A
- Han B
- Han S
- Hanak P
- Hanefeld M
- Hangyal T
- Hansson A
- Hanustiakova A
- Hao Y
- Hardas S
- Hardee L
- Harrell W
- Harrington A
- Harris B
- Hartleib M
- Hartwell J
- Hasan F
- Hasbani E
- Hasegawa K
- Hattler B
- Haughton G
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- Hegedus V
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- Henriksson A
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- Hernández N
- Herrman Jp
- Herzog W
- Hess E
- Hettwer Magedanz E
- Hickey L
- Hiden C
- Hielscher S
- Higuchi T
- Higuchi Y
- Hilkert R
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- Himpel-Boenninghoff A
- Hinderaker P
- Hioki M
- Hirayama A
- Hiroma J
- Ho Cj
- Hodnett P
- Hoffman M
- Hofsoey K
- Hogan C
- Hollanders G
- Holmes Z
- Holoubek D
- Holscher A
- Hominal M
- Homza M
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- Hoogslag Pam
- Horackova K
- Horak A
- Hornig M
- Horvat P
- Hosokawa S
- Hotchkiss D
- Houra M
- Hristova K
- Hsieh Ic
- Huang A
- Huang P
- Huang Ph
- Humbert J
- Hurtig U
- Hutchens E
- Huynh T
- Hwang Jj
- Hwang Jj
- Hyun K
- Härstedt N
- Høivik Ho
- I Ilic
- I Ivanov
- Iachini K
- Iannopollo G
- Ibarra J
- Ibarra M
- Ibañez J
- Iby M
- Ichisawa M
- Igbokidi O
- Iijima T
- Ilahi T
- Ilic S
- Ilsley M
- Imbrognio M
- Imre Bs
- Inada T
- Inagaki M
- Indolfi C
- Infusino F
- Invitti C
- Ipp E
- Isaza D
- Istratoaie O
- Istvan Kp
- Iteld B
- Ito K
- Ivan P
- Iveta H
- Izmozherova N
- J Jiang
- J Johnson
- J Johnston
- J Jose
- Jacques G
- Jafri A
- Jafry B
- Jagtap P
- Jaguszewska G
- Jain A
- Jansen M
- Jardula M
- Jayasinghe R
- Jefferson D
- Jenkins R
- Jensen Ed
- Jeric M
- Jerzewski A
- Jeserich M
- Jia Z
- Jiang T
- Jiang X
- Jimenez D
- Jirvankar P
- Johansen Bb
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- Joosten C
- Joshi U
- Julien Ve
- Julião K
- Jure D
- Jure H
- Jutrisa N
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- K Katahira
- K Kiroglu
- K Kordic
- K Kostov
- Kabakchieva Vm
- Kaczmarek N
- Kafarakis P
- Kaiserova L
- Kajihara S
- Kala P
- Kaldara E
- Kalina A
- Kalkman C
- Kam J
- Kamensky G
- Kamiya H
- Kamiya J
- Kan G
- Kaneno Y
- Kanitz S
- Kapp I
- Kara Yd
- Karakai H
- Karel I
- Karpuram M
- Karsai Xz
- Kastelein Jjp
- Kataoka M
- Katona A
- Katova T
- Kaur H
- Kawahara M
- Kawai M
- Kawasaki T
- Kawka-Urbanek T
- Kazanskay E
- Ke Y
- Keba E
- Keenan S
- Kelehan S
- Kellnerova I
- Kelly R
- Kelt T
- Kendall T
- Kereiakes D
- Khan A
- Khan M
- Khan R
- Khan S
- Khariouzov A
- Khirmanov V
- Khromtsova O
- Kick J
- Kiefer R
- Kietselaer B
- Kim B
- Kim Ks
- Kim M
- Kimmel M
- King A
- King T
- Kirkland S
- Kiss Rg
- Kissel S
- Kitchens D
- Klamm M
- Klein C
- Klein P
- Klemsdal To
- Kleve R
- Klugherz B
- Knight J
- Knutsson A
- Koba M
- Kobalava Z
- Kodem Dr
- Koeitti P
- Koenig W
- Kojima E
- Kok M
- Koldas N
- Koleckar P
- Kolikova V
- Kolleroy C
- Kolokathis F
- Komati S
- Komura Y
- Kondagunta V
- Konradi A
- Kooiman E
- Kopaczewski J
- Kopczyńska M
- Korban E
- Koren M
- Kormann A
- Korte M
- Korth-Wiemann B
- Kose V
- Kosmacheva E
- Kostakou P
- Kostis J
- Kotek L
- Kouz Sm
- Kovacic D
- Kovacs A
- Kozak M
- Kozlova S
- Krapivsky A
- Kreckova M
- Kreutter F
- Krupciakova B
- Krupicka J
- Kuenzler J
- Kulibaba E
- Kulkarni L
- Kullal P
- Kultursay H
- Kumar Ks
- Kumbla M
- Kuntzsch A
- Kuo Jy
- Kuramochi T
- Kuruma T
- Kusnick B
- Kuzin A
- Kyo E
- L Levinson
- L Lim
- L Link
- L Liu
- Laane E
- Labovitz R
- Lachance P
- Lai Wt
- Lail J
- Lainscak M
- Lake J
- Lal S
- Lamance J
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- Lambert J
- Lameira A
- Lamontagne C
- Landers B
- Landolfi A
- Landzberg J
- Lang C
- Langdon J
- Laniec M
- Lappo M
- Lardinois R
- Laszlo Z
- Latheef K
- Laube S
- Lauzon C
- Lavoie W
- Lazov P
- Ledger G
- Lee Hn
- Lee J
- Lee Jh
- Lee K
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- Lee Kr
- Lee Sc
- Lee Sh
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- Leggewie S
- Lehman Kf
- Lehman R
- Lehmann D
- Leimbach W
- Lekakis J
- Lembo G
- Lenderink T
- Lennard M
- Lenner E
- Lennerova J
- Leon S
- Lepage S
- Lepor N
- Lepp H
- Lester F
- Levin P
- Levine D
- Lewis D
- Li W
- Li X
- Li Y
- Li Y
- Li Y
- Li Yh
- Li Z
- Libby P
- Liberato Nl
- Libov I
- Lierse T
- Ligueros M
- Lillo J
- Lima F
- Limaye Ap
- Lin T
- Lindholm Cj
- Lindner C
- Liniado G
- Lino E
- Lipchenko A
- Liu B
- Liu B
- Liu Hm
- Liu P
- Liu S
- Liu Y
- Liviu C
- Lock E
- Lohkare M
- Lok Dja
- Long C
- Longaker R
- Lopes R
- Lopez P
- Lorch G
- Lorenc Z
- Lorenzatti A
- Lousberg A
- Lozhkina N
- Lu Z
- Luciardi H
- Lucksinger G
- Luecke-Uzar M
- Luedemann J
- Lukac J
- Lundqvist M
- Lupkovics G
- Luquez H
- Luz Serrano H
- Lv Y
- Lynd S
- Lysek R
- Lönnberg I
- M Malek
- M Mallagray
- M Mandati
- M Mandviwala
- M Marsters
- M Mays
- M Mcdonald
- M Medvegy
- M Meinrich
- M Mikus
- M Milanova
- M Moustafa
- Ma C
- Ma G
- Maboyi S
- Macdonald J
- Macfadyen Jg
- Machova V
- Madder R
- Maehara G
- Maffei L
- Magness K
- Maheshwari A
- Maheux K
- Maia L
- Majercak I
- Majul C
- Makedonska Jj
- Makhe B
- Makotoko E
- Malchikova S
- Maletz L
- Malhotra S
- Malhotra V
- Malik J
- Mancikova I
- Mandic L
- Manenti E
- Manfreda S
- Manga P
- Mani Ck
- Mani H
- Manne S
- Manning B
- Mannucci E
- Manolis A
- Manolis Aj
- Manov E
- Mantas I
- Manuel J
- Manukov D
- Manukov I
- Manyari D
- Manzur F
- Marcela Wenetz Lm
- Marchelletta N
- Marchi Al
- Marcinkeviciene J
- Marcun R
- Marengo Garcia De Carvalho L
- Marinaro S
- Marino P
- Mariottoni B
- Maron B
- Marschke T
- Marshall L
- Martin E
- Martin L
- Martinez E
- Martinez J
- Maruzzo S
- Marziali A
- Masarikova L
- Massaccesi R
- Mathew A
- Matyasek I
- Mauersberger K
- Maus O
- Mavromatis K
- Maximov D
- Mayer T
- Maynard R
- Mays B
- Mazutavicius R
- Mbulaiteye A
- Mcalister R
- Mccoy C
- Mccrary D Jr
- Mccullough-O'Brien H
- Mcgill J
- Mcgrew F
- Mcintosh C
- Mckenzie A
- Mckenzie C
- Mckibbin A
- Mclaurin B
- Mclellan Ba
- Mcmahon G
- Mcneil D
- Mcneill R
- Mcpherson C
- Medina F
- Megalou A
- Mehrle A
- Mehta A
- Mehta S
- Meijlis P
- Meissner A
- Mejia I
- Melbie K
- Mellberg L
- Melliza T
- Mendoza N
- Mendoza Y
- Mercuro G
- Merkely B
- Messina T
- Mestdagh I
- Meyer R
- Michalaros Y
- Michalska A
- Michaud N
- Michel K
- Mickel C
- Micko K
- Mihaly N
- Mikdadi G
- Mikusova T
- Milicic D
- Militaru C
- Miliuniene R
- Milkas A
- Miller A
- Miller C
- Miller G
- Miller R
- Miller W
- Minescu B
- Minocha G
- Mitchell J
- Mittal A
- Miyamoto T
- Moats Djr
- Modi R
- Mody F
- Moehring B
- Moen S
- Moffat J
- Mohan K
- Molina Di
- Molk B
- Molter D
- Monroe T
- Montana O
- Montenegro E
- Montenegro P
- Montero H
- Montgomery R
- Monti L
- Moodh J
- Mooe T
- Mookherjee D
- Moon K
- Moraes J Jr
- Moran J
- Moreira L
- Morell Y
- Moriarty P
- Morii I
- Morinaga Y
- Morisawa T
- Morozov E
- Morrison J
- Morton D
- Mos L
- Moshayedi P
- Mosley J
- Motiejuniene R
- Muehlhaus J
- Mueller S
- Muenter Kc
- Muenzel T
- Mulder R
- Munoz N
- Munoz R
- Munshi K
- Muntaner J
- Mureddu V
- Murphy G
- Murray A
- Mustafa J
- Musumeci Mb
- Muñoz W
- Myslyaeva L
- Nadar V
- Nagai Y
- Nagele-Luse I
- Nagy Ac
- Naidu R
- Naka T
- Nakamura S
- Nakamura Y
- Nakayoshi K
- Nalley J
- Nanas J
- Nandy P
- Naumann R
- Navarrete S
- Navy S
- Nebel J
- Neil L
- Nema D
- Neumann J
- Neutel Jm
- Niblack P
- Nicely V
- Nicolai M
- Nicolau J
- Nijmeh G
- Nikas A
- Nikoletta P
- Nikolic L
- Nikyar A
- Nilsen V
- Ning M
- Nishibe A
- Nixon S
- Nociar J
- Noori E
- Norin V
- Norkiene S
- Norkute-Macijauske U
- Norman L
- Noto G
- Nour K
- Novo S
- Nuding S
- Nugent A
- Nugteren Skz
- Ocman B
- Odegard A
- Ogawa H
- Ogawa M
- Okada Y
- Okawa M
- Okeefe D
- Olenchock B
- Olmedo M
- Olofsson M
- Olsen S
- Olsson Gh
- Olympios Cd
- Ondrasik J
- Onuchina E
- Oomman A
- Ord M
- Ortiz-Carrasquillo R
- Ossino N
- Otasevic P
- Otava M
- Otis R
- Otterstad Je
- Ouimet F
- Overhoff U
- Ozcan It
- O’Neil G
- P Pais
- P Peters
- P Piatti
- P Poliacik
- P Povolny
- P Purnell
- Pacora Ff
- Paez H
- Paganini M
- Page A
- Pagett K
- Pagnan M
- Pai R
- Pai V
- Palaniswami N
- Palatkina T
- Palchick B
- Pales J
- Paliwal Y
- Palka J Jr
- Palubova L
- Pande R
- Pandey S
- Paniagua A
- Pannell R
- Panov A
- Pansheriya A
- Panzarino C
- Papke B
- Parekh N
- Parente A
- Parepa I
- Parfait V
- Park B
- Park C
- Parmon E
- Partridge J
- Patel B
- Patel J
- Patel M
- Patel R
- Patel R
- Patel S
- Patino Jm
- Patole T
- Patsilinakos S
- Paulweber B
- Pavlickova L
- Paysor C
- Paz S
- Peck C
- Pella D
- Pena A
- Pencz I
- Peng L
- Penzes J
- Pereira S
- Perez Manghi F
- Perez A
- Perez M
- Perkins H
- Perkins L
- Perlstein T
- Perotti M
- Perperis A
- Perry B
- Pesce F
- Petelina T
- Peter Y
- Peterka M
- Petrauskiene B
- Petrescu L
- Petrillo C
- Petrov D
- Petrova I
- Petrusheva T
- Pettersen Ki
- Peukert Am
- Phillippi C
- Phillips A
- Phillips A
- Piacente R
- Pieretti Hb
- Pinheiro L
- Pintado M
- Pirenne B
- Pish R
- Piskorz D
- Pitt W
- Planinc I
- Ploechl A
- Plotz M
- Podoleanu C
- Pogson A
- Pokorna B
- Polato C
- Poling T
- Pomposini D
- Ponce T
- Poock J
- Pool T
- Poor F
- Pop Cf
- Popa V
- Popescu E
- Popovic Z
- Potts J
- Poudrier R
- Poulimenos L
- Pradhan A
- Pramatarova I
- Praveen M
- Prenner A
- Price D
- Price R
- Prior J
- Priori S
- Pritchard C
- Procter K
- Pupic L
- Purighalla R
- Pye M
- Qing L
- Quddusi K
- Quinones J
- Quinton D
- R Rauch
- R Recoaro
- R Reyes
- R Roettges
- R Rummel
- Racca V
- Radde I
- Radeljic V
- Radhakrishnan V
- Radin M
- Radoi M
- Radojcsics B
- Radvan M
- Raev D
- Ragghianti B
- Raghu C
- Rajan B A
- Rajasekhar D
- Rajput B
- Raju Ss
- Rama B
- Ramdas S
- Ramos G
- Ramos M
- Rancane G
- Randvee L
- Ranjith N
- Rao M
- Rao Mb
- Rao Nm
- Rassi S
- Rathnavel S
- Rathore A
- Rathore Srs
- Ratnik E
- Rau T
- Rawat S
- Raynes K
- Reber Am
- Reddy J
- Reddy Nc
- Redfearn H
- Rees Dh
- Reeves M
- Regner S
- Reichenbach D
- Reilly K
- Reimand M
- Reimer D
- Reinmets S
- Reis G
- Reis H
- Ren L
- Renaud K
- Renda G
- Repin A
- Resende I
- Resnick H
- Rewbury J
- Reznakova S
- Reznik I
- Rhudy Jm
- Richardson M
- Richert L
- Rickova Z
- Ridker Pm
- Riethof M
- Righini V
- Rinke A
- Risberg K
- Risenfors M
- Riser J
- Rivis L
- Robbins K
- Roberts-Thomson P
- Robinson S
- Rodero M
- Rodriguez Araya E
- Rodriguez A
- Rodriguez D
- Rodriguez J
- Rodriguez Lm
- Rodriguez Sm
- Roel A
- Romano A
- Romanski A
- Roos J
- Roper L
- Ross B
- Rossi Prf
- Rost N
- Roszkowska P
- Rotreklova M
- Roy A
- Roy C
- Roy M
- Rozeman P
- Ruder D
- Rudys A
- Ruffini L
- Rugo H
- Runev N
- Runquist L
- Rupka D
- Ruschel K
- Ryding A
- Rönndahl M
- Rønnevik P
- Rønnevik Td
- S Sarah
- S Sasaki
- S Sathe
- S Seki
- S Sharma
- S Shayani
- S Shetty
- S Shustov
- S Srivastava
- S Stadelmeier
- S Stoltz
- S Strand
- S Strugatsky
- S Such
- Sabo L
- Sack G
- Sahin M
- Sahin T
- Saini R
- Saint-Jacques H
- Saka B
- Sakamoto Y
- Sakurada M
- Salfity M
- Salinger M
- Salko T
- Sall N
- Saloustros I
- Salvador L
- Sam K
- Samal A
- Samer H
- Samkova D
- Sanchez Vallejo G
- Sanchez A
- Sanchez D
- Sang X
- Santiago J Jr
- Santosh Mj
- Sanuri M
- Saporito W
- Saraiva Jf
- Saravia Ma
- Sarbu I
- Sarcone M
- Sarjanovich R
- Sarma R
- Sarnighausen He
- Sarszegi Z
- Sattar N
- Saunders K
- Savard D
- Savignano C
- Saylor R
- Sazonova E
- Scaro G
- Scheffel M
- Scheibner T
- Schermaul Kh
- Schiavi Lb
- Schifferdecker B
- Schindler A
- Schindler A
- Schindler E
- Schlundt C
- Schmidt E
- Schmidt K
- Schnabel A
- Schneider P
- Schneider R
- Schnitzler R
- Schoen N
- Schorn K
- Schrager B
- Schroeder T
- Schulenburg D
- Schultz C
- Schulz M
- Schulze J
- Schulze U
- Schumacher M
- Schwartz A
- Schwerin G
- Schwerin M
- Schäfer B
- Sciborski R
- Scott J
- Scott R
- Seals A
- Senni M
- Sergienko T
- Seroqui M
- Servaes V
- Sesto I
- Seung Kb
- Shah A
- Shah Av
- Shah J
- Shaikh P
- Shanahan T
- Shaposhnik I
- Shapovalova Y
- Sharma K
- Sharma T
- Sharp A
- Shatsky K
- Shaw P
- Shealy N
- Sheets L
- Shelley J
- Shepard P
- Shetty P
- Shimokawa H
- Shimomura H
- Shinozaki T
- Shvarts Y
- Sidhu G
- Siemann M
- Sigurdadottir E
- Sigurdsson A
- Silva R
- Silver K
- Simay A
- Sime I
- Simon J
- Simon M
- Simons N
- Simpson H
- Singerling M
- Singh K
- Singh N
- Singh V
- Singhal A
- Sinnaeve P
- Siostrzonek P
- Sirakova-Taseva A
- Sirnes Pa
- Sizemore Bc
- Skalicka H
- Skatrud L
- Skjelvan G
- Skopets I
- Skubova K
- Skuladottir F
- Skuratova M
- Slanina M
- Slapikas R
- Slayton C
- Slechticka A
- Slimak V
- Sloane G
- Smallwood B
- Smeele F
- Smik R
- Smith B
- Smith G
- Smith J
- Smith J
- Smith M
- Smith M
- Smith P
- Smith T
- Smith W
- Smith W
- Smolenskaya O
- Soca Y
- Socoteanu E
- Socoteanu G
- Sofley C
- Sohi Gs
- Solares A
- Soler J
- Solovev O
- Song M
- Sopko K
- Soro E
- Sorodoc L
- Sosa-Padilla M
- Sotolongo R
- Sotomayor A
- Soucy D
- Spiridon M
- Sprinkle B
- Squire I
- Srdos V
- Srinath Vs
- St Amour E
- Stahl A
- Stahl Hd
- Stanciulescu G
- Starzec M
- Stefanescu M
- Steinhoff J
- Stelly L
- Steringer-Mascherbauer R
- Stern M
- Sternthal P
- Stinson J
- Stitova M
- Stockhausen G
- Stockhausen J
- Stoddard M
- Stoessel J
- Stofkova D
- Stokuca-Korac N
- Stolze K
- Stone B
- Stonkute K
- Storey R
- Stover T
- Strain J
- Stratmann M
- Strazdiene D
- Strbova J
- Stroes E
- Strohner-Kaestenbauer H
- Stys T
- Sugimoto N
- Suleman A
- Sullivan P
- Sun Z
- Sundelin R
- Suorra I
- Sutalo K
- Suzuki A
- Swart Hp
- Szacinski G
- Szakal I
- Szatmarine V
- Szocs A
- Szpajer M
- Szymanowski N
- T Tase
- T Tekten
- T Thuren
- T Tjaden
- Taguchi S
- Tahk S
- Tahon S
- Takahashi J
- Takase S
- Talliard C
- Tamburrini P
- Tamesby G
- Tamez W
- Tan M
- Tan R
- Tanabe K
- Tanaka A
- Tanaseanu C
- Tandon N
- Tani S
- Taqueti V
- Taran A
- Taverner P
- Tawfik R
- Teenan M
- Telekes P
- Teltser M
- Ten Holt W
- Terry K
- Terry Ps
- Tesak M
- Teschner Ab
- Teske A
- Tessmar C
- Thakkar B
- Thekkoott D
- Theunissen E
- Thiessen S
- Thomas D
- Thomas Dm
- Thomas H
- Thompson E
- Thompson J
- Thornton A
- Tijuneliene E
- Tinnirello V
- Tisheva-Gospodinova S
- Tobias C
- Todorova A
- Tomassi A
- Tomioka J
- Toom M
- Topper J
- Torgersruud M
- Torstensson I
- Torun A
- Toth P
- Townend J
- Tran A
- Treasure C
- Trenkamp P
- Trevelyan J
- Trevino M
- Trofimov V
- Troquay Rpt
- Tsai Mc
- Tsao Hm
- Tsioufis K
- Tsorbatzoglou K
- Tsou L
- Tsuboi H
- Tsuji M
- Tsujita K
- Tsujiyama S
- Tudoran M
- Tuholske C
- Turner F
- Tusek S
- Tzekova M
- Tzong L
- Ucar N
- Uecker C
- Ueng Kc
- Umesu A
- Unterkircher B
- Urbonas G
- Uresin S
- Urgeova L
- Urina M
- Urina-Triana M
- Uy W
- V Vahula
- V Vijan
- V Vora
- Vahtel M
- Vaid B
- Valenzuela M
- Valle M
- Vallejo Ma
- Vallone L
- Van Der Wal M
- Van Der Zwaan C
- Van Genechten G
- Van Kempen Ww
- Van Maarseveen M
- Van Stein I
- Vanagiene S
- Vance A
- Vandam J
- Vanhecke T
- Vanness WC Iii
- Vardas P
- Vargas R
- Varigos J
- Vasiliev M
- Vaz S
- Vazquez Tanus J
- Veerina K
- Vega J
- Vegsundvåg J
- Veit S
- Velusamy K
- Vento A
- Venturini C
- Vertes G
- Vervoort G
- Vesely J
- Vesely P
- Vesga B
- Vettus R
- Veze I
- Vezikova N
- Vezina M
- Vibert J
- Vicente C
- Vico Ml
- Vida-Simiti L
- Vieira N
- Viergever Ep
- Viezelis M
- Vijay N
- Villani Gq
- Vinanska D
- Vincelli G
- Vins P
- Viola Hg
- Visseren Flj
- Vissers C
- Vitovec M
- Vodnansky P
- Voelker F
- Voeller H
- Vogel M
- Vogt E
- Vold D
- Volpe M
- Voors C
- Vora K
- Vorster M
- Voyzey Ej
- Vozzhaev A
- Vranckx P
- Vrolix M
- Vuriya Ak
- W Wu
- Wade Rd
- Wadell C
- Wakeling J
- Waksman R
- Walker K
- Walker K
- Wallace K
- Walter I
- Walter J
- Walther I
- Walukiewicz P
- Wanderley Ff
- Wang Cp
- Wang Hc
- Wang J
- Wang Y
- Wang Yl
- Warren M
- Washam M
- Watson B
- Webel R
- Weber Hg
- Wei J
- Wei N
- Weimer J
- Weisnagel Sj
- Wells T
- West M
- Westberg Jc
- Whitaker J
- White A
- White A
- White C
- White J
- Wichterich K
- Wiebusch A
- Wilhoit G
- Wilkins M
- Wilkinson S
- William M
- Willingham K
- Willmerdinger M
- Willner C
- Wilson S
- Wilson V
- Winkelmann B
- Winkler J
- Wise J
- Wistuba T
- Woehrle J
- Woelcke J
- Wohnlich T
- Wolf S
- Woodall S
- Woods A
- Woyczak D
- Wrage P
- Wright J
- Wu J
- Wu J
- Wujkowski M
- Wyss F
- Xavier Jp
- Xu H
- Xu Zj
- Yakovova S
- Yakushin S
- Yamada T
- Yamaguchi E
- Yamamoto H
- Yamamoto T
- Yamane M
- Yan J
- Yanase T
- Yanev T
- Yang Cc
- Yang K
- Yang P
- Yao Z
- Yaoqing H
- Yarows S
- Yasuoka S
- Yasutake M
- Yigit Z
- Yilmaz Mb
- Yim Kh
- Yim S
- Yokoyama M
- Yong H
- Yoshida M
- Yoshimoto E
- Yossen M
- Young A
- Younis L
- Youssef G
- Yuan Z
- Yunoki C
- Yupanqui H
- Z Zhai
- Z Zilahi
- Zadionchenko V
- Zadra R
- Zagozen P
- Zaidman C
- Zalazar L
- Zaman A
- Zangroniz P
- Zarate J
- Zareczky P
- Zarifis I
- Zdrenghea D
- Zebrack J
- Zena N
- Zhang J
- Zhang W
- Zhang Y
- Zhao R
- Zhou H
- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
A comprehensive overview of radioguided surgery using gamma detection probe technology
- Author
- A Agrawal
- A Ayhan
- A Ayhan
- A Bembenek
- A Bembenek
- A Benevento
- A Blom
- A Chella
- A Cuschieri
- A Gil-Moreno
- A Gonfiotti
- A Gruaz-Guyon
- A Hubalewska
- A Hubalewska-Dydejczyk
- A Häcker
- A Iagaru
- A Lal
- A Leibovitz
- A Luini
- A Meyer
- A Mussa
- A Muxi
- A Patel
- A Renda
- A Sardi
- A Sardi
- A Schattner
- A Seal
- A Sherif
- A Sherif
- A Thor
- A Thor
- A Thor
- A Woznick
- AA Dunne
- AC Barros
- AC Federico
- AC Morris Jr
- AC van Akkooi
- ACG Mitchell
- AD Hill
- AF Kovács
- AF Kovács
- AH Chakera
- AJ Bilchik
- AJ Bilchik
- AJ Cochran
- AJ Wilhelm
- AK Buck
- AM Cohen
- AM Perrone
- AN Fader
- AP Dackiw
- AP Lont
- AR Shaha
- AS Bats
- AS Bats
- AS Bats
- AS Caudle
- AY de Kanter
- B Akduman
- B Brennhovd
- B Esmaeli
- B Esmaeli
- B Esmaeli
- B Frerich
- B Geissler
- B Ghelman
- B Kirchner
- B Li
- B Meller
- B Meller
- B Selverstone
- B Vucetić
- B Zulfikaroglu
- BD Collier
- BD Todd
- BG Liu
- BJ Sickle-Santanello
- BJ Van Royen
- BK Kroon
- BL Franc
- BM Clary
- BM Stiles
- BO Helal
- BR Haugen
- C Altgassen
- C Atinkaya
- C Bastide
- C Curtet
- C De Cicco
- C De Cicco
- C de Labriolle-Vaylet
- C Duport
- C Levenback
- C Levenback
- C Merisio
- C Michl
- C Mojzisik
- C Murphy
- C Nwogu
- C Ohyama
- C Ulmer
- C Ulmer
- C Wang
- CA Hoefnagel
- CA Nieroda
- CA Nieroda
- CA Nieroda
- CA Pettaway
- CA Proye
- Cathy M Mojzisik
- CC Harris
- CC Rhim
- CC Solorzano
- CE Schmalbach
- CF Heyns
- CF Levenback
- CK Axelsson
- CK Bichakjian
- CL Colton
- CM Intenzo
- CM Mojzisik
- CR Divgi
- CR Thind
- CS Landry
- CS Ubhi
- D Carrera
- D Casara
- D Casara
- D Casara
- D Clement
- D Colcher
- D Colcher
- D Colcher
- D Colcher
- D Colcher
- D Daryanani
- D Desai
- D Krag
- D Lardinois
- D Ozçelik
- D Perera
- D Quinlan
- D Rubello
- D Rubello
- D Rubello
- D Rubello
- D Rubello
- D Rubello
- D Rubello
- D Rubello
- D Rubello
- D Rubello
- D Rubello
- D Sandrock
- D Sarlos
- D Sortini
- D Sortini
- D Stramignoni
- D Sun
- D Weckermann
- D Weckermann
- D Weckermann
- D Wydra
- D Wydra
- DA Martinez
- DA Martinez
- David M O'Malley
- DC Damin
- DC Damin
- DC Desai
- DC Slavin-Chiorini
- DE Cohn
- DG Blazer 3rd
- DG McIntosh
- DG Sheer
- DI Wasserman
- DJ Bertsch
- DL Damian
- DL Morton
- DL Morton
- DM Agnese
- DM Goldenberg
- DM Goldenberg
- DM Goldenberg
- DM Herlyn
- DM Kushner
- DN Krag
- DN Krag
- DN Krag
- DN Krag
- Douglas A Murrey
- DP Kwo
- DR Aitken
- DR Aitken
- DS Fernandes
- DT Martin
- E Barranger
- E Barranger
- E Barranger
- E Barranger
- E Di Lieto
- E Gay
- E Gitsch
- E Gitsch
- E Grossrubatscher
- E Heckathorne
- E Kaplan
- E Kebebew
- E Lambaudie
- E Lucisano
- E Migliano
- E Migliano
- E Mochiki
- E Oosterwijk
- E Pelosi
- E Pelosi
- E Perinetti
- E Rault
- E Wespes
- EA Gould
- EC Hsueh
- Edward W Martin
- EE Argenyi
- EE Zervos
- EJ Hoffman
- EK Pauwels
- EL Grogan
- EL Mazzaferri
- EP Krenning
- EW Martin Jr
- EW Martin Jr
- EW Martin Jr
- EW Martin Jr
- EW Martin Jr
- EW Martin Jr
- EW Martin Jr
- EW Martin Jr
- F Amersi
- F Badellino
- F Civantos
- F Daghighian
- F Davini
- F De Corti
- F Grünwald
- F Khoury-Collado
- F Kraeber-Bodéré
- F Liedberg
- F Liedberg
- F Picciotto
- F Raspagliesi
- F Wawroschek
- F Wawroschek
- F Wawroschek
- F Wawroschek
- FE Schmidt
- FJ Civantos
- FL Moffat Jr
- FM Melfi
- FM Melfi
- FW van der Ent
- G Boni
- G Cuccia
- G D'Errico
- G Hinkle
- G Köhler
- G Landi
- G Mariani
- G McGreal
- G Mura
- G Navarra
- G Navarra
- G Paganelli
- G Péley
- G Sliutz
- G Weber
- G Xu
- G Åkerström
- G Åkerströom
- GA Porter
- GD Albert
- George H Hinkle
- GH Hinkle
- GH Hinkle
- GJ LaValle
- GL Ross
- GM Duarte
- GM Duarte
- GW Carlson
- H Abdel-Nabi
- H Arima
- H Chen
- H Chen
- H De Boeck
- H Fasshauer
- H Gallowitsch
- H Geiger
- H Göttlinger
- H Hayashi
- H Kato
- H Martelli
- H Medina-Franco
- H Medina-Franco
- H Niikura
- H Niikura
- H Niikura
- H Nomori
- H Nomori
- H Nomori
- H Nomori
- H Otsuka
- H Otsuka
- H Takashima
- H Takeuchi
- H Takeyama
- H Tonouchi
- H Tonouchi
- H Tonouchi
- H Uemura
- H Vogt
- H Wengenmair
- H Wengenmair
- HA Heij
- HB Barber
- HB Breitz
- HC Steinert
- HG Göttlinger
- HJ Sprenger
- HL Neville
- HL Rossi
- HM Kroon
- HM Lou
- HM McMulkin
- HR Maecke
- HS Ramesh
- HT Harcke
- HU Ahmed
- HY Tien
- HY Wang
- I Brenot-Rossi
- I Brenot-Rossi
- I Düker
- I Roca
- I Sarikaya
- I Sarikaya
- I Stárek
- IA Jacobs
- IA Jacobs
- ICRP Publication 103
- ICRP Publication 60
- IG Sergides
- IM van der Ploeg
- J Arbizu
- J Barbet
- J Bell
- J Bowles
- J Burdine
- J Fass
- J Gu
- J Hauspy
- J Hauspy
- J Matejka
- J Norman
- J Norman
- J Norman
- J Ortin-Perez
- J Packeisen
- J Serrano
- J van de Lande
- J Xiao
- J Zgajnar
- JA de Hullu
- JA de Hullu
- JA Kuhn
- JA Leijte
- JA Norton
- JA Werner
- JB McHugh
- JC Alex
- JC Alex
- JC Alex
- JD Wagner
- JE Fowler Jr
- JE Frödin
- JE Gershenwald
- JF Delaloye
- JF Rodier
- JF Rodier
- JG Touzios
- JH Lee
- JH Lee
- JH Wong
- JJ Albertini
- JJ Bonenkamp
- JL Messina
- JM Benejam Gual
- JM Martínez-Palones
- JM Woolfenden
- JM Woolfenden
- JP Travagli
- JR Siewert
- JS Fowler
- JS Kettunen
- JS Stehlin Jr
- JY Bobin
- JY Bobin
- K Chikamatsu
- K Nouri
- K Pityñski
- K Placzkowski
- K Sugi
- K Sugi
- K Sugi
- K Sugi
- K Tanaka
- K Ueda
- K Zámbó
- KA Schwarz
- KK Dhar
- KK Dhar
- KL Molpus
- KM McMasters
- KM McMasters
- KS Pentlow
- KU Sian
- KY Terada
- KY Terada
- L Abramova
- L Fang
- L Feggi
- L Jansen
- L Lelièvre
- L Mansi
- L Mansi
- L Perez-Naranjo
- L Rettenbacher
- L Rob
- L Rob
- L Sevcík
- LA Robinson
- LA Robinson
- LB Silva
- LC Patten
- LF Glass
- LF Gonzaga-Silva
- LK Rodrigues
- LM Puig-Tintoré
- LR Petty
- LY Cheng
- M Amato
- M Ballester
- M Baroody
- M Burian
- M Catarci
- M Egawa
- M Etchebehere
- M Frumovitz
- M Frumovitz
- M Frumovitz
- M Frumovitz
- M Fukuda
- M Grazia
- M Hampl
- M Harwood
- M Herlyn
- M Lacheretz
- M Maccauro
- M Manner
- M Mistrangelo
- M Mistrangelo
- M Mistrangelo
- M Moreno
- M Nap
- M Nuti
- M Piert
- M Piert
- M Plante
- M Ricard
- M Ricard
- M Riveros
- M Rudoni
- M Salvatori
- M Sasako
- M Satoh
- M Shabtai
- M Sideri
- M Stokkel
- M Tomifuji
- M Wioland
- M Yüksel
- MB Flynn
- MC Cuntz
- MC Kelley
- MC Kim
- MC Kim
- MC Thelmo
- MC van Rijk
- MD McCarter
- ME Wechter
- MG Vigili
- Michael V Knopp
- MJ Liptay
- MJ Liptay
- MJ Liptay
- MJ Liptay
- MJ Reinhardt
- MJ Reschly
- ML Kayton
- MO Thurston
- MP Cózar
- MP Stokkel
- MR Buist
- MR Keshtgar
- MR Pelizzo
- MR Pelizzo
- MS Alam
- MS Brady
- MW Arnold
- MW Arnold
- MW Arnold
- MW Arnold
- MW Wilson
- N Fersis
- N Hernández-Toris
- N Mozzillo
- N Nijhawan
- N Ohuchi
- N Pateisky
- N Pelaez
- N Silva Jr
- N Wada
- Nathan C Hall
- NC Hall
- NC Hall
- NC Zeitouni
- NW Merrall
- O Albores-Zúñiga
- O Kraft
- O Olsha
- O Schillaci
- O Tiffet
- O Ugur
- O Vilela Filho
- O Warburg
- P Carcoforo
- P Dzvincuk
- P Hadway
- P Hladik
- P Lechner
- P Lechner
- P Nastro
- P Paredes
- P Paredes
- P Peltier
- P Percivale
- P Percivale
- P Rabbitt
- P van Dam
- P Zanzonico
- P Zanzonico
- PA Andersen
- PA van Dam
- PE Spiess
- PF Nichol
- PJ Allen
- PJ Lamb
- PJ O'Dwyer
- PJ Tanis
- PJ Tanis
- PJ Tanis
- PM Dawson
- PN Bogner
- PU Tunn
- PV Loar 3rd
- R Angioli
- R Bekiş
- R Bekiş
- R Delgado
- R Essner
- R Essner
- R Gennari
- R Gruber
- R Haddad
- R Muraro
- R Muraro
- R Nadeem
- R Pijpers
- R Pijpers
- R Pijpers
- R Pratali
- R Robbins
- R Ronka
- R Vassilopoulou-Sellin
- R Vassilopoulou-Sellin
- RA Audisio
- RA Badalament
- RA Valdés Olmos
- RC Martin 2nd
- RE Emery
- RE Goldstein
- RE Goldstein
- RE Jimenez
- RE Perrott
- RF Uren
- RF Uren
- RG Moore
- RH Jesse
- RH Machado
- RH Nyberg
- RH Verheijen
- RJ Gray
- RJ Gray
- RJ Gray
- RJ van Ginkel
- RM Byers
- RM Cabanas
- RN Uppot
- RR Raylman
- RR Raylman
- RR Raylman
- RS Anderson
- RS Andrade
- RS Lawson
- RS Rampaul
- RW Schroff
- Ryan L Neff
- S Adams
- S Adams
- S Adams
- S Adams
- S Ariyan
- S Avital
- S Avital
- S Bertoglio
- S Corvin
- S Gretschel
- S Gretschel
- S Gretschel
- S Gretschel
- S Hammarström
- S Hautmann
- S Horenblas
- S Ishigami
- S Jeschke
- S Jeschke
- S Johann
- S Kamprath
- S Khandelwal
- S Kosugi
- S Kurul
- S Malur
- S Maza
- S Monti
- S Ogi
- S Panareo
- S Perdonà
- S Perdonà
- S Rubí
- S Saha
- S Schneebaum
- S Schneebaum
- S Sodha
- S Van Esser
- S van Esser
- S Vidal-Sicart
- S Vidal-Sicart
- S Wiseman
- S Yamamoto
- S Yamamoto
- S Yasuda
- S Yasuda
- S Yasuda
- SA Gulec
- SA Gulec
- SA Gulec
- SA Gulec
- SA Gulec
- SA Thurman
- SD Fosså
- SD Moffatt-Bruce
- SD Moffatt-Bruce
- SD Nathanson
- SD Trocha
- SE Ames
- SE Snyder
- SH Warncke
- SJ Lim
- SJ Stoeckli
- SJ Stoeckli
- SK Grebe
- SL Decesare
- SL Stratmann
- SL Wong
- SP Leong
- SP Povoski
- SP Povoski
- SP Povoski
- SP Povoski
- SP Povoski
- SS Gambhir
- Stephen P Povoski
- SV Kashmiri
- SV Litvinov
- T Aikou
- T Asao
- T Atula
- T Gargiulo
- T Ichikura
- T Kojima
- T Kojima
- T Lantzsch
- T Mariolis-Sapsakos
- T Matsuzuka
- T Negele
- T Sera
- T Shimotake
- T Tajima
- T Tiourina
- T van Mesdag
- TE Ind
- TJ Selman
- TL Klausen
- TM Daniel
- U Öhrvall
- V Argenzio
- V Argenzio
- V Descheemaeker
- V Lavoué
- V Lavoué
- VE Strong
- VG Johnson
- VH Ho
- W Jäger
- W Kitagawa
- W Meinhardt
- W Rzyman
- WA Waddington
- WB Al-Refaie
- WC Barker
- WC Harvey
- WC Scurry
- WE Burak
- WE Burak Jr
- WJ Schirmer
- WK Stadelmann
- WL Tse
- XG Sheng
- Y Bhanot
- Y Delpech
- Y Kitagawa
- Y Kitagawa
- Y Kitagawa
- Y Kitagawa
- Y Kitagawa
- Y Kitagawa
- Y Saikawa
- Y Sanli
- Y Uenosono
- Y Uenosono
- YA Chung
- YJ Lee
- YK Chen
- YQ Wang
- YS Lin
- ZR Shi
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
The concept of radioguided surgery, which was first developed some 60 years ago, involves the use of a radiation detection probe system for the intraoperative detection of radionuclides. The use of gamma detection probe technology in radioguided surgery has tremendously expanded and has evolved into what is now considered an established discipline within the practice of surgery, revolutionizing the surgical management of many malignancies, including breast cancer, melanoma, and colorectal cancer, as well as the surgical management of parathyroid disease. The impact of radioguided surgery on the surgical management of cancer patients includes providing vital and real-time information to the surgeon regarding the location and extent of disease, as well as regarding the assessment of surgical resection margins. Additionally, it has allowed the surgeon to minimize the surgical invasiveness of many diagnostic and therapeutic procedures, while still maintaining maximum benefit to the cancer patient. In the current review, we have attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
- Alings M
- Alonso Martin JJ
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
- Amlani M
- Amosova E
- Amuchastegui M
- Andersen K
- Andersen R
- Anderson J
- Ando K
- Angel Hominal M
- Annam S
- Anscombe R
- Apostolovic SR
- Appel K-F
- Arandjelovic A
- Araneda G
- Arango Benecke JL
- Arbel Y
- Arif I
- Armaganijan L
- Arroyo JAC
- Arstall MA
- Asanin MR
- Atar S
- Athyros V
- Auguadro C
- Ayala CAC
- Aylward PE
- Azizad MM
- Bagai A
- Bagriy A
- Bahit MC
- Bai F
- Balaguer Recena J
- Baldari D
- Balinovac J
- Ball E
- Bang LE
- Banuru S
- Barakovic F
- Baranov E
- Baranova E
- Barbarash OL
- Barbato E
- Barna OM
- Barone-Rochette G
- Barr C
- Barrucco R
- Bartels GL
- Bashir R
- Basson MMDV
- Bastos JM
- Bata I
- Batushkin V
- Bayat J
- Bayram Llamas EA
- Bayron C
- Beauloye C
- Bednarski J
- Behrens S
- Belhassane A
- Benedicto A
- Bengus CM
- Benov HO
- Berger R
- Berglund S
- Berk M
- Berland J
- Berli MA
- Berlowitz M
- Berman B
- Bernan A
- Berti S
- Bhagwat A
- Bhagwat R
- Bhansali P
- Bhatt DL
- Binder R
- Birchem J
- Bittner VA
- Blicharski T
- Blok T
- Blumberg EDS
- Boccara F
- Bodanese LC
- Bodi Peris V
- Boecker D
- Bojovski S
- Bokarev I
- Bokern MJJA
- Bonfanti AJC
- Bono JOE
- Bordonava AP
- Borse R
- Bortnick A
- Bos RJ
- Botas Rodriguez J
- Botelho A
- Botelho RV
- Botia DCL
- Bottcher M
- Bourgeois R
- Brabham D
- Braganza D
- Braun-Dullaeus R
- Breedveld RW
- Brennan JM
- Brodison A
- Bronzwaer PNA
- Brueren BRG
- Bruguera Cortada J
- Budaj A
- Bugan V
- Busmane A
- Bustamante Labarta MH
- Busz-Papiez B
- Butler R
- Bystryk L
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- Camsari A
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- Carey C
- Carlson E
- Carnero GS
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- Carroll PA
- Cartasegna LR
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- Caruso OC
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- Castadot M
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- Cerqueira MJAG
- Cestari HG
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- Chae I-H
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- Chaleff F
- Chambilla JMC
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- Chane M
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- Chavez V-CER
- Chen D
- Chen J
- Chen Y
- Cheng S-C
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- Chiang C-E
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- Chopra VK
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- Chumburidze V
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- Clemmensen P
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- Concha YMR
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- Coufal Z
- Coverdale SGM
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- Cruz Fernandez JM
- Cuccia C
- Cui L
- Cyster HP
- Czerski T
- D'Urso M
- Daboul N
- Dagher G
- Dahl C
- Dai K
- Dalby AJ
- Dalby AJ
- Danchin N
- Dandillaya R
- Daniels C
- Das S
- Davidovic G
- Davidsen F
- Davies R
- Davis W
- De Berrazueta Fernandez JR
- De Cesare NB
- De Leo A
- De Luca G
- De Mora Martin M
- De Pellegrin A
- De Salazar DIM
- de Santos MON
- de Silva HA
- de Souza JA
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- Devarapalli SK
- DeVore AD
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- Diaz A
- Diaz R
- Dickey S
- Dilic M
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- Dimov BI
- Dincic DV
- Ding C
- Dion D
- Dodic S
- Dombrowski K
- Doncovska S
- Dong S
- Dong Y
- Dorobantu M
- Dorsel T
- Dran RD
- Drexel H
- Drzewiecka A
- Ducas J
- Ducrocq G
- Duda N
- Dujardin K
- Dukat A
- Dulak E
- Dupuis R
- Durak-Nalbantic A
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- Zrazhevsky K
- Zuniga JDH
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Aims The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Adam Bourdarios C
- Adamczyk L
- Adamek L
- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ahuja S
- Ai X
- Aielli G
- Aikot A
- Ait Tamlihat M
- Aitbenchikh B
- Aizenberg I
- Akbiyik M
- Akimov AV
- Akiyama D
- Akolkar NN
- Al Khoury K
- Alberghi GL
- Albert J
- Albicocco P
- Albouy GL
- Alderweireldt S
- Aleksa M
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- Zhemchugov A
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
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- Yin P
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- Zaazoua M
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- Zaid E
- Zak ZK
- Zakareishvili T
- Zakharchuk N
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- Zamora Saa JA
- Zang J
- Zanzi D
- Zaplatilek O
- Zeitnitz C
- Zeng H
- Zeng JC
- Zenger DT
- Zenin O
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- Zerradi S
- Zerwas D
- Zhai M
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- Zhang P
- Zhang R
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- Zhang S
- Zhang T
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao H
- Zhao T
- Zhao Y
- Zhao Z
- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
- Zhou B
- Zhou H
- Zhou N
- Zhou Y
- Zhou Y
- Zhu CG
- Zhu J
- Zhu Y
- Zhu Y
- Zhuang X
- Zhukov K
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Vascular Disruption and the Role of Angiogenic Proteins After Spinal Cord Injury
- Author
- A Anagnostopoulos
- A Armulik
- A Farry
- A Guha
- A Hartmann
- A Papapetropoulos
- A Papapetropoulos
- A Stratmann
- AE Mautes
- AG Kermode
- AL Wong
- Anthea T. Stammers
- AR Allen
- AS Fanning
- B Bolton
- B Crabtree
- B Witzenbichler
- BK Kwon
- BK Kwon
- BK Kwon
- BK Kwon
- BK Kwon
- BR Stevenson
- Brian K. Kwon
- BY Reed
- C Daly
- C Daly
- C Dray
- C Goritz
- C Moreau
- C Schulze
- C Sundberg
- CB Jaeger
- CG Hatalski
- CG Hatalski
- CH Tator
- CH Tator
- CX Wang
- CY Hsu
- D Attwell
- D Kieran
- D Wu
- DJ Donnelly
- DJ Dumont
- DJ Dumont
- DJ Strydom
- DN Loy
- DP Hughes
- E Kaptanoglu
- E Nelson
- F Baffert
- FAX Schanne
- G Bravo
- G Hu
- G Savettieri
- GD Yancopoulos
- GF Hu
- GF Hu
- GF Hu
- GF Hu
- GHW Wong
- GT Casella
- GT Casella
- GW Hawryluk
- H Hisai
- H Karapinar
- H Miyake
- H Oh
- HF Cserr
- HG Augustin
- HJ Kwak
- HJ Senter
- HJ Senter
- HM Kim
- I Cascone
- I Galea
- I Helfrich
- I Kim
- I Kim
- I Kim
- I Kim
- I Kim
- I Kim
- I Martin-Padura
- IB Lobov
- IM Turnbull
- IM Turnbull
- IM Turnbull
- IR Griffiths
- IR Griffiths
- IR Griffiths
- J Fenstermacher
- J Fuxe
- J Holash
- J Ilzecka
- J Moroianu
- J Sebastia
- J Siebert
- J Zhang
- JA Holash
- JD Balentine
- JF Harrington
- JG Kim
- JJ Herrera
- JM Simard
- JR Gamble
- JR Wrathall
- JV Patel
- JW Fett
- JW Rowland
- JX Chen
- JY Choe
- K Fujikawa
- K Kishimoto
- K Kurachi
- K Maxwell
- KR Acharya
- KT Kim
- L Huang
- LJ Noble
- M Furuse
- M Furuse
- M Furuse
- M Moenner
- M Nakamura
- M Ramsauer
- M Risling
- M Scharpfenecker
- M Thomas
- M Yamakawa
- MEL Berg van den
- MF Ritz
- Michelle T. L. Ng
- MJ Greenway
- MT Ng
- MW Brightman
- N Lukacova
- NA Abdel-Malak
- NJ Abbott
- NL Martirosyan
- O Hassler
- OH Lee
- P Pichiule
- P Saharinen
- PB Andersson
- PB Andersson
- PC Maisonpierre
- PD Adelson
- PG Popovich
- PH Chan
- PM Knopf
- R Harfouche
- R Harfouche
- R Harfouche
- R Harfouche
- R Sedlakova
- R Shapiro
- R Shapiro
- RC Janzer
- RE Billingham
- RL Benton
- RO Hynes
- S Cronin
- S Davis
- S Davis
- S Fukuhara
- S Han
- S Holmin
- S Hori
- S Joshi
- S Liu
- S Molica
- S Verstovsek
- SA Lipton
- SE Schutzer
- SJ Mandriota
- SM Dallabrida
- SM Dallabrida
- SW Lee
- T Takigawa
- T Tsuji
- TI Koblizek
- TP Curran
- TP Curran
- TS Reese
- U Fiedler
- U Fiedler
- U Fiedler
- V Bhandari
- V Bhandari
- V Gerzanich
- V Subramanian
- W Tetzlaff
- WA Barton
- WA Barton
- WD Whetstone
- WF Hickey
- WF Hickey
- WH Oldendorf
- WN Procopio
- Y Hayashi
- Y Xu
- YS Mukouyama
- Z Xu
- Z Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effect of alirocumab on mortality after acute coronary syndromes. An analysis of the ODYSSEY OUTCOMES randomized clinical trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abdullkutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adamo A
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Agnetti V
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
- Alexopoulos D
- Alings M
- Alonso Martin JJ
- Alonso Orcajo N
- Alsweiler C
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
- Amlani M
- Amosova E
- Amuchastegui M
- Anchante Hernandez HA
- Andersen D
- Andersen K
- Andersen R
- Anderson J
- Ando K
- Angel Hominal M
- Annam S
- Anscombe R
- Apostolovic SR
- Appel K-F
- Arandjelovic A
- Araneda G
- Arbel Y
- Arif I
- Armaganijan L
- Aroney C
- Arroyo JAC
- Arstall MA
- Asanin MR
- Atar S
- Athyros V
- Auguadro C
- Aylward P
- Aylward PE
- Aylward PE
- Azizad MM
- Badreddine E
- Bagai A
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- Bahit MC
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- Baldari D
- Balinovac J
- Ball E
- Bang LE
- Banuru S
- Barakovic F
- Baranov E
- Baranova E
- Barbarash OL
- Barbato E
- Barna OM
- Barone-Rochette G
- Barr C
- Barraud P
- Barrucco R
- Bartels GL
- Bashir R
- Basson MMDV
- Bastos JM
- Bata I
- Batushkin V
- Bayat J
- Bayram Llamas EA
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- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 04/01/2019
- Field of study
Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; Pinteraction=0.007). In the alirocumab group, all-cause death declined wit h achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for ≥3 years, if baseline LDL-C is ≥100 mg/dL, or if achieved LDL-C is low. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402
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