Escuta-me... sou criança! Estou aqui!

Mestrado em Ciências da EducaçãoO projeto de investigação Escuta-me… sou Criança! Estou aqui! foi desenvolvido no âmbito do Mestrado de Ciências de Educação, na especialização de Educação Social e Intervenção Comunitária. As crianças envolvidas neste projeto pertencem à etnia cigana e são moradoras de um Bairro Social de Aveiro. O grupo de crianças que participaram neste projeto, era constituído por 2 meninas, com 8 e 9 anos, e 2 meninos de 8 anos e frequentavam a EB1 DE Santiago. A EB1 de Santiago envolveu-se neste projeto de participação num compromisso de mudança social, tornando visível os dilemas dos atores sociais deste projeto. A preocupação subjacente à este projeto, relacionava-se com as crianças pertencentes a etnia cigana, considerada a maior minoria étnica em Portugal, ainda hoje alvo de processos de exclusão social, e consequentemente, sem representação nos espaços públicos de decisão. Recorremos à Investigação-ação participativa considerando as características do grupo aliado aos objetivos pretendidos com este projeto: mobilizar para a participação infantil de crianças de etnia cigana. Neste sentido, através de processos de escuta, este grupo foi progressivamente assumindo um papel mais interventivo, envolvendo-se no projeto Cidade Amiga das Crianças e lançando esse desafio à escola, à Associação de Pais e à Camara Municipal de Aveiro, num processo de mobilização e de construção de espaços de cidadania efetiva. A Urbanização de Santiago e as melhorias urgentes e necessárias foram o assunto que uniu as crianças, e as projetou para espaços de ação politica. Neste momento, encontra-se em processo de análise junto da Camara Municipal de Aveiro, as orientações e sugestões/soluções debatidas pelas crianças, pelo que seria importante dar continuidade a este projeto.The research project, listen to me ... I'm Child! I'm Here! was developed under the Master of Science in Education, specializing in Social Education and Community Intervention. The children involved in this project belong to the Roma and are living in a Neighborhood Social Aveiro. The group of children who participated in this project consisted of two girls, 8 and 9, and 2 boys 8 years and attended EB1 de Santiago. The EB1 Santiago became involved in this project share a commitment to social change, making visible the dilemmas of social actors of this project. The concern underlying this project was related to the children belonging to the Roma, the largest ethnic minority in Portugal, still subject to processes of social exclusion, and consequently no representation in public decision. Resorted to participatory action research considering the characteristics of the group allied to the intended goals with this project: to mobilize the participation of children of Roma children. In this sense, through processes of listening, this group was gradually taking on a more active role, engaging in designing Friendly City Children and throwing this challenge to school, Parents Association and the Camara Municipal de Aveiro, a mobilization process and construction of spaces for effective citizenship. The Urbanization of Santiago and the improvements were necessary and urgent matter that united children, and designed spaces for political action. At this time, is in the process of analysis with the Camara Municipal de Aveiro, guidelines and suggestions / solutions discussed by children, so it would be important to continue this project

Qualidade de vida de pacientes mastectomizadas: uma revisão integrativa

A mama é um órgão que possui fundamental importância no corpo feminino, tanto para função reprodutora, quanto na imagem que a mulher tem de si mesma. Estudos relatam que a perda da mama gera dificuldades de adaptação a realidade e de imagem corporal, além de dificuldades físicas. O objetivo do estudo trata-se de verificar alterações de qualidade de vida em pacientes submetidas à mastectomia devido ao câncer de mama e possíveis intervenções para melhoria desta qualidade de vida. Trata-se de uma revisão integrativa onde foram selecionados   15 artigos por busca ativa nas bases de dados “PUBMED”, “SCIELO”, “LILACS”, “LATINDEX”. Como critério de busca como usados os seguintes unitermos: “qualidade de vida”; “mastectomizadas”. A presente pesquisa demonstrou que em todos os artigos analisados havia um prejuízo na qualidade de vida e sexualidade de pacientes submetidas à mastectomia. Observou-se, também, que a qualidade de vida melhorava quando a mobilidade daquela paciente era maior e a mesma podia exercer suas funções diárias, no trabalho e domésticas. Outrossim, os piores escores encontrados pelos estudos na qualidade de vidas de pacientes mastectomizadas foram: emocional e físico. Outro fator observado foi que pacientes submetidas à reconstrução mamária apresentaram melhor qualidade de vida, devido ao fator autoestima, autoimagem, prazer com o próprio corpo e com as vestimentas. Além disso, verificou-se que a fisioterapia pode ser um grande fator aliado para melhora da mobilidade, do edema e da função motora em geral, contribuindo para incremento no escore de aptidão física destas pacientes

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Open Repository - Esketamine for unipolar major depression with psychotic features: a retrospective chart review and comparison with non-psychotic depression

Article link: https://journals.lww.com/psychopharmacology/Abstract/2022/07000/Esketamine_for_Unipolar_Major_Depression_With.15.aspx?context=LatestArticle

Draft genome assembly of Colletotrichum musae, the pathogen of banana fruit

Colletotrichum musae is an important cosmopolitan pathogenic fungus that causes anthracnose in banana fruit. The entire genome of C. musae isolate GM20 (CMM 4420), originally isolated from infected banana fruit from Alagoas State, Brazil, was sequenced and annotated. The pathogen genomic DNA was sequenced on HiSeq Illumina platform. The C. musae GM20 genome has 50,635,197 bp with G + C content of 53.74% and in its present assembly has 2763 scaffolds, harboring 13,451 putative genes with an average length of 1626 bp. Gene prediction and annotation was performed by Funannotate pipeline, using a pattern for gene identification based on BUSCO

Supplementation of in vitro culture medium with FSH to grow follicles and mature oocytes can be replaced by extracts of Justicia insularis.

The present study evaluated the effect of supplementing in vitro culture medium with J. insularis compared to FSH on isolated secondary follicles and in vitro maturation of oocytes from those follicles. Secondary follicles were isolated from sheep ovaries and individually cultured for 18 days in α-MEM+ (Control), α-MEM+ supplemented with 100 ng/mL recombinant bovine follicle stimulating hormone (FSH) or with 0.3, 1.25, or 2.5 mg/mL of J. insularis extract (JI0.3, JI1.25, and JI2.5, respectively). Culture medium collected every 2 days was used to measure ROS levels. At the end of the culture period, cumulus oocytes complex (COCs) were collected and matured in vitro. Follicular walls were used for mRNA quantitation. JI0.3 led to a higher (P < 0.05) percentages of intact follicles than other groups after 18 days of culture. While follicular diameter remained unchanged from Day 6 onwards with JI0.3 and FSH, percentages of antral cavity formation were higher (P < 0.05) with JI0.3 at Day 6 than in all other treatments. No differences were observed between controls and treatment groups regarding ROS levels and mRNA expression of genes. Viability of resulting oocytes was higher (P < 0.05) in JI0.3 compared to FSH. Interestingly, in control experiment, supplementation of maturation medium with JI0.3 led to higher (P < 0.05) percentages of metaphase II compared to controls. Although more validations will be needed, it seems that this natural extract could be used as a cheap and easily available alternative to commercial FSH