161 research outputs found
The origin of the Acheulean: the 1.7 million-year-old site of FLK West, Olduvai Gorge (Tanzania)
The appearance of the Acheulean is one of the hallmarks of human evolution. It represents the
emergence of a complex behavior, expressed in the recurrent manufacture of large-sized tools, with
standardized forms, implying more advance forethought and planning by hominins than those required
by the precedent Oldowan technology. The earliest known evidence of this technology dates back to
c. 1.7 Ma. and is limited to two sites (Kokiselei [Kenya] and Konso [Ethiopia]), both of which lack fauna.
The functionality of these earliest Acheulean assemblages remains unknown. Here we present the
discovery of another early Acheulean site also dating to c. 1.7 Ma from Olduvai Gorge. This site provides
evidence of the earliest steps in developing the Acheulean technology and is the oldest Acheulean site in
which stone tools occur spatially and functionally associated with the exploitation of fauna. Simple and
elaborate large-cutting tools (LCT) and handaxes co-exist at FLK West, showing that complex cognition
was present from the earliest stages of the Acheulean. Here we provide a detailed technological study
and evidence of the use of these tools on the butchery and consumption of fauna, probably by early
Homo erectus sensu lato
Beta-decay of Mn-65 to Fe-65
The low energy structure of Fe-65 has been studied by means of gamma- and
fast-timing spectroscopy. A level scheme of Fe-65 populated following the
beta-decay of Mn-65 was established for the first time. It includes 41 levels
and 85 transitions. The excitation energy of the beta-decaying isomer in Fe-65
has been precisely determined at 393.7(2) keV. The beta delayed neutron
emission branch was measured as Pn = 7.9(12)%, which cannot be reconciled with
the previously reported value of 21.0(5)%. Four gamma-rays and four excited
states in Fe-64 were identified as being populated following the beta-n decay.
Four lifetimes and five lifetime limits in the subnanosecond range have been
measured using the Advanced Time-Delayed Method. The level scheme is compared
with shell-model calculations. Tentative spin and parity assignments are
proposed based on the observed transition rates, the calculations and the
systematics of the region.Comment: Accepted in Physical Review
Neutrino Masses at LHC: Minimal Lepton Flavour Violation in Type-III See-saw
We study the signatures of minimal lepton flavour violation in a simple
Type-III see - saw model in which the flavour scale is given by the new fermion
triplet mass and it can be naturally light enough to be produced at the LHC. In
this model the flavour structure of the lepton number conserving couplings of
the triplet fermions to the Standard Model leptons can be reconstructed from
the neutrino mass matrix and the smallness of the neutrino mass is associated
with a tiny violation of total lepton number. Characteristic signatures of this
model include suppressed lepton number violation decays of the triplet
fermions, absence of displaced vertices in their decays and predictable lepton
flavour composition of the states produced in their decays. We study the
observability of these signals in the processes pp\rightarrow 3\ell + 2j
+\Sla{E_T} and with or taking into
account the present low energy data on neutrino physics and the corresponding
Standard Model backgrounds. Our results indicate that the new fermionic states
can be observed for masses up to 500 GeV depending on the CP violating Majorana
phase for an integrated luminosity of 30 fb. Moreover, the flavour of
the final state leptons in the above processes can shed light on the neutrino
mass ordering.Comment: 31 pages, 11 Figures, matches published versio
Surgical treatment for colorectal cancer: Analysis of the influence of an enhanced recovery programme on long-term oncological outcomes-a study protocol for a prospective, multicentre, observational cohort study
Introduction
The evidence currently available from enhanced recovery after surgery (ERAS) programmes concerns their benefits in the immediate postoperative period, but there is still very little evidence as to whether their correct implementation benefits patients in the long term. The working hypothesis here is that, due to the lower response to surgical aggression and lower rates of postoperative complications, ERAS protocols can reduce colorectal cancer-related mortality. The main objective of this study is to analyse the impact of an ERAS programme for colorectal cancer on 5-year survival. As secondary objectives, we propose to analyse the weight of each of the predefined items in the oncological results as well as the quality of life.
Methods and analysis
A multicentre prospective cohort study was conducted in patients older than 18 years of age who are scheduled to undergo surgery for colorectal cancer. The study involved 12 hospitals with an implemented enhanced recovery protocol according to the guidelines published by the Spanish National Health Service. The intervention group includes patients with a minimum implementation level of 70%, and the control group includes those who fail to reach this level. Compliance will be studied using 18 key performance indicators, and the results will be analysed using cancer survival indicators, including overall survival, cancer-specific survival and relapse-free survival. The time to recurrence, perioperative morbidity and mortality, hospital stay and quality of life will also be studied, the latter using the validated EuroQol Five questionnaire. The propensity index method will be used to create comparable treatment and control groups, and a multivariate regression will be used to study each variable. The Kaplan-Meier estimator will be used to estimate survival and the log-rank test to make comparisons. A p value of less than 0.05 (two-tailed) will be considered to be significant.
Ethics and dissemination
Ethical approval for this study was obtained from the Aragon Ethical Committee (C.P.-C.I. PI20/086) on 4 March 2020. The findings of this study will be submitted to peer-reviewed journals (BMJ Open, JAMA Surgery, Annals of Surgery, British Journal of Surgery). Abstracts will be submitted to relevant national and international meetings.
Trial registration number NCT04305314
Vacuum Instabilities with a Wrong-Sign Higgs-Gluon-Gluon Amplitude
The recently discovered 125 GeV boson appears very similar to a Standard
Model Higgs, but with data favoring an enhanced h to gamma gamma rate. A number
of groups have found that fits would allow (or, less so after the latest
updates, prefer) that the h-t-tbar coupling have the opposite sign. This can be
given meaning in the context of an electroweak chiral Lagrangian, but it might
also be interpreted to mean that a new colored and charged particle runs in
loops and produces the opposite-sign hGG amplitude to that generated by
integrating out the top, as well as a contribution reinforcing the W-loop
contribution to hFF. In order to not suppress the rate of h to WW and h to ZZ,
which appear to be approximately Standard Model-like, one would need the loop
to "overshoot," not only canceling the top contribution but producing an
opposite-sign hGG vertex of about the same magnitude as that in the SM. We
argue that most such explanations have severe problems with fine-tuning and,
more importantly, vacuum stability. In particular, the case of stop loops
producing an opposite-sign hGG vertex of the same size as the Standard Model
one is ruled out by a combination of vacuum decay bounds and LEP constraints.
We also show that scenarios with a sign flip from loops of color octet charged
scalars or new fermionic states are highly constrained.Comment: 20 pages, 8 figures; v2: references adde
Recent Results from the SAFIR Project
The "Seyfert and star formation Activity in the Far-Infrared" (SAFIR) project is aimed at studying the physical nature of the nuclear IR emission and star formation properties of a small sample of nearby Seyfert galaxies observed with the PACS and SPIRE instruments on board the Herschel space observatory. In this paper, we review the achieved results, that reveal the importance of the far-IR range to improve the quality and reliability of the estimates of basic AGN torus parameters, and describe some preliminary outcome from the on-going work on the dust properties of resolved AGN host galaxies
Gaia Data Release 2: The astrometric solution
Gaia Data Release 2 (Gaia DR2) contains results for 1693 million sources in the magnitude range 3 to 21 based on observations collected by the European Space Agency Gaia satellite during the first 22 months of its operational phase. We describe the input data, models, and processing used for the astrometric content of Gaia DR2, and the validation of these results performed within the astrometry task. Some 320 billion centroid positions from the pre-processed astrometric CCD observations were used to estimate the five astrometric parameters (positions, parallaxes, and proper motions) for 1332 million sources, and approximate positions at the reference epoch J2015.5 for an additional 361 million mostly faint sources. Special validation solutions were used to characterise the random and systematic errors in parallax and proper motion. For the sources with five-parameter astrometric solutions, the median uncertainty in parallax and position at the reference epoch J2015.5 is about 0.04 mas for bright (G<14 mag) sources, 0.1 mas at G=17 mag, and 0.7 mas at G=20 mag. In the proper motion components the corresponding uncertainties are 0.05, 0.2, and 1.2 mas/yr, respectively. The optical reference frame defined by Gaia DR2 is aligned with ICRS and is non-rotating with respect to the quasars to within 0.15 mas/yr. From the quasars and validation solutions we estimate that systematics in the parallaxes depending on position, magnitude, and colour are generally below 0.1 mas, but the parallaxes are on the whole too small by about 0.03 mas. Significant spatial correlations of up to 0.04 mas in parallax and 0.07 mas/yr in proper motion are seen on small (<1 deg) and intermediate (20 deg) angular scales. Important statistics and information for the users of the Gaia DR2 astrometry are given in the appendices.Includes STFC
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