Every town should have one: the role of the arts centre in community development and employment provision

No abstract available.Article digitised using: Suprascan 1000 RGB scanner, scanned at 400 dpi; 24-bit colour; 100% Image derivating - Software used: Adobe Photoshop CS3 - Image levels, crop, deskew Abbyy Fine Reader No.9 - Image manipulation + OCR Adobe Acrobat 9 (PDF

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.

Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease

The contributuion of the community arts centre to capital building for socio-economic development in South Africa

The concepts "capital building" and 'Institutionalisation" are analysed and applied to community arts centres as instruments for socio-economic development (SED) in South Africa. Theories of neo-classicism, Marxism, development economics and socio-economic development show that building physical, financial, human, social and cultural capital in a complementary configuration is crucial to sustainable socio-economic development. The concept "capital building for SED" is formulated in this regard. New institutional economics and critical extensions of this theory show that institutions play a key role in capital building for SED, as they entail embeddedness, normativity, e-ntreprcneurship, partnership, structure and complementarity. The arts sector contributes considerably to capital building for SED, in particular arts centres in marginalized communities in the UK, USA and South Africa. Community arts centres built political, cultural and human capital in black townships during the South African democratic struggle (1950-92). In accordance with proposals from the arts sector, the post-1994 South African government developed 42 arts centres. However, the contribution of most old and new centres to socio-economic development appears to be insignificant and few are sustainable. The causes of failure are difficult to explain due to lack of information and theory. Through the application of a theoretical framework to the South African arts sector and three case studies the hypothesis is tested that community arts centres can contribute considerably to capital building for SED if they are appropriately institutionalised, while an appropriate focus on capital building for SED results in stronger institutions. An analysis of arts sector shows that strong institutions achieve high returns on investments in capital building, but that few benefit the poor. The application of an analytical matrix consisting of indicators of the above-mentioned five types of capital and six institutional components, shows significant positive correlations between the levels of inslitutionalisation and capital building for SED in the Community Arts Project, the Katlehong Art Centre and ArtsforAIl. The findings result in recommendations on policy and practice of community arts centre development in South Africa.Development studiesD. Litt. et Phil. (Development Studies

Paradigmatiese verskuiwings in die Suid-Afrikaanse kunsgeskiedskrywing

Twee kunshistoriese metodes word bespreek. "Kanonisering" beklemtoon die kunstenaar as geisoleerd van sy omgewing en as 'n voorbeeld van ideologiese of estetiese voorkeure van groepe wat strewe na dominansie. Coert Steynberg word getoon as verteenwoordigend van die Afrikaner-nasionalisme en Edoardo Villa as verteenwoordiger van die moderne kunswereld. "Kontekstualisering" wat die verband tussen die kunstenaar, die kunswerk en die samelewing waarbinne die werk gemaak en ontvang is, beklemtoon, word as 'n moontlike alternatief aangebied. Dit impliseer 'n rekonstruksie van paradigmas en normsisteme wat gemeenskaplik is aan beide die kunswerk en die samelewing.Two art-historical methods are discussed. "Canonisation" emphasising the artist as isolated from his context and as an example of either ideological or aesthetic preferences of groups striving for dominance. Coert Steynberg is shown as a representative of Afrikaner nationalism, Edoardo Villa as representing the modern art establishment. "Contextualisation", emphasising the relationship between the artist, artwork and the society in which the work is produced and received, is offered as a possible alternative. This implies a reconstruction of paradigms and normative systems that are common to both the artwork and the society.Article digitised using: Suprascan 1000 RGB scanner, scanned at 400 dpi; 24-bit colour; 100% Image derivating - Software used: Adobe Photoshop CS3 - Image levels, crop, deskew Abbyy Fine Reader No.9 - Image manipulation + OCR Adobe Acrobat 9 (PDF