Blockade of TIGIT-PVR Axis can Treat Breast Cancer

This review covers the identification and application of anti-TIGIT antibodies as checkpoint inhibitors for the treatment of triple-negative breast cancers. The original article, Targeting the TIGIT-PVR Immune Checkpoint Axis as Novel Therapeutic Option in Breast Cancer, was published by Stamm et al. in Oncoimmunology in October of 2019

Historical approach to citizen participation in Venezuela: from the relationship state-society models (1958-2012)

La dominación política se estructura y presenta como formas institucionalizadas, conocidas como: Estado, partidos políticos, ideologías, creencias políticas, las cuales se expresan a través de la socialización y las prácticas colectivas. En ese orden de ideas, el Estado es una estructura que organiza al poder y sienta las bases de la preeminencia que en una sociedad democrática deriva en la existencia de un juego de intereses sociales cuya configuración, valorización y jerarquía condiciona la dinámica socio-política en general. En consecuencia, el modelo de relación Estado-sociedad se determina por las interacciones entre los diferentes actores del proceso político, en tal sentido, el objetivo de esta disertación es identificar cómo este modelo puede regular, controlar, cooptar o incentivar la participación ciudadana, para tales efectos, la revisión bibliográfica-documental desde una perspectiva hermenéutica e interpretativa, permitió la revisión y el acercamiento histórico-comparativo al modelo de relación del Estado-Sociedad en Venezuela, del período de 1958 hasta el 2012, lo cual facilitó el reconociendo de algunas lógicas, pautas e intereses involucrados, tal comprensión derivó en una postura crítica, concluyendo, que las prácticas políticas de representación y participación democrática en Venezuela estructuraron un patrón de sometimiento, diferenciado por las posiciones ideológicas antagónicas de los gobiernos de turno.Political domination is structured and presented as institutionalized forms, known such as; State, politicians parties, ideologies, political beliefs, which are expressed through socialization and collectives’ practices. In this order of ideas, the State is a structure that organizes the power and sets the preeminence basis that in a democratic society derives in the existence of a set of social interests whose configuration, assessment and hierarchy determines the dynamics socio-political in general. Consequently, the relationship model State-Society is determined by the interactions between the different actors in the political process, in this sense, the objective of this dissertation is identify how this model can regulate, control, co-opt or encourage citizen participation, for such purposes, the bibliographic-documental review from a perspective of hermeneutics and interpretive, enabled a historical-comparative review and approach to the model of relationship of the State-Society in Venezuela, of the period 1958 until 2012, which facilitated the recognizing some logics, guidelines and interests involved, such understanding resulted in a critical, concluding stance, to the political practices of representation and democratic participation in Venezuela they structured a pattern of subjugation, differentiated by the conflicting ideological positions of governments turn

An epistemological discussion on citizen participation management

En este trabajo se abordan perspectivas epistémicas sobre la gestión de la participación ciudadana, desde la deconstrucción de categorías clave asociadas tales como; el Estado, en su andamiaje axiológico jurídico y el ciudadano en la plenitud de su ejercicio en el contexto público desde su rol protagónico activo participativo. Dilucidar una conceptualización ajustada a los referentes teóricos obtenida desde un enfoque hermenéutico – interpretativo, método documental-bibliográfico. Concluyéndose que la gestión de participación ciudadana se construye a través de mecanismos efectivos en un sistema democrático, en un marco social de derecho y en la conciencia colectiva del empoderamiento de la ciudadanía.This work addresses perspectives epistemic management of citizen participation, from the deconstruction of associated key categories such as; the State, in its legal axiological scaffolding and citizen in the fullness of its exercise in the public context from its active lead participatory role. Elucidate a conceptualization adjusted to the theoretical references obtained from a hermeneutic–interpretative approach, documental-bibliographic method. Concluding that citizen participation management is built through effective mechanisms under a democratic system, in a social framework of law and in the collective consciousness of citizen empowerment

Responsabilidade universitária e desenvolvimento sustentável: Promovendo uma educação inclusiva e de qualidade

Introduction. Social responsibility and sustainable development are elements that promote proactive organizational management; for example, in the educational system, in this context, the university has a great challenge, which is to assume the training of competent and apt individuals to face the future, which is characterized by being unpredictable and increasingly complex. The objective is to understand and reflect on university social responsibility and sustainable development as drivers and promoters of inclusive and quality university education. The qualitative paradigm was proposed as a method. It is cross-sectional, where documentary observation and hermeneutics allow us to conclude that clearly defined elements drive universities to generate an inclusive and high-quality education that, although they have joined forces to reach this maximum, there is still a long way to go. University institutions are recommended to redefine priority lines of research adjusted to the immediate social realities.Introducción. La responsabilidad social y el desarrollo sostenible constituyen elementos que promueven una gestión organizativa asertiva, por ejemplo, en el sistema educativo, en este contexto, la universidad tiene un gran reto, que es asumir la formación de individuos competentes y aptos para afrontar el futuro, que se caracteriza por ser impredecible y cada vez más complejo. Se plantea como objetivo comprender y reflexionar sobre la responsabilidad social universitaria y el desarrollo sostenible como impulsores, promotores de la educación universitaria inclusiva y de calidad. Se planteó como método el paradigma cualitativo, es de corte transeccional, donde a través de la observación documental y la hermenéutica permitiendo concluir que existen elementos claramente definidos que impulsan a las universidades a generar una educación inclusiva y de calidad que, aunque estas han aunado esfuerzos para alcanzar esta máxima falta camino por recorrer. Se recomienda a las instituciones universitarias que redefinan líneas prioritarias de investigación ajustadas a las realidades sociales inmediatas.Introdução. A responsabilidade social e o desenvolvimento sustentável constituem elementos que promovem uma gestão organizacional assertiva, por exemplo, no sistema educacional, neste contexto, a universidade tem um grande desafio, que é assumir a formação de indivíduos competentes e capazes de enfrentar o futuro, que se caracteriza por ser imprevisível e cada vez mais complexo. O objetivo é compreender e refletir sobre a responsabilidade social universitária e o desenvolvimento sustentável como motores e promotores da educação universitária inclusiva e de qualidade. O paradigma qualitativo foi proposto como método, é transecional, onde através da observação documental e da hermenêutica nos permite concluir que existem elementos claramente definidos que impulsionam as universidades a gerar uma educação inclusiva e de qualidade que, embora tenham unido forças para alcançar este máximo há ainda é um caminho a percorrer. Recomenda-se às instituições universitárias que redefinam linhas prioritárias de investigação ajustadas às realidades sociais imediatas

Primary elections and electoral outcomes: evidence from the Spanish Socialist Party

Using a regression discontinuity design and primary elections to select Spanish Socialist Party (PSOE) mayoral candidates as a case study, this paper investigates the causal link between primary elections and electoral outcomes. The results suggest that selecting the PSOE’s mayoral candidate through primary elections has no effect on the percentage of votes and total votes received by the PSOE’s candidate in local elections, the probability of gaining the mayorship and the local government’s stability. On the other hand, the results suggest that PSOE’s primary elections result in increased votes for competing political parties to the right of the PSOE and in reduced votes for competing parties to the left of the PSO

Effect of Chitosan Edible Coating on the Biochemical and Physical Characteristics of Carp Fillet (Cyprinus carpio) Stored at −18ºC.

The effect of an edible coating (EC) with 1.5% chitosan as an additive, on common carp (Cyprinus carpio) fillet, was determined evaluating the biochemical, physicochemical, textural, microbiological, and nutritional characteristics periodically during its hydroperoxides content (HPC) (0.8324 nM hydroperoxides/mg of protein versus 0.5540 nM/mg with regard to the EC sample), as well as protein carbonyl content (PCC) (0.5860 nM versus 0.4743 nM of reactive carbonyl groups/mg of protein of noncoated material), keeping properties for a longer period of time, and a lower protein solubility (7.8 mg of supernatant protein/mg of total microbialgrowth,thecountwas2.2×10 CFU/gofsampleinmesophilesversus4.7×10 intheECsample.Theresultsindicatethat the use of EC added with chitosan maintains the quality of the product regarding lipid and protein oxidation until fourth month of storage, maintaining moisture content without variation for at least 3 months, and inhibits microbial growth up to 2 logarithmic units, during five months of frozen storage

Estudio del tratado de libre comercio Colombia – Estados Unidos: Iowa, Kansas, Kentucky, Luisiana y Maine

Con el proceso de globalización que se evidencia actualmente, el comercio entre países ha sido uno de los factores más relevantes a través del tiempo y Colombia no ha sido excluyente a esta situación. Es por la importancia del asunto, que la Escuela de Administración dentro de sus múltiples proyectos de investigación busca la identificación de oportunidades para PYMES colombianas en mercados extranjeros, específicamente en Estados Unidos, asumiendo los retos que trae consigo un Tratado de Libre Comercio, las implicaciones en cuanto a los procesos de intercambio (importaciones y exportaciones) en sus diversos ámbitos y el impacto que genera dicho proceso en la balanza comercial colombiana. Debido a esto, se ha propuesto el desarrollo de un trabajo de grado que analice el Tratado de Libre Comercio (TLC) entre Colombia y Estados Unidos, enfocándose en los perfiles de cada mercado y las necesidades de los mismos, con el fin de identificar oportunidades generadas desde su puesta en marcha. En busca de un análisis detallado, el trabajo en mención hace énfasis en cinco estados de Estados Unidos (Iowa, Kansas, Kentucky, Luisiana y Maine) y los 32 departamentos de Colombia. Con el objetivo de realizar un análisis más efectivo se tomaron en cuenta las características de cada mercado y su relación comercial. A partir del previo proceso de investigación, se pretende identificar y definir oportunidades comerciales que evidencian una evolución comercial (mayor número de importaciones y exportaciones). Dichas oportunidades identificadas son el resultado de un análisis cualitativo tras desarrollar matrices de los principales diez productos más demandados por los Estados mencionados y los principales productos ofertados por los departamentos colombianos. Gracias a lo que enmarca un TLC dentro de un proceso de negociación, se proyecta identificar según las necesidades de las partes, es decir, oferta y demanda de bienes y/o 9 servicios, cada una de las oportunidades claves para los comerciantes nacionales que se involucran dentro del acuerdo aprobado.With the globalization process-taking place nowadays, the trade between countries has been one of the most significant agents through time and Colombia has been part of it. For that reason, this project looks up opportunities for Colombian SMEs in foreign markets, specifically in United States, assuming the challenges that come with the Free Trade Agreement, the implications between the exchange processes, and the impact of the balance of trade, mainly in Colombia. Due to this situation, we proposed to develop a project, that focuses on the FTA’s analysis and impact, taking into account each market profiles and its needs, with the purpose of identify opportunities generated by the FTA start up and developing, between Colombia and United States. The project above consists in the analysis of five states (Iowa, Kansas, Kentucky, Louisiana and Maine) and the 32 Colombia´s departments. From previous research of both Colombian and American markets, the main idea is to identify and define strategic sectors for commercial progress (higher imports and exports) that will provide potential opportunities to Colombian entrepreneurs. Thanks to framing a FTA within a process of negotiation, the projected identifies the needs of the parties, that is, supply and demand of goods and / or services, each of the key opportunities for national officials involved under the agreement approved.Universidad del Rosari

Impact of migration on the occurrence of new cases of Chagas disease in Buenos Aires city, Argentina

Chagas disease, also known as American Trypanosomiasis, is endemic in the Americas, especially Central and South America. Chagas disease is a zoonotic disease caused by the parasite Trypanosoma cruzi. Most of the infections take place in children by vector or congenital transmission, with other modes of infection such as blood transfusion, organ transplants, and oral route being less frequent. In areas under vectorial control, congenital transmission is the most common way of accruing the diseaseFil: Moscatelli, Guillermo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garcia Bournissen, Facundo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Freillij, Hector. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Berenstein, Ada. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Tarlovsky, Ana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Moroni, Samanta. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Ballering, Griselda. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Biancardi, Miguel Angel. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Siniawski, Susana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Schwarcz, Marta. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Hernandez, Susana. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Espejo Cozzi, Andres. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Altcheh, Jaime Marcelo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Modulating climacteric intensity in melon through QTL stacking

Fruit ripening is one of the main processes affecting fruit quality and shelf life. In melon there are both climacteric and non-climacteric genotypes, making it a suitable species to study fruit ripening. In the current study, in order to fine tune ripening, we have pyramided three climacteric QTLs in the non-climacteric genotype “Piel de Sapo”: ETHQB3.5, ETHQV6.3 and ETHQV8.1. The results showed that the three QTLs interact epistatically, affecting ethylene production and ripening-related traits such as aroma profile. Each individual QTL has a specific role in the ethylene production profile. ETHQB3.5 accelerates the ethylene peak, ETHQV6.3 advances the ethylene production and ETHQV8.1 enhances the effect of the other two QTLs. Regarding aroma, the three QTLs independently activated the production of esters changing the aroma profile of the fruits, with no significant effects in fruit firmness, soluble solid content and fruit size. Understanding the interaction and the effect of different ripening QTLs offers a powerful knowledge for candidate gene identification as well as for melon breeding programs, where fruit ripening is one of the main objectives.info:eu-repo/semantics/publishedVersio

Shame from Smiling and Speaking Due to Oral Health Problems in Brazilian Adolescents: A Nationwide Population-Based Study

Objective: To investigate the association between oral health problems and being ashamed of smiling or speaking among Brazilian adolescents. Material and Methods: This was a population-based cross-sectional study carried out with secondary data from 7,328 12-year-old Brazilian adolescents from the latest Brazilian national oral health survey (SB Brasil 2010). The question “In the previous 6 months, have you been ashamed of smiling or speaking due to your teeth?” was the outcome variable. Calibrated examiners performed clinical examinations on adolescents for the diagnosis of dental caries (DMF-T), dental trauma, dental fluorosis and occlusal alterations. Data were analyzed descriptively and by Poisson unadjusted and adjusted Poisson regression analysis (p<0.05). The final model was controlled by family income. Results: The prevalence of being ashamed of smiling or speaking was 13.6%. The following variables were associated with the outcome: female sex (PR=1.33; 95% CI: 1.17-1.53), cavitated dental caries on upper incisors (PR=1.81; 95% CI: 1.51-2.15), dental trauma (PR=1.36; 95% CI:1.16-1.60), increased maxillary overjet (PR=1.36; 95% CI:1.18-1.57), dental crowding (PR=1.60; 95% CI:1.40-1.83), midline diastema (PR=1.30; 95% CI:1.11-1.44), tooth loss (PR=1.45; 95% CI:1.16-1.80), mild/questionable dental fluorosis (PR=1.23; 95% CI:1.06-1.44) and moderate/severe dental fluorosis (PR=1.67; 95% CI:1.15-2.44). Conclusion: Oral health problems that impact dental aesthetics were predisposing factors for being ashamed of smiling or speaking in Brazilian adolescents