Effectiveness of antipsychotic treatment for schizophrenia: Italian results of the pan-European Schizophrenia Outpatient Health Outcomes (SOHO) study after 12 months Efficacia della terapia antipsicotica per la schizofrenia: i risultati italiani a 12 mesi

Summary Objectives Schizophrenia therapy aims to control clinical symptoms and improve patient quality of life and functioning. The aim of this study was to present the 12-month outcomes associated with antipsychotic treatment of Italian patients participating in the Schiz Results A large proportion of completers responded to treatment (improvement in Clinical Global Impression-overall symptoms) during the 12 months, ranging from 53% in the depot typical cohort to 72% in the clozapine cohort . Clinical response to treatment was comparable between clozapine and olanzapine, but patients treated with clozapine were more likely to be socially inactive at 12 months. Patient quality of life improved in all treatment cohorts (measured using the EuroQol-5D visual analogue scale, EQ-5D VAS), but there was a significantly greater improvement in EQ-5D VAS with olanzapine than with risperidone or depot typical antipsychotic