74 research outputs found
Lagrangian and Hamiltonian two-scale reduction
Studying high-dimensional Hamiltonian systems with microstructure, it is an
important and challenging problem to identify reduced macroscopic models that
describe some effective dynamics on large spatial and temporal scales. This
paper concerns the question how reasonable macroscopic Lagrangian and
Hamiltonian structures can by derived from the microscopic system.
In the first part we develop a general approach to this problem by
considering non-canonical Hamiltonian structures on the tangent bundle. This
approach can be applied to all Hamiltonian lattices (or Hamiltonian PDEs) and
involves three building blocks: (i) the embedding of the microscopic system,
(ii) an invertible two-scale transformation that encodes the underlying scaling
of space and time, (iii) an elementary model reduction that is based on a
Principle of Consistent Expansions.
In the second part we exemplify the reduction approach and derive various
reduced PDE models for the atomic chain. The reduced equations are either
related to long wave-length motion or describe the macroscopic modulation of an
oscillatory microstructure.Comment: 40 page
Boundary effects on the dynamics of chains of coupled oscillators
We study the dynamics of a chain of coupled particles subjected to a
restoring force (Klein-Gordon lattice) in the cases of either periodic or
Dirichlet boundary conditions. Precisely, we prove that, when the initial data
are of small amplitude and have long wavelength, the main part of the solution
is interpolated by a solution of the nonlinear Schr\"odinger equation, which in
turn has the property that its Fourier coefficients decay exponentially. The
first order correction to the solution has Fourier coefficients that decay
exponentially in the periodic case, but only as a power in the Dirichlet case.
In particular our result allows one to explain the numerical computations of
the paper \cite{BMP07}
Bifurcations of discrete breathers in a diatomic Fermi-Pasta-Ulam chain
Discrete breathers are time-periodic, spatially localized solutions of the
equations of motion for a system of classical degrees of freedom interacting on
a lattice. Such solutions are investigated for a diatomic Fermi-Pasta-Ulam
chain, i. e., a chain of alternate heavy and light masses coupled by anharmonic
forces. For hard interaction potentials, discrete breathers in this model are
known to exist either as ``optic breathers'' with frequencies above the optic
band, or as ``acoustic breathers'' with frequencies in the gap between the
acoustic and the optic band. In this paper, bifurcations between different
types of discrete breathers are found numerically, with the mass ratio m and
the breather frequency omega as bifurcation parameters. We identify a period
tripling bifurcation around optic breathers, which leads to new breather
solutions with frequencies in the gap, and a second local bifurcation around
acoustic breathers. These results provide new breather solutions of the FPU
system which interpolate between the classical acoustic and optic modes. The
two bifurcation lines originate from a particular ``corner'' in parameter space
(omega,m). As parameters lie near this corner, we prove by means of a center
manifold reduction that small amplitude solutions can be described by a
four-dimensional reversible map. This allows us to derive formally a continuum
limit differential equation which characterizes at leading order the
numerically observed bifurcations.Comment: 30 pages, 10 figure
Transform Autism Education - Final Report
The Transform Autism Education (TAE) project focused on the domain of ‘good autism practice’ in the education of pupils with autism in the UK, Greece and Italy with the overall objectives to:• Research good autism practice in education.• Create professional development programmes in Greece and Italy.• Enhance the knowledge and practice of school staff.• Facilitate the inclusion of autistic children in primary schools in those countries.Funded by the European Commission through Erasmus Plus Key Action 2, Strategic Partnerships scheme, and led by Principal Investigator Dr. Karen Guldberg, the project involved a range of Greek, Italian and UK partners. It employed the Autism Education Trust (AET) collaborative training schemes in the UK as a founding model. While the requirements of each country were distinct, and so necessitated careful adaptations of the materials to their specific needs, what united all aspects of the project was a desire to improve the educational inclusion of autistic children, as well as their general experiences in school and their outcomes
PLUGAM: Plug-In-Based Adaptation Middleware for Network Layer Protocols for Vehicular Ad Hoc Networks
Communicating Auditory Impairments Using Electroacoustic Composition
Changes in human sensory perception can occur for a variety of reasons. In the case of distortions or transformations in the human auditory system, the aetiology may include factors such as medical conditions affecting cognition or physiology, interaction of the ears with mechanical waves, or stem from chemically induced sources, such the consumption of alcohol. These changes may be permanent, intermittent, or temporary. In order to communicate such effects to an audience in an accessible, and easily understood manner, a series of electroacoustic compositions were produced. This concept follows on from previous work on the theme of representing auditory hallucinations. Specifically, these compositions relate to auditory impairments that humans can experience due to tinnitus or through the consumption of alcohol. In the case of tinnitus, whilst much is known about the causes and symptoms, the experience of what it is like to live with tinnitus is less explored and those who have acquired the condition may often feel frustration when trying to convey the experience of ‘what it is like’ for them. In terms of impairment from alcohol consumption, whilst there is much hearsay, little research exists on the immediate and short-term effects of alcohol consumption on the human auditory system, despite over half of the UK population reported as consuming alcohol in 2017. The methodology employed to design these compositions draws upon scientific research findings, including experimental and explorative studies involving human participants, coupled with electroacoustic composition techniques. The pieces are typically constructed by mixing field recordings with synthesised materials and incorporating a range of temporal and frequency domain manipulations to the elements therein. In this way, the listener is able to experience the phenomenon in a recognisable context, where distortions of reality can be emulated to varying degrees. It is intended that these compositions can serve as easily accessible and understood examples of auditory impairments and that they might find utility in the communication of symptoms to those who have never experienced the underlying causes or conditions. This presents opportunities for pieces like these to be used in scenarios such as education and public health awareness campaigns
Telerobotic Pointing Gestures Shape Human Spatial Cognition
This paper aimed to explore whether human beings can understand gestures
produced by telepresence robots. If it were the case, they can derive meaning
conveyed in telerobotic gestures when processing spatial information. We
conducted two experiments over Skype in the present study. Participants were
presented with a robotic interface that had arms, which were teleoperated by an
experimenter. The robot could point to virtual locations that represented
certain entities. In Experiment 1, the experimenter described spatial locations
of fictitious objects sequentially in two conditions: speech condition (SO,
verbal descriptions clearly indicated the spatial layout) and speech and
gesture condition (SR, verbal descriptions were ambiguous but accompanied by
robotic pointing gestures). Participants were then asked to recall the objects'
spatial locations. We found that the number of spatial locations recalled in
the SR condition was on par with that in the SO condition, suggesting that
telerobotic pointing gestures compensated ambiguous speech during the process
of spatial information. In Experiment 2, the experimenter described spatial
locations non-sequentially in the SR and SO conditions. Surprisingly, the
number of spatial locations recalled in the SR condition was even higher than
that in the SO condition, suggesting that telerobotic pointing gestures were
more powerful than speech in conveying spatial information when information was
presented in an unpredictable order. The findings provide evidence that human
beings are able to comprehend telerobotic gestures, and importantly, integrate
these gestures with co-occurring speech. This work promotes engaging remote
collaboration among humans through a robot intermediary.Comment: 27 pages, 7 figure
Impact of Safety-Related Dose Reductions or Discontinuations on Sustained Virologic Response in HCV-Infected Patients: Results from the GUARD-C Cohort.
BACKGROUND: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. METHODS: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. RESULTS: SVR24 rates were 46.1% (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1, 2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced ≥1 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with ≥1 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not ≥5. CONCLUSIONS: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginterferon alfa-2a/ribavirin.This study was sponsored by F. Hoffmann-La Roche Ltd, Basel, Switzerland. Support for third-party writing
assistance for this manuscript, furnished by Blair Jarvis MSc, ELS, of Health Interactions, was provided by F. Hoffmann-La Roche Ltd, Basel, Switzerland
Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort
Background: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. Methods: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. Results: SVR24 rates were 46.1 % (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1,2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced 651 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with 651 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not 655. Conclusions: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginter-feron alfa-2a/ribavirin
Indicators of "Healthy Aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival
<p>Abstract</p> <p>Background</p> <p>Prediction of long-term survival in healthy adults requires recognition of features that serve as early indicators of successful aging. The aims of this study were to identify predictors of long-term survival in older women and to develop a multivariable model based upon longitudinal data from the Study of Osteoporotic Fractures (SOF).</p> <p>Methods</p> <p>We considered only the youngest subjects (<it>n </it>= 4,097) enrolled in the SOF cohort (65 to 69 years of age) and excluded older SOF subjects more likely to exhibit a "frail" phenotype. A total of 377 phenotypic measures were screened to determine which were of most value for prediction of long-term (19-year) survival. Prognostic capacity of individual predictors, and combinations of predictors, was evaluated using a cross-validation criterion with prediction accuracy assessed according to time-specific AUC statistics.</p> <p>Results</p> <p>Visual contrast sensitivity score was among the top 5 individual predictors relative to all 377 variables evaluated (mean AUC = 0.570). A 13-variable model with strong predictive performance was generated using a forward search strategy (mean AUC = 0.673). Variables within this model included a measure of physical function, smoking and diabetes status, self-reported health, contrast sensitivity, and functional status indices reflecting cumulative number of daily living impairments (HR ≥ 0.879 or RH ≤ 1.131; P < 0.001). We evaluated this model and show that it predicts long-term survival among subjects assigned differing causes of death (e.g., cancer, cardiovascular disease; P < 0.01). For an average follow-up time of 20 years, output from the model was associated with multiple outcomes among survivors, such as tests of cognitive function, geriatric depression, number of daily living impairments and grip strength (P < 0.03).</p> <p>Conclusions</p> <p>The multivariate model we developed characterizes a "healthy aging" phenotype based upon an integration of measures that together reflect multiple dimensions of an aging adult (65-69 years of age). Age-sensitive components of this model may be of value as biomarkers in human studies that evaluate anti-aging interventions. Our methodology could be applied to data from other longitudinal cohorts to generalize these findings, identify additional predictors of long-term survival, and to further develop the "healthy aging" concept.</p
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