A Prehispanic Maya Pit Oven? Microanalysis of Fired Clay Balls from the Puuc Region, Yucatán, Mexico

This is a postprint (author's final draft) version of an article published in Journal of Archaeological Science in 2013. The final version of this article may be found at http://dx.doi.org/10.1016/j.jas.2012.10.014 (login may be required). The version made available in OpenBU was supplied by the author.Excavations of a kitchen at Escalera al Cielo in the Puuc Maya region of Yucatán, Mexico uncovered a concentration of fired clay balls (ca. 3–5 cm in diameter), in addition to other de facto domestic refuse. The kitchen pertains to an intensively excavated elite residential group that was rapidly abandoned sometime near the end of the Terminal Classic period (A.D. 800–950), resulting in floor assemblages that provide an opportunity to explore the types and distribution of daily household activities. The results of experimental replications and a suite of analyses comprising modal analysis, ceramic petrography, Fourier transform infrared spectroscopy (FTIR), and microbotanical residue analysis reveal aspects of clay preparation, firing temperatures, repeated use of the balls, firing conditions, and specific plant food or fuel residues adhering to them. We show that the fired clay balls were manufactured with local, clay-rich soil and employed by the inhabitants of Escalera al Cielo as heating elements; relatively high concentrations of microbotanical residues from edible plants adhering to them support the hypothesis that they were involved in kitchen activities related to food processing

Evidence from Escalera al Cielo: Abandonment of a Terminal Classic Puuc Maya Hill Complex in Yucatán, Mexico

This is a postprint (author's final draft) version of an article published in Journal of Field Arhcaeology in 2012. The final version of this article may be found at http://dx.doi.org/10.1179/0093469012Z.00000000025 (login may be required). The version made available in OpenBU was supplied by the author.Excavations at the hilltop site of Escalera al Cielo, located in the Puuc Maya region of Yucatán, Mexico, have uncovered evidence of a planned abandonment at the end of the Terminal Classic period (A.D. 800–950). Six buildings investigated among three residential groups contain rich floor assemblages similar to those known from only a few rapidly abandoned sites in the Maya area. Through an analysis of de facto refuse—most of which was recovered in locations of storage and provisional discard—and midden refuse, this paper illustrates how the assemblages represent an example of household-level abandonment with anticipated return. We also consider Escalera al Cielo in light of our present understanding of the political and environmental history of the Puuc region during the late 9th century A.D

Trowels, Trenches, and Transformation: A Case Study of Archaeologists Learning, Teaching, and Enacting Environmentally-Friendly, Community-Inclusive Practices

Guided by the framework of “critical transformative learning,” this study explores archaeologists as adult learners and seeks to understand how they are learning to practice a new vision of archaeology in Mexico. In this project, personal transformation is linked to disciplinary and social transformation

How to discuss gene therapy for haemophilia? A patient and physician perspective

Gene therapy has the potential to revolutionise treatment for patients with haemophilia and is close to entering clinical practice. While factor concentrates have improved outcomes, individuals still face a lifetime of injections, pain, progressive joint damage, the potential for inhibitor development and impaired quality of life. Recently published studies in adeno‐associated viral (AAV) vector‐mediated gene therapy have demonstrated improvement in endogenous factor levels over sustained periods, significant reduction in annualised bleed rates, lower exogenous factor usage and thus far a positive safety profile. In making the shared decision to proceed with gene therapy for haemophilia, physicians should make it clear that research is ongoing and that there are remaining evidence gaps, such as long‐term safety profiles and duration of treatment effect. The eligibility criteria for gene therapy trials mean that key patient groups may be excluded, eg children/adolescents, those with liver or kidney dysfunction and those with a prior history of factor inhibitors or pre‐existing neutralising AAV antibodies. Gene therapy offers a life‐changing opportunity for patients to reduce their bleeding risk while also reducing or abrogating the need for exogenous factor administration. Given the expanding evidence base, both physicians and patients will need sources of clear and reliable information to be able to discuss and judge the risks and benefits of treatment

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe

The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis

Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled "International Natural Product Sciences Taskforce" (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools. Methods: In this work, we present a general overview of INPST activities and showcase the specific use of Twitter as a powerful networking tool that was used to host a one-week "2021 INPST Twitter Networking Event" (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST. Results and Conclusion: The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event's achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events

Stroke in women — from evidence to inequalities

Stroke is the second largest cause of disability-adjusted life-years lost worldwide. The prevalence of stroke in women is predicted to rise rapidly, owing to the increasing average age of the global female population. Vascular risk factors differ between women and men in terms of prevalence, and evidence increasingly supports the clinical importance of sex differences in stroke. The influence of some risk factors for stroke — including diabetes mellitus and atrial fibrillation — are stronger in women, and hypertensive disorders of pregnancy also affect the risk of stroke decades after pregnancy. However, in an era of evidence-based medicine, women are notably under-represented in clinical trials — despite governmental actions highlighting the need to include both men and women in clinical trials — resulting in a reduced generalizability of study results to women. The aim of this Review is to highlight new insights into specificities of stroke in women, to plan future research priorities, and to influence public health policies to decrease the worldwide burden of stroke in women

Proyecto Arqueológico Regional de Bolonchén, Temporada de Campo 2009

Annual field report for the Bolonchén Regional Archaeology Project. Principal Investigators: Tomás Gallareta Negrón, George J. Bey, III, and William M. Ringle

Proyecto Arqueológico Regional de Bolonchén, Temporada de Campo 2010

Annual field report for the Bolonchén Regional Archaeology Project. Principal Investigators: Tomás Gallareta Negrón, George J. Bey, III, and William M. Ringle