The Experimental Status of the Standard Electroweak Model at the End of the LEP-SLC Era

A method is proposed to calculate the confidence level for agreement of data with the Standard Model (SM) by combining information from direct and indirect Higgs Boson searches. Good agreement with the SM is found for $m_H \simeq 120$ GeV using the observables most sensitive to $m_H$: $A_l$ and $m_W$. In particular, quantum corrections, as predicted by the SM, are observed with a statistical significance of forty-four standard deviations. However, apparent deviations from the SM of 3.7$\sigma$ and 2.8$\sigma$ are found for the Z$\nu \bar{\nu}$ and right-handed Zb$\bar{{\rm b}}$ couplings respectively. The maximum confidence level for agreement with the SM of the entire data set considered is $\simeq 0.006$ for $m_H \simeq 180$ GeV. The reason why confidence levels about an order of magnitude higher than this have been claimed for global fits to similar data sets is explained.Comment: 47 pages, 8 figures, 24 tables. An in-depth study of statistical issues related to the comparison of precision EW data to the S

Unique Features of Odorant-Binding Proteins of the Parasitoid Wasp Nasonia vitripennis Revealed by Genome Annotation and Comparative Analyses

Insects are the most diverse group of animals on the planet, comprising over 90% of all metazoan life forms, and have adapted to a wide diversity of ecosystems in nearly all environments. They have evolved highly sensitive chemical senses that are central to their interaction with their environment and to communication between individuals. Understanding the molecular bases of insect olfaction is therefore of great importance from both a basic and applied perspective. Odorant binding proteins (OBPs) are some of most abundant proteins found in insect olfactory organs, where they are the first component of the olfactory transduction cascade, carrying odorant molecules to the olfactory receptors. We carried out a search for OBPs in the genome of the parasitoid wasp Nasonia vitripennis and identified 90 sequences encoding putative OBPs. This is the largest OBP family so far reported in insects. We report unique features of the N. vitripennis OBPs, including the presence and evolutionary origin of a new subfamily of double-domain OBPs (consisting of two concatenated OBP domains), the loss of conserved cysteine residues and the expression of pseudogenes. This study also demonstrates the extremely dynamic evolution of the insect OBP family: (i) the number of different OBPs can vary greatly between species; (ii) the sequences are highly diverse, sometimes as a result of positive selection pressure with even the canonical cysteines being lost; (iii) new lineage specific domain arrangements can arise, such as the double domain OBP subfamily of wasps and mosquitoes.Rothamsted Research receives grant-aided support from the BBSRC of the UK. The authors thank Prof. David M. Shuker, University of Edinburgh, UK, who provided us with N. vitripennis. FGV was supported by a predoctoral fellowship SFRH/BD/22360/2005 from the ‘Fundac¸a˜o para a Cieˆncia e a Tecnologı´a’ (Portugal). This work was funded by grants BFU2007-62927 and BFU2010-15484 from the ‘Direccio´n General de Investigacio´n Cientı´fica y Te´cnica’ (Spain) to JR. JR was partially supported by ICREA Academia (Generalitat de Catalunya). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Sex-biased parental care and sexual size dimorphism in a provisioning arthropod

The diverse selection pressures driving the evolution of sexual size dimorphism (SSD) have long been debated. While the balance between fecundity selection and sexual selection has received much attention, explanations based on sex-specific ecology have proven harder to test. In ectotherms, females are typically larger than males, and this is frequently thought to be because size constrains female fecundity more than it constrains male mating success. However, SSD could additionally reflect maternal care strategies. Under this hypothesis, females are relatively larger where reproduction requires greater maximum maternal effort – for example where mothers transport heavy provisions to nests. To test this hypothesis we focussed on digger wasps (Hymenoptera: Ammophilini), a relatively homogeneous group in which only females provision offspring. In some species, a single large prey item, up to 10 times the mother’s weight, must be carried to each burrow on foot; other species provide many small prey, each flown individually to the nest. We found more pronounced female-biased SSD in species where females carry single, heavy prey. More generally, SSD was negatively correlated with numbers of prey provided per offspring. Females provisioning multiple small items had longer wings and thoraxes, probably because smaller prey are carried in flight. Despite much theorising, few empirical studies have tested how sex-biased parental care can affect SSD. Our study reveals that such costs can be associated with the evolution of dimorphism, and this should be investigated in other clades where parental care costs differ between sexes and species

The Crystal Structure of Odorant Binding Protein 7 from Anopheles gambiae Exhibits an Outstanding Adaptability of Its Binding Site

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Evidence of Endemic Hendra Virus Infection in Flying-Foxes (Pteropus conspicillatus)—Implications for Disease Risk Management

This study investigated the seroepidemiology of Hendra virus in a spectacled flying-fox (Pteropus conspicillatus) population in northern Australia, near the location of an equine and associated human Hendra virus infection in late 2004. The pattern of infection in the population was investigated using a serial cross-sectional serological study over a 25-month period, with blood sampled from 521 individuals over six sampling sessions. Antibody titres to the virus were determined by virus neutralisation test. In contrast to the expected episodic infection pattern, we observed that seroprevalence gradually increased over the two years suggesting infection was endemic in the population over the study period. Our results suggested age, pregnancy and lactation were significant risk factors for a detectable neutralizing antibody response. Antibody titres were significantly higher in females than males, with the highest titres occurring in pregnant animals. Temporal variation in antibody titres suggests that herd immunity to the virus may wax and wane on a seasonal basis. These findings support an endemic infection pattern of henipaviruses in bat populations suggesting their infection dynamics may differ significantly from the acute, self limiting episodic pattern observed with related viruses (e.g. measles virus, phocine distemper virus, rinderpest virus) hence requiring a much smaller critical host population size to sustain the virus. These findings help inform predictive modelling of henipavirus infection in bat populations, and indicate that the life cycle of the reservoir species should be taken into account when developing risk management strategies for henipaviruses

Evidence of Endemic Hendra Virus Infection in Flying-Foxes (Pteropus conspicillatus)—Implications for Disease Risk Management

This study investigated the seroepidemiology of Hendra virus in a spectacled flying-fox (Pteropus conspicillatus) population in northern Australia, near the location of an equine and associated human Hendra virus infection in late 2004. The pattern of infection in the population was investigated using a serial cross-sectional serological study over a 25-month period, with blood sampled from 521 individuals over six sampling sessions. Antibody titres to the virus were determined by virus neutralisation test. In contrast to the expected episodic infection pattern, we observed that seroprevalence gradually increased over the two years suggesting infection was endemic in the population over the study period. Our results suggested age, pregnancy and lactation were significant risk factors for a detectable neutralizing antibody response. Antibody titres were significantly higher in females than males, with the highest titres occurring in pregnant animals. Temporal variation in antibody titres suggests that herd immunity to the virus may wax and wane on a seasonal basis. These findings support an endemic infection pattern of henipaviruses in bat populations suggesting their infection dynamics may differ significantly from the acute, self limiting episodic pattern observed with related viruses (e.g. measles virus, phocine distemper virus, rinderpest virus) hence requiring a much smaller critical host population size to sustain the virus. These findings help inform predictive modelling of henipavirus infection in bat populations, and indicate that the life cycle of the reservoir species should be taken into account when developing risk management strategies for henipaviruses

Dislocation Loops in Proton Irradiated Uranium-Nitrogen-Oxygen System

In this study, we investigated the type of dislocation loops formed in the proton-irradiated uranium-nitrogen-oxygen (U-N-O) system, which involves uranium mononitride (UN), uranium sesquinitride (α-U2N3), and uranium dioxide (UO2) phases. The dislocation loop formation is examined using specimens irradiated at 400°C and 710°C. Based on the detailed transmission-based electron microscopy characterization with i) the morphology-based on-zone and ii) the invisibility-criterion based two-beam condition imaging techniques, only a single type of dislocation loop in each phase is found: a/2⟨110⟩, a/2⟨111⟩, or a/3⟨111⟩ dislocation loops in UN, α-U2N3, and UO2 phases, respectively. Molecular statics calculations for the formation energy of perfect and faulted dislocation loops in the UN phase indicate a critical loop size of ∼6 nm, above which perfect loops are thermodynamically favorable. This could explain the absence of faulted loops in the experimental observation of the irradiated UN phase at two temperatures. This work will enhance the understanding of irradiation induced microstructural evolution for uranium mononitride as an advanced nuclear fuel for the next-generation nuclear reactors.</p

Hecke Groups, Dessins d’Enfants and the Archimedean Solids

Grothendieck’s dessins d’enfants arise with ever-increasing frequency in many areas of 21st century mathematical physics. In this paper, we review the connections between dessins and the theory of Hecke groups. Focussing on the restricted class of highly symmetric dessins corresponding to the so-called Archimedean solids, we apply this theory in order to provide a means of computing representatives of the associated conjugacy classes of Hecke subgroups in each case. The aim of this paper is to demonstrate that dessins arising in mathematical physics can point to new and hitherto unexpected directions for further research. In addition, given the particular ubiquity of many of the dessins corresponding to the Archimedean solids, the hope is that the computational results of this paper will prove useful in the further study of these objects in mathematical physics contexts

Probing Shadowed Nuclear Sea with Massive Gauge Bosons in the Future Heavy-Ion Collisions

The production of the massive bosons $Z^0$ and $W^{\pm}$ could provide an excellent tool to study cold nuclear matter effects and the modifications of nuclear parton distribution functions (nPDFs) relative to parton distribution functions (PDFs) of a free proton in high energy nuclear reactions at the LHC as well as in heavy-ion collisions (HIC) with much higher center-of mass energies available in the future colliders. In this paper we calculate the rapidity and transverse momentum distributions of the vector boson and their nuclear modification factors in p+Pb collisions at $\sqrt{s_{NN}}=63$TeV and in Pb+Pb collisions at $\sqrt{s_{NN}}=39$TeV in the framework of perturbative QCD by utilizing three parametrization sets of nPDFs: EPS09, DSSZ and nCTEQ. It is found that in heavy-ion collisions at such high colliding energies, both the rapidity distribution and the transverse momentum spectrum of vector bosons are considerably suppressed in wide kinematic regions with respect to p+p reactions due to large nuclear shadowing effect. We demonstrate that in the massive vector boson productions processes with sea quarks in the initial-state may give more contributions than those with valence quarks in the initial-state, therefore in future heavy-ion collisions the isospin effect is less pronounced and the charge asymmetry of W boson will be reduced significantly as compared to that at the LHC. Large difference between results with nCTEQ and results with EPS09 and DSSZ is observed in nuclear modifications of both rapidity and $p_T$ distributions of $Z^0$ and $W$ in the future HIC.Comment: 13 pages, 21 figures, version accepted for publication in Eur. Phys. J.