Notas sobre el género Lepiota (Pers.: Fr.) Gray (Agaricales, Basidiomycotina) en el sudeste español

Se aportan datos corológicos de los 31 txones pertenecientes al género Lepiota (Pers.: Fr.) Gray ss. Kühner (1980) encontrados en el S.E. de la península ibérica. Se propone una nueva combinación: Lepiota subsquarrosa (Locq.) Gea et Honrubia.Notes on the genus Lepiota (Pers.: Fr.) Gray (Agaricales, Basidiomycotina) in South-Fast Spain. Thirty-one taxa of the genus Lepiota (Pers.: Fr.) Gray, sensu Kühner (1980) are recorded. Lepiota subsquarrosa (Locq.) Gea et Honrubia nov. comb. is proposed

Notas sobre el género Lepiota (Pers.: Fr.) Gray (Agaricales, Basidiomycotina) en el sudeste español

Se aportan datos corológicos de los 31 txones pertenecientes al género Lepiota (Pers.: Fr.) Gray ss. Kühner (1980) encontrados en el S.E. de la península ibérica. Se propone una nueva combinación: Lepiota subsquarrosa (Locq.) Gea et Honrubia.Notes on the genus Lepiota (Pers.: Fr.) Gray (Agaricales, Basidiomycotina) in South-Fast Spain. Thirty-one taxa of the genus Lepiota (Pers.: Fr.) Gray, sensu Kühner (1980) are recorded. Lepiota subsquarrosa (Locq.) Gea et Honrubia nov. comb. is proposed

Engineering new mycobacterial vaccine design for HIV-TB pediatric vaccine vectored by lysine auxotroph of BCG

In this study, we have engineered a new mycobacterial vaccine design by using an antibiotic-free plasmid selection system. We assembled a novel Escherichia coli (E. coli)-mycobacterial shuttle plasmid p2auxo.HIVA, expressing the HIV-1 clade A immunogen HIVA. This shuttle vector employs an antibiotic resistance-free mechanism for plasmid selection and maintenance based on glycine complementation in E. coli and lysine complementation in mycobacteria. This plasmid was first transformed into glycine auxotroph of E. coli strain and subsequently transformed into lysine auxotroph of Mycobacterium bovis BCG strain to generate vaccine BCG.HIVA 2auxo. We demonstrated that the episomal plasmid p2auxo.HIVA was stable in vivo over a 7-week period and genetically and phenotypically characterized the BCG.HIVA 2auxo vaccine strain. The BCG.HIVA 2auxo vaccine in combination with modified vaccinia virus Ankara (MVA). HIVA was safe and induced HIV-1 and Mycobacterium tuberculosis -specific interferon-γ-producing T-cell responses in adult BALB/c mice. Polyfunctional HIV-1-specific CD8+ T cells, which produce interferon-γ and tumor necrosis factor-α and express the degranulation marker CD107a, were induced. Thus, we engineered a novel, safer, good laboratory practice-compatible BCG-vectored vaccine using prototype immunogen HIVA. This antibiotic-free plasmid selection system based on "double" auxotrophic complementation might be a new mycobacterial vaccine platform to develop not only recombinant BCG-based vaccines expressing second generation of HIV-1 immunogens but also other major pediatric pathogens to prime protective response soon after birth

Sleep quality among inpatients of Spanish public hospitals

Sleep is a complex process and is needed both in health and illness. Deprivation of sleep is known to have multiple negative physiological effects on people's bodies and minds. Despite the awareness of these harmful effects, previous studies have shown that sleep is poor among hospitalised patients. We utilized an observational design with 343 patients recruited from medical and surgical units in 12 hospitals located in nine Spanish regions. Sociodemographic and clinical characteristics of patients were collected. Sleep quality at admission and during hospitalisation was measured by the Pittsburgh Sleep Quality Index. Sleep quantity was self-reported by patients in hours and minutes. Mean PSQI score before and during hospitalisation were respectively 8.62 ± 4.49 and 11.31 ± 4.04. Also, inpatients slept about an hour less during their hospital stay. Lower educational level, sedative medication intake, and multi-morbidity was shown to be associated with poorer sleep quality during hospitalisation. A higher level of habitual physical activity has shown to correlate positively with sleep quality in hospital. Our study showed poor sleep quality and quantity of inpatients and a drastic deterioration of sleep in hospital versus at home. These results may be helpful in drawing attention to patients' sleep in hospitals and encouraging interventions to improve sleep.This project received a research grant from the Carlos III Institute of Health, Ministry of Economy and Competitiveness (Spain), awarded on the 2018 call under the Health Strategy Action 2013–2016, with reference PI18/00732, PI18/00743, PI18CIII/0012, co-funded with the European Union ERDF funds (European Reginal Development Fund “a way to make Europe) and the Predoctoral staff in training program from the University of Lleida, Jade Plus and La Caixa Bank Foundation 2019.S

Recommended Common Data Elements for International Research in Long-Term Care Homes: Exploring the Workforce and Staffing Concepts of Staff Retention and Turnover

The aim of this review is to develop a common data element for the concept of staff retention and turnover within the domain of workforce and staffing. This domain is one of four core domains identified by the WE-THRIVE (Worldwide Elements to Harmonize Research in Long-Term Care Living Environments) group in an effort to establish an international, person-centered long-term care research infrastructure. A rapid review identified different measurement methods to assess either turnover or retention at facility level or intention to leave or stay at the individual staff level. The selection of a recommended measurement was guided by the WE-THRIVE group’s focus on capacity rather than deficits, the expected availability of internationally comparable data, and the goal to provide a short, ecologically viable measurement. We therefore recommend to measure staff’s intention to stay with a single item, at the individual staff level. This element, we argue, is an indicator of staff stability, which is important for reduced organizational cost and improved productivity, positive work environment, and better resident–staff relationships and quality of care

Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality?

The aim of this study was to assess the association between alcohol intake and premature mortality (younger than 65 years) and to explore the effect of potential alcohol underreporting by heavy drinkers. We followed-up 20 272 university graduates. Four categories of alcohol intake were considered (abstainer, light, moderate and heavy consumption). Repeated measurements of alcohol intake and updated information on confounders were used in time-dependent Cox models. Potential underreporting of alcohol intake by some heavy drinkers (likely misclassified as light or moderate drinkers) was explicitly addressed in an attempt to correct potential underreporting by using indirect information. During 12·3 years of median follow-up (interquartile range: 6·8–15·0), 226 participants died before their 65th birthday. A higher risk of early mortality was found for the highest category of alcohol intake (≥50 g/d) in comparison with abstention (multivariable-adjusted hazard ratio (HR) = 2·82, 95 % CI 1·38, 5·79). In analyses of alcohol as a continuous variable, the multivariable-adjusted HR was 1·17 (95 % CI 1·08, 1·26), for each 10 g/d of alcohol. This harmful linear association was present both in uncorrected models and in models corrected for potential underreporting. No significant inverse association between light or moderate alcohol intake and premature mortality was observed, even after correcting for potential misclassification. Alcohol intake exhibited a harmful linear dose–response association with premature mortality (<65 years) in this young and highly educated Mediterranean cohort. Our attempts to correct for potential misclassification did not substantially change these results

Patient profile and management of delirium in older adults hospitalized due to COVID-19

SARS-CoV-2 can cause neurologic symptoms, as well as respiratory ones. Older adults are at risk of developing acute delirium in older persons (ADOP). The combination of experiencing respiratory isolation due to COVID-19, as well as other associated risk factors for older adults, may have had an impact on ADOP and ADOP management in the acute hospital setting. This study aimed to analyze the characteristics of ADOP in patients admitted to a COVID-19 unit. An observational prospective study on a sample of 108 patients was carried out between November 2020 and May 2021. The following data were collected: sociodemographic characteristics, risk factors for ADOP, management of ADOP, and impact on ADOP on both functional and cognitive deteriora-tion. A 29.6% proportion of older adults admitted to an acute COVID-19 unit presented hyperactive ADOP, mainly during the night. Management of ADOP in our sample involved mainly pharmaco-logical treatment and had a serious impact on hospital stay and both functional and cognitive dete-rioration. Preventive strategies and being accompanied by a relative or a carer may be useful to manage ADOP during hospital admission due to COVID-19

Lavadero comunitario con agua caliente a partir de energía solar para la comunidad de Las Capillas

En la localidad de Las Capillas, Departamento de Iruya, Provincia de Salta, se realizó un relevamiento de las problemáticas de la comunidad, detectándose como una de las más importantes las dificultades para el lavado de ropa debido a la temperatura muy fría o congelamiento del agua. En el marco del Programa de Voluntariado Universitario 2006 del Ministerio de Educación se diseñó y construyó un lavadero comunitario con agua caliente a partir de energía solar. Además de resolver el problema específico, la experiencia resultó un proceso de aprendizaje para la comunidad destinataria y para el equipo de la universidad que participó en el proyecto.In the locality of Las Capillas, Department of Iruya, Province of Salta, was made a study of the communitys problematic, detecting like one of the most important the difficulties for the washing of clothes due to the very cold temperature or freezing of the water. Within the framework of the Program of University Voluntary 2006 of the Ministry of Education a communitarian laundry with hot water from solar energy was designed and constructed. Besides to solve the specific problem, the experience turned out a process from learning for the community and the university group.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Lavadero comunitario con agua caliente a partir de energía solar para la comunidad de Las Capillas

En la localidad de Las Capillas, Departamento de Iruya, Provincia de Salta, se realizó un relevamiento de las problemáticas de la comunidad, detectándose como una de las más importantes las dificultades para el lavado de ropa debido a la temperatura muy fría o congelamiento del agua. En el marco del Programa de Voluntariado Universitario 2006 del Ministerio de Educación se diseñó y construyó un lavadero comunitario con agua caliente a partir de energía solar. Además de resolver el problema específico, la experiencia resultó un proceso de aprendizaje para la comunidad destinataria y para el equipo de la universidad que participó en el proyecto.In the locality of Las Capillas, Department of Iruya, Province of Salta, was made a study of the communitys problematic, detecting like one of the most important the difficulties for the washing of clothes due to the very cold temperature or freezing of the water. Within the framework of the Program of University Voluntary 2006 of the Ministry of Education a communitarian laundry with hot water from solar energy was designed and constructed. Besides to solve the specific problem, the experience turned out a process from learning for the community and the university group.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES