446 research outputs found
Better living with non-memory led dementia: Protocol for a feasibility randomised controlled trial of a web-based caregiver educational programme
Background
Non-memory-led dementias such as posterior cortical atrophy (PCA), primary progressive aphasia (PPA) and behavioural variant frontotemporal dementia (bvFTD) are low prevalent and often affect individuals under the age of 65. Tailored educational and support resources for caregivers of people living with these dementia phenotypes are scarce and unevenly distributed geographically. Web-based educational programmes are emerging as promising alternatives to improve caregiver self-efficacy and well-being. Here, we present the protocol of a study aiming to assess the feasibility of a co-produced online educational programme for caregivers of people living PCA, PPA and bvFTD: the Better Living with Non-memory-led Dementia programme.
Methods
A randomised controlled feasibility trial will be conducted on a sample of 30 caregivers of people living with PCA, PPA and bvFTD. Participants will be recruited among members of the support organisation Rare Dementia Support (based at UCL in the UK). The intervention group will be given access to an 8-week co-produced web-based educational programme consisting of 6 modules addressing education about PCA, PPA and bvFTD and support strategies for the person with dementia and for the caregiver. The control group will receive treatment as usual (TAU). Feasibility will be measured through feasibility of recruitment, clinical measurement tools and acceptability. Clinical measures will be used to assess preliminary efficacy and data on completion rates, missing data and variability used to decide on measures to be included in a full-scale trial.
Allocation ratio will be 2:1 (intervention:control) stratified by diagnosis. Feasibility of recruitment and acceptability will be assessed. Clinical measures will be administered at baseline and 8-week and 3-month post-randomisation. The control group will be offered access to the intervention at the completion of data collection. Participants will be unblinded, and all measures will be self-reported online.
Discussion
Online-delivered educational programmes show potential for improving care competency of caregivers and may contribute to overcoming geographical inequalities in local provision of support services. This pilot study will inform a fully powered international trial to determine the effectiveness of Better Living with Non-memory-led Dementia.
Trial registration
This trial has been registered prospectively on the Clinical Trials Registry on 1st September 2022, registration number NCT05525377
Chandra Smells a RRAT: X-ray Detection of a Rotating Radio Transient
"Rotating RAdio Transients" (RRATs) are a newly discovered astronomical
phenomenon, characterised by occasional brief radio bursts, with average
intervals between bursts ranging from minutes to hours. The burst spacings
allow identification of periodicities, which fall in the range 0.4 to 7
seconds. The RRATs thus seem to be rotating neutron stars, albeit with
properties very different from the rest of the population. We here present the
serendipitous detection with the Chandra X-ray Observatory of a bright
point-like X-ray source coincident with one of the RRATs. We discuss the
temporal and spectral properties of this X-ray emission, consider counterparts
in other wavebands, and interpret these results in the context of possible
explanations for the RRAT population.Comment: 5 pages, 2 b/w figures, 1 color figure. To appear in the proceedings
of "Isolated Neutron Stars", Astrophysics & Space Science, in pres
Faraday rotation in graphene
We study magneto--optical properties of monolayer graphene by means of
quantum field theory methods in the framework of the Dirac model. We reveal a
good agreement between the Dirac model and a recent experiment on giant Faraday
rotation in cyclotron resonance. We also predict other regimes when the effects
are well pronounced. The general dependence of the Faraday rotation and
absorption on various parameters of samples is revealed both for suspended and
epitaxial graphene.Comment: 10 pp; v2: typos corrected and references added, v3, v4: small
changes and more reference
Answering a Basic Objection to Bang/Crunch Holography
The current cosmic acceleration does not imply that our Universe is basically
de Sitter-like: in the first part of this work we argue that, by introducing
matter into *anti-de Sitter* spacetime in a natural way, one may be able to
account for the acceleration just as well. However, this leads to a Big Crunch,
and the Euclidean versions of Bang/Crunch cosmologies have [apparently]
disconnected conformal boundaries. As Maldacena and Maoz have recently
stressed, this seems to contradict the holographic principle. In the second
part we argue that this "double boundary problem" is a matter not of geometry
but rather of how one chooses a conformal compactification: if one chooses to
compactify in an unorthodox way, then the appearance of disconnectedness can be
regarded as a *coordinate effect*. With the kind of matter we have introduced
here, namely a Euclidean axion, the underlying compact Euclidean manifold has
an unexpectedly non-trivial topology: it is in fact one of the 75 possible
underlying manifolds of flat compact four-dimensional Euclidean spaces.Comment: 29 pages, 3 figures, added references and comparison with "cyclic"
cosmology, JHEP versio
Stability analysis of agegraphic dark energy in Brans-Dicke cosmology
Stability analysis of agegraphic dark energy in Brans-Dicke theory is
presented in this paper. We constrain the model parameters with the
observational data and thus the results become broadly consistent with those
expected from experiment. Stability analysis of the model without best fitting
shows that universe may begin from an unstable state passing a saddle point and
finally become stable in future. However, with the best fitted model, There is
no saddle intermediate state. The agegraphic dark energy in the model by itself
exhibits a phantom behavior. However, contribution of cold dark matter on the
effective energy density modifies the state of teh universe from phantom phase
to quintessence one. The statefinder diagnosis also indicates that the universe
leaves an unstable state in the past, passes the LCDM state and finally
approaches the sable state in future.Comment: 15 pages, 12 figure
Balloon Measurements of Cosmic Ray Muon Spectra in the Atmosphere along with those of Primary Protons and Helium Nuclei over Mid-Latitude
We report here the measurements of the energy spectra of atmospheric muons
and of the cosmic ray primary proton and helium nuclei in a single experiment.
These were carried out using the MASS superconducting spectrometer in a balloon
flight experiment in 1991. The relevance of these results to the atmospheric
neutrino anomaly is emphasized. In particular, this approach allows
uncertainties caused by the level of solar modulation, the geomagnetic cut-off
of the primaries and possible experimental systematics to be decoupled in the
comparison of calculated fluxes of muons to measured muon fluxes. The muon
observations cover the momentum and depth ranges of 0.3-40 GeV/c and 5-886
g/cmsquared, respectively. The proton and helium primary measurements cover the
rigidity range from 3 to 100 GV, in which both the solar modulation and the
geomagnetic cut-off affect the energy spectra at low energies.Comment: 31 pages, including 17 figures, simplified apparatus figure, to
appear in Phys. Rev.
Theory of inelastic lifetimes of low-energy electrons in metals
Electron dynamics in the bulk and at the surface of solid materials are well
known to play a key role in a variety of physical and chemical phenomena. In
this article we describe the main aspects of the interaction of low-energy
electrons with solids, and report extensive calculations of inelastic lifetimes
of both low-energy electrons in bulk materials and image-potential states at
metal surfaces. New calculations of inelastic lifetimes in a homogeneous
electron gas are presented, by using various well-known representations of the
electronic response of the medium. Band-structure calculations, which have been
recently carried out by the authors and collaborators, are reviewed, and future
work is addressed.Comment: 28 pages, 18 figures, to appear in Chem. Phy
QCD Corrections to QED Vacuum Polarization
We compute QCD corrections to QED calculations for vacuum polarization in
background magnetic fields. Formally, the diagram for virtual loops
is identical to the one for virtual loops. However due to
confinement, or to the growth of as decreases, a direct
calculation of the diagram is not allowed. At large we consider the
virtual diagram, in the intermediate region we discuss the role of
the contribution of quark condensates \left and at the
low-energy limit we consider the , as well as charged pion
loops. Although these effects seem to be out of the measurement accuracy of
photon-photon laboratory experiments they may be relevant for -ray
burst propagation. In particular, for emissions from the center of the galaxy
(8.5 kpc), we show that the mixing between the neutral pseudo-scalar pion
and photons renders a deviation from the power-law spectrum in the
range. As for scalar quark condensates \left and
virtual loops are relevant only for very high radiation density
and very strong magnetic fields of order .Comment: 15 pages, 4 figures; Final versio
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