Review of \u3ci\u3eJulius Seyler and the Blackfeet: An Impressionist at Glacier National Park\u3c/i\u3e by William E. Farr

The turn from the nineteenth to the twentieth century saw the conclusion of the Great Northern Railway (1893) and the birth of Glacier National Park in Montana (1910), two events so tightly interrelated through the family of railroad tycoon James J. Hill and his son Louis W. Hill that they would come to be automatically associated in the minds of many twentieth-century Americans-especially the prospective middle-class tourists from the metropolitan East who were following the Hills\u27 promotional exhortation to See America First and experience a tamed version of western wilderness at Glacier Park: outdoor adventure and close contact with what was deemed the remnant of a prior era, the Indian included. In the course of these campaigns, Louis Hill engaged a number of visual artists-painters, graphic artists, photographers, and filmmakers- to create lasting and iconic images to be associated with the Park

Crisis and Legitimacy in Atlantic American Narratives of Piracy, 1678-1865

The book traces the construction and function of the pirate in transatlantic American literature from the late 17th century to the Civil War, exploring in what ways the cultural imaginary teased out the pirate’s ambivalent potential as a figure of both identification and Othering, and how it has been used to negotiate ideas of legitimacy. The study recasts piracy as a discursive category moving in a continuum between the propagation of (post-)colonial adventure and accumulation on the one hand and critical commentary on exploitation and oppression on the other. Reading piracy narratives as symptomatic of various crisis scenarios in the US context, the book examines how the pirate was imbued with (de)legitimatory meaning during such periods in both elite and popular texts.Die Studie zeichnet die Konstruktion und Funktion des Piraten in der transatlantisch-amerikanischen Erzählliteratur vom späten 17. Jahrhundert bis zum Sezessionskrieg nach und untersucht, wie das ambivalente Potential der Figur zwischen Identifikation und Alterisierung genutzt wurde, um Vorstellungen von Legitimität und Macht zur Verhandlung zu stellen. Das Buch begreift Piraterie als diskursive Kategorie im Kontinuum zwischen Propagierung (post-)kolonialen Abenteuers und Akkumulation einerseits und kritischem Kommentar zu Ausbeutung und Unterdrückung andererseits. Piratenerzählungen werden als symptomatisch im Kontext verschiedener kolonialer und nationaler Krisenszenarien verstanden, die u.a. Sklaverei, Geschlecht oder Identität zur Diskussion stellen

Review of \u3ci\u3eJulius Seyler and the Blackfeet: An Impressionist at Glacier National Park\u3c/i\u3e by William E. Farr

The turn from the nineteenth to the twentieth century saw the conclusion of the Great Northern Railway (1893) and the birth of Glacier National Park in Montana (1910), two events so tightly interrelated through the family of railroad tycoon James J. Hill and his son Louis W. Hill that they would come to be automatically associated in the minds of many twentieth-century Americans-especially the prospective middle-class tourists from the metropolitan East who were following the Hills\u27 promotional exhortation to See America First and experience a tamed version of western wilderness at Glacier Park: outdoor adventure and close contact with what was deemed the remnant of a prior era, the Indian included. In the course of these campaigns, Louis Hill engaged a number of visual artists-painters, graphic artists, photographers, and filmmakers- to create lasting and iconic images to be associated with the Park

On the Asphalt Frontier: American Women’s Road Narratives, Spatiality, and Transgression

In this article, I am going to analyze the concept of “gendered space” as it appears in select post-1970s US-American road narratives produced by women writers of various ethnic and social backgrounds. Drawing on recent re-mappings in cultural geography, I will cross disciplinary boundaries and argue that for female literary protagonists, the “open road” appears as a dangerous frontier—in which women’s physical and emotional well-being is always at perilous stake—rather than as an adventurous playground. In women’s road stories, the American highway does not maintain its mythical, iconic status, signifying freedom and the heroic quest for identity, which has been ascribed to it at least since the legendary accounts of the flight from domesticity by Jack Kerouac and his fellow (anti-)heroes of the Beat generation. Female protagonists, too, it will be shown, feel the luring of the road, or see cross-country travel as a way out of the ideology of separate spheres—and, from a socio-historical perspective, they indeed have much more reason for doing so than their male counterparts. However, more often than not, women come to realize that they are “prisoners of the white lines of the freeway” (as Joni Mitchell puts it in her famous road-song “Coyote”), and as such are not liberated by mere motion, but confronted with spatial limitations not much different from those encountered at the hearth. Nevertheless, by embracing these multiple confrontations for the challenges they present, and by deliberately transgressing gendered boundaries of public vs. private and cultural vs. natural space, the itinerant protagonists of the texts under discussion eventually re-appropriate their share of the road

Key Data Elements in Myeloid Leukemia

Data standards consisting of key data elements for clinical routine and trial documentation harmonize documentation within and across different health care institutions making documentation more efficient and improving scientific data analysis. This work focusses on the field of myeloid leukemia (ML), where a semantic core of common data elements (CDEs) in routine and trial documentation is established by automatic UMLS-based form analysis of existing documentation models. These CDEs (n=227) were initially reviewed and commented by leukemia experts before they were systematically surveyed by an international voting process through seven hematologists of four countries. The total agreement score was 86%. 116 elements (51%) of these share an agreement score of 100%. This work generated CDEs with language-independent semantic codes and international clinical expert review to build a first approach towards an international data standard for ML. A first version of the CDE list is implemented in the data standard Operational Data Model and additional other data formats for reuse in different medical information systems

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

OBJECTIVE: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS: Nine SNPs at eight loci were associated with proinsulin levels (P < 5 × 10(-8)). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 × 10(-4)), improved β-cell function (P = 1.1 × 10(-5)), and lower risk of T2D (odds ratio 0.88; P = 7.8 × 10(-6)). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS: We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis

Review of: Nina Degele, Sigrid Schmitz, Marion Mangelsdorf, Elke Gramespacher (Hg.): Gendered Bodies in Motion. Opladen u.a.: Budrich UniPress 2010.

Dieser gelungene Band – Ergebnis einer Fachtagung im Bereich Gender Studies an der Universität Freiburg und zugleich Jubiläumsband anlässlich des zehnjährigen Bestehens der Freiburger Koordinierungsstelle Gender Studies – beleuchtet den Nexus Körper und Geschlecht als dynamische Figuration an der Schnittstelle unterschiedlicher Wissenschaftsdiskurse. Die Autor/-innen stellen sich der interdisziplinären Herausforderung eines Dialogs zwischen Natur- und Technikwissenschaften einerseits und Gesellschafts- und Kulturwissenschaften andererseits, wenn auch mit z. T. unterschiedlichem Erfolg. Der Band bietet seinen Leser/-innen einen spannenden Einblick in die Dynamik körperlicher Signifikationen und vergesellschaftlichter Materialitäten und eröffnet vielfältige, innovative Forschungsperspektiven im Bereich der body studies.This successful volume – result of a symposium in the field of Gender Studies at the University of Freiburg and at the same time anniversary edition in celebration of the ten year existence of the Freiburg coordination site for Gender Studies – examines the nexus body and gender as a dynamic figuration at the intersection of various scientific discourses. The authors face the interdisciplinary challenge of a dialogue between natural and technical sciences as well as social and cultural studies, even though with in parts varying success. This volume offers exciting insights into the dynamics of bodily significations and socialized materialities to its readers, while opening manifold innovative perspectives in the field of body studies