306 research outputs found
Kinetic Parameter Estimation of Solvent Free ReactionsMonitored by 13C NMR Spectroscopy. A Case Study: Mono andDi-(hydroxy)ethylation of Aniline with EthyleneCarbonate
The kinetics of solvent-free reactions can be followed in situ by 13C NMR spectroscopy, provided that the reaction mixture can be maintained liquid at the monitoring temperature. The pros and cons of the technique and the correct translation of the signal
intensities into concentrations are discussed. A good model for this investigation is the reaction of ethylene carbonate (1) with aniline (2): at 140 °C, two alkylation products of N-mono- and
N,N-bis-(2-hydroxy)ethylation of aniline form (compounds 3 and 4, respectively). The overall reaction occurs with heavy volume shrinking, so that the physical as well as the chemical features evolve during the course of the process. The chemical evolution is described by the kinetic constants k1 and k2 of the two N-alkylation steps, the physical evolution by the time dependent activity coefficients α(t). Two complementary procedures are utilized for the determination of these parameters
Superfluorinated Ionic Liquid Crystals Based on Supramolecular, Halogen-Bonded Anions
Unconventional ionic liquid crystals in which the liquid crystallinity is enabled by halogen-bonded supramolecular anions [CnF2n+1-I···I···I-CnF2n+1]- are reported. The material system is unique in many ways, demonstrating for the first time 1)ionic, halogen-bonded liquid crystals, and 2)imidazolium-based ionic liquid crystals in which the occurrence of liquid crystallinity is not driven by the alkyl chains of the cation
Mass Spectrometric Back Reaction Screening of Quasi-Enantiomeric Products as a Mechanistic Tool
In this account, we discuss a mass spectrometric method that enables unambiguous identification of intermediates involved in the enantioselective step of a catalytic cycle. This method, which we originally developed for rapid evaluation of chiral catalysts, is based on monitoring the back reaction of mass-labeled quasi-enantiomeric products by ESI-MS. In this way, the intrinsic enantioselectivity of a chiral catalyst can be determined directly by quantification of catalytically relevant intermediates. By comparing the results from the forward and back reaction, direct evidence for the involvement of a catalytic intermediate in the enantioselective step can be obtained. In addition, insights about the energy profile of the catalytic cycle may be gained. The potential of back reaction screening as a mechanistic tool is demonstrated for organocatalytic aldol reactions, 1,4-additions of aldehydes to nitroolefins, Diels-Alder reactions, Michael additions, and Morita-Baylis-Hillman reactions
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The ionic liquid–vacuum outer atomic surface: a low-energy ion scattering study
We have identified elements present in the ionic liquid–vacuum outer atomic surface of 23 ionic liquids using high sensitivity low-energy ion scattering (LEIS), a very surface sensitive technique. We show that the probability of cationic heteroatoms being present at the ionic liquid–vacuum outer atomic surface is very low; we detected imidazolium nitrogen for only one of the 18 imidazolium based ionic liquids investigated, no nitrogen for the two ammonium based ionic liquids and a very small amount of phosphorus for two of the three phosphonium-based ionic liquids. We determine that the anion is always present at the ionic liquid–vacuum outer atomic surface, even for very large cations containing dodecyl alkyl chains or longer; these chains dominate the ionic liquid–vacuum outer atomic surface, but are not sufficiently densely packed to completely cover the anions. We demonstrate the presence of strong hydrogen bond acceptor adsorption sites at the ionic liquid–vacuum outer atomic surface. We demonstrate that the amount of ion present at the ionic liquid–vacuum outer atomic surface can be tuned by varying the size of the other ion; larger cations (or anions) occupy more of the ionic liquid–vacuum outer atomic surface, leaving less room for anions (or cations). By identifying elements present at the ionic liquid–vacuum outer atomic surface, conclusions can be drawn on the orientations of anions nearest the vacuum. We show that for five different anions there is a most probable ion orientation, but other anion orientations also exist, demonstrating the presence of multiple anion orientations. The imidazolium cations nearest to the vacuum also show similar multi-orientation behaviour. This variety of atoms present and therefore ion orientations is expected to be central to controlling surface reactivity. In addition, our results can be used to quantitatively validate simulations of the ionic liquid–vacuum surface at a molecular level. Overall, our studies, in combination with literature data from different techniques and simulations, provide a clear picture of ionic liquid–vacuum outer atomic surfaces
Improving the hyperpolarization of (31)p nuclei by synthetic design
Traditional (31)P NMR or MRI measurements suffer from low sensitivity relative to (1)H detection and consequently require longer scan times. We show here that hyperpolarization of (31)P nuclei through reversible interactions with parahydrogen can deliver substantial signal enhancements in a range of regioisomeric phosphonate esters containing a heteroaromatic motif which were synthesized in order to identify the optimum molecular scaffold for polarization transfer. A 3588-fold (31)P signal enhancement (2.34% polarization) was returned for a partially deuterated pyridyl substituted phosphonate ester. This hyperpolarization level is sufficient to allow single scan (31)P MR images of a phantom to be recorded at a 9.4 T observation field in seconds that have signal-to-noise ratios of up to 94.4 when the analyte concentration is 10 mM. In contrast, a 12 h 2048 scan measurement under standard conditions yields a signal-to-noise ratio of just 11.4. (31)P-hyperpolarized images are also reported from a 7 T preclinical scanner
Ionic liquids at electrified interfaces
Until recently, “room-temperature” (<100–150 °C) liquid-state electrochemistry was mostly electrochemistry of diluted electrolytes(1)–(4) where dissolved salt ions were surrounded by a considerable amount of solvent molecules. Highly concentrated liquid electrolytes were mostly considered in the narrow (albeit important) niche of high-temperature electrochemistry of molten inorganic salts(5-9) and in the even narrower niche of “first-generation” room temperature ionic liquids, RTILs (such as chloro-aluminates and alkylammonium nitrates).(10-14) The situation has changed dramatically in the 2000s after the discovery of new moisture- and temperature-stable RTILs.(15, 16) These days, the “later generation” RTILs attracted wide attention within the electrochemical community.(17-31) Indeed, RTILs, as a class of compounds, possess a unique combination of properties (high charge density, electrochemical stability, low/negligible volatility, tunable polarity, etc.) that make them very attractive substances from fundamental and application points of view.(32-38) Most importantly, they can mix with each other in “cocktails” of one’s choice to acquire the desired properties (e.g., wider temperature range of the liquid phase(39, 40)) and can serve as almost “universal” solvents.(37, 41, 42) It is worth noting here one of the advantages of RTILs as compared to their high-temperature molten salt (HTMS)(43) “sister-systems”.(44) In RTILs the dissolved molecules are not imbedded in a harsh high temperature environment which could be destructive for many classes of fragile (organic) molecules
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