Mineralogy and composition of Archean Crust, Greenland: A pilot study

The Portable Instant Display and Analysis Spectrometer (PIDAS) was taken to southwestern Greenland to investigate in situ the potential application of AVIRIS to estimate the mineralogy and composition of rocks exposed in Archean terranes. The goal was to determine the feasibility of using a high spectral resolution scanner to find and study pristine rocks, those that have not been altered by subsequent deformation and metamorphism. The application of AVIRIS data to the problems in Greenland is logical. However, before a costly deployment of the U-2 aircraft to Greenland is proposed, this study was undertaken to acquire the spectral data necessary to verify that mineralogical mapping in the environmental conditions found there is possible. Although field conditions were far from favorable, all of the major objectives of the study were addressed. One of the major concerns was that lichens would obscure the rock surfaces. It was found that the spectral signature of the lichens was distinct from the underlying rocks. Thus, a spectrum of a rock outcrop, with its partial cover of lichens, can be un-mixed into rock and lichen components. The data acquired during the course of this study supports the conclusion that areas of pristine Archean crust can be differentiated from that which has experienced low grade alteration associated with Proterizoic faulting

Upper mantle anisotropy beneath Australia and Tahiti from P wave polarization: Implications for real-time earthquake location

International audienceWe report measurements of long-period P wave polarization (P pol) in Australia and Tahiti made by combining modeling of the polarization deviation and harmonic analysis. The analysis of the deviation of the horizontal polarization of the P wave as a function of event back azimuth may be used to obtain information about (1) sensor misorientation, (2) dipping discontinuities, (3) seismic anisotropy, and (4) velocity heterogeneities beneath a seismic station. The results from harmonic analysis and a grid search using Snell's law suggest the presence of a dipping seismic discontinuity beneath stations CTAO and CAN in Australia. These results are consistent with published receiver function studies for these stations. The P pol fast axis orientation is close to the N–S absolute plate motion direction at station TAU (Tasmania), which may be due to plate-motion-driven alignment of olivine crystals in the asthenosphere. Interestingly, measurements of SKS splitting at Tahiti (French Polynesia) show an apparent isotropy, whereas an inversion of P pol observations at PPTL seismic station located in Tahiti suggests the presence of two anisotropic layers. The fast axis azimuth is oriented E–W in the upper layer, and it is close to the NW–SE orientation in the lower layer. Since P pol orientations are used for real-time earthquake locations, especially in poorly instrumented areas such as the South Pacific, we show that the bias from anisotropy and sensor misorientation determined here can be corrected to improve the location accuracy, which yields fundamental data for rapid location necessary for effective tsunami warning

Accurate measurement of the time delay in the response of the LIGO gravitational wave detectors

We present a method to precisely calibrate the time delay in a long baseline gravitational-wave interferometer. An accurate time stamp is crucial for data analysis of gravitational wave detectors, especially when performing coincidence and correlation analyses between multiple detectors. Our method uses an intensity-modulated radiation pressure force to actuate on the mirrors. The time delay is measured by comparing the phase of the signal at the actuation point with the phase of the recorded signal within the calibrated data stream used for gravitational wave searches. Because the signal-injection path is independent of the interferometer's control system, which is used for the standard calibration, this method can be an independent verification of the timing error in the system. A measurement performed with the 4 km interferometer at the LIGO Hanford Observatory shows a 1 µs relative accuracy when averaging over 50 min. Our understanding of the systematic time delay in the detector response has reached the level of 10 µs

On the magnetic characteristics of magnetic holes in the solar wind between Mercury and Venus

The occurrence rate of linear and pseudo magnetic holes has been determined during MESSENGER's cruise phase starting from Venus (2007) and arriving at Mercury (2011). It is shown that the occurrence rate of linear magnetic holes, defined as a maximum of 10∘ rotation of the magnetic field over the hole, slowly decreases from Mercury to Venus. The pseudo magnetic holes, defined as a rotation between 10 and 45∘ over the hole, have mostly a constant occurrence rate

Antibiotic stewardship implementation and patient-level antibiotic use at hospitals with and without on-site Infectious Disease specialists.

Many US hospitals lack Infectious Disease (ID) specialists, which may hinder antibiotic stewardship efforts. We sought to compare patient-level antibiotic exposure at Veterans Health Administration (VHA) hospitals with and without an on-site ID specialist, defined as an ID physician and/or ID pharmacist. This retrospective VHA cohort included all acute-care patient-admissions during 2016. A mandatory survey was used to identify hospitals' antibiotic stewardship processes and their access to an on-site ID specialist. Antibiotic use was quantified as days of therapy (DOT) per days-present and categorized based on National Healthcare Safety Network definitions. A negative binomial regression model with risk adjustment was used to determine the association between presence of an on-site ID specialist and antibiotic use at the level of patient-admissions. Eighteen of 122 (14.8%) hospitals lacked an on-site ID specialist; there were 525,451 (95.8%) admissions at ID hospitals and 23,007 (4.2%) at non-ID sites. In the adjusted analysis, presence of an ID specialist was associated with lower total inpatient antibacterial use [OR 0.92, (95% CI, 0.85-0.99)]. Presence of an ID specialist was also associated with lower use of broad-spectrum antibacterials [OR 0.61 (95% CI, 0.54-0.70)] and higher narrow-spectrum beta-lactam use [OR 1.43 (95% CI, 1.22-1.67)]. Total antibacterial exposure (inpatient plus post-discharge) was lower among patients at ID versus non-ID sites [OR 0.92 (95% CI, 0.86-0.99)]. Patients at hospitals with an ID specialist received antibiotics in a way more consistent with stewardship principles. The presence of an ID specialist may be important to effective antibiotic stewardship

Antibiotic Stewardship Implementation and Antibiotic Use at Hospitals With and Without On-site Infectious Disease Specialists.

BackgroundMany US hospitals lack infectious disease (ID) specialists, which may hinder antibiotic stewardship efforts. We sought to compare patient-level antibiotic exposure at Veterans Health Administration (VHA) hospitals with and without an on-site ID specialist, defined as an ID physician and/or ID pharmacist.MethodsThis retrospective VHA cohort included all acute-care patient admissions during 2016. A mandatory survey was used to identify hospitals' antibiotic stewardship processes and their access to an on-site ID specialist. Antibiotic use was quantified as days of therapy per days present and categorized based on National Healthcare Safety Network definitions. A negative binomial regression model with risk adjustment was used to determine the association between presence of an on-site ID specialist and antibiotic use at the level of patient admissions.ResultsEighteen of 122 (14.8%) hospitals lacked an on-site ID specialist; there were 525 451 (95.8%) admissions at ID hospitals and 23 007 (4.2%) at non-ID sites. In the adjusted analysis, presence of an ID specialist was associated with lower total inpatient antibacterial use (odds ratio, 0.92; 95% confidence interval, .85-.99). Presence of an ID specialist was also associated with lower use of broad-spectrum antibacterials (0.61; .54-.70) and higher narrow-spectrum β-lactam use (1.43; 1.22-1.67). Total antibacterial exposure (inpatient plus postdischarge) was lower among patients at ID versus non-ID sites (0.92; .86-.99).ConclusionsPatients at hospitals with an ID specialist received antibiotics in a way more consistent with stewardship principles. The presence of an ID specialist may be important to effective antibiotic stewardship

Resource Land Loss and Forest Vulnerability in the Chesapeake Bay Watershed

The contemporary pattern of urban development in industrialized countries is increasingly taking the form of low density, decentralized residential and commercial development. In the Chesapeake Bay watershed, which is located within the mid-Atlantic region of the United States, dispersed development patterns have been linked to habitat fragmentation and declining water quality. Our objectives were to document how this urbanization process has expanded throughout the watershed and to explore how lands comprising the natural resource base, particularly forests, have been replaced by a matrix of the built environment

Size-fractionated characterization and quantification of nanoparticle release rates from a consumer spray product containing engineered nanoparticles

This study describes methods developed for reliable quantification of size- and element-specific release of engineered nanoparticles (ENP) from consumer spray products. A modified glove box setup was designed to allow controlled spray experiments in a particle-minimized environment. Time dependence of the particle size distribution in a size range of 10-500nm and ENP release rates were studied using a scanning mobility particle sizer (SMPS). In parallel, the aerosol was transferred to a size-calibrated electrostatic TEM sampler. The deposited particles were investigated using electron microscopy techniques in combination with image processing software. This approach enables the chemical and morphological characterization as well as quantification of released nanoparticles from a spray product. The differentiation of solid ENP from the released nano-sized droplets was achieved by applying a thermo-desorbing unit. After optimization, the setup was applied to investigate different spray situations using both pump and gas propellant spray dispensers for a commercially available water-based nano-silver spray. The pump spray situation showed no measurable nanoparticle release, whereas in the case of the gas spray, a significant release was observed. From the results it can be assumed that the homogeneously distributed ENP from the original dispersion grow in size and change morphology during and after the spray process but still exist as nanometer particles of size <100nm. Furthermore, it seems that the release of ENP correlates with the generated aerosol droplet size distribution produced by the spray vessel type used. This is the first study presenting results concerning the release of ENP from spray product

GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease

BackgroundAgonism at the receptor for the glucose-dependent insulinotropic polypeptide (GIPR) is a key component of the novel unimolecular GIPR:GLP-1R co-agonists, which are among the most promising drugs in clinical development for the treatment of obesity and type 2 diabetes. The therapeutic effect of chronic GIPR agonism to treat dyslipidemia and thus to reduce the cardiovascular disease risk independently of body weight loss has not been explored yet.MethodsAfter 8 weeks on western diet, LDL receptor knockout (LDLR-/-) male mice were treated with daily subcutaneous injections of long-acting acylated GIP analog (acyl-GIP;10nmol/kg body weight) for 28 days. Body weight, food intake, whole-body composition were monitored throughout the study. Fasting blood glucose and intraperitoneal glucose tolerance test (ipGTT) were determined on day 21 of the study. Circulating lipid levels, lipoprotein profiles and atherosclerotic lesion size was assessed at the end of the study. Acyl-GIP effects on fat depots were determined by histology and transcriptomics.ResultsHerein we found that treatment with acyl-GIP reduced dyslipidemia and atherogenesis in male LDLR-/- mice. Acyl-GIP administration resulted in smaller adipocytes within the inguinal fat depot and RNAseq analysis of the latter revealed that acyl-GIP may improve dyslipidemia by directly modulating lipid metabolism in this fat depot.ConclusionsThis study identified an unanticipated efficacy of chronic GIPR agonism to improve dyslipidemia and cardiovascular disease independently of body weight loss, indicating that treatment with acyl-GIP may be a novel approach to alleviate cardiometabolic disease