Evaluation of systems for delivering Rumensin to cattle on pasture

Two trials, involving 40 yearling steers at the University of Tennessee Blount Farm and 60 yearling heifers at Ames Plantation were conducted to evaluate two methods of delivering monensin sodium (Rumensin) to cattle grazing pasture. Salt and a salt-cottonseed meal mixture, each containing ICQ mg of Rumensin per oz, were fed free-choice and salt intake, Rumensin intake and animal performance were compared to that of cattle fed salt free-choice. Average daily consumption of Rumensin was about.70 mg per animal per day in both trials when mixed with loose salt at the rate of 100 mg per oz. Average daily consumption was 111 mg per animal when suppled at the rate of 100 mg per oz of a salt-cottonseed meal mixture (1:1) at Ames Plantation. Average daily salt and Rumensin intake (calculated on a moisutre constant basis) varied from week to week and tended to increase as elapsed days of supplementation increased. Increasing the Rumensin level in the carriers from 100 to 200 mg per oz during the latter periods of the trial increased (P \u3c .05) Rumensin intake. However, salt consumption of cattle consuming the salt-cottonseed meal Rumensin mixture was decreased. Rate of gain was similar for the control animals and the Rumensin-supplemented animals in the Blount trial (P \u3e .05). However, Rumensin supplemented animals increased in weight slower (P \u3c .05) than the control animals at Ames Plantation. Two questions with respect to efficacy of these two mixtures as delivery systems for Rumensin to cattle on pasture were identified in this study. If variation of daily Rumensin intake inhibits the ability of Rumensin to change rumen VFA proportions, this addition of Rumensin to salt as a method of delivering Rumensin to cattle on pasture may not be satisfactory. Higher levels of cottonseed-meal may result in a more palatable mixture and increased Rumensin intake, but the effect of such mixtures on salt consumption needs study. In this study, Rumensin intake using either of the two delivery systems (salt + Rumensin and salt + cottonseed meal + Rumensin) was within the effective dosage level (50 to 200 mg per animal per day). When the Rumensin content was increased to 200 mg per oz of carrier, average daily intake was within the range of the most efficient dosage level (100 to 200 mg per animal per day) which was observed when.daily intake was controlled

SP701-A-Growing and Harvesting Switchgrass for Ethanol Production in Tennessee

Switchgrass is a warm-season perennial grass native to North America. The plant can reach heights up to 10 feet with an extensive root system. Once established, switchgrass well-managed for biomass should have a productive life of 10-20 years. Within the stand, switchgrass is an extremely strong competitor. However, it is not considered an invasive plant. Switchgrass adapts well to a variety of soil and climatic conditions. It is most productive on moderately well to well-drained soils of medium fertility and a soil pH at 5.0 or above. The high cellulosic content of switchgrass makes it a favorable feedstock for ethanol production. It is anticipated that switchgrass can yield sufficient biomass to produce approximately 500 gallons of ethanol per acre. While the Tennessee Biofuels Initiative includes a demonstration plant to make ethanol from switchgrass, the market for switchgrass as an energy crop remains limited. Producers will likely need to be located within 30 to 50 miles of a cellulosic ethanol plant. Producing switchgrass for energy generally occurs under some form of contractual arrangement with the end-user. To reap potential benefits from using switchgrass for cellulosic ethanol production, the system of production must be profitable for farmers and energy producers, as well as cost effective for consumers

Hundreds of variants clustered in genomic loci and biological pathways affect human height

Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait. The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P < 0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways.

Early Infant Morbidity in the City of São Paulo, Brazil

BACKGROUND: Early infant morbidities may produce adverse outcomes in subsequent life. A low Apgar score is a convenient measure of early infant morbidity. We study determinants of early infant morbidity (sex, plurality, mode of delivery, prior losses, gestational age, prenatal care and birth weight, parity and maternal age, race, maternal education and community development) for the 1998-birth cohort, City of São Paulo, Brazil. METHODS: This study identified all deliveries that took place in the City of São Paulo during 1998. Information was extracted from 209,628 birth records. We used multivariate logistic regression to assess the effect of each independent variable on Apgar score less than seven at one minute and Apgar score less than seven at five minutes. RESULTS: Low birth weight, prematurity and community development were found to be strong predictors of morbidity. Maternal education showed strong negative correlation with both Apgar scores. The negative correlations between maternal schooling and Apgar scores were observed after prenatal care, parity and maternal age were included in the model. Unmeasured proximate factors may thus be the true source of disparity between educational groups. Children of very young adolescent mothers had lower Apgar scores at one minute (but not at five minutes) than those born to mothers 15 to 19. Parity one or higher was associated with decreased odds of low Apgar scores. Cesarean section and operative delivery were associated with higher odds of early infant morbidity. CONCLUSION: Education may allow mothers to have better care in the peripartum period. More educated mothers may be more likely to recognize certain morbidities through the pregnancy period and the monitoring of such morbidities yields better infant outcomes. Also, having less than seven prenatal care visits was found to predict early infant morbidity and one way to increase the use of such services is to focus on aspects of care that may lead to easier accessibility and continuity of prenatal care. Physicians should inform mothers about the risks associated with high number of children for a next infant and also about the risks for the infant associated with unnecessary cesarean sections. Special attention should be paid to adolescent mothers, since much of their increased risk is likely to be minimized by counseling

Roadmap on Photovoltaic Absorber Materials for Sustainable Energy Conversion

Photovoltaics (PVs) are a critical technology for curbing growing levels of anthropogenic greenhouse gas emissions, and meeting increases in future demand for low-carbon electricity. In order to fulfil ambitions for net-zero carbon dioxide equivalent (CO2eq) emissions worldwide, the global cumulative capacity of solar PVs must increase by an order of magnitude from 0.9 TWp in 2021 to 8.5 TWp by 2050 according to the International Renewable Energy Agency, which is considered to be a highly conservative estimate. In 2020, the Henry Royce Institute brought together the UK PV community to discuss the critical technological and infrastructure challenges that need to be overcome to address the vast challenges in accelerating PV deployment. Herein, we examine the key developments in the global community, especially the progress made in the field since this earlier roadmap, bringing together experts primarily from the UK across the breadth of the photovoltaics community. The focus is both on the challenges in improving the efficiency, stability and levelized cost of electricity of current technologies for utility-scale PVs, as well as the fundamental questions in novel technologies that can have a significant impact on emerging markets, such as indoor PVs, space PVs, and agrivoltaics. We discuss challenges in advanced metrology and computational tools, as well as the growing synergies between PVs and solar fuels, and offer a perspective on the environmental sustainability of the PV industry. Through this roadmap, we emphasize promising pathways forward in both the short- and long-term, and for communities working on technologies across a range of maturity levels to learn from each other.Comment: 160 pages, 21 figure

17th IEEE Real-Time Systems Symposium: Work in Progress Sessions

The Table of Contents for the workshop is contained in 1996-027-00main.pdfDear Colleagues: This year marks the beginning of a new tradition within the Real-Time Systems Symposium, that of holding special sessions for the presentation of new and on-going projects in real-time systems. The prime purpose of these Work In Progress (WIP) sessions is to provide researchers in Academia and Industry an opportunity to discuss their evolving ideas and gather feedback thereon from the real-time community at large. The idea of holding these sessions is timely, and I am pleased to report that this year RTSS'96 WIP received 22 submissions, of which 14 have been accepted for presentation during the symposium and for inclusion in RTSS'96 WIP proceedings. Many people worked hard to make the idea of holding the WIP sessions a reality. In particular, I would like to thank Sang Son for his hard work in accommodating the WIP sessions within the busy schedule of RTSS'96. Also, I would like to thank all members of the RTSS'96 Program Committee, Al Mok and Doug Locke in particular, for their encouragement and constructive feedback regarding the organization of these sessions. Finally, I would like to thank all those who submitted their work to RTSS'96 WIP and those from RTSS'96 program committee who helped review these submissions. I hope these sessions will prove beneficial, both to the WIP presenters and to RTSS'96 attendees. Azer Bestavros RTSS'96 WIP Chair December 1996.IEEE-CS TC-RT

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P &lt; 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

A global horizon scan of the future impacts of robotics and autonomous systems on urban ecosystems

Technology is transforming societies worldwide. A major innovation is the emergence of robotics and autonomous systems (RAS), which have the potential to revolutionize cities for both people and nature. Nonetheless, the opportunities and challenges associated with RAS for urban ecosystems have yet to be considered systematically. Here, we report the findings of an online horizon scan involving 170 expert participants from 35 countries. We conclude that RAS are likely to transform land use, transport systems and human–nature interactions. The prioritized opportunities were primarily centred on the deployment of RAS for the monitoring and management of biodiversity and ecosystems. Fewer challenges were prioritized. Those that were emphasized concerns surrounding waste from unrecovered RAS, and the quality and interpretation of RAS-collected data. Although the future impacts of RAS for urban ecosystems are difficult to predict, examining potentially important developments early is essential if we are to avoid detrimental consequences but fully realize the benefits