4,747 research outputs found
ProsocialLearn: D2.3 - 1st system requirements and architecture
This document present the first version of the ProsocialLearn architecture covering the principle definition, the requirement collection, the “business”, “information system”, “technology” architecture as defined in the TOGAF methodology
Velocity-Based Heuristic Evaluation for Path Planning and Vehicle Routing for Victim Assistance in Disaster Scenarios
Published in "Robot 2019: Fourth Iberian Robotics Conference. Advances in Intelligent Systems and Computing, Vol 1093. Silva M., LuĂs Lima J., Reis L., Sanfeliu A., Tardioli D. (eds)" published by Springer, Cham. Avalaible online at: https://doi.org/10.1007.987-3-030-36150-1_10Natural and human-made disasters require effective victim
assistance and last-mile relief supply operations with teams of ground vehicles.
In these applications, digital elevation models (DEM) can provide
accurate knowledge for safe vehicle motion planning but grid representation
results in very large search graphs. Furthermore, travel time, which
becomes a crucial cost optimization criterion, may be affected by inclination
and other challenging terrain characteristics. In this paper, our goal
is to evaluate a search heuristic function based on anisotropic vehicle velocity
restrictions for building the cost matrix required for multi-vehicle
routing on natural terrain and disaster sites. The heuristic is applied to
compute the fastest travel times between every pair of matrix elements
by means of a path planning algorithm. The analysis is based on a case
study on the ortophotographic-based DEM of natural terrain with different
target points, where theUniversidad de Málaga. Campus de Excelencia Internacional AndalucĂa Tech.
This work has received funding from the national project RTI2018-093421-B-I00
(Spanish Government), the University of Malaga (AndalucĂa Tech) and the grant
BES-2016-077022 of the European Social Fund
TomografĂa por emisiĂłn de positrones con fluordeoxiglucosa (FDG-PET) en neurologĂa
El objetivo de este informe es establecer, a la vista de la evidencia cientĂfica disponible, la contribuciĂłn relativa de la PET-FDG al manejo de pacientes neurolĂłgicos. Se excluyen de esta revisiĂłn trabajos realizados con otros radiotrazadores PET menos usuales y el ámbito de la psiquiatrĂa (excepciĂłn hecha de la enfermedad de Alzheimer).IntroducciĂłn y objetivo del Informe, MetodologĂa, Resultados ClĂnicos: Enfermedad de Alzheimer y otras demencias, Resultados ClĂnicos: Parkinsonismos, Resultados ClĂnicos: Atrofias, Resultados ClĂnicos: PatologĂa asociada a trastornos sistĂ©micos, Resultados ClĂnicos: Epilepsias, Resultados ClĂnicos: Tumores Cerebrales, DiscusiĂłn. Conclusiones. Recomendaciones. Abreviaturas. Referencias. ANEXO: ResĂşmenes de los artĂculos seleccionados
Records of Olive Ridley Marine Turtles (Lepidochelys olivacea Eschscholtz 1829) in Venezuelan Waters: A Review of Historical Data Sets and Threats
We assess all the records of olive ridley turtles (Lepidochelys olivacea) in an exhaustive review of multiple data sources between 1977 and 2018 in Venezuela. We compiled 35 records of olive ridleys in the country. Our findings confirm the almost year-round presence of this species in Venezuelan waters
Physical interactions between MCM and Rad51 facilitate replication fork lesion bypass and ssDNA gap filling by non-recombinogenic functions
The minichromosome maintenance (MCM) helicase physically interacts with the recombination proteins Rad51 and Rad52 from yeast to human cells. We show, in Saccharomyces cerevisiae, that these interactions occur within a nuclease-insoluble scaffold enriched in replication/repair factors. Rad51 accumulates in a MCM- and DNA-binding-independent manner and interacts with MCMhelicases located outside of the replication origins and forks. MCM, Rad51, and Rad52 accumulate in this scaffold in G1 and are released during the S phase. In the presence of replication-blocking lesions, Cdc7 prevents their release from the scaffold, thus maintaining the interactions. We identify a rad51 mutant that is impaired in its ability to bind to MCM but not to the scaffold. This mutant is proficient in recombination but partially defective in single-stranded DNA (ssDNA) gap filling and replication fork progression through damaged DNA. Therefore, cells accumulate MCM/Rad51/Rad52 complexes at specific nuclear scaffolds in G1 to assist stressed forks through non-recombinogenic functions.Cancer Signaling networks and Molecular Therapeutic
The molecular basis and biologic significance of the β-dystroglycan-emerin interaction
β-dystroglycan (β-DG) assembles with lamins A/C and B1 and emerin at the nuclear envelope (NE) to maintain proper nuclear architecture and function. To provide insight into the nuclear function of β-DG, we characterized the interaction between β-DG and emerin at the molecular level. Emerin is a major NE protein that regulates multiple nuclear processes and whose deficiency results in Emery–Dreifuss muscular dystrophy (EDMD). Using truncated variants of β-DG and emerin, via a series of in vitro and in vivo binding experiments and a tailored computational analysis, we determined that the β-DG–emerin interaction is mediated at least in part by their respective transmembrane domains (TM). Using surface plasmon resonance assays we showed that emerin binds to β-DG with high affinity (KD in the nanomolar range). Remarkably, the analysis of cells in which DG was knocked out demonstrated that loss of β-DG resulted in a decreased emerin stability and impairment of emerin-mediated processes. β-DG and emerin are reciprocally required for their optimal targeting within the NE, as shown by immunofluorescence, western blotting and immunoprecipitation assays using emerin variants with mutations in the TM domain and B-lymphocytes of a patient with EDMD. In summary, we demonstrated that β-DG plays a role as an emerin interacting partner modulating its stability and function
Genomic adaptations to aquatic and aerial life in mayflies and the origin of insect wings
The evolution of winged insects revolutionized terrestrial ecosystems and led to the largest animal radiation on Earth. However, we still have an incomplete picture of the genomic changes that underlay this diversification. Mayflies, as one of the sister groups of all other winged insects, are key to understanding this radiation. Here, we describe the genome of the mayfly Cloeon dipterum and its gene expression throughout its aquatic and aerial life cycle and specific organs. We discover an expansion of odorant-binding-protein genes, some expressed specifically in breathing gills of aquatic nymphs, suggesting a novel sensory role for this organ. In contrast, flying adults use an enlarged opsin set in a sexually dimorphic manner, with some expressed only in males. Finally, we identify a set of wing-associated genes deeply conserved in the pterygote insects and find transcriptomic similarities between gills and wings, suggesting a common genetic program. Globally, this comprehensive genomic and transcriptomic study uncovers the genetic basis of key evolutionary adaptations in mayflies and winged insects
Quality evaluation of olive oil by statistical analysis of multicomponent stable isotope dilution assay data of aroma active compounds
An instrumental method for the evaluation of olive oil quality was developed. Twenty-one relevant aroma active compounds were quantified in 95 olive oil samples of different quality by headspace solid phase microextraction (HS-SPME) and dynamic headspace coupled to GC-MS. On the basis of these stable isotope dilution assay results, statistical evaluation by partial least-squares discriminant analysis (PLS-DA) was performed. Important variables were the odor activity values of ethyl isobutanoate, ethyl 2-methylbutanoate, 3-methylbutanol, butyric acid, E,E-2,4-decadienal, hexanoic acid, guaiacol, 2-phenylethanol, and the sum of the odor activity values of Z-3-hexenal, E-2-hexenal, Z-3-hexenyl acetate, and Z-3-hexenol. Classification performed with these variables predicted 88% of the olive oils? quality correctly. Additionally, the aroma compounds, which are characteristic for some off-flavors, were dissolved in refined plant oil. Sensory evaluation of these models demonstrated that the off-flavors rancid, fusty, and vinegary could be successfully simulated by a limited number of odorants
Multi-Wavelength Observations of the Blazar 1ES 1011+496 in Spring 2008
The BL Lac object 1ES 1011+496 was discovered at Very High Energy gamma-rays
by MAGIC in spring 2007. Before that the source was little studied in different
wavelengths. Therefore a multi-wavelength (MWL) campaign was organized in
spring 2008. Along MAGIC, the MWL campaign included the Metsahovi radio
observatory, Bell and KVA optical telescopes and the Swift and AGILE
satellites. MAGIC observations span from March to May, 2008 for a total of 27.9
hours, of which 19.4 hours remained after quality cuts. The light curve showed
no significant variability. The differential VHE spectrum could be described
with a power-law function. Both results were similar to those obtained during
the discovery. Swift XRT observations revealed an X-ray flare, characterized by
a harder when brighter trend, as is typical for high synchrotron peak BL Lac
objects (HBL). Strong optical variability was found during the campaign, but no
conclusion on the connection between the optical and VHE gamma-ray bands could
be drawn. The contemporaneous SED shows a synchrotron dominated source, unlike
concluded in previous work based on nonsimultaneous data, and is well described
by a standard one zone synchrotron self Compton model. We also performed a
study on the source classification. While the optical and X-ray data taken
during our campaign show typical characteristics of an HBL, we suggest, based
on archival data, that 1ES 1011+496 is actually a borderline case between
intermediate and high synchrotron peak frequency BL Lac objects.Comment: 13 pages, accepted for publication in MNRA
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