Stellenwert der Strahlentherapie bei Aggressiver Fibromatose

Stellenwert der Strahlentherapie bei Aggressiver Fibromatose. Die vorliegende Arbeit untersuchte den Effekt einer Strahlentherapie auf die Tumorkontrollrate bei 14 Patienten (10-68 Jahre; 9 Frauen) mit Aggressiver Fibromatose. Die Desmoide hatten ihren Sitz extraabdmoninell (72%) im Bereich der Extremitäten (n=9) und der Thoraxwand (n=1), gefolgt von intraabdominellen Tumoren (21%, n=3) und einem Desmoid der Bauchwand. Alle Tumoren waren primär chirurgisch reseziert worden, die Resektionsgrade waren R0 in vier Fällen (29%), R1 in fünf Fällen und R2 in fünf Fällen

High-Precision Orientation of Three-Component Magnetic Downhole Logs

The possible benefits of measuring the magnetic flux density in three components continuously along a borehole have been recognized a long time ago by researchers who developed models and interpretation schemes for 3-component magnetic borehole data (Parker and Daniell,1979; Gallet and Courtillot, 1989).Common borehole methods provide data not allowing for an orientation with respect to a global reference, since this requires a highly accurate orienta tion system independent of the magnetic measurements. A first attempt to obtain the orientation of the sonde was made by Bosum et al. (1988) using a mechanical gyro and accelerometers. However, at that time the data quality of the gyro did not allow for a continuous 3-component measurement. Steveling et al. (2003) provide an example from the Hawaii Scientific Drilling Project (HSDP) drill hole, where directional information of magnetization was used to separate massive lavas from hyaloclastites. However, their directional analysis was limited to the inclination because information on the tool rotation around the vertical axis was not available.Here, we describe the successful development of an orientation procedure with very high resolution independent of magnetic data. Test data were acquired in the 2.5-km-deep ICDP Outokumpu Research Hole in eastern Finland (Kukkonen, 2007) with the so-called Göttinger Borehole Magnetometer (GBM). The sonde uses three fiber optic gyros (FOGs) exhibiting a small drift of 1.5°h-1 and a high resolution of 9x10-5 degrees. In combination with a built-in Förster magnetometer triplet, the GBM can record the magnetic field in three components as well as the tool orientation continuously. In the Outokumpu drill hole, errors (root mean square) were 0.14° for the inclination and 1.4° for the declination of the magnetic flux density

Analysis of 1,000+ Type-Strain Genomes Substantially Improves Taxonomic Classification of Alphaproteobacteria.

The class Alphaproteobacteria is comprised of a diverse assemblage of Gram-negative bacteria that includes organisms of varying morphologies, physiologies and habitat preferences many of which are of clinical and ecological importance. Alphaproteobacteria classification has proved to be difficult, not least when taxonomic decisions rested heavily on a limited number of phenotypic features and interpretation of poorly resolved 16S rRNA gene trees. Despite progress in recent years regarding the classification of bacteria assigned to the class, there remains a need to further clarify taxonomic relationships. Here, draft genome sequences of a collection of genomes of more than 1000 Alphaproteobacteria and outgroup type strains were used to infer phylogenetic trees from genome-scale data using the principles drawn from phylogenetic systematics. The majority of taxa were found to be monophyletic but several orders, families and genera, including taxa recognized as problematic long ago but also quite recent taxa, as well as a few species were shown to be in need of revision. According proposals are made for the recognition of new orders, families and genera, as well as the transfer of a variety of species to other genera and of a variety of genera to other families. In addition, emended descriptions are given for many species mainly involving information on DNA G+C content and (approximate) genome size, both of which are confirmed as valuable taxonomic markers. Similarly, analysis of the gene content was shown to provide valuable taxonomic insights in the class. Significant incongruities between 16S rRNA gene and whole genome trees were not found in the class. The incongruities that became obvious when comparing the results of the present study with existing classifications appeared to be caused mainly by insufficiently resolved 16S rRNA gene trees or incomplete taxon sampling. Another probable cause of misclassifications in the past is the partially low overall fit of phenotypic characters to the sequence-based tree. Even though a significant degree of phylogenetic conservation was detected in all characters investigated, the overall fit to the tree varied considerably

Broadband spectral induced polarization for the detection of Permafrost and an approach to ice content estimation – a case study from Yakutia, Russia

The reliable detection of subsurface ice using non-destructive geophysical methods is an important objective in permafrost research. The ice content of the frozen ground is an essential parameter for further interpretation, for example in terms of risk analysis and for the description of permafrost carbon feedback by thawing processes. The high-frequency induced polarization method (HFIP) enables the measurement of the frequency-dependent electrical conductivity and permittivity of the subsurface, in a frequency range between 100 Hz and 100 kHz. As the electrical permittivity of ice exhibits a strong characteristic behaviour in this frequency range, HFIP in principle is suitable to estimate ice content. Here, we present methodological advancements of the HFIP method and suggest an explicit procedure for ice content estimation. A new measuring device, the Chameleon-II (Radic Research), was used for the first time. Compared to a previous generation, the new system is equipped with longer cables and higher power, such that we can now achieve larger penetration depths up to 10 m. Moreover, it is equipped with technology to reduce electromagnetic coupling effects which can distort the desired subsurface signal. The second development is a method to estimate ice content quantitatively from five Cole–Cole parameters obtained from spectral two-dimensional inversion results. The method is based on a description of the subsurface as a mixture of two components (matrix and ice) and uses a previously suggested relationship between frequency-dependent electrical permittivity and ice content. In this model, the ice relaxation is considered the dominant process in the frequency range around 10 kHz. Measurements on a permafrost site near Yakutsk, Russia, were carried out to test the entire procedure under real conditions at the field scale. We demonstrate that the spectral signal of ice can clearly be identified even in the raw data and show that the spectral 2-D inversion algorithm is suitable to obtain the multidimensional distribution of electrical parameters. The parameter distribution and the estimated ice content agree reasonably well with previous knowledge of the field site from borehole and geophysical investigations. We conclude that the method is able to provide quantitative ice content estimates and that relationships that have been tested in the laboratory may be applied at the field scale.</p

Untersuchung von hydrologischen Parametern und Spektren der Induzierten Polarisation an Lockersedimentproben

Im Rahmen eines gemeinsamen Projektes des Instituts für Geophysik und extraterrestrische Physik und des Instituts für Geoökologie der TU Braunschweig werden Zusammenhänge zwischen bodenhydrologischen und elektrischen Parametern untersucht. Für die Messungen an verschiedenen Boden-proben wurde eine Messzelle entwickelt, die sowohl die Bestimmung der hydro-logischen Eigenschaften durch Multi-Step-Ausflussexperimente (MSO) als auch die Untersuchung mittels spektraler Induzierter Polarisation (SIP) an Locker-sedimenten ermöglicht. Das Proben-material verbleibt bei beiden Verfahren in derselben Messzelle. Eine Veränderung der Probeneigenschaften durch den Aus- und Wiedereinbau des Materials wird ausgeschlossen. Die Messzelle und Ergebnisse der ersten Untersuchungen werden vorgestellt

Rock Glacier Characteristics Under Semiarid Climate Conditions in the Western Nyainqêntanglha Range, Tibetan Plateau

Abstract Rock glaciers are receiving increased attention as a potential source of water and indicator of climate change in periglacial landscapes. They consist of an ice‐debris mixture, which creeps downslope. Although rock glaciers are a wide‐spread feature on the Tibetan Plateau, characteristics such as its ice fraction are unknown as a superficial debris layer inhibits remote assessments. We investigate one rock glacier in the semiarid western Nyainqêntanglha range (WNR) with a multi‐method approach, which combines geophysical, geological and geomorphological field investigations with remote sensing techniques. Long‐term kinematics of the rock glacier are detected by 4‐year InSAR time series analysis. The ice content and the active layer are examined by electrical resistivity tomography, ground penetrating radar, and environmental seismology. Short‐term activity (11‐days) is captured by a seismic network. Clast analysis shows a sorting of the rock glacier's debris. The rock glacier has three zones, which are defined by the following characteristics: (a) Two predominant lithology types are preserved separately in the superficial debris patterns, (b) heterogeneous kinematics and seismic activity, and (c) distinct ice fractions. Conceptually, the studied rock glacier is discussed as an endmember of the glacier—debris‐covered glacier—rock glacier continuum. This, in turn, can be linked to its location on the semiarid lee‐side of the mountain range against the Indian summer monsoon. Geologically preconditioned and glacially overprinted, the studied rock glacier is suggested to be a recurring example for similar rock glaciers in the WNR. This study highlights how geology, topography and climate influence rock glacier characteristics and development.Plain Language Summary Climate change has begun to impact all regions of our planet. In cold regions, such as high‐mountain areas, rising temperatures lead to massive melting of glaciers. Besides this evident loss of ice, permafrost, a long‐term ice resource hidden in the subsurface, has started to thaw. Rock glaciers as visible permafrost‐related landforms consist of an ice‐debris mixture, which makes them creep downslope. Due to this movement and their recognizable shape, rock glaciers are permafrost indicators in high‐mountain areas. We investigate one rock glacier in the western Nyaingêntanglha Range (Tibetan Plateau) using field and remote sensing methods to understand its development and to know the current state of its ice core. Our main outcome is, that the heterogeneous creeping behavior, the properties of the debris cover as well as the internal distribution of ice are the results of a continuous development from a glacier into today's rock glacier. In particular, the high ice content in particular sections points to such a glacial precondition. The debris layer covering the internal ice attenuates the effect of climate warming. This makes the rock glacier and similar rock glaciers found in the northern part of the mountain range important future water resources for the semiarid region.Key Points Geophysical and remote sensing methods in concert reveal the morphostructure, ice fraction, and kinematics of the studied rock glacier Rock glacier characteristics are controlled by geology, topography and climate on the Tibetan Plateau The studied rock glacier is conceptually interpreted as the endmember of a glacier—debris‐covered glacier—rock glacier continuu

Two-dimensional inversion of wideband spectral data from the capacitively coupled resistivity method – first applications in periglacial environments

The DC resistivity method is a common tool in periglacial research because it can delineate zones of large resistivities, which are often associated with frozen water. The interpretation can be ambiguous, however, because large resistivities may also have other causes, like solid dry rock. One possibility to reduce the ambiguity is to measure the frequency-dependent resistivity. At low frequencies (< 100 Hz) the corresponding method is called induced polarization, which has also been used in periglacial environments. For the detection and possibly quantification of water ice, a higher frequency range, between 100 Hz and 100 kHz, may be particularly interesting because in that range, the electrical properties of water ice exhibit a characteristic behaviour. In addition, the large frequencies allow a capacitive coupling of the electrodes, which may have logistical advantages. The capacitively coupled resistivity (CCR) method tries to combine these logistical advantages with the potential scientific benefit of reduced ambiguity. In this paper, we discuss CCR data obtained at two field sites with cryospheric influence: the Schilthorn massif in the Swiss Alps and the frozen Lake Prestvannet in the northern part of Norway. One objective is to add examples to the literature where the method is assessed in different conditions. Our results agree reasonably well with known subsurface structure: at the Prestvannet site, the transition from a frozen lake to the land is clearly visible in the inversion results, whereas at the Schilthorn site, the boundary between a snow cover and the bedrock below can be nicely delineated. In both cases, the electrical parameters are consistent with those expected from literature. The second objective is to discuss useful methodological advancements: first, we investigate the effect of capacitive sensor height above the surface and corroborate the assumption that it is negligible for highly resistive conditions. For the inversion of the data, we modified an existing 2-D inversion code originally developed for low-frequency induced polarization data by including a parametrization of electrical permittivity. The new inversion code allows the extraction of electrical parameters that may be directly compared with literature values, which was previously not possible

The MASCOT Magnetometer

The Mobile Asteroid Scout (MASCOT) is a small lander on board the Hayabusa2 mission of the Japan Aerospace Exploration Agency to the asteroid 162173 Ryugu. Among the instruments on MASCOT is a fluxgate magnetometer, the MASCOT Magnetometer (MasMag). The magnetometer is a lightweight ( ∼280 g∼280 g ) and low power ( ∼0.5 W∼0.5 W ) triaxial fluxgate magnetometer. Magnetic field measurements during the landing period and during the surface operational phase shall provide information about any intrinsic magnetic field of the asteroid and its remanent magnetization. This could provide important constraints on planet formation and the thermal and aqueous evolution of primitive asteroids.Thomas F. PetersonUnited States. National Aeronautics and Space Administration. Emerging Worlds Progra