Elementary matrix decomposition and the computation of Darmon points with higher conductor

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Turismo y crisis: el comportamiento del inmobiliario turístico en la montaña española durante la última década. Estudio de casos: la Val d’Aran y Sierra Nevada

En esta comunicación se analiza, como respuesta al enunciado del título, la evolución reciente del parque de viviendas que puede estar vinculado a una función turístico-residencial. Se pretende valorar, a partir de los resultados, el papel que desempeña esta función en el proceso de dinamización local y de renovación de la montaña española como escenario turístico y detectar, asimismo, otros posibles fundamentos de dicha renovación. Se analizan específicamente los datos de los censos de vivienda y las estadísticas de viviendas construidas en destinos significativos previamente seleccionados. El estudio se centra en los últimos quince años, y se realiza a escala municipal. La comarca y el municipio constituyen unidades espaciales operativas idóneas a efectos del tratamiento estadístico de la información obtenida

X-chromosome tiling path array detection of copy number variants in patients with chromosome X-linked mental retardation

Contiene 3 ficheros adicionales con información suplementaria.-- et al.[Background] Aproximately 5–10% of cases of mental retardation in males are due to copy number variations (CNV) on the X chromosome. Novel technologies, such as array comparative genomic hybridization (aCGH), may help to uncover cryptic rearrangements in X-linked mental retardation (XLMR) patients. We have constructed an X-chromosome tiling path array using bacterial artificial chromosomes (BACs) and validated it using samples with cytogenetically defined copy number changes. We have studied 54 patients with idiopathic mental retardation and 20 controls subjects.[Results] Known genomic aberrations were reliably detected on the array and eight novel submicroscopic imbalances, likely causative for the mental retardation (MR) phenotype, were detected. Putatively pathogenic rearrangements included three deletions and five duplications (ranging between 82 kb to one Mb), all but two affecting genes previously known to be responsible for XLMR. Additionally, we describe different CNV regions with significant different frequencies in XLMR and control subjects (44% vs. 20%).[Conclusion] This tiling path array of the human X chromosome has proven successful for the detection and characterization of known rearrangements and novel CNVs in XLMR patients.The authors thank the "Genoma España" and Genome Canada joint R+D+I projects in human health, plants and aquiculture; the former "Departament d'Universitats i Societat de la Informació" (DURSI) and the "Departament de Salut", from the Catalan Autonomous Government (2005SGR00008 - Generalitat de Catalunya); the Instituto de Salud Carlos III (PI041126, CIBER-ESP), the EU's Sixth Framework Programme [FP6-2005-LIFESCIHEALTH-7; ANEUPLOIDY No. 037627] and Fundación Areces (U-2006-FARECES-O).Peer reviewe

Semantic Segmentation of Histopathological Slides for the Classification of Cutaneous Lymphoma and Eczema

Mycosis fungoides (MF) is a rare, potentially life threatening skin disease, which in early stages clinically and histologically strongly resembles Eczema, a very common and benign skin condition. In order to increase the survival rate, one needs to provide the appropriate treatment early on. To this end, one crucial step for specialists is the evaluation of histopathological slides (glass slides), or Whole Slide Images (WSI), of the patients' skin tissue. We introduce a deep learning aided diagnostics tool that brings a two-fold value to the decision process of pathologists. First, our algorithm accurately segments WSI into regions that are relevant for an accurate diagnosis, achieving a Mean-IoU of 69% and a Matthews Correlation score of 83% on a novel dataset. Additionally, we also show that our model is competitive with the state of the art on a reference dataset. Second, using the segmentation map and the original image, we are able to predict if a patient has MF or Eczema. We created two models that can be applied in different stages of the diagnostic pipeline, potentially eliminating life-threatening mistakes. The classification outcome is considerably more interpretable than using only the WSI as the input, since it is also based on the segmentation map. Our segmentation model, which we call EU-Net, extends a classical U-Net with an EfficientNet-B7 encoder which was pre-trained on the Imagenet dataset.Comment: Submitted to https://link.springer.com/chapter/10.1007/978-3-030-52791-4_

"I want to be a furious leopard with magical wings and super power": developing an ethico-interpretive framework for detecting Chinese students' funds of identity

The Avatar Project was a two-week English project in which Chinese high school students in an internationalised school in Shanghai China explored the topic of cultural and individual identity. The project synthesised prospective education with the Funds of Identity approach, both of which have particular relevance within an internationalised teaching context. During the project, students created three identity texts: a written reflection, a word cloud and an avatar which were later used as data for this article. This article presents findings from the project and critically evaluates the effectiveness of avatars and word clouds as strategies for detecting students’ funds of identity. A multimodal approach to data collection and analysis was adopted in order to ensure that the interpretation of students’ work remained situated within their lived experience. The project revealed the existence of social, practical, institutional and cultural funds of identity. However, it also detected more problematic forms of funds of identity related to political and philosophical beliefs which I label ideological and existential funds of identity. While avatars and word clouds were effective in drawing out students’ out-of-school identities, the written reflections were ultimately more useful in revealing students’ funds of identity and also ensuring that any interpretations remained within the participants’ horizon of intended meaning. The project also brought about significant transformation in the way I viewed my students

Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors

Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence. Conversely, THC also has potentially therapeutic effects, including analgesia, muscle relaxation, and neuroprotection. However, the mechanisms that dissociate these responses are still not known. Using mice lacking the serotonin receptor 5-HT2A, we revealed that the analgesic and amnesic effects of THC are independent of each other: while amnesia induced by THC disappears in the mutant mice, THC can still promote analgesia in these animals. In subsequent molecular studies, we showed that in specific brain regions involved in memory formation, the receptors for THC and the 5-HT2A receptors work together by physically interacting with each other. Experimentally interfering with this interaction prevented the memory deficits induced by THC, but not its analgesic properties. Our results highlight a novel mechanism by which the beneficial analgesic properties of THC can be dissociated from its cognitive side effects

Naloxone's Pentapeptide Binding Site on Filamin A Blocks Mu Opioid Receptor–Gs Coupling and CREB Activation of Acute Morphine

Chronic morphine causes the mu opioid receptor (MOR) to switch its coupling from Gi/o to Gs, resulting in excitatory signaling via both Gαs and its Gβγ dimer. Ultra-low-dose naloxone (NLX) prevents this switch and attenuates opioid tolerance and dependence. This protective effect is mediated via a high-affinity interaction of NLX to a pentapeptide region in c-terminal filamin A (FLNA), a scaffolding protein interacting with MOR. In organotypic striatal slice cultures, we now show that acute morphine induces a dose-dependent Go-to-Gs coupling switch at 5 and 15 min that resolves by 1 hr. The acute Gs coupling induced by 100 µM morphine was completely prevented by co-treatment with 100 pM NLX, (+)NLX, or naltrexone (NTX), or their pentapeptide binding site (FLNA2561–2565), which we show can act as a decoy for MOR or bind to FLNA itself. All of these co-treatments presumably prevent the MOR–FLNA interaction. Since ultra-low-dose NTX also attenuates the addictive properties of opioids, we assessed striatal cAMP production and CREB phosphorylation at S133. Correlating with the Gs coupling, acute morphine induced elevated cAMP levels and a several-fold increase in pS133CREB that were also completely blocked by NLX, NTX or the FLNA pentapeptide. We propose that acute, robust stimulation of MOR causes an interaction with FLNA that allows an initially transient MOR–Gs coupling, which recovers with receptor recycling but persists when MOR stimulation is repeated or prolonged. The complete prevention of this acute, morphine-induced MOR–Gs coupling by 100 pM NLX/NTX or 10 µM pentapeptide segment of FLNA further elucidates both MOR signaling and the mechanism of action of ultra-low-dose NLX or NTX in attenuating opioid tolerance, dependence and addictive potential

Recomanacions de retorn d’activitat dels serveis de cardiologia en el procés de desconfinament per COVID-19

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Servei de cardiologia; Desconfinament; Mesures de proteccióCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Servicio de cardiología; Desconfinamiento; Medidas de protecciónCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Cardiology service; No confinement; Protection measuresAquest document recull les recomanacions de les societats científiques i professionals, per encàrrec del CatSalut i sota la coordinació del Pla Director de Malalties de l’Aparell Circulatori, pel retorn d’activitat de la pràctica clínica en els serveis de cardiologia en l’escenari actual de brot de COVID-19