148 research outputs found
Association of Liver X Receptor Alpha and Beta Genes with Carcass Lean and Fat Content in Pigs
A three-generation resource family of a cross between the Berkshire and Yorkshire (BY) pig breeds and four pig commercial populations were used to investigate whether the Liver X Receptor Alpha (LXRA) and Beta (LXRB) genes play a role in influencing lean and fat growth in pigs. Our current findings from this study have suggested that LXRA and LXRB might have potential effects, especially for loin lean and fat content
Extreme stability in de novo-designed repeat arrays is determined by unusually stable short-range interactions
Dynabench: Rethinking Benchmarking in NLP
We introduce Dynabench, an open-source platform for dynamic dataset creation and model benchmarking. Dynabench runs in a web browser and supports human-and-model-in-the-loop dataset creation: annotators seek to create examples that a target model will misclassify, but that another person will not. In this paper, we argue that Dynabench addresses a critical need in our community: contemporary models quickly achieve outstanding performance on benchmark tasks but nonetheless fail on simple challenge examples and falter in real-world scenarios. With Dynabench, dataset creation, model development, and model assessment can directly inform each other, leading to more robust and informative benchmarks. We report on four initial NLP tasks, illustrating these concepts and highlighting the promise of the platform, and address potential objections to dynamic benchmarking as a new standard for the field
SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration
High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. Here we show that secretory autophagy (SA), a non-lytic modality of autophagy for secretion of vesicular cargo, regulates neuroinflammation-mediated neurodegeneration via SKA2 and FKBP5 signaling. SKA2 inhibits SA-dependent IL-1ÎČ release by counteracting FKBP5 function. Hippocampal Ska2 knockdown in male mice hyperactivates SA resulting in neuroinflammation, subsequent neurodegeneration and complete hippocampal atrophy within six weeks. The hyperactivation of SA increases IL-1ÎČ release, contributing to an inflammatory feed-forward vicious cycle including NLRP3-inflammasome activation and Gasdermin D-mediated neurotoxicity, which ultimately drives neurodegeneration. Results from protein expression and co-immunoprecipitation analyses of male and female postmortem human brains demonstrate that SA is hyperactivated in Alzheimer's disease. Overall, our findings suggest that SKA2-regulated, hyperactive SA facilitates neuroinflammation and is linked to Alzheimer's disease, providing mechanistic insight into the biology of neuroinflammation
Constant Velocity Constraints for Self-Supervised Monocular Depth Estimation
We present a new method for self-supervised monocular depth estimation. Contemporary monocular depth estimation methods use a triplet of consecutive video frames to estimate the central depth image. We make the assumption that the ego-centric view progresses linearly in the scene, based on the kinematic and physical properties of the camera. During the training phase, we can exploit this assumption to create a depth estimation for each image in the triplet. We then apply a new geometry constraint that supports novel synthetic views, thus providing a strong supervisory signal. Our contribution is simple to implement, requires no additional trainable parameter, and produces competitive results when compared with other state-of-the-art methods on the popular KITTI corpus
Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences
The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & NemĂ©sio 2007; Donegan 2008, 2009; NemĂ©sio 2009aâb; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported
by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on
18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based
researchers who signed it in the short time span from 20 September to 6 October 2016
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