Lo trágico en un relato de Jean-Marie Le Clézio: La ronde.

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La Réticence de Jean-Philippe Toussaint: el detective no sabe que la curiosidad mató al gato.

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La Légende d 'Assassaint Julien l'Hospitalier. Un estudio de dinámica narrativa.

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Las infancias de Nathalie Sarraute (A propósito de Enfance) (1):Pacto autotextual vs. Pacto autobiográfico.

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Ceci n'est pas un conte: [Existir - Contar] en Denis Diderot.

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Herrero Cecilia, Juan. Estética y Pragmática de lo fantástico.

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Consideraciones sobre el profetismo en los escritos de Joseph de Maistre

La relación de los ensayos de Joseph de Maistre con el profetismo ha constituido un tema privilegiado en los estudios dedicados al autor. El artículo revisa y matiza dicho enfoque distinguiendo dentro de la obra maistriniana los caracteres teóricos de la perspectiva profética en tres etapas de análisis: las opiniones del escritor sobre la visión y el hacer proféticos, los testimonios que singulares contemporáneos formularon sobre el alcance profético de sus obras y, por último, la consideración de su discurso como discurso profético, tanto por determinados rasgos retóricos como por su temática, centrada en la evolución de las propuestas de su profetismo político. La investigación concluye resaltando que la noción de impulso profético es la clave cohesionadora del corpus maistriniano.La relation entre les essais de Joseph de Maistre et le prophétisme a été un thème privilégié dans les études consacrées à l’auteur. Cet article examine et nuance cette approche en distinguant dans l’œuvre maistrinienne les caractères théoriques du prophétisme en trois étapes d’analyse : les opinions de l’écrivain sur la vision et l’action prophétiques, les témoignages que des contemporains singuliers ont formulés sur la portée prophétique de ses œuvres et, enfin, la considération de son discours en tant que discours prophétique, aussi bien pour certains traits rhétoriques que pour sa thématique, centrée sur l’évolution de son prophétisme politique. La recherche conclut en soulignant que la notion d’élan prophétique est l’élément clé de la cohésion du corpus maistrinien.The relationship of Joseph de Maistre’s essays with prophetism has been a central theme in the studies dedicated to the author. This article reviews and qualifies this approach by distinguishing within Maistre’s work the theoretical characteristics of the prophetic perspective in three stages of analysis: the writer’s opinions on prophetic vision and prophetic action, the testimonies that singular contemporaries formulated on the prophetic scope of his works and, finally, the consideration of his discourse as a prophetic discourse, both for certain rhetorical features and for its subject matter, centered on the evolution of the proposals of his political prophetism. The research concludes by highlighting that the notion of prophetic impulse is the key to the cohesion of the Maistrinian corpus

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Plan gallego de hospitalización a domicilio. Estrategia HADO 2019-2023

Documento estratéxico que pretende potenciar e consolidar a hospitalización a domicilio como un modelo asistencial do Servizo Galego de Saúde e garantir o seu desenvolvemento nos próximos seis anos, establecendo criterios homoxéneos de atención coa finalidade de normalizar os modelos asistenciais, carteira de servizos e fluxos de traballo para asegurar una asistencia sanitaria de calidadeDocumento estratégico que pretende potenciar y consolidar la hospitalización a domicilio como un modelo asistencial del Servicio Gallego de Salud y garantizar su desarrollo en los próximos seis años, estableciendo criterios homogéneos de atención con la finalidad de normalizar los modelos asistenciales, cartera de servicios y flujos de trabajo para asegurar una asistencia sanitaria de calida

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research