Evaluating Virtual Reality And Artificial Intelligence As Solutions For Delayed Flight Progress In Aviation Pilot Training

Three studies in this dissertation examined a topic centered around delayed flight progress in aviation pilot training. Study one explored the impact of nonconcurrent flight laboratory training on the academic outcomes of collegiate aviation students, while studies two and three explored virtual reality and artificial intelligence as potential solutions to help alleviate the strain of delayed flight progress on the flight training organization. In the first study (n = 144), it was found that concurrent enrollment in an aviation classroom ground course and flight training laboratory positively impacts the mean academic block exam scores of students. In study two (n = 120), virtual reality was shown to be an effective training technology in the quantitative measure of pilot performance, as well as the qualitative measures of acceptance and adoption of the technology. Finally, the third study (n = 37) showed that an artificial intelligence-based flight instructor performs comparably to a human flight instructor, when transferring a student pilot’s skills from the simulator to the aircraft. Findings from each of these studies are valuable for flight training organizations looking to find ways of better preparing their student pilots and supplementing the strain of reduced flight instructor staffing within the organization

Evaluating the Efficacy of Virtual Reality (VR) Training Devices for Pilot Training

Virtual Reality (VR) technology is a quickly advancing field that has many documented benefits, including highly detailed environments, accuracy to the real world, and low cost of entry in the flight simulation market. At the time of this study, VR technology has not been well tested or widely accepted in the aviation industry. In this mixed methods study, quantitative and qualitative data was collected on beginning-level instrument pilots (n = 120) while performing a visual traffic pattern at an airport. A one-way ANOVA was used to evaluate the equivalence of each group in the study based on previous flight and VR experience. Then, a one-way ANOVA was conducted on pre-test/post-test gain scores to compare each training group, as well as a post hoc Tukey HSD to conduct multiple comparisons and evaluate mean differences between the groups. The results show that participants who train in a VR simulator perform similarly to students who conduct training in a PC-based simulator. Both training groups performed significantly better than the control group, which conducted no training between the pre-test and post-test. Finally, survey data was evaluated to find that students who trained in VR simulators believed they performed better on the post-test than the pre-test and most felt that VR simulators could be an acceptable training technology for use in the flight training curriculum. These results will help inform flight training organizations who are considering new technology that provides a low-cost and high-value alternative to costlier, fixed-based simulators

Technical and Regulatory Factors of Adopting Electric Training Aircraft in a Collegiate Aviation Setting

Electric-powered aircraft have entered the market. The arrival of the Pipistrel Velis Electro and other developmental efforts by companies such as Bye Aerospace, Piper, and eViation, have signaled to the aviation community that more electric-powered aircraft can be expected in the coming years. But how useful are they for training pilots in a Federal Aviation Administration (FAA) approved Part 141 collegiate aviation environment? To identify candidate flight courses and lessons, the authors examine flight hour distributions of a one-year window of invoiced flights (N = 52,728), including flight hour data cut-points at 60 minutes (n = 6,050) and 90 minutes (n = 25,439). The data distribution suggests that approximately 11.5% of the candidate flights would fall within a 60-minute expected flight duration, whereas 48% of flights would fall within a 90-minute flight duration. These calculations provide realistic targets for designed minimum flight duration (plus the inclusion of required FAA reserve) in order to be determined a feasible trainer in many high-volume FAA Part 141 training environments. Detailed course-level analysis suggests the Instrument Flight Instructor (CFII) flight course as a potential launch point for electric flight due to the relatively lower flight hour per lesson. In addition to minimum flight duration, other feasibility questions are included in this analysis, such as regulatory requirements, battery duration, aircraft turnaround time, multiple charge-discharge cycles per day, environmental factors, airport charging infrastructure, and maintenance factors. Additional research will benefit this developing area of electric aircraft in flight training environments

Internal standard-based analysis of microarray data2—Analysis of functional associations between HVE-genes

In this work we apply the Internal Standard-based analytical approach that we described in an earlier communication and here we demonstrate experimental results on functional associations among the hypervariably-expressed genes (HVE-genes). Our working assumption was that those genetic components, which initiate the disease, involve HVE-genes for which the level of expression is undistinguishable among healthy individuals and individuals with pathology. We show that analysis of the functional associations of the HVE-genes is indeed suitable to revealing disease-specific differences. We show also that another possible exploit of HVE-genes for characterization of pathological alterations is by using multivariate classification methods. This in turn offers important clues on naturally occurring dynamic processes in the organism and is further used for dynamic discrimination of groups of compared samples. We conclude that our approach can uncover principally new collective differences that cannot be discerned by individual gene analysi

Internal standard-based analysis of microarray data2—Analysis of functional associations between HVE-genes

In this work we apply the Internal Standard-based analytical approach that we described in an earlier communication and here we demonstrate experimental results on functional associations among the hypervariably-expressed genes (HVE-genes). Our working assumption was that those genetic components, which initiate the disease, involve HVE-genes for which the level of expression is undistinguishable among healthy individuals and individuals with pathology. We show that analysis of the functional associations of the HVE-genes is indeed suitable to revealing disease-specific differences. We show also that another possible exploit of HVE-genes for characterization of pathological alterations is by using multivariate classification methods. This in turn offers important clues on naturally occurring dynamic processes in the organism and is further used for dynamic discrimination of groups of compared samples. We conclude that our approach can uncover principally new collective differences that cannot be discerned by individual gene analysis

ABIN1 dysfunction as a genetic basis for lupus nephritis

The genetic factors underlying the pathogenesis of lupus nephritis associated with systemic lupus erythematosus are largely unknown, although animal studies indicate that nuclear factor (NF)-?B is involved. We reported previously that aknockin mouse expressinganin active form of ABIN1 (ABIN1[D485N]) develops lupus-like autoimmune disease and demonstrates enhanced activation of NF-?B and mitogen-activated protein kinases in immune cells after toll-like receptor stimulation. In the current study, we show that ABIN1[D485N] mice develop progressive GN similar to class III and IV lupus nephritis in humans. To investigate the clinical relevance of ABIN1 dysfunction, we genotyped five single-nucleotide polymorphisms in the gene encoding ABIN1, TNIP1, in samples from European-American, African American, Asian, Gullah, and Hispanic participants in the Large Lupus Association Study 2. Comparing cases of systemic lupus erythematosus with nephritis and cases ofsystemic lupus erythematosus without nephritis revealed strong associations with lupus nephritis at rs7708392 in European Americans and rs4958881 in African Americans. Comparing cases of systemic lupus erythematosus with nephritis and healthy controls revealed a stronger association at rs7708392 in European Americans but not at rs4958881 in African Americans. Our data suggest that variants in the TNIP1 gene are associated with the risk for lupus nephritis and could be mechanistically involved in disease development via aberrant regulation of NF-?B and mitogen-activated protein kinase activity. Copyright © 2013 by the American Society of Nephrology

Lancet

BACKGROUND: In 2015, the second cycle of the CONCORD programme established global surveillance of cancer survival as a metric of the effectiveness of health systems and to inform global policy on cancer control. CONCORD-3 updates the worldwide surveillance of cancer survival to 2014. METHODS: CONCORD-3 includes individual records for 37.5 million patients diagnosed with cancer during the 15-year period 2000-14. Data were provided by 322 population-based cancer registries in 71 countries and territories, 47 of which provided data with 100% population coverage. The study includes 18 cancers or groups of cancers: oesophagus, stomach, colon, rectum, liver, pancreas, lung, breast (women), cervix, ovary, prostate, and melanoma of the skin in adults, and brain tumours, leukaemias, and lymphomas in both adults and children. Standardised quality control procedures were applied; errors were rectified by the registry concerned. We estimated 5-year net survival. Estimates were age-standardised with the International Cancer Survival Standard weights. FINDINGS: For most cancers, 5-year net survival remains among the highest in the world in the USA and Canada, in Australia and New Zealand, and in Finland, Iceland, Norway, and Sweden. For many cancers, Denmark is closing the survival gap with the other Nordic countries. Survival trends are generally increasing, even for some of the more lethal cancers: in some countries, survival has increased by up to 5% for cancers of the liver, pancreas, and lung. For women diagnosed during 2010-14, 5-year survival for breast cancer is now 89.5% in Australia and 90.2% in the USA, but international differences remain very wide, with levels as low as 66.1% in India. For gastrointestinal cancers, the highest levels of 5-year survival are seen in southeast Asia: in South Korea for cancers of the stomach (68.9%), colon (71.8%), and rectum (71.1%); in Japan for oesophageal cancer (36.0%); and in Taiwan for liver cancer (27.9%). By contrast, in the same world region, survival is generally lower than elsewhere for melanoma of the skin (59.9% in South Korea, 52.1% in Taiwan, and 49.6% in China), and for both lymphoid malignancies (52.5%, 50.5%, and 38.3%) and myeloid malignancies (45.9%, 33.4%, and 24.8%). For children diagnosed during 2010-14, 5-year survival for acute lymphoblastic leukaemia ranged from 49.8% in Ecuador to 95.2% in Finland. 5-year survival from brain tumours in children is higher than for adults but the global range is very wide (from 28.9% in Brazil to nearly 80% in Sweden and Denmark). INTERPRETATION: The CONCORD programme enables timely comparisons of the overall effectiveness of health systems in providing care for 18 cancers that collectively represent 75% of all cancers diagnosed worldwide every year. It contributes to the evidence base for global policy on cancer control. Since 2017, the Organisation for Economic Co-operation and Development has used findings from the CONCORD programme as the official benchmark of cancer survival, among their indicators of the quality of health care in 48 countries worldwide. Governments must recognise population-based cancer registries as key policy tools that can be used to evaluate both the impact of cancer prevention strategies and the effectiveness of health systems for all patients diagnosed with cancer. FUNDING: American Cancer Society; Centers for Disease Control and Prevention; Swiss Re; Swiss Cancer Research foundation; Swiss Cancer League; Institut National du Cancer; La Ligue Contre le Cancer; Rossy Family Foundation; US National Cancer Institute; and the Susan G Komen Foundation

Trends in hospital admissions for conditions associated with child maltreatment, Northern Territory, 1999-2010

OBJECTIVE: To use hospital admissions data to investigate trends in maltreatment among Northern Territory Aboriginal and non-Aboriginal children. DESIGN, SETTING AND PARTICIPANTS: A historical cohort study using diagnosis and external cause codes from hospital admissions among children aged 0-17 years. MAIN OUTCOME MEASURES: Annual rates of admission with either a definitive or indicative code for child maltreatment. RESULTS: From 1 January 1999 to 31 December 2010, the average annual rates of hospital admission of NT Aboriginal and non-Aboriginal children with a definitive code of maltreatment were 8.8 (95% CI, 7.4-10.2) and 0.91 (95% CI, 0.59-1.22) per 10 000 children, respectively. There was no evidence for change over time in either population. The corresponding rates of admission with a code indicative of maltreatment were 28.4 (95% CI, 25.8-31.1) and 5.2 (95% CI, 4.4-6.0) per 10 000 children, with average annual increases of 3% (incidence rate ratio [IRR], 1.03; 95% CI, 1.00-1.07) and 4% (IRR, 1.04; 95% CI, 0.96-1.11). Physical abuse was the prominent type of maltreatment-related admission in both populations. There were increases in rates of admission for older Aboriginal children (13-17 years) and older non-Aboriginal boys. Most perpetrators in the assault of younger children were family members, while among older children most were not specified. CONCLUSION: Our study shows the utility of hospital admissions for population surveillance of child maltreatment. The relatively stable rate of maltreatment-related hospital admissions among NT Aboriginal children shown here is in contrast to substantial increases reported from child protection data. The results also highlight the overlap between violence within families and in the wider community, particularly for older children, and lends support for population-level interventions to protect vulnerable children.Steven L Guthridge, Philip Ryan, John R Condon, John R Moss, John Lync

Trends in reports of child malreatment in the Northern Territory, 1999-2010

OBJECTIVE: To examine trends in reports of child maltreatment to the Northern Territory Department of Children and Families among Aboriginal and non-Aboriginal children. DESIGN, SETTING AND SUBJECTS: A historical cohort study using administrative data collections of notifications and substantiated cases of maltreatment among children aged from 0 to 17 years. MAIN OUTCOME MEASUReS: Annual rates of notification and substantiation of different types of child maltreatment. RESULTS: From 1999 to 2010, the overall annual rates of notification for maltreatment of Aboriginal children showed an average increase of 21% (incidence rate ratio [IRR], 1.21; 95% CI, 1.19–1.24). The greatest increases were in notifications for neglect and emotional abuse. There were parallel increases in rates of substantiated cases of maltreatment. Among non-Aboriginal children, the overall annual rates of notification also increased (IRR, 1.10; 95% CI, 1.07–1.14); however, changes in annual rates of substantiated cases for all types of maltreatment were not statistically significant. CONCLUSION: There have been considerable increases in both notifications and substantiated cases of child maltreatment, most prominently among Aboriginal children. It is possible that the observed increases reflect increasing incidence of maltreatment; however, they are also consistent with a mix of increased surveillance, improved service access, changes in policy and a shift in public attitudes.Steven L. Guthridge, Philip Ryan, John R. Condon, Leah M. Bromfield, John R. Moss and John W. Lync