Acoustoelastic Measurement of Second- and Third-Order Elastic Constants in Silicon Carbide and Alumina Particulate-Reinforced Aluminum Metal Matrix Composites

Metal Matrix Composites (MMCs) can offer increased specific strength and stiffness, increased toughness, and an ability to operate at high temperatures. However, the mechanical properties of MMCs can be greatly influenced by residual stresses that result during fabrication from the differences in coefficients of thermal expansion of the constituents [1]. There are a number of non-destructive techniques for measuring residual stresses in these types of composites. The two most widely used techniques are x-ray and neutron diffraction. The x-ray diffraction technique is limited in that it has small penetration depths and beam sizes which are generally much greater than the reinforcement diameter. Although the neutron diffraction technique can provide through-thickness measurements, the availability of the specialized test equipment is a limitation, due to the necessity for using a neutron source [2]. An alternative technique for measuring residual stresses is using ultrasound

Development of a Breadboard Instrument for the Ultrasonic Measurement of Stress

The measurement of stress is a generic problem which constantly occurs in nondestructive evaluation applications. X-ray diffraction provides the most successful approach, but suffers from the limitation that only a very near surface layer is sensed. Ultrasonic measurements, based on the stress dependence of the wave speed, have the capability of sampling bulk material. However, they suffer from some practical problems, including degradations in accuracy due to competing sources of wave speed shifts and difficulties of making measurements in complex geometries. The former problem has, in principle, been overcome by an approach recently developed as discussed below

Adaptation and application of the large LAERTES-EU regional climate model ensemble for modeling hydrological extremes: a pilot study for the Rhine basin

Enduring and extensive heavy precipitation events associated with widespread river floods are among the main natural hazards affecting central Europe. Since such events are characterized by long return periods, it is difficult to adequately quantify their frequency and intensity solely based on the available observations of precipitation. Furthermore, long-term observations are rare, not homogeneous in space and time, and thus not suitable to running hydrological models (HMs) with respect to extremes. To overcome this issue, we make use of the recently introduced LAERTES-EU (LArge Ensemble of Regional climaTe modEl Simulations for EUrope) data set, which is an ensemble of regional climate model simulations providing over 12 000 simulated years. LAERTES-EU is adapted for use in an HM to calculate discharges for large river basins by applying quantile mapping with a parameterized gamma distribution to correct the mainly positive bias in model precipitation. The Rhine basin serves as a pilot area for calibration and validation. The results show clear improvements in the representation of both precipitation (e.g., annual cycle and intensity distributions) and simulated discharges by the HM after the bias correction. Furthermore, the large size of LAERTES-EU also improves the statistical representativeness for high return values above 100 years of discharges. We conclude that the bias-corrected LAERTES-EU data set is generally suitable for hydrological applications and posterior risk analyses. The results of this pilot study will soon be applied to several large river basins in central Europe

Adaptation and application of the large LAERTES-EU RCM ensemble for modeling hydrological extremes: A pilot study for the Rhine basin

Enduring and extensive heavy precipitation associated with widespread river floods are among the main natural hazards affecting Central Europe. Since such events are characterized by long return periods, it is difficult to adequately quantify their frequency and intensity solely based on the available observations of precipitation. Furthermore, long-term observations are rare, not homogeneous in space and time, and thus not suitable to run hydrological models (HMs) with respect to extremes. To overcome this issue, we make use of the recently introduced LAERTES-EU (LArge Ensemble of Regional climaTe modEl Simulations for EUrope) data set, which is an ensemble of regional climate model simulations providing over 12.000 simulated years. LAERTES-EU is adapted for the use in an HM to calculate discharges for large river basins by applying a quantile mapping with a fixed density function to correct the mainly positive bias in model precipitation. The Rhine basin serves as a pilot area for calibration and validation. The results show clear improvements in the representation of both precipitation (e.g., annual cycle and intensity distributions) and simulated discharges by the HM after the bias correction. Furthermore, the large size of LAERTES-EU improves the statistical representativeness also for high return values above 100 years of discharges. We conclude that the bias-corrected LAERTES-EU data set is generally suitable for hydrological applications and posterior risk analyses. The results of this pilot study will soon be applied to several large river basins in Central Europe

Advancing the global public health agenda for NAFLD: a consensus statement

Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-ranging social and economic implications. It is a multisystem disease and is considered the hepatic component of metabolic syndrome. Unlike other highly prevalent conditions, NAFLD has received little attention from the global public health community. Health system and public health responses to NAFLD have been weak and fragmented, and, despite its pervasiveness, NAFLD is largely unknown outside hepatology and gastroenterology. There is only a nascent global public health movement addressing NAFLD, and the disease is absent from nearly all national and international strategies and policies for non-communicable diseases, including obesity. In this global Delphi study, a multidisciplinary group of experts developed consensus statements and recommendations, which a larger group of collaborators reviewed over three rounds until consensus was achieved. The resulting consensus statements and recommendations address a broad range of topics — from epidemiology, awareness, care and treatment to public health policies and leadership — that have general relevance for policy-makers, health-care practitioners, civil society groups, research institutions and affected populations. These recommendations should provide a strong foundation for a comprehensive public health response to NAFLD

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes

The endoplasmic reticulum (ER) is broadly distributed throughout the cytoplasm of pancreatic beta cells, and this is where all proinsulin is initially made. Healthy beta cells can synthesize 6000 proinsulin molecules per second. Ordinarily, nascent proinsulin entering the ER rapidly folds via the formation of three evolutionarily conserved disulfide bonds (B7–A7, B19–A20, and A6–A11). A modest amount of proinsulin misfolding, including both intramolecular disulfide mispairing and intermolecular disulfide‐linked protein complexes, is a natural by‐product of proinsulin biosynthesis, as is the case for many proteins. The steady‐state level of misfolded proinsulin—a potential ER stressor—is linked to (1) production rate, (2) ER environment, (3) presence or absence of naturally occurring (mutational) defects in proinsulin, and (4) clearance of misfolded proinsulin molecules. Accumulation of misfolded proinsulin beyond a certain threshold begins to interfere with the normal intracellular transport of bystander proinsulin, leading to diminished insulin production and hyperglycemia, as well as exacerbating ER stress. This is most obvious in mutant INS gene–induced Diabetes of Youth (MIDY; an autosomal dominant disease) but also likely to occur in type 2 diabetes owing to dysregulation in proinsulin synthesis, ER folding environment, or clearance.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143748/1/nyas13531.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/143748/2/nyas13531_am.pd

Optimization of Muscle Activity for Task-Level Goals Predicts Complex Changes in Limb Forces across Biomechanical Contexts

Optimality principles have been proposed as a general framework for understanding motor control in animals and humans largely based on their ability to predict general features movement in idealized motor tasks. However, generalizing these concepts past proof-of-principle to understand the neuromechanical transformation from task-level control to detailed execution-level muscle activity and forces during behaviorally-relevant motor tasks has proved difficult. In an unrestrained balance task in cats, we demonstrate that achieving task-level constraints center of mass forces and moments while minimizing control effort predicts detailed patterns of muscle activity and ground reaction forces in an anatomically-realistic musculoskeletal model. Whereas optimization is typically used to resolve redundancy at a single level of the motor hierarchy, we simultaneously resolved redundancy across both muscles and limbs and directly compared predictions to experimental measures across multiple perturbation directions that elicit different intra- and interlimb coordination patterns. Further, although some candidate task-level variables and cost functions generated indistinguishable predictions in a single biomechanical context, we identified a common optimization framework that could predict up to 48 experimental conditions per animal (n = 3) across both perturbation directions and different biomechanical contexts created by altering animals' postural configuration. Predictions were further improved by imposing experimentally-derived muscle synergy constraints, suggesting additional task variables or costs that may be relevant to the neural control of balance. These results suggested that reduced-dimension neural control mechanisms such as muscle synergies can achieve similar kinetics to the optimal solution, but with increased control effort (≈2×) compared to individual muscle control. Our results are consistent with the idea that hierarchical, task-level neural control mechanisms previously associated with voluntary tasks may also be used in automatic brainstem-mediated pathways for balance

Asymmetric Responses of Primary Productivity to Altered Precipitation Simulated by Ecosystem Models across Three Long-term Grassland Sites

Field measurements of aboveground net primary productivity (ANPP) in temperate grasslands suggest that both positive and negative asymmetric responses to changes in precipitation (<i>P</i>) may occur. Under normal range of precipitation variability, wet years typically result in ANPP gains being larger than ANPP declines in dry years (positive asymmetry), whereas increases in ANPP are lower in magnitude in extreme wet years compared to reductions during extreme drought (negative asymmetry). Whether the current generation of ecosystem models with a coupled carbon–water system in grasslands are capable of simulating these asymmetric ANPP responses is an unresolved question. In this study, we evaluated the simulated responses of temperate grassland primary productivity to scenarios of altered precipitation with 14 ecosystem models at three sites: Shortgrass steppe (SGS), Konza Prairie (KNZ) and Stubai Valley meadow (STU), spanning a rainfall gradient from dry to moist. We found that (1) the spatial slopes derived from modeled primary productivity and precipitation across sites were steeper than the temporal slopes obtained from inter-annual variations, which was consistent with empirical data; (2) the asymmetry of the responses of modeled primary productivity under normal inter-annual precipitation variability differed among models, and the mean of the model ensemble suggested a negative asymmetry across the three sites, which was contrary to empirical evidence based on filed observations; (3) the mean sensitivity of modeled productivity to rainfall suggested greater negative response with reduced precipitation than positive response to an increased precipitation under extreme conditions at the three sites; and (4) gross primary productivity (GPP), net primary productivity (NPP), aboveground NPP (ANPP) and belowground NPP (BNPP) all showed concave-down nonlinear responses to altered precipitation in all the models, but with different curvatures and mean values. Our results indicated that most models overestimate the negative drought effects and/or underestimate the positive effects of increased precipitation on primary productivity under normal climate conditions, highlighting the need for improving eco-hydrological processes in those models in the future

Observation of the doubly charmed baryon decay Ξcc++→Ξc′+π+

The Ξcc++→Ξc′+π+ decay is observed using proton-proton collisions collected by the LHCb experiment at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 5.4 fb−1. The Ξcc++→Ξc′+π+ decay is reconstructed partially, where the photon from the Ξc′+→Ξc+γ decay is not reconstructed and the pK−π+ final state of the Ξc+ baryon is employed. The Ξcc++→Ξc′+π+branching fraction relative to that of the Ξcc++→Ξc+π+ decay is measured to be 1.41 ± 0.17 ± 0.10, where the first uncertainty is statistical and the second systematic. [Figure not available: see fulltext.

Study of charmonium and charmonium-like contributions in B+ → J/ψηK+ decays

A study of B+→ J/ψηK+ decays, followed by J/ψ → μ+μ− and η → γγ, is performed using a dataset collected with the LHCb detector in proton-proton collisions at centre-of-mass energies of 7, 8 and 13 TeV, corresponding to an integrated luminosity of 9 fb−1. The J/ψη mass spectrum is investigated for contributions from charmonia and charmonium-like states. Evidence is found for the B+→ (ψ2(3823) → J/ψη)K+ and B+→ (ψ(4040) → J/ψη)K+ decays with significance of 3.4 and 4.7 standard deviations, respectively. This constitutes the first evidence for the ψ2(3823) → J/ψη decay