227 research outputs found
Sex-related differences of fatty acid-binding protein 4 and leptin levels in atrial fibrillation
Aims: Adiposity plays a key role in the pathogenesis of atrial fibrillation (AF). Our aim was to study the sex differences in adipokines levels according to AF burden. Methods and results: Two independent cohorts of patients were studied: (i) consecutive patients with AF undergoing catheter ablation (n = 217) and (ii) a control group (n = 105). (i) Adipokines, oxidative stress, indirect autonomic markers, and leucocytes mRNA levels were analysed; (ii) correlation between biomarkers was explored with heatmaps and Kendall correlation coefficients; and (iii) logistic regression and random forest model were used to determine predictors of AF recurrence after ablation. Our results showed that: (i) fatty acid-binding protein 4 (FABP4) and leptin levels were higher in women than in men in both cohorts (P < 0.01). In women, FABP4 levels were higher on AF cohort (20 ± 14 control, 29 ± 18 paroxysmal AF and 31 ± 17 ng/mL persistent AF; P < 0.01). In men, leptin levels were lower on AF cohort (22 ± 15 control, 13 ± 16 paroxysmal AF and 13 ± 11 ng/mL persistent AF; P < 0.01). (ii) In female with paroxysmal AF, there was a lower acetylcholinesterase and higher carbonic anhydrase levels with respect to men (P < 0.05). (iii) Adipokines have an important role on discriminate AF recurrence after ablation. In persistent AF, FABP4 was the best predictor of recurrence after ablation (1.067, 95% confidence interval 1-1.14; P = 0.046). Conclusion: The major finding of the present study is the sex-based differences of FABP4 and leptin levels according to AF burden. These adipokines are associated with oxidative stress, inflammatory and autonomic indirect markers, indicating that they may play a role in AF perpetuation.This study was supported by projects (PI16/01282 and PI18/01584) integrated in the Plan Estatal de I+D+I 2016â2019 and cofounded by ISCIII-SubdirecciĂłn General de EvaluaciĂłn y Fomento de la InvestigaciĂłn del Fondo Europeo de Desarrollo Regional (FEDER). J.N.L.-C. and M.R.-M. were a recipient of a Sociedade Galega de CardioloxĂa (SOGACAR) research grant. D.d.G.-C. was a recipient of a Juan de la Cierva-IncorporaciĂłn grant from the Ministry of Science Innovation and Universities (IJCI-2016-29393). CIBER Cardiovascular (CB16/11/00403 to V.Ll.-C. and D.d.G.-C.) is a project from Carlos III Health Institute.Peer reviewe
Tocilizumab in refractory Caucasian Takayasu's arteritis: a multicenter study of 54 patients and literature review
Objective: To assess the efficacy and safety of tocilizumab (TCZ) in Caucasian patients with refractory Takayasu's arteritis (TAK) in clinical practice.
Methods: A multicenter study of Caucasian patients with refractory TAK who received TCZ. The outcome variables were remission, glucocorticoid-sparing effect, improvement in imaging techniques, and adverse events. A comparative study between patients who received TCZ as monotherapy (TCZMONO) and combined with conventional disease modifying anti-rheumatic drugs (cDMARDs) (TCZCOMBO) was performed.
Results: The study comprised 54 patients (46 women/8 men) with a median [interquartile range (IQR)] age of 42.0 (32.5-50.5) years. TCZ was started after a median (IQR) of 12.0 (3.0-31.5) months since TAK diagnosis. Remission was achieved in 12/54 (22.2%), 19/49 (38.8%), 23/44 (52.3%), and 27/36 (75%) patients at 1, 3, 6, and 12 months, respectively. The prednisone dose was reduced from 30.0 mg/day (12.5-50.0) to 5.0 (0.0-5.6) mg/day at 12 months. An improvement in imaging findings was reported in 28 (73.7%) patients after a median (IQR) of 9.0 (6.0-14.0) months. Twenty-three (42.6%) patients were on TCZMONO and 31 (57.4%) on TCZCOMBO: MTX (n = 28), cyclosporine A (n = 2), azathioprine (n = 1). Patients on TCZCOMBO were younger [38.0 (27.0-46.0) versus 45.0 (38.0-57.0)] years; difference (diff) [95% confidence interval (CI) = -7.0 (-17.9, -0.56] with a trend to longer TAK duration [21.0 (6.0-38.0) versus 6.0 (1.0-23.0)] months; diff 95% CI = 15 (-8.9, 35.5), and higher c-reactive protein [2.4 (0.7-5.6) versus 1.3 (0.3-3.3)] mg/dl; diff 95% CI = 1.1 (-0.26, 2.99). Despite these differences, similar outcomes were observed in both groups (log rank p = 0.862). Relevant adverse events were reported in six (11.1%) patients, but only three developed severe events that required TCZ withdrawal.
Conclusion: TCZ in monotherapy, or combined with cDMARDs, is effective and safe in patients with refractory TAK of Caucasian origin.Funding: This work was partially supported by RETICS Programs, RD08/0075 (RIER), RD12/0009/0013 and RD16/0012 from âInstituto de Salud Carlos IIIâ (ISCIII) (Spain)
Acceptability and feasibility of a virtual community of practice to primary care professionals regarding patient empowerment : A qualitative pilot study
Background: Virtual communities of practice (vCoPs) facilitate online learning via the exchange of experiences and knowledge between interested participants. Compared to other communities, vCoPs need to overcome technological structures and specific barriers. Our objective was to pilot the acceptability and feasibility of a vCoP aimed at improving the attitudes of primary care professionals to the empowerment of patients with chronic conditions. Methods: We used a qualitative approach based on 2 focus groups: one composed of 6 general practitioners and the other of 6 practice nurses. Discussion guidelines on the topics to be investigated were provided to the moderator. Sessions were audio-recorded and transcribed verbatim. Thematic analysis was performed using the ATLAS-ti software. Results: The available operating systems and browsers and the lack of suitable spaces and time were reported as the main difficulties with the vCoP. The vCoP was perceived to be a flexible learning mode that provided up-to-date resources applicable to routine practice and offered a space for the exchange of experiences and approaches. Conclusions: The results from this pilot study show that the vCoP was considered useful for learning how to empower patients. However, while vCoPs have the potential to facilitate learning and as shown create professional awareness regarding patient empowerment, attention needs to be paid to technological and access issues and the time demands on professionals. We collected relevant inputs to improve the features, content and educational methods to be included in further vCoP implementation. Trial registration: ClinicalTrials.gov, NCT02757781. Registered on 25 April 2016
Acceptability and feasibility of a virtual community of practice to primary care professionals regarding patient empowerment: A qualitative pilot study
Background: Virtual communities of practice (vCoPs) facilitate online learning via the exchange of experiences and knowledge between interested participants. Compared to other communities, vCoPs need to overcome technological structures and specific barriers. Our objective was to pilot the acceptability and feasibility of a vCoP aimed at improving the attitudes of primary care professionals to the empowerment of patients with chronic conditions. Methods: We used a qualitative approach based on 2 focus groups: one composed of 6 general practitioners and the other of 6 practice nurses. Discussion guidelines on the topics to be investigated were provided to the moderator. Sessions were audio-recorded and transcribed verbatim. Thematic analysis was performed using the ATLAS-ti software. Results: The available operating systems and browsers and the lack of suitable spaces and time were reported as the main difficulties with the vCoP. The vCoP was perceived to be a flexible learning mode that provided up-to-date resources applicable to routine practice and offered a space for the exchange of experiences and approaches. Conclusions: The results from this pilot study show that the vCoP was considered useful for learning how to empower patients. However, while vCoPs have the potential to facilitate learning and as shown create professional awareness regarding patient empowerment, attention needs to be paid to technological and access issues and the time demands on professionals. We collected relevant inputs to improve the features, content and educational methods to be included in further vCoP implementation. Trial registration: ClinicalTrials.gov, NCT02757781. Registered on 25 April 2016.This study was financed by Instituto de Salud Carlos III and Cofinanced by Fondo
Europeo de Desarrollo Regional (FEDER). Ministerio de EconomĂa
y Competitividad. Gobierno de España. (PI15/00164, PI15/00586, PI15/00566
New Code-Based Privacy-Preserving Cryptographic Constructions
Code-based cryptography has a long history but did suffer from periods of slow development. The field has recently attracted a lot of attention as one of the major branches of post-quantum cryptography. However, its subfield of privacy-preserving cryptographic constructions is still rather underdeveloped, e.g., important building blocks such as zero-knowledge range proofs and set membership proofs, and even proofs of knowledge of a hash preimage, have not been known under code-based assumptions. Moreover, almost no substantial technical development has been introduced in the last several years.
This work introduces several new code-based privacy-preserving cryptographic constructions that considerably advance the state-of-the-art in code-based cryptography. Specifically, we present major contributions, each of which potentially yields various other applications. Our first contribution is a code-based statistically hiding and computationally binding commitment scheme with companion zero-knowledge (ZK) argument of knowledge of a valid opening that can be easily extended to prove that the committed bits satisfy other relations. Our second contribution is the first code-based zero-knowledge range argument for committed values, with communication cost logarithmic in the size of the range. A special feature of our range argument is that, while previous works on range proofs/arguments (in all branches of cryptography) only address ranges of non-negative integers, our protocol can handle signed fractional numbers, and hence, can potentially find a larger scope of applications. Our third contribution is the first code-based Merkle-tree accumulator supported by ZK argument of membership, which has been known to enable various interesting applications. In particular, it allows us to obtain the first code-based ring signatures and group signatures with logarithmic signature sizes
Search of the early O3 LIGO data for continuous gravitational waves from the Cassiopeia A and Vela Jr. supernova remnants
partially_open1412sĂŹWe present directed searches for continuous gravitational waves from the neutron stars in the Cassiopeia A (Cas A) and Vela Jr. supernova remnants. We carry out the searches in the LIGO detector data from the first six months of the third Advanced LIGO and Virgo observing run using the weave semicoherent method, which sums matched-filter detection-statistic values over many time segments spanning the observation period. No gravitational wave signal is detected in the search band of 20â976 Hz for assumed source ages greater than 300 years for Cas A and greater than 700 years for Vela Jr. Estimates from simulated continuous wave signals indicate we achieve the most sensitive results to date across the explored parameter space volume, probing to strain magnitudes as low as
âŒ6.3Ă10^â26 for Cas A and âŒ5.6Ă10^â26 for Vela Jr. at frequencies near 166 Hz at 95% efficiency.openAbbott, R.; Abbott, T.âD.; Acernese, F.; Ackley, K.; Adams, C.; Adhikari, N.; Adhikari, R.âX.; Adya, V.âB.; Affeldt, C.; Agarwal, D.; Agathos, M.; Agatsuma, K.; Aggarwal, N.; Aguiar, O.âD.; Aiello, L.; Ain, A.; Ajith, P.; Albanesi, S.; Allocca, A.; Altin, P.âA.; Amato, A.; Anand, C.; Anand, S.; Ananyeva, A.; Anderson, S.âB.; Anderson, W.âG.; Andrade, T.; Andres, N.; AndriÄ, T.; Angelova, S.âV.; Ansoldi, S.; Antelis, J.âM.; Antier, S.; Appert, S.; Arai, K.; Araya, M.âC.; Areeda, J.âS.; ArĂšne, M.; Arnaud, N.; Aronson, S.âM.; Arun, K.âG.; Asali, Y.; Ashton, G.; Assiduo, M.; Aston, S.âM.; Astone, P.; Aubin, F.; Austin, C.; Babak, S.; Badaracco, F.; Bader, M.âK.âM.; Badger, C.; Bae, S.; Baer, A.âM.; Bagnasco, S.; Bai, Y.; Baird, J.; Ball, M.; Ballardin, G.; Ballmer, S.âW.; Balsamo, A.; Baltus, G.; Banagiri, S.; Bankar, D.; Barayoga, J.âC.; Barbieri, C.; Barish, B.âC.; Barker, D.; Barneo, P.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barta, D.; Bartlett, J.; Barton, M.âA.; Bartos, I.; Bassiri, R.; Basti, A.; Bawaj, M.; Bayley, J.âC.; Baylor, A.âC.; Bazzan, M.; BĂ©csy, B.; Bedakihale, V.âM.; Bejger, M.; Belahcene, I.; Benedetto, V.; Beniwal, D.; Bennett, T.âF.; Bentley, J.âD.; BenYaala, M.; Bergamin, F.; Berger, B.âK.; Bernuzzi, S.; Bersanetti, D.; Bertolini, A.; Betzwieser, J.; Beveridge, D.; Bhandare, R.; Bhardwaj, U.; Bhattacharjee, D.; Bhaumik, S.; Bilenko, I.âA.; Billingsley, G.; Bini, S.; Birney, R.; Birnholtz, O.; Biscans, S.; Bischi, M.; Biscoveanu, S.; Bisht, A.; Biswas, B.; Bitossi, M.; Bizouard, M.-A.; Blackburn, J.âK.; Blair, C.âD.; Blair, D.âG.; Blair, R.âM.; Bobba, F.; Bode, N.; Boer, M.; Bogaert, G.; Boldrini, M.; Bonavena, L.âD.; Bondu, F.; Bonilla, E.; Bonnand, R.; Booker, P.; Boom, B.âA.; Bork, R.; Boschi, V.; Bose, N.; Bose, S.; Bossilkov, V.; Boudart, V.; Bouffanais, Y.; Bozzi, A.; Bradaschia, C.; Brady, P.âR.; Bramley, A.; Branch, A.; Branchesi, M.; Brau, J.âE.; Breschi, M.; Briant, T.; Briggs, J.âH.; Brillet, A.; Brinkmann, M.; Brockill, P.; Brooks, A.âF.; Brooks, J.; Brown, D.âD.; Brunett, S.; Bruno, G.; Bruntz, R.; Bryant, J.; Bulik, T.; Bulten, H.âJ.; Buonanno, A.; Buscicchio, R.; Buskulic, D.; Buy, C.; Byer, R.âL.; Cadonati, L.; Cagnoli, G.; Cahillane, C.; Bustillo, J. CalderĂłn; Callaghan, J.âD.; Callister, T.âA.; Calloni, E.; Cameron, J.; Camp, J.âB.; Canepa, M.; Canevarolo, S.; Cannavacciuolo, M.; Cannon, K.âC.; Cao, H.; Capote, E.; Carapella, G.; Carbognani, F.; Carlin, J.âB.; Carney, M.âF.; Carpinelli, M.; Carrillo, G.; Carullo, G.; Carver, T.âL.; Diaz, J. Casanueva; Casentini, C.; Castaldi, G.; Caudill, S.; CavagliĂ , M.; Cavalier, F.; Cavalieri, R.; Ceasar, M.; Cella, G.; CerdĂĄ-DurĂĄn, P.; Cesarini, E.; Chaibi, W.; Chakravarti, K.; Subrahmanya, S. Chalathadka; Champion, E.; Chan, C.-H.; Chan, C.; Chan, C.âL.; Chan, K.; Chandra, K.; Chanial, P.; Chao, S.; Charlton, P.; Chase, E.âA.; Chassande-Mottin, E.; Chatterjee, C.; Chatterjee, Debarati; Chatterjee, Deep; Chaturvedi, M.; Chaty, S.; Chen, H.âY.; Chen, J.; Chen, X.; Chen, Y.; Chen, Z.; Cheng, H.; Cheong, C.âK.; Cheung, H.âY.; Chia, H.âY.; Chiadini, F.; Chiarini, G.; Chierici, R.; Chincarini, A.; Chiofalo, M.âL.; Chiummo, A.; Cho, G.; Cho, H.âS.; Choudhary, R.âK.; Choudhary, S.; Christensen, N.; Chu, Q.; Chua, S.; Chung, K.âW.; Ciani, G.; Ciecielag, P.; CieĆlar, M.; Cifaldi, M.; Ciobanu, A.âA.; Ciolfi, R.; Cipriano, F.; Cirone, A.; Clara, F.; Clark, E.âN.; Clark, J.âA.; Clarke, L.; Clearwater, P.; Clesse, S.; Cleva, F.; Coccia, E.; Codazzo, E.; Cohadon, P.-F.; Cohen, D.âE.; Cohen, L.; Colleoni, M.; Collette, C.âG.; Colombo, A.; Colpi, M.; Compton, C.âM.; Constancio, M.; Conti, L.; Cooper, S.âJ.; Corban, P.; Corbitt, T.âR.; Cordero-CarriĂłn, I.; Corezzi, S.; Corley, K.âR.; Cornish, N.; Corre, D.; Corsi, A.; Cortese, S.; Costa, C.âA.; Cotesta, R.; Coughlin, M.âW.; Coulon, J.-P.; Countryman, S.âT.; Cousins, B.; Couvares, P.; Coward, D.âM.; Cowart, M.âJ.; Coyne, D.âC.; Coyne, R.; Creighton, J.âD.âE.; Creighton, T.âD.; Criswell, A.âW.; Croquette, M.; Crowder, S.âG.; Cudell, J.âR.; Cullen, T.âJ.; Cumming, A.; Cummings, R.; Cunningham, L.; Cuoco, E.; CuryĆo, M.; Dabadie, P.; Canton, T. Dal; DallâOsso, S.; DĂĄlya, G.; Dana, A.; DaneshgaranBajastani, L.âM.; DâAngelo, B.; Danilishin, S.; DâAntonio, S.; Danzmann, K.; Darsow-Fromm, C.; Dasgupta, A.; Datrier, L.âE.âH.; Datta, S.; Dattilo, V.; Dave, I.; Davier, M.; Davies, G.âS.; Davis, D.; Davis, M.âC.; Daw, E.âJ.; Dean, R.; DeBra, D.; Deenadayalan, M.; Degallaix, J.; De Laurentis, M.; DelĂ©glise, S.; Del Favero, V.; De Lillo, F.; De Lillo, N.; Del Pozzo, W.; DeMarchi, L.âM.; De Matteis, F.; DâEmilio, V.; Demos, N.; Dent, T.; Depasse, A.; De Pietri, R.; De Rosa, R.; De Rossi, C.; DeSalvo, R.; De Simone, R.; Dhurandhar, S.; DĂaz, M.âC.; Diaz-Ortiz, M.; Didio, N.âA.; Dietrich, T.; Di Fiore, L.; Di Fronzo, C.; Di Giorgio, C.; Di Giovanni, F.; Di Giovanni, M.; Di Girolamo, T.; Di Lieto, A.; Ding, B.; Di Pace, S.; Di Palma, I.; Di Renzo, F.; Divakarla, A.âK.; Dmitriev, A.; Doctor, Z.; DâOnofrio, L.; Donovan, F.; Dooley, K.âL.; Doravari, S.; Dorrington, I.; Drago, M.; Driggers, J.âC.; Drori, Y.; Ducoin, J.-G.; Dupej, P.; Durante, O.; DâUrso, D.; Duverne, P.-A.; Dwyer, S.âE.; Eassa, C.; Easter, P.âJ.; Ebersold, M.; Eckhardt, T.; Eddolls, G.; Edelman, B.; Edo, T.âB.; Edy, O.; Effler, A.; Eichholz, J.; Eikenberry, S.âS.; Eisenmann, M.; Eisenstein, R.âA.; Ejlli, A.; Engelby, E.; Errico, L.; Essick, R.âC.; EstellĂ©s, H.; Estevez, D.; Etienne, Z.; Etzel, T.; Evans, M.; Evans, T.âM.; Ewing, B.âE.; Fafone, V.; Fair, H.; Fairhurst, S.; Farah, A.âM.; Farinon, S.; Farr, B.; Farr, W.âM.; Farrow, N.âW.; Fauchon-Jones, E.âJ.; Favaro, G.; Favata, M.; Fays, M.; Fazio, M.; Feicht, J.; Fejer, M.âM.; Fenyvesi, E.; Ferguson, D.âL.; Fernandez-Galiana, A.; Ferrante, I.; Ferreira, T.âA.; Fidecaro, F.; Figura, P.; Fiori, I.; Fishbach, M.; Fisher, R.âP.; Fittipaldi, R.; Fiumara, V.; Flaminio, R.; Floden, E.; Fong, H.; Font, J.âA.; Fornal, B.; Forsyth, P.âW.âF.; Franke, A.; Frasca, S.; Frasconi, F.; Frederick, C.; Freed, J.âP.; Frei, Z.; Freise, A.; Frey, R.; Fritschel, P.; Frolov, V.âV.; FronzĂ©, G.âG.; Fulda, P.; Fyffe, M.; Gabbard, H.âA.; Gadre, B.âU.; Gair, J.âR.; Gais, J.; Galaudage, S.; Gamba, R.; Ganapathy, D.; Ganguly, A.; Gaonkar, S.âG.; Garaventa, B.; GarcĂa-NĂșñez, C.; GarcĂa-QuirĂłs, C.; Garufi, F.; Gateley, B.; Gaudio, S.; Gayathri, V.; Gemme, G.; Gennai, A.; George, J.; Gerberding, O.; Gergely, L.; Gewecke, P.; Ghonge, S.; Ghosh, Abhirup; Ghosh, Archisman; Ghosh, Shaon; Ghosh, Shrobana; Giacomazzo, B.; Giacoppo, L.; Giaime, J.âA.; Giardina, K.âD.; Gibson, D.âR.; Gier, C.; Giesler, M.; Giri, P.; Gissi, F.; Glanzer, J.; Gleckl, A.âE.; Godwin, P.; Goetz, E.; Goetz, R.; Gohlke, N.; Goncharov, B.; GonzĂĄlez, G.; Gopakumar, A.; Gosselin, M.; Gouaty, R.; Gould, D.âW.; Grace, B.; Grado, A.; Granata, M.; Granata, V.; Grant, A.; Gras, S.; Grassia, P.; Gray, C.; Gray, R.; Greco, G.; Green, A.âC.; Green, R.; Gretarsson, A.âM.; Gretarsson, E.âM.; Griffith, D.; Griffiths, W.; Griggs, H.âL.; Grignani, G.; Grimaldi, A.; Grimm, S.âJ.; Grote, H.; Grunewald, S.; Gruning, P.; Guerra, D.; Guidi, Gianluca; Guimaraes, A.âR.; GuixĂ©, G.; Gulati, H.âK.; Guo, H.-K.; Guo, Y.; Gupta, Anchal; Gupta, Anuradha; Gupta, P.; Gustafson, E.âK.; Gustafson, R.; Guzman, F.; Haegel, L.; Halim, O.; Hall, E.âD.; Hamilton, E.âZ.; Hammond, G.; Haney, M.; Hanks, J.; Hanna, C.; Hannam, M.âD.; Hannuksela, O.; Hansen, H.; Hansen, T.âJ.; Hanson, J.; Harder, T.; Hardwick, T.; Haris, K.; Harms, J.; Harry, G.âM.; Harry, I.âW.; Hartwig, D.; Haskell, B.; Hasskew, R.âK.; Haster, C.-J.; Haughian, K.; Hayes, F.âJ.; Healy, J.; Heidmann, A.; Heidt, A.; Heintze, M.âC.; Heinze, J.; Heinzel, J.; Heitmann, H.; Hellman, F.; Hello, P.; Helmling-Cornell, A.âF.; Hemming, G.; Hendry, M.; Heng, I.âS.; Hennes, E.; Hennig, J.; Hennig, M.âH.; Hernandez, A.âG.; Vivanco, F. Hernandez; Heurs, M.; Hild, S.; Hill, P.; Hines, A.âS.; Hochheim, S.; Hofman, D.; Hohmann, J.âN.; Holcomb, D.âG.; Holland, N.âA.; Hollows, I.âJ.; Holmes, Z.âJ.; Holt, K.; Holz, D.âE.; Hopkins, P.; Hough, J.; Hourihane, S.; Howell, E.âJ.; Hoy, C.âG.; Hoyland, D.; Hreibi, A.; Hsu, Y.; Huang, Y.; HĂŒbner, M.âT.; Huddart, A.âD.; Hughey, B.; Hui, V.; Husa, S.; Huttner, S.âH.; Huxford, R.; Huynh-Dinh, T.; Idzkowski, B.; Iess, A.; Ingram, C.; Isi, M.; Isleif, K.; Iyer, B.âR.; JaberianHamedan, V.; Jacqmin, T.; Jadhav, S.âJ.; Jadhav, S.âP.; James, A.âL.; Jan, A.âZ.; Jani, K.; Janquart, J.; Janssens, K.; Janthalur, N.âN.; Jaranowski, P.; Jariwala, D.; Jaume, R.; Jenkins, A.âC.; Jenner, K.; Jeunon, M.; Jia, W.; Johns, G.âR.; Jones, A.âW.; Jones, D.âI.; Jones, J.âD.; Jones, P.; Jones, R.; Jonker, R.âJ.âG.; Ju, L.; Junker, J.; Juste, V.; Kalaghatgi, C.âV.; Kalogera, V.; Kamai, B.; Kandhasamy, S.; Kang, G.; Kanner, J.âB.; Kao, Y.; Kapadia, S.âJ.; Kapasi, D.âP.; Karat, S.; Karathanasis, C.; Karki, S.; Kashyap, R.; Kasprzack, M.; Kastaun, W.; Katsanevas, S.; Katsavounidis, E.; Katzman, W.; Kaur, T.; Kawabe, K.; KĂ©fĂ©lian, F.; Keitel, D.; Key, J.âS.; Khadka, S.; Khalili, F.âY.; Khan, S.; Khazanov, E.âA.; Khetan, N.; Khursheed, M.; Kijbunchoo, N.; Kim, C.; Kim, J.âC.; Kim, K.; Kim, W.âS.; Kim, Y.-M.; Kimball, C.; Kinley-Hanlon, M.; Kirchhoff, R.; Kissel, J.âS.; Kleybolte, L.; Klimenko, S.; Knee, A.âM.; Knowles, T.âD.; Knyazev, E.; Koch, P.; Koekoek, G.; Koley, S.; Kolitsidou, P.; Kolstein, M.; Komori, K.; Kondrashov, V.; Kontos, A.; Koper, N.; Korobko, M.; Kovalam, M.; Kozak, D.âB.; Kringel, V.; Krishnendu, N.âV.; KrĂłlak, A.; Kuehn, G.; Kuei, F.; Kuijer, P.; Kumar, A.; Kumar, P.; Kumar, Rahul; Kumar, Rakesh; Kuns, K.; Kuwahara, S.; Lagabbe, P.; Laghi, D.; Lalande, E.; Lam, T.âL.; Lamberts, A.; Landry, M.; Lane, B.âB.; Lang, R.âN.; Lange, J.; Lantz, B.; La Rosa, I.; Lartaux-Vollard, A.; Lasky, P.âD.; Laxen, M.; Lazzarini, A.; Lazzaro, C.; Leaci, P.; Leavey, S.; Lecoeuche, Y.âK.; Lee, H.âM.; Lee, H.âW.; Lee, J.; Lee, K.; Lehmann, J.; LemaĂźtre, A.; Leroy, N.; Letendre, N.; Levesque, C.; Levin, Y.; Leviton, J.âN.; Leyde, K.; Li, A.âK.âY.; Li, B.; Li, J.; Li, T.âG.âF.; Li, X.; Linde, F.; Linker, S.âD.; Linley, J.âN.; Littenberg, T.âB.; Liu, J.; Liu, K.; Liu, X.; Llamas, F.; Llorens-Monteagudo, M.; Lo, R.âK.âL.; Lockwood, A.; London, L.âT.; Longo, A.; Lopez, D.; Portilla, M. Lopez; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lott, T.âP.; Lough, J.âD.; Lousto, C.âO.; Lovelace, G.; Lucaccioni, J.âF.; LĂŒck, H.; Lumaca, D.; Lundgren, A.âP.; Lynam, J.âE.; Macas, R.; MacInnis, M.; Macleod, D.âM.; MacMillan, I.âA.âO.; Macquet, A.; Hernandez, I. Magaña; MagazzĂč, C.; Magee, R.âM.; Maggiore, R.; Magnozzi, M.; Mahesh, S.; Majorana, E.; Makarem, C.; Maksimovic, I.; Maliakal, S.; Malik, A.; Man, N.; Mandic, V.; Mangano, V.; Mango, J.âL.; Mansell, G.âL.; Manske, M.; Mantovani, M.; Mapelli, M.; Marchesoni, F.; Marion, F.; Mark, Z.; MĂĄrka, S.; MĂĄrka, Z.; Markakis, C.; Markosyan, A.âS.; Markowitz, A.; Maros, E.; Marquina, A.; Marsat, S.; Martelli, F.; Martin, I.âW.; Martin, R.âM.; Martinez, M.; Martinez, V.âA.; Martinez, V.; Martinovic, K.; Martynov, D.âV.; Marx, E.âJ.; Masalehdan, H.; Mason, K.; Massera, E.; Masserot, A.; Massinger, T.âJ.; Masso-Reid, M.; Mastrogiovanni, S.; Matas, A.; Mateu-Lucena, M.; Matichard, F.; Matiushechkina, M.; Mavalvala, N.; McCann, J.âJ.; McCarthy, R.; McClelland, D.âE.; McClincy, P.âK.; McCormick, S.; McCuller, L.; McGhee, G.âI.; McGuire, S.âC.; McIsaac, C.; McIver, J.; McRae, T.; McWilliams, S.âT.; Meacher, D.; Mehmet, M.; Mehta, A.âK.; Meijer, Q.; Melatos, A.; Melchor, D.âA.; Mendell, G.; Menendez-Vazquez, A.; Menoni, C.âS.; Mercer, R.âA.; Mereni, L.; Merfeld, K.; Merilh, E.âL.; Merritt, J.âD.; Merzougui, M.; Meshkov, S.; Messenger, C.; Messick, C.; Meyers, P.âM.; Meylahn, F.; Mhaske, A.; Miani, A.; Miao, H.; Michaloliakos, I.; Michel, C.; Middleton, H.; Milano, L.; Miller, A.; Miller, A.âL.; Miller, B.; Millhouse, M.; Mills, J.âC.; Milotti, E.; Minazzoli, O.; Minenkov, Y.; Mir, Ll.âM.; Miravet-TenĂ©s, M.; Mishra, C.; Mishra, T.; Mistry, T.; Mitra, S.; Mitrofanov, V.âP.; Mitselmakher, G.; Mittleman, R.; Mo, Geoffrey; Moguel, E.; Mogushi, K.; Mohapatra, S.âR.âP.; Mohite, S.âR.; Molina, I.; Molina-Ruiz, M.; Mondin, M.; Montani, M.; Moore, C.âJ.; Moraru, D.; Morawski, F.; More, A.; Moreno, C.; Moreno, G.; Morisaki, S.; Mours, B.; Mow-Lowry, C.âM.; Mozzon, S.; Muciaccia, F.; Mukherjee, Arunava; Mukherjee, D.; Mukherjee, Soma; Mukherjee, Subroto; Mukherjee, Suvodip; Mukund, N.; Mullavey, A.; Munch, J.; Muñiz, E.âA.; Murray, P.âG.; Musenich, R.; Muusse, S.; Nadji, S.âL.; Nagar, A.; Napolano, V.; Nardecchia, I.; Naticchioni, L.; Nayak, B.; Nayak, R.âK.; Neil, B.âF.; Neilson, J.; Nelemans, G.; Nelson, T.âJ.âN.; Nery, M.; Neubauer, P.; Neunzert, A.; Ng, K.âY.; Ng, S.âW.âS.; Nguyen, C.; Nguyen, P.; Nguyen, T.; Nichols, S.âA.; Nissanke, S.; Nitoglia, E.; Nocera, F.; Norman, M.; North, C.; Nuttall, L.âK.; Oberling, J.; OâBrien, B.âD.; OâDell, J.; Oelker, E.; Oganesyan, G.; Oh, J.âJ.; Oh, S.âH.; Ohme, F.; Ohta, H.; Okada, M.âA.; Olivetto, C.; Oram, R.; OâReilly, B.; Ormiston, R.âG.; Ormsby, N.âD.; Ortega, L.âF.; OâShaughnessy, R.; OâShea, E.; Ossokine, S.; Osthelder, C.; Ottaway, D.âJ.; Overmier, H.; Pace, A.âE.; Pagano, G.; Page, M.âA.; Pagliaroli, G.; Pai, A.; Pai, S.âA.; Palamos, J.âR.; Palashov, O.; Palomba, C.; Pan, H.; Panda, P.âK.; Pang, P.âT.âH.; Pankow, C.; Pannarale, F.; Pant, B.âC.; Panther, F.âH.; Paoletti, F.; Paoli, A.; Paolone, A.; Park, H.; Parker, W.; Pascucci, D.; Pasqualetti, A.; Passaquieti, R.; Passuello, D.; Patel, M.; Pathak, M.; Patricelli, B.; Patron, A.âS.; Paul, S.; Payne, E.; Pedraza, M.; Pegoraro, M.; Pele, A.; Penn, S.; Perego, A.; Pereira, A.; Pereira, T.; Perez, C.âJ.; PĂ©rigois, C.; Perkins, C.âC.; Perreca, A.; PerriĂšs, S.; Petermann, J.; Petterson, D.; Pfeiffer, H.âP.; Pham, K.âA.; Phukon, K.âS.; Piccinni, O.âJ.; Pichot, M.; Piendibene, M.; Piergiovanni, F.; Pierini, L.; Pierro, V.; Pillant, G.; Pillas, M.; Pilo, F.; Pinard, L.; Pinto, I.âM.; Pinto, M.; Piotrzkowski, K.; Pirello, M.; Pitkin, M.âD.; Placidi, E.; Planas, L.; Plastino, W.; Pluchar, C.; Poggiani, R.; Polini, E.; Pong, D.âY.âT.; Ponrathnam, S.; Popolizio, P.; Porter, E.âK.; Poulton, R.; Powell, J.; Pracchia, M.; Pradier, T.; Prajapati, A.âK.; Prasai, K.; Prasanna, R.; Pratten, G.; Principe, M.; Prodi, G.âA.; Prokhorov, L.; Prosposito, P.; Prudenzi, L.; Puecher, A.; Punturo, M.; Puosi, F.; Puppo, P.; PĂŒrrer, M.; Qi, H.; Quetschke, V.; Quitzow-James, R.; Raab, F.âJ.; Raaijmakers, G.; Radkins, H.; Radulesco, N.; Raffai, P.; Rail, S.âX.; Raja, S.; Rajan, C.; Ramirez, K.âE.; Ramirez, T.âD.; Ramos-Buades, A.; Rana, J.; Rapagnani, P.; Rapol, U.âD.; Ray, A.; Raymond, V.; Raza, N.; Razzano, M.; Read, J.; Rees, L.âA.; Regimbau, T.; Rei, L.; Reid, S.; Reid, S.âW.; Reitze, D.âH.; Relton, P.; Renzini, A.; Rettegno, P.; Rezac, M.; Ricci, F.; Richards, D.; Richardson, J.âW.; Richardson, L.; Riemenschneider, G.; Riles, K.; Rinaldi, S.; Rink, K.; Rizzo, M.; Robertson, N.âA.; Robie, R.; Robinet, F.; Rocchi, A.; Rodriguez, S.; Rolland, L.; Rollins, J.âG.; Romanelli, M.; Romano, R.; Romel, C.âL.; Romero-RodrĂguez, A.; Romero-Shaw, I.âM.; Romie, J.âH.; Ronchini, S.; Rosa, L.; Rose, C.âA.; RosiĆska, D.; Ross, M.âP.; Rowan, S.; Rowlinson, S.âJ.; Roy, S.; Roy, Santosh; Roy, Soumen; Rozza, D.; Ruggi, P.; Ryan, K.; Sachdev, S.; Sadecki, T.; Sadiq, J.; Sakellariadou, M.; Salafia, O.âS.; Salconi, L.; Saleem, M.; Salemi, F.; Samajdar, A.; Sanchez, E.âJ.; Sanchez, J.âH.; Sanchez, L.âE.; Sanchis-Gual, N.; Sanders, J.âR.; Sanuy, A.; Saravanan, T.âR.; Sarin, N.; Sassolas, B.; Satari, H.; Sathyaprakash, B.âS.; Sauter, O.; Savage, R.âL.; Sawant, D.; Sawant, H.âL.; Sayah, S.; Schaetzl, D.; Scheel, M.; Scheuer, J.; Schiworski, M.; Schmidt, P.; Schmidt, S.; Schnabel, R.; Schneewind, M.; Schofield, R.âM.âS.; Schönbeck, A.; Schulte, B.âW.; Schutz, B.âF.; Schwartz, E.; Scott, J.; Scott, S.âM.; Seglar-Arroyo, M.; Sellers, D.; Sengupta, A.âS.; Sentenac, D.; Seo, E.âG.; Sequino, V.; Sergeev, A.; Setyawati, Y.; Shaffer, T.; Shahriar, M.âS.; Shams, B.; Sharma, A.; Sharma, P.; Shawhan, P.; Shcheblanov, N.âS.; Shikauchi, M.; Shoemaker, D.âH.; Shoemaker, D.âM.; ShyamSundar, S.; Sieniawska, M.; Sigg, D.; Singer, L.âP.; Singh, D.; Singh, N.; Singha, A.; Sintes, A.âM.; Sipala, V.; Skliris, V.; Slagmolen, B.âJ.âJ.; Slaven-Blair, T.âJ.; Smetana, J.; Smith, J.âR.; Smith, R.âJ.âE.; Soldateschi, J.; Somala, S.âN.; Son, E.âJ.; Soni, K.; Soni, S.; Sordini, V.; Sorrentino, F.; Sorrentino, N.; Soulard, R.; Souradeep, T.; Sowell, E.; Spagnuolo, V.; Spencer, A.âP.; Spera, M.; Srinivasan, R.; Srivastava, A.âK.; Srivastava, V.; Staats, K.; Stachie, C.; Steer, D.âA.; Steinlechner, J.; Steinlechner, S.; Stops, D.âJ.; Stover, M.; Strain, K.âA.; Strang, L.âC.; Stratta, G.; Strunk, A.; Sturani, R.; Stuver, A.âL.; Sudhagar, S.; Sudhir, V.; Suh, H.âG.; Summerscales, T.âZ.; Sun, H.; Sun, L.; Sunil, S.; Sur, A.; Suresh, J.; Sutton, P.âJ.; Swinkels, B.âL.; SzczepaĆczyk, M.âJ.; Szewczyk, P.; Tacca, M.; Tait, S.âC.; Talbot, C.âJ.; Talbot, C.; Tanasijczuk, A.âJ.; Tanner, D.âB.; Tao, D.; Tao, L.; MartĂn, E.âN. Tapia San; Taranto, C.; Tasson, J.âD.; Tenorio, R.; Terhune, J.âE.; Terkowski, L.; Thirugnanasambandam, M.âP.; Thomas, M.; Thomas, P.; Thompson, J.âE.; Thondapu, S.âR.; Thorne, K.âA.; Thrane, E.; Tiwari, Shubhanshu; Tiwari, Srishti; Tiwari, V.; Toivonen, A.âM.; Toland, K.; Tolley, A.âE.; Tonelli, M.; Torres-FornĂ©, A.; Torrie, C.âI.; e Melo, I. Tosta; TöyrĂ€, D.; Trapananti, A.; Travasso, F.; Traylor, G.; Trevor, M.; Tringali, M.âC.; Tripathee, A.; Troiano, L.; Trovato, A.; Trozzo, L.; Trudeau, R.âJ.; Tsai, D.âS.; Tsai, D.; Tsang, K.âW.; Tse, M.; Tso, R.; Tsukada, L.; Tsuna, D.; Tsutsui, T.; Turbang, K.; Turconi, M.; Ubhi, A.âS.; Udall, R.âP.; Ueno, K.; Unnikrishnan, C.âS.; Urban, A.âL.; Utina, A.; Vahlbruch, H.; Vajente, G.; Vajpeyi, A.; Valdes, G.; Valentini, M.; Valsan, V.; van Bakel, N.; van Beuzekom, M.; van den Brand, J.âF.âJ.; Van Den Broeck, C.; Vander-Hyde, D.âC.; van der Schaaf, L.; van Heijningen, J.âV.; Vanosky, J.; van Remortel, N.; Vardaro, M.; Vargas, A.âF.; Varma, V.; VasĂșth, M.; Vecchio, A.; Vedovato, G.; Veitch, J.; Veitch, P.âJ.; Venneberg, J.; Venugopalan, G.; Verkindt, D.; Verma, P.; Verma, Y.; Veske, D.; Vetrano, F.; Vicere', Andrea; Vidyant, S.; Viets, A.âD.; Vijaykumar, A.; Villa-Ortega, V.; Vinet, J.-Y.; Virtuoso, A.; Vitale, S.; Vo, T.; Vocca, H.; von Reis, E.âR.âG.; von Wrangel, J.âS.âA.; Vorvick, C.; Vyatchanin, S.âP.; Wade, L.âE.; Wade, M.; Wagner, K.âJ.; Walet, R.âC.; Walker, M.; Wallace, G.âS.; Wallace, L.; Walsh, S.; Wang, J.âZ.; Wang, W.âH.; Ward, R.âL.; Warner, J.; Was, M.; Washington, N.âY.; Watchi, J.; Weaver, B.; Webster, S.âA.; Weinert, M.; Weinstein, A.âJ.; Weiss, R.; Weldon, G.; Weller, C.âM.; Wellmann, F.; Wen, L.; WeĂels, P.; Wette, K.; Whelan, J.âT.; White, D.âD.; Whiting, B.âF.; Whittle, C.; Wilken, D.; Williams, D.; Williams, M.âJ.; Williamson, A.âR.; Willis, J.âL.; Willke, B.; Wilson, D.âJ.; Winkler, W.; Wipf, C.âC.; Wlodarczyk, T.; Woan, G.; Woehler, J.; Wofford, J.âK.; Wong, I.âC.âF.; Wu, D.âS.; Wysocki, D.âM.; Xiao, L.; Yamamoto, H.; Yang, F.âW.; Yang, L.; Yang, Yang; Yang, Z.; Yap, M.âJ.; Yeeles, D.âW.; Yelikar, A.âB.; Ying, M.; Yoo, J.; Yu, Hang; Yu, Haocun; ZadroĆŒny, A.; Zanolin, M.; Zelenova, T.; Zendri, J.-P.; Zevin, M.; Zhang, J.; Zhang, L.; Zhang, T.; Zhang, Y.; Zhao, C.; Zhao, G.; Zhao, Yue; Zhou, R.; Zhou, Z.; Zhu, X.âJ.; Zimmerman, A.âB.; Zucker, M.âE.; Zweizig, J.Abbott, R.; Abbott, T. âD.; Acernese, F.; Ackley, K.; Adams, C.; Adhikari, N.; Adhikari, R. âX.; Adya, V. âB.; Affeldt, C.; Agarwal, D.; Agathos, M.; Agatsuma, K.; Aggarwal, N.; Aguiar, O. âD.; Aiello, L.; Ain, A.; Ajith, P.; Albanesi, S.; Allocca, A.; Altin, P. âA.; Amato, A.; Anand, C.; Anand, S.; Ananyeva, A.; Anderson, S. âB.; Anderson, W. âG.; Andrade, T.; Andres, N.; AndriÄ, T.; Angelova, S. âV.; Ansoldi, S.; Antelis, J. âM.; Antier, S.; Appert, S.; Arai, K.; Araya, M. âC.; Areeda, J. âS.; ArĂšne, M.; Arnaud, N.; Aronson, S. âM.; Arun, K. âG.; Asali, Y.; Ashton, G.; Assiduo, M.; Aston, S. âM.; Astone, P.; Aubin, F.; Austin, C.; Babak, S.; Badaracco, F.; Bader, M. âK. âM.; Badger, C.; Bae, S.; Baer, A. âM.; Bagnasco, S.; Bai, Y.; Baird, J.; Ball, M.; Ballardin, G.; Ballmer, S. âW.; Balsamo, A.; Baltus, G.; Banagiri, S.; Bankar, D.; Barayoga, J. âC.; Barbieri, C.; Barish, B. âC.; Barker, D.; Barneo, P.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barta, D.; Bartlett, J.; Barton, M. âA.; Bartos, I.; Bassiri, R.; Basti, A.; Bawaj, M.; Bayley, J. âC.; Baylor, A. âC.; Bazzan, M.; BĂ©csy, B.; Bedakihale, V. âM.; Bejger, M.; Belahcene, I.; Benedetto, V.; Beniwal, D.; Bennett, T. âF.; Bentley, J. âD.; Benyaala, M.; Bergamin, F.; Berger, B. âK.; Bernuzzi, S.; Bersanetti, D.; Bertolini, A.; Betzwieser, J.; Beveridge, D.; Bhandare, R.; Bhardwaj, U.; Bhattacharjee, D.; Bhaumik, S.; Bilenko, I. âA.; Billingsley, G.; Bini, S.; Birney, R.; Birnholtz, O.; Biscans, S.; Bischi, M.; Biscoveanu, S.; Bisht, A.; Biswas, B.; Bitossi,
The population of merging compact binaries inferred using gravitational waves through GWTC-3
We report on the population properties of 76 compact binary mergers detected with gravitational waves below a false alarm rate of 1 per year through GWTC-3. The catalog contains three classes of binary mergers: BBH, BNS, and NSBH mergers. We infer the BNS merger rate to be between 10 and 1700 and the NSBH merger rate to be between 7.8 and 140 , assuming a constant rate density versus comoving volume and taking the union of 90% credible intervals for methods used in this work. Accounting for the BBH merger rate to evolve with redshift, we find the BBH merger rate to be between 17.9 and 44 at a fiducial redshift (z=0.2). We obtain a broad neutron star mass distribution extending from to . We can confidently identify a rapid decrease in merger rate versus component mass between neutron star-like masses and black-hole-like masses, but there is no evidence that the merger rate increases again before 10 . We also find the BBH mass distribution has localized over- and under-densities relative to a power law distribution. While we continue to find the mass distribution of a binary's more massive component strongly decreases as a function of primary mass, we observe no evidence of a strongly suppressed merger rate above . The rate of BBH mergers is observed to increase with redshift at a rate proportional to with for . Observed black hole spins are small, with half of spin magnitudes below . We observe evidence of negative aligned spins in the population, and an increase in spin magnitude for systems with more unequal mass ratio
Constraints on dark photon dark matter using data from LIGO's and Virgo's third observing run
We present a search for dark photon dark matter that could couple to
gravitational-wave interferometers using data from Advanced LIGO and Virgo's
third observing run. To perform this analysis, we use two methods, one based on
cross-correlation of the strain channels in the two nearly aligned LIGO
detectors, and one that looks for excess power in the strain channels of the
LIGO and Virgo detectors. The excess power method optimizes the Fourier
Transform coherence time as a function of frequency, to account for the
expected signal width due to Doppler modulations. We do not find any evidence
of dark photon dark matter with a mass between eV/, which corresponds to frequencies between 10-2000
Hz, and therefore provide upper limits on the square of the minimum coupling of
dark photons to baryons, i.e. dark matter. For the
cross-correlation method, the best median constraint on the squared coupling is
at eV/; for the
other analysis, the best constraint is at eV/. These limits improve upon those obtained
in direct dark matter detection experiments by a factor of for
eV/, and are, in absolute terms, the
most stringent constraint so far in a large mass range eV/.Comment: 20 pages, 7 figure
- âŠ