Antiepileptic drugs for the treatment of neuropathic pain : a systematic review

Many therapies have been proposed for the management of neuropathic pain, and they include the use of different antiepileptic drugs. However, the lack of high quality studies indicates that results on the different neuropathic disorders under study do not recommend a particular drug treatment. This study makes a systematic review of the published literature on the use of several antiepileptic drugs to treat neuropathic pain, and has the objective of considering both its clinical characteristics and pharmacological use, which will depend on their level of scientific evidence and will follow the principles of evidence-based dentistry. The articles were stratified according to their scientific evidence using the SORT criteria (Strength of Recommendation Taxonomy), and it included those articles that only have level 1 or 2. Randomized clinical trials were stratified according to their level of quality using the JADAD scale, an instrument described by Jadad et al . (7) . to assess the quality of clinical trials, while studies with a level below 3 were discarded. Recently, type A or B recommendations are given in favor or against the use of antiepileptic drugs to treat neuropathic pain on the basis of their scientific quality

Kinematics and stellar populations in active galaxies: the LINER NGC 4579 (M58)

This is an electronic version of an article published in Astronomy and Astrophysics. Palacios, J., García-Vargas, M.L., Diaz, A., Terlevich, R. and E. Terlevich. Kinematics and stellar populations in active galaxies: the LINER NGC 4579 (M58). Astronomy and Astrophysics 323 (1997): 749-76

The biogeochemical context of marine planktonic ecosystems

En prens

MEGARA cryogenic system

MEGARA (Multi Espectrógrafo en GTC de Alta Resolución para Astronomía) is the new integral field unit (IFU) and multi-object spectrograph (MOS) instrument for the Gran Telescopio Canarias (GTC). The selected cryogenic device to harbor the CCD detector for the MEGARA spectrograph is a liquid nitrogen open-cycle cryostat. The LN2 open-cycle cryostat is a custom made product which has been designed by the INAOE astronomical instrumentation group. The proposed cryostat offers modular stages for easy assembly and testing whilst also allowing future modifications to accommodate the required CCDs, electronics and optics

Liderazgo Personalista Integral. Un modelo para el liderazgo en las organizaciones

In the study of leadership ethics in organizations, a descriptive perspective predominates, which, based on the analysis of the leader’s behavior and empirical evidence, is partial and fragmented. A deeper understanding of this phenomenon requires solid anthropology, which explains the concept of the person that underlies it since how the leader conceives the person determines his leadership style and objectives. In this research, we made a literary review of Personalism to have a person’s systematic notion, which contemplates it in all its complexity. On this basis, we propose a model of Comprehensive Personalist Leadership, with an ethical and transcendent sense, in which the leader rethinks his priorities and strives to align the interests of people and the organization towards the common good.En el estudio de la ética del liderazgo en las organizaciones predomina una perspectiva descriptiva, que al fundamentarse en el análisis de las conductas del líder y en la evidencia empírica, es parcial y fragmentada. Una comprensión más profunda de este fenómeno requiere de una antropología sólida, que explique el concepto de persona que subyace en él, pues la manera en que el líder concibe a la persona determina su estilo de liderazgo y sus objetivos. En esta investigación se hace una revisión literaria del Personalismo, para disponer de una noción sistemática de la persona, que la contemple en toda su complejidad. Sobre esta base, se propone un modelo de Liderazgo Personalista Integral, con sentido ético y trascendente, en el que líder se replantea sus prioridades y se esfuerza por alinear los intereses de las personas y de la organización hacia el bien común

Fertilization and connectivity in the Garrucha Canyon (SE-Spain) Implications for Marine Spatial Planning

Postprin

The RADMED monitoring program as a tool for MSFD implementation: toward an ecosystem based approach

In the western Mediterranean Sea, the RADMED monitoring programme is already conducting several of the evaluations required under the Marine Strategy Framework Directive (MFSD) along the Spanish Mediterranean coast. The different aspects of the ecosystem that are regularly sampled under this monitoring programme are the physical environment and the chemical and biological variables of the water column, together with the planktonic communities, biomass and structure. Moreover, determinations of some anthropogenic stressors on the marine environment, such as contaminants and microplastics, are under development. Data are managed and stored at the Instituto Español de Oceanografía (IEO) Data Centre that works under the Sea- DataNet infrastructure, and are also stored in the IBAMar database. In combination with remote sensing data, they are used to address open questions on the ecosystems in the western Mediterranean Sea.Postprint2,293

The nature of the Cygnus extreme B supergiant 2MASS J20395358+4222505

2MASS J20395358+4222505 is an obscured early B supergiant near the massive OB star association Cygnus OB2. Despite its bright infrared magnitude (Ks = 5.82) it has remained largely ignored because of its dim optical magnitude (B = 16.63, V = 13.68). In a previous paper, we classified it as a highly reddened, potentially extremely luminous, early B-type supergiant. We obtained its spectrum in the U, B and R spectral bands during commissioning observations with the instrument MEGARA at the Gran Telescopio CANARIAS. It displays a particularly strong Hα emission for its spectral type, B1 Ia. The star seems to be in an intermediate phase between supergiant and hypergiant, a group that it will probably join in the near (astronomical) future. We observe a radial velocity difference between individual observations and determine the stellar parameters, obtaining Teff = 24 000 K and log gc = 2.88 ± 0.15. The rotational velocity found is large for a B supergiant, v sin i = 110 ± 25 kms−1⁠. The abundance pattern is consistent with solar, with a mild C underabundance (based on a single line). Assuming that J20395358+4222505 is at the distance of Cyg OB2, we derive the radius from infrared photometry, finding R = 41.2 ± 4.0 R⊙, log(L/L⊙) = 5.71 ± 0.04 and a spectroscopic mass of 46.5 ± 15.0 M⊙. The clumped mass-loss rate (clumping factor 10) is very high for the spectral type, M˙ = 2.4 × 10−6 M⊙ a−1. The high rotational velocity and mass-loss rate place the star at the hot side of the bi-stability jump. Together with the nearly solar CNO abundance pattern, they may also point to evolution in a binary system, J20395358+4222505 being the initial secondary.SS-D and AH acknowledge support from the Spanish Government Ministerio de Ciencia e Innovación through grants PGC-2018-091 3741-B-C22 and CEX2019-000920-S and from the Canarian Agency for Research, Innovation and Information Society (ACIISI), of the Canary Islands Government, and the European Regional Development Fund (ERDF), under grant with reference ProID2020010016. MG and FN acknowledge financial support through Spanish grant PID2019-105552RB-C41 (MINECO/MCIU/AEI/FEDER) and from the Spanish State Research Agency (AEI) through the Unidad de Excelencia ‘María de Maeztu’-Centro de Astrobiología (CSIC-INTA) project No. MDM-2017-0737. SRB acknowledges support by the Spanish Government under grants AYA2015-68012-C2-2-P and PGC2018-093741-B-C21/C22 (MICIU/AEI/FEDER, UE). SRA acknowledges funding support from the FONDECYT Iniciación project 11171025 and the FONDECYT Regular project 1201490. JIP acknowledges finantial support from projects Estallidos6 AYA2016-79724-C4 (Spanish Ministerio de Economia y Competitividad), Estallidos7 PID2019-107408GB-C44 (Spanish Ministerio de Ciencia e Innovacion), grant P18-FR-2664 (Junta de Andalucía), and grant SEV-2017-0709 ‘Centro de Excelencia Severo Ochoa Program’ (Spanish Science Ministry). AGP, SP, AG-M, JG and NC acknowledge support from the Spanish MCI through project RTI2018-096188-B-I00

The exposure of the hybrid detector of the Pierre Auger Observatory

The Pierre Auger Observatory is a detector for ultra-high energy cosmic rays. It consists of a surface array to measure secondary particles at ground level and a fluorescence detector to measure the development of air showers in the atmosphere above the array. The "hybrid" detection mode combines the information from the two subsystems. We describe the determination of the hybrid exposure for events observed by the fluorescence telescopes in coincidence with at least one water-Cherenkov detector of the surface array. A detailed knowledge of the time dependence of the detection operations is crucial for an accurate evaluation of the exposure. We discuss the relevance of monitoring data collected during operations, such as the status of the fluorescence detector, background light and atmospheric conditions, that are used in both simulation and reconstruction.Comment: Paper accepted by Astroparticle Physic