Coupling dynamics of a geared multibody system supported by Elastohydrodynamic lubricated cylindrical joints

A comprehensive computational methodology to study the coupling dynamics of a geared multibody system supported by ElastoHydroDynamic (EHD) lubricated cylindrical joints is proposed throughout this work. The geared multibody system is described by using the Absolute-Coordinate-Based (ACB) method that combines the Natural Coordinate Formulation (NCF) describing rigid bodies and the Absolute Nodal Coordinate Formulation (ANCF) characterizing the flexible bodies. Based on the finite-short bearing approach, the EHD lubrication condition for the cylindrical joints supporting the geared system is considered here. The lubrication forces developed at the cylindrical joints are obtained by solving the Reynolds’ equation via the finite difference method. For the evaluation of the normal contact forces of gear pair along the Line Of Action (LOA), the time-varying mesh stiffness, mesh damping and Static Transmission Error (STE) are utilized. The time-varying mesh stiffness is calculated by using the Chaari’s methodology. The forces of sliding friction along the Off-Line-Of-Action (OLOA) are computed by using the Coulomb friction models with a time-varying coefficient of friction under the EHD lubrication condition of gear teeth. Finally, two numerical examples of application are presented to demonstrate and validate the proposed methodology.National Natural Science Foundations of China under Grant 11290151, 11221202 and 11002022, Beijing Higher Education Young Elite Teacher Project under Grant YETP1201

Deformations of nearly Kähler instantons

We formulate the deformation theory for instantons on nearly Kähler six-manifolds using spinors and Dirac operators. Using this framework we identify the space of deformations of an irreducible instanton with semisimple structure group with the kernel of an elliptic operator, and prove that abelian instantons are rigid. As an application, we show that the canonical connection on three of the four homogeneous nearly Kähler six-manifolds G/H is a rigid instanton with structure group H. In contrast, these connections admit large spaces of deformations when regarded as instantons on the tangent bundle with structure group SU(3)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

One-step electrodeposition synthesis of silver-nanoparticle-decorated graphene on indium-tin-oxide for enzymeless hydrogen peroxide detection

Silver-nanoparticles-decorated reduced graphene oxide (rGO) was electrodeposited on indium tin oxide (ITO) by a cyclic voltammetry method. The results of X-ray diffraction, Fourier-transform infrared transmission spectroscopy and Raman spectroscopy confirmed the simultaneous formation of cubic phase silver nanoparticles and reduction of GO through the electrodeposition process. Field emission scanning electron microscope images showed a uniform distribution of nanometer-sized silver nanoparticles with a narrow size distribution on the RGO sheets, which could only be achieved using silver ammonia complex instead of silver nitrate as precursor. The composite deposited on ITO exhibited notable electrocatalytic activity for the reduction of H2O2, leading to an enzymeless electrochemical sensor with a fast amperometric response time less than 2 s. The corresponding calibration curve of the current response showed a linear detection range of 0.1 mM to 100 mM (R2 = 0.9992) while the limit of detection was estimated to be 5 μM