1,858 research outputs found
Applying matrix product operators to model systems with long-range interactions
An algorithm is presented which computes a translationally invariant matrix
product state approximation of the ground state of an infinite 1D system; it
does this by embedding sites into an approximation of the infinite
``environment'' of the chain, allowing the sites to relax, and then merging
them with the environment in order to refine the approximation. By making use
of matrix product operators, our approach is able to directly model any
long-range interaction that can be systematically approximated by a series of
decaying exponentials. We apply our techniques to compute the ground state of
the Haldane-Shastry model and present results.Comment: 7 pages, 3 figures; manuscript has been expanded and restructured in
order to improve presentation of the algorith
An examination of health care utilization during the COVID-19 pandemic among women with early-stage hormone receptor-positive breast cancer
Background: Women undergoing treatment for breast cancer require frequent clinic visits for maintenance of therapy. With COVID-19 causing health care disruptions, it is important to learn about how this populationâs access to health care has changed. This study compares self-reported health care utilization and changes in factors related to health care access among women treated at a cancer center in the mid-South US before and during the pandemic. Methods: Participants (N = 306) part of a longitudinal study to improve adjuvant endocrine therapy (AET) adherence completed pre-intervention baseline surveys about their health care utilization prior to AET initiation. Questions about the impact of COVID-19 were added after the pandemic started assessing financial loss and factors related to care. Participants were categorized into three time periods based on the survey completion date: (1) pre-COVID (December 2018 to March 2020), (2) early COVID (April 2020 â December 2020), and later COVID (January 2021 to June 2021). Negative binomial regression analyses used to compare health care utilization at different phases of the pandemic controlling for patient characteristics. Results: Adjusted analyses indicated office visits declined from pre-COVID, with an adjusted average of 17.7 visits, to 12.1 visits during the early COVID period (p = 0.01) and 9.9 visits during the later COVID period (p < 0.01). Hospitalizations declined from an adjusted average 0.45 admissions during early COVID to 0.21 during later COVID, after vaccines became available (p = 0.05). Among COVID period participants, the proportion reporting changes/gaps in health insurance coverage increased from 9.5% participants during early-COVID to 14.8% in the later-COVID period (p = 0.05). The proportion reporting financial loss due to the pandemic was similar during both COVID periods (34.3% early- and 37.7% later-COVID, p = 0.72). The proportion of participants reporting delaying care or refilling prescriptions decreased from 15.2% in early-COVID to 4.9% in the later-COVID period (p = 0.04). Conclusion: COVID-19 caused disruptions to routine health care for women with breast cancer. Patients reported having fewer office visits at the start of the pandemic that continued to decrease even after vaccines were available. Fewer patients reported delaying in-person care as the pandemic progressed.National Cancer Institute ; Division of Cancer Prevention, National Cancer Institute ; Center for Strategic Scientific Initiatives, National Cancer Institute ; Division of Cancer Epidemiology and Genetics, National Cancer Institut
The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
In the lactating breast, ERBB4 localizes to the nuclei of secretory epithelium while regulating activities of the signal transducer and activator of transcription (STAT) 5A transcription factor essential for milk-gene expression. We have identified an intrinsic ERBB4 NLS (residues 676â684) within the ERBB4 intracellular domain (4ICD) that is essential for nuclear accumulation of 4ICD. To determine the functional significance of 4ICD nuclear translocation in a physiologically relevant system, we have demonstrated that cotransfection of ERBB4 and STAT5A in a human breast cancer cell line stimulates ÎČ-casein promoter activity. Significantly, nuclear localization of STAT5A and subsequent stimulation of the ÎČ-casein promoter requires nuclear translocation of 4ICD. Moreover, 4ICD and STAT5A colocalize within nuclei of heregulin ÎČ1 (HRG)-stimulated cells and both proteins bind to the endogenous ÎČ-casein promoter in T47D breast cancer cells. Together, our results establish a novel molecular mechanism of transmembrane receptor signal transduction involving nuclear cotranslocation of the receptor intracellular domain and associated transcription factor. Subsequent binding of the two proteins at transcription factor target promoters results in activation of gene expression
Planet Migration and Disk Destruction due to Magneto-Centrifugal Stellar Winds
This paper investigates the influence of magneto-centrifugally driven or
simply magnetic winds of rapidly-rotating, strongly-magnetized T Tauri stars in
causing the inward or outward migration of close-in giant planets. The
azimuthal ram pressure of the magnetized wind acting on the planet tends to
increase the planet's angular momentum and cause outward migration if the
star's rotation period is less than the planet's orbital period . In
the opposite case, , the planet migrates inward. Thus, planets
orbiting at distances larger (smaller) than
tend to be pushed outward (inward), where is the rotation period of the
star assumed to have the mass of the sun. The magnetic winds are likely to
occur in T Tauri stars where the thermal speed of the gas close to the star is
small, where the star's magnetic field is strong, and where the star rotates
rapidly. The time-scale for appreciable radial motion of the planet is
estimated as Myr. A sufficiently massive close-in planet may
cause tidal locking and once this happens the radial migration due to the
magnetic wind ceases. The magnetic winds are expected to be important for
planet migration for the case of a multipolar magnetic field rather than a
dipole field where the wind is directed away from the equatorial plane and
where a magnetospheric cavity forms. The influence of the magnetic wind in
eroding and eventually destroying the accretion disk is analyzed. A momentum
integral is derived for the turbulent wind/disk boundary layer and this is used
to estimate the disk erosion time-scale as Myr, with the lower
value favored.Comment: 8 pages, 6 figure
Characterizing CO Fourth Positive Emission in Young Circumstellar Disks
Carbon Monoxide is a commonly used IR/sub-mm tracer of gas in protoplanetary
disks. We present an analysis of ultraviolet CO emission in {HST}-COS spectra
for 12 Classical T Tauri stars. Several ro-vibrational bands of the CO A^1\Pi -
X^1\Sigma^+ (Fourth Positive) electronic transition system are spectrally
resolved from emission of other atoms and H_2. The CO A^1\Pi v'=14 state is
populated by absorption of Ly\alpha photons, created at the accretion column on
the stellar surface. For targets with strong CO emission, we model the Ly\alpha
radiation field as an input for a simple fluorescence model to estimate CO
rotational excitation temperatures and column densities. Typical column
densities range from N_{CO} = 10^{18} - 10^{19} cm^{-2}. Our measured
excitation temperatures are mostly below T_{CO} = 600 K, cooler than typical
M-band CO emission. These temperatures and the emission line widths imply that
the UV emission originates in a different population of CO than that which is
IR-emitting. We also find a significant correlation between CO emission and the
disk accretion rate M_{acc} and age. Our analysis shows that ultraviolet CO
emission can be a useful diagnostic of CTTS disk gas
The Far-Ultraviolet "Continuum" in Protoplanetary Disk Systems II: CO Fourth Positive Emission and Absorption
We exploit the high sensitivity and moderate spectral resolution of the
-Cosmic Origins Spectrograph to detect far-ultraviolet spectral features
of carbon monoxide (CO) present in the inner regions of protoplanetary disks
for the first time. We present spectra of the classical T Tauri stars HN Tau,
RECX-11, and V4046 Sgr, representative of a range of CO radiative processes. HN
Tau shows CO bands in absorption against the accretion continuum. We measure a
CO column density and rotational excitation temperature of N(CO) = 2 +/- 1
10 cm and T_rot(CO) 500 +/- 200 K for the absorbing gas.
We also detect CO A-X band emission in RECX-11 and V4046 Sgr, excited by
ultraviolet line photons, predominantly HI LyA. All three objects show emission
from CO bands at 1560 \AA, which may be excited by a combination
of UV photons and collisions with non-thermal electrons. In previous
observations these emission processes were not accounted for due to blending
with emission from the accretion shock, collisionally excited H, and
photo-excited H2; all of which appeared as a "continuum" whose components could
not be separated. The CO emission spectrum is strongly dependent upon the shape
of the incident stellar LyA emission profile. We find CO parameters in the
range: N(CO) 10 cm, T_{rot}(CO) > 300 K for the LyA-pumped
emission. We combine these results with recent work on photo- and
collisionally-excited H emission, concluding that the observations of
ultraviolet-emitting CO and H2 are consistent with a common spatial origin. We
suggest that the CO/H2 ratio in the inner disk is ~1, a transition between the
much lower interstellar value and the higher value observed in solar system
comets today, a result that will require future observational and theoretical
study to confirm.Comment: 12 pages, 7 figures, 3 tables. ApJ - accepte
MuirâTorre syndrome appropriate use criteria: Effect of patient age on appropriate use scores
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/150503/1/cup13459_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150503/2/cup13459.pd
Very Large Baseline Array observations of Mrk 6 : probing the jet-lobe connection
We present the results of high-resolution VLBI (very long baseline interferometry) observations at 1.6 and 4.9 GHz of the radio-loud Seyfert galaxy, Mrk 6. These observations are able to detect a compact radio core in this galaxy for the first time. The core has an inverted spectral index (α1.6 4.9 = +1.0 ± 0.2) and a brightness temperature of 1 Ă 108 K. Three distinct radio components, which resemble jet elements and/or hotspots, are also detected. The position angles of these elongated jet elements point not only to a curved jet in Mrk 6, but also towards a connection between the AGN and the kpc-scale radio lobes/bubbles in this galaxy. Firmer constraints on the star formation rate provided by new Herschel observations (SFR <0.8 Mâ yr-1) make the starburst-wind-powered bubble scenario implausible. From plasma speeds, obtained via prior Chandra X-ray observations, and ram pressure balance arguments for the interstellar medium and radio bubbles, the north-south bubbles are expected to take 7.5 Ă 106 yr to form, and the east-west bubbles 1.4 Ă 106 yr. We suggest that the jet axis has changed at least once in Mrk 6 within the last â107 yr. A comparison of the nuclear radio-loudness of Mrk 6 and a small sample of Seyfert galaxies with a subset of low-luminosity FR I radio galaxies reveals a continuum in radio properties.Peer reviewe
Appropriate use criteria in dermatopathology: Initial recommendations from the American Society of Dermatopathology
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/145218/1/cup13142.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/145218/2/cup13142_am.pd
Hubble Space Telescope hot Jupiter transmission spectral survey: a detection of Na and strong optical absorption in HAT-P-1b
We present an optical to near-infrared transmission spectrum of the hot Jupiter HAT-P-1b, based on Hubble Space Telescope observations, covering the spectral regime from 0.29 to 1.027âÎŒm with Space Telescope Imaging Spectrograph (STIS), which is coupled with a recent Wide Field Camera 3 (WFC3) transit (1.087 to 1.687âÎŒm). We derive refined physical parameters of the HAT-P-1 system, including an improved orbital ephemeris. The transmission spectrum shows a strong absorption signature shortward of 0.55âÎŒm, with a strong blueward slope into the near-ultraviolet. We detect atmospheric sodium absorption at a 3.3Ï significance level, but find no evidence for the potassium feature. The red data imply a marginally flat spectrum with a tentative absorption enhancement at wavelength longer than ⌠0.85âÎŒm. The STIS and WFC3 spectra differ significantly in absolute radius level (4.3 ± 1.6 pressure scaleheights), implying strong optical absorption in the atmosphere of HAT-P-1b. The optical to near-infrared difference cannot be explained by stellar activity, as simultaneous stellar activity monitoring of the G0V HAT-P-1b host star and its identical companion show no significant activity that could explain the result. We compare the complete STIS and WFC3 transmission spectrum with theoretical atmospheric models which include haze, sodium and an extra optical absorber. We find that both an optical absorber and a supersolar sodium to water abundance ratio might be a scenario explaining the HAT-P-1b observations. Our results suggest that strong optical absorbers may be a dominant atmospheric feature in some hot Jupiter exoplanets
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