Editorial: Ethics, Values, and Designer Responsibility

As we rely upon increasingly complex sociotechnical systems to support ourselves and, by extension, the structures of society, it becomes yet more important to consider how ethics and values intertwine in design activity. Numerous methods that address issues related to ethics and value-centeredness in design activity exist, but it is unclear what role the design research and practice communities should play in shaping the future of these design approaches. Importantly, how might researchers and practitioners become more aware of the normative assumptions that underlie both their design activity and the design artifacts that result

Frames for Justice Consciousness

We describe how UX design students become aware of citizen-engaged design work, and indicate the extent to which a progression toward social justice-focused design work might be possible in a single project cycle. Our study site is a sophomore-level UX design studio at a large Midwestern US university—part of a five-semester sequence in which students engage in a range of projects that address competence in user research, prototyping, and evaluation. The project cycle we focus on directly challenges the apolitical framing in most foundational UX methods literature, explicitly asking students to engage with issues of power disparities. We analyzed three years of digital civics-focused project work (2018 n=6 groups; 2019 n=7; 2020 n=8) undertaken by students in groups of five over a seven-week period, representing the work of 100 students over three years of this course offering. We analyzed the resulting data that supported the development of the Frames for Justice Consciousness model, mapping a range of trajectories of student engagement with social justice-focused design philosophies, highlighting cases where students were able to successfully “pivot” or re-frame the design situation in ways that were consistent with the digital civics philosophy of engagement, addressing goals of participation and advocacy, as well as cases where students tended to repeat common solutionist framings of work within an “apolitical” or product-focused human-centered philosophy. The model facilitates instructor reflection on differing student trajectories that may inform changes to the types of critique given or instructional scaffolds provided in social justice-informed design work

Interferon Gamma, but not Calcitriol Improves the Osteopetrotic Phenotypes in ADO2 Mice

ADO2 is a heritable osteosclerotic disorder that usually results from heterozygous missense dominant negative mutations in the chloride channel 7 gene (CLCN7). ADO2 is characterized by a wide range of features and severity, including multiple fractures, impaired vision due to secondary bony overgrowth and/or the lack of the optical canal enlargement with growth, and osteonecrosis/osteomyelitis. The disease is presently incurable, although anecdotal evidence suggests that calcitriol and interferon gamma-1b (IFN-G) may have some beneficial effects. To identify the role of these drugs for the treatment of ADO2, we utilized a knock-in (G213R mutation in Clcn7) ADO2 mouse model that resembles the human disease. Six-week-old ADO2 heterozygous mice were administered vehicle (PBS) or calcitriol or IFN-G 5 times per week for 8 weeks. We determined bone phenotypes using DXA and μCT, and analyzed serum biochemistry and bone resorption markers. ADO2 mice treated with all doses of IFN-G significantly (p<0.05) attenuated the increase of whole body aBMD and distal femur BV/TV gain in both male and female compared to the vehicle group. In contrast, mice treated with low and medium doses of calcitriol showed a trend of higher aBMD and BV/TV whereas high dose calcitriol significantly (p<0.05) increased bone mass compared to the vehicle group. The calcium and phosphorus levels did not differ between vehicle and IFN-G or calcitriol treated mice; however, we detected significantly (p<0.05) elevated levels of CTX/TRAP5b ratio in IFN-G treated mice. Our findings indicate that while IFN-G at all doses substantially improved the osteopetrotic phenotypes in ADO2 heterozygous mice, calcitriol treatment at any dose did not improve the phenotype and at high dose further increased bone mass. Thus, use of high dose calcitriol therapy in ADO2 patients merits serious reconsideration. Importantly, our data support the prospect of a clinical trial of IFN-G in ADO2 patients

Thiopentone sedation for sedation of acutely agitated, violent, intoxicated patients: Evaluation of 2 cases

Two cases of violent, drug-intoxicated patients who presented considerable problems in management, and were resistant to standard sedative agents, are described. Effective and safe sedation, without the need for full anaesthesia and endotracheal intubation, was achieved using titrated doses of thiopentone. The merits of selecting this agent in these circumstances are discussed

Age-related differences in socio-demographic and behavioral determinants of HIV testing and counseling in HPTN 043/NIMH Project Accept

Youth represent a large proportion of new HIV infections worldwide, yet their utilization of HIV testing and counseling (HTC) remains low. Using the post-intervention, cross-sectional, population-based household survey done in 2011 as part of HPTN 043/NIMH Project Accept, a cluster-randomized trial of community mobilization and mobile HTC in South Africa (Soweto and KwaZulu Natal), Zimbabwe, Tanzania and Thailand, we evaluated age-related differences among socio-demographic and behavioral determinants of HTC in study participants by study arm, site, and gender. A multivariate logistic regression model was developed using complete individual data from 13,755 participants with recent HIV testing (prior 12 months) as the outcome. Youth (18–24 years) was not predictive of recent HTC, except for high-risk youth with multiple concurrent partners, who were less likely (aOR 0.75; 95% CI 0.61–0.92) to have recently been tested than youth reporting a single partner. Importantly, the intervention was successful in reaching men with site specific success ranging from aOR 1.27 (95% CI 1.05–1.53) in South Africa to aOR 2.30 in Thailand (95% CI 1.85–2.84). Finally, across a diverse range of settings, higher education (aOR 1.67; 95% CI 1.42, 1.96), higher socio-economic status (aOR 1.21; 95% CI 1.08–1.36), and marriage (aOR 1.55; 95% CI 1.37–1.75) were all predictive of recent HTC, which did not significantly vary across study arm, site, gender or age category (18–24 vs. 25–32 years)

Transnational higher education partnerships and the role of operational faculty members: developing an alternative theoretical approach for empirical research

For too long, transnational higher education (TNE) has been linked to discourse predominately focused upon strategic implementation, quality assurance and pedagogy. Whilst these aspects are important when designing and managing overseas provisions, there is a lack of research focusing on the social interactions that influence the pace and development of TNE partnerships. This gap is particularly evident at the operational phase of TNE partnerships. This conceptual article therefore offers an alternative way in which to research TNE partnerships, in relation to the interactions of faculty members delivering at the operational level. It provides an integrated theoretical framework, comprising of three different theoretical approaches in order to provide a conceptual tool in which to investigate and evaluate TNE partnership development. The article concludes that by understanding how relationships develop between faculty members tasked with delivering TNE, international partnerships can be significantly strengthened in terms of their progression and value

Pharmacists in Pharmacovigilance: Can Increased Diagnostic Opportunity in Community Settings Translate to Better Vigilance?

The pharmacy profession has undergone substantial change over the last two to three decades. Whilst medicine supply still remains a central function, pharmacist’s roles and responsibilities have become more clinic and patient focused. In the community (primary care), pharmacists have become important providers of healthcare as Western healthcare policy advocates patient self-care. This has resulted in pharmacists taking on greater responsibility in managing minor illness and the delivery of public health interventions. These roles require pharmacists to more fully use their clinical skills, and often involve diagnosis and therapeutic management. Community pharmacists are now, more than ever before, in a position to identify, record and report medication safety incidents. However, current research suggests that diagnostic ability of community pharmacists is questionable and they infrequently report to local or national schemes. The aim of this paper is to highlight current practice and suggest ways in which community pharmacy can more fully contribute to patient safety

Solar Signals in CMIP-5 Simulations: The Ozone Response

A multiple linear regression statistical method is applied to model data taken from the Coupled Model Intercomparison Project, phase 5 (CMIP-5) to estimate the 11-yr solar cycle responses of stratospheric ozone, temperature, and zonal wind during the 1979-2005 period. The analysis is limited to the six CMIP-5 models that resolve the stratosphere (high-top models) and that include interactive ozone chemistry. All simulations assumed a conservative 11-yr solar spectral irradiance (SSI) variation based on the NRL model. These model responses are then compared to corresponding observational estimates derived from two independent satellite ozone profile data sets and from ERA Interim Reanalysis meteorological data. The models exhibit a range of 11-yr responses with three models (CESM1-WACCM, MIROC-ESM-CHEM, and MRI-ESM1) yielding substantial solar-induced ozone changes in the upper stratosphere that compare favorably with available observations. The remaining three models do not, apparently because of differences in the details of their radiation and photolysis rate codes. During winter in both hemispheres, the three models with stronger upper stratospheric ozone responses produce relatively strong latitudinal gradients of ozone and temperature in the upper stratosphere that are associated with accelerations of the polar night jet under solar maximum conditions. This behavior is similar to that found in the satellite ozone and ERA Interim data except that the latitudinal gradients tend to occur at somewhat higher latitudes in the models. The sharp ozone gradients are dynamical in origin and assist in radiatively enhancing the temperature gradients, leading to a stronger zonal wind response. These results suggest that simulation of a realistic solar-induced variation of upper stratospheric ozone, temperature and zonal wind in winter is possible for at least some coupled climate models even if a conservative SSI variation is adopted

Identification of limb-specific Lmx1b auto-regulatory modules with Nail-patella syndrome pathogenicity

© The Author(s) 2021.LMX1B haploinsufficiency causes Nail-patella syndrome (NPS; MIM 161200), characterized by nail dysplasia, absent/hypoplastic patellae, chronic kidney disease, and glaucoma. Accordingly in mice, Lmx1b has been shown to play crucial roles in the development of the limb, kidney and eye. Although one functional allele of Lmx1b appears adequate for development, Lmx1b null mice display ventral-ventral distal limbs with abnormal kidney, eye and cerebellar development, more disruptive, but fully concordant with NPS. In Lmx1b functional knockouts (KOs), Lmx1b transcription in the limb is decreased nearly 6-fold, indicating autoregulation. Herein, we report on two conserved Lmx1b-associated cis-regulatory modules (LARM1 and LARM2) that are bound by Lmx1b, amplify Lmx1b expression with unique spatial modularity in the limb, and are necessary for Lmx1b-mediated limb dorsalization. These enhancers, being conserved across vertebrates (including coelacanth, but not other fish species), and required for normal locomotion, provide a unique opportunity to study the role of dorsalization in the fin to limb transition. We also report on two NPS patient families with normal LMX1B coding sequence, but with loss-of-function variations in the LARM1/2 region, stressing the role of regulatory modules in disease pathogenesis.This work was supported in part by grants from the Spanish Ministerio de Ciencia, Innovación y Universidades (M.A.R) (BFU2017-88265-P); the National Organization for Rare Disorders (K.C.O.), and the Loma Linda University Pathology Research Endowment Fund (K.C.O.)