An examination of family nutrition programs implemented by Mississippi State University Extension Service in Jackson public schools

The Supplemental Nutrition Assistance Program-Education (SNAP-Ed) includes programs and educational curricula that promote healthy behaviors for people receiving nutrition assistance benefits, or eligible for benefits. This study investigated whether information given to children through SNAP-Ed nutrition education programs implemented in schools was taken home to educate parents. After programs were delivered to students by Mississippi State University Extension Service Nutrition Educators, parents (N=302, response rate=43.1%) of elementary students in eight public schools in Jackson, Mississippi, reported changes they made in their households. These changes included eating more fruits and vegetables or trying different fruits and vegetables, and being more physically active (p\u3c0.001). A majority (63.9%) of parents reported that after their children participated in nutrition education programs, their children talked to them about healthy foods, and 73.2% reported their children asked for more fruits, vegetables, milk, or yogurt. Teachers (N=19, response rate=38.0%) rated the SNAP-Ed education programs favorably

An examination of family nutrition programs implemented by Mississippi State University Extension Service in Jackson public schools

The Supplemental Nutrition Assistance Program-Education (SNAP-Ed) includes programs and educational curricula that promote healthy behaviors for people receiving nutrition assistance benefits, or eligible for benefits. This study investigated whether information given to children through SNAP-Ed nutrition education programs implemented in schools was taken home to educate parents. After programs were delivered to students by Mississippi State University Extension Service Nutrition Educators, parents (N=302, response rate=43.1%) of elementary students in eight public schools in Jackson, Mississippi, reported changes they made in their households. These changes included eating more fruits and vegetables or trying different fruits and vegetables, and being more physically active (p\u3c0.001). A majority (63.9%) of parents reported that after their children participated in nutrition education programs, their children talked to them about healthy foods, and 73.2% reported their children asked for more fruits, vegetables, milk, or yogurt. Teachers (N=19, response rate=38.0%) rated the SNAP-Ed education programs favorably

Crescimento e produção de compostos bioativos da macroalga Kappaphycus alvarezii cultivada in vitro com efluente de bioflocos e extrato de ascophyllum nodosum

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Aqüicultura, Florianópolis, 2015.Este trabalho teve como objetivo determinar o efeito bioestimulante do efluente do cultivo de Litopenaeus vannamei em sistema de bioflocos (BFT) e do extrato comercial de Ascophyllum nodosum (AMPEP) no crescimento e perfil metabólico (carotenóides e compostos fenólicos) da macroalga Kappaphycus alvarezii cultivada in vitro. Os meios de cultura contendo água do mar esterilizada (controle) adicionada de solução von Stosch 50% (Vs), efluente de BFT 25% (BFT), AMPEP (0,1g L-1, 30 min - Ap) e as combinações de tratamentos Vs+Ap e BFT+Ap mostraram-se adequados à sobrevivência de 100% dos talos. Em todos os tratamentos foi detectado a ocorrência da ?doença? ice-ice. As amostras tratadas com Vs e BFT apresentaram as maiores taxas médias de crescimento, 1,70 ± 0,14 % dia-1 e 1,56 ± 0,08 % dia-1 respectivamente, não diferindo (p>0,05) entre si. De outra forma, menores e similares incrementos de biomassa foram observados nos tratamentos controle (0,51 ± 0,05 % dia-1) e Ap (0,57 ± 0,07 % dia-1). A suplementação do meio de cultura com BFT estimulou a biossíntese de compostos fenólicos (92,2 ± 22,4 µg g-1 biomassa seca) e flavonóides totais (18,8 ± 0,6 µg g-1 biomassa seca), enquanto talos cultivados em BFT+Ap apresentaram conteúdos de carotenóides totais (239,3 ± 9,3 µg g-1 biomassa seca) superiores (pAbstract : This work aimed to determine in vitro the biostimulant effect of Litopenaeus vannamei effluent cultivation in bio-flocs system (BFT) and the commercial extract of Ascophyllum nodosum (AMPEP) on growth and metabolic profile (carotenoids and phenolic compounds) of the seaweed Kappaphycus alvarezii. Culture media containing sterilized seawater (control) added with von Stosch solution 50% (Vs), BFT effluent 25% (BFT), AMPEP (0.1g L-1, 30 min - Ap), and combinations of treatments Vs Ap and BFT Ap allowed 100% survival of the propagules. In all treatments, ice-ice "disease" was detected. The samples treated with Vs and BFT had the highest average growth rates, i.e., 1.70 ± 0.14% day-1 and 1.56 ± 0.08% day-1 respectively, not differing (p<0.05) each other. Otherwise, smaller and similar increments of biomass were observed in the control (0.51% ± 0.05 day-1) and Ap (0.57 ± 0.07% day-1). Supplementation of culture medium with BFT stimulated biosynthesis of phenolic compounds (92.2 ± 22.4 µg g-1 dry weight) and flavonoids (18.8 ± 0.6 µg g-1 dry weight), while propagules grown on BFT Ap presented superior total carotenoid content (239.3 ± 9.3 µg g-1 dry weight, p <0.05). Higher values (p <0.05) of inhibition of the DPPH radical were observed in seaweed methanolic extracts treated with Vs (13.4 ± 1.5%) and Vs+Ap (13.4 ± 0.6%). Results demonstrated that the treatments effectively altered both K. alvarezii´s growth and secondary metabolism, especially with supplementation of the seawater with Vs and BFT. These treatments produced increases of biomass and carotenoids and phenolic compounds of recognized biological effects (e.g., antioxidants). In addition, the BFT treatment highlight from others with significant increase of total phenolics and flavonoids suggesting an interesting context to the analysis of epigenetic manipulation of K. alvarezii crops on a large scale and their possible outcome in aquaculture engineering and related production sectors

Proof of a Stable Fixed Point for Strongly Correlated Electron Matter

We establish the Hatsugai-Kohmoto model as a stable quartic fixed point (distinct from Wilson-Fisher) by computing the $\beta-$function in the presence of perturbing local interactions. In vicinity of the half-filled doped Mott state, the $\beta-$function vanishes for all local interactions regardless of their sign. The only flow away from the HK model is through the superconducting channel which lifts the spin degeneracy as does any ordering tendency. The superconducting instability is identical to that established previously\cite{nat1}. A corollary of this work is that Hubbard repulsive interactions flow into the HK stable fixed point in the vicinity of half-filling. Consequently, although the HK model has all-to-all interactions, nothing local destroys it. The consilience with Hubbard arises because both models break the $Z_2$ symmetry on a Fermi surface, the HK model being the simplest to do so. Indeed, the simplicity of the HK model belies its robustness and generality

Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles

Citation: Waite, K. A., De-La Mota-Peynado, A., Vontz, G., & Roelofs, J. (2016). Starvation Induces Proteasome Autophagy with Different Pathways for Core and Regulatory Particles. Journal of Biological Chemistry, 291(7), 3239-3253. doi:10.1074/jbc.M115.699124The proteasome is responsible for the degradation of many cellular proteins. If and how this abundant and normally stable complex is degraded by cells is largely unknown. Here we show that in yeast, upon nitrogen starvation, proteasomes are targeted for vacuolar degradation through autophagy. Using GFP-tagged proteasome subunits, we observed that autophagy of a core particle (CP) subunit depends on the deubiquitinating enzyme Ubp3, although a regulatory particle (RP) subunit does not. Furthermore, upon blocking of autophagy, RP remained largely nuclear, although CP largely localized to the cytosol as well as granular structures within the cytosol. In all, our data reveal a regulated process for the removal of proteasomes upon nitrogen starvation. This process involves CP and RP dissociation, nuclear export, and independent vacuolar targeting of CP and RP. Thus, in addition to the well characterized transcriptional up-regulation of genes encoding proteasome subunits, cells are also capable of down-regulating cellular levels of proteasomes through proteaphagy

Benefícios e oportunidades metodológicos da aplicação do PCN de arte e a proposta triangular no Ensino Fundamental I

Monografia (graduação)—Universidade de Brasília, Instituto de Artes, Departamento de Artes Visuais, 2012.A disciplina de Arte no Ensino Fundamental I apresenta uma série de objetivos a serem alcançados, tendo como principal referência os Parâmetros Curriculares Nacionais (PCN) de Arte para o ciclo I. Juntamente com os Parâmetros Curriculares Nacionais, o estudo da arte-educadora Ana Mae Barbosa que aborda a Proposta Triangular, apresenta alternativas para que o ensino de artes seja desenvolvido de acordo com a realidade do educando através da experimentação. Este trabalho tem como objetivo, através de uma pesquisa de campo e estudo teórico, traçar diretrizes que levarão o educador a compreender e refletir sobre os principais desafios que para a inserção destas metodologias na prática escolar dos professores de 1º ao 5º Ano do Ensino Fundamental da Escola Municipal José Sebastião Herrera, localizada em Itapeva/SP, e que foi objeto da pesquisa de campo. Além disso, serão apontados os benefícios que este processo trará aos alunos e profissionais envolvidos na implantação de seus métodos, diante das dificuldades apresentadas pelos professores em desenvolver o processo de ensino e aprendizagem na disciplina de Artes, perante a escassez de recursos materiais, da falta de formação continuada e de aptidão com a disciplina, entre outros fatores. Os dados foram levantados por meio de pesquisa de campo com todos os professores de Ensino Fundamental I, direção e coordenação da escola. Durante o período de pesquisa, onde foram elaborados os questionários e observações de planos de aula, ocorreu a predominância do ensino das Artes Visuais em suas aulas, com pouco envolvimento da música, dança e teatro. Noventa por cento dos professores pesquisados mostraram estratégias aproximadas da proposta triangular de Ana Mae Barbosa. No entanto, a leitura de imagem foi pouco explorada. A partir desses dados, foram apresentadas algumas estratégias para que o processo de ensino em artes de acordo com os PCN e a proposta triangular possa acontecer

One-carbon metabolism in children with marasmus and kwashiorkor

BACKGROUND: Kwashiorkor is a childhood syndrome of edematous malnutrition. Its precise nutritional precipitants remain uncertain despite nine decades of study. Remarkably, kwashiorkor\u27s disturbances resemble the effects of experimental diets that are deficient in one-carbon nutrients. This similarity suggests that kwashiorkor may represent a nutritionally mediated syndrome of acute one-carbon metabolism dysfunction. Here we report findings from a cross-sectional exploration of serum one-carbon metabolites in Malawian children. METHODS: Blood was collected from children aged 12-60 months before nutritional rehabilitation: kwashiorkor (N = 94), marasmic-kwashiorkor (N = 43) marasmus (N = 118), moderate acute malnutrition (N = 56) and controls (N = 46). Serum concentrations of 16 one-carbon metabolites were quantified using LC/MS techniques, and then compared across participant groups. FINDINGS: Twelve of 16 measured one-carbon metabolites differed significantly between participant groups. Measured outputs of one-carbon metabolism, asymmetric dimethylarginine (ADMA) and cysteine, were lower in marasmic-kwashiorkor (median µmol/L (± SD): 0·549 (± 0·217) P = 0·00045 & 90 (± 40) P \u3c 0·0001, respectively) and kwashiorkor (0·557 (± 0·195) P \u3c 0·0001 & 115 (± 50) P \u3c 0·0001), relative to marasmus (0·698 (± 0·212) & 153 (± 42)). ADMA and cysteine were well correlated with methionine in both kwashiorkor and marasmic-kwashiorkor. INTERPRETATION: Kwashiorkor and marasmic-kwashiorkor were distinguished by evidence of one-carbon metabolism dysfunction. Correlative observations suggest that methionine deficiency drives this dysfunction, which is implicated in the syndrome\u27s pathogenesis. The hypothesis that kwashiorkor can be prevented by fortifying low quality diets with methionine, along with nutrients that support efficient methionine use, such as choline, requires further investigation. FUNDING: The Hickey Family Foundation, the American College of Gastroenterology, the NICHD, and the USDA/ARS

A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma.

BACKGROUND: This Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients with relapsed / refractory lymphoma or advanced solid organ cancers and to assess HR23B protein expression by immunohistochemistry as a biomarker of HDAC inhibitor sensitivity. METHODS: Patients with advanced solid-organ cancers with high HR23B expression or lymphomas received CXD101 at the recommended phase 2 dose (RP2D). Key exclusions: corrected QT > 450 ms, neutrophils  1. Baseline HR23B expression was assessed by immunohistochemistry. RESULTS: Fifty-one patients enrolled between March 2014 and September 2019, 47 received CXD101 (19 solid-organ cancer, 28 lymphoma). Thirty-four patients received ≥80% RP2D. Baseline characteristics: median age 57.4 years, median prior lines 3, male sex 57%. The most common grade 3-4 adverse events were neutropenia (32%), thrombocytopenia (17%), anaemia (13%), and fatigue (9%) with no deaths on CXD101. No responses were seen in solid-organ cancers, with disease stabilisation in 36% or patients; the overall response rate in lymphoma was 17% with disease stabilisation in 52% of patients. Median progression-free survival was 1.2 months (95% confidence interval (CI) 1.2-5.4) in solid-organ cancers and 2.6 months (95%CI 1.2-5.6) in lymphomas. HR23B status did not predict response. CONCLUSIONS: CXD101 showed acceptable tolerability with efficacy seen in Hodgkin lymphoma, T-cell lymphoma and follicular lymphoma. Further studies assessing combination approaches are warranted. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT01977638 . Registered 07 November 2013

Inhibitory control performance is repeatable over time and across contexts in a wild bird population

Inhibitory control is one of several cognitive mechanisms required for self-regulation, decision making and attention towards tasks. Inhibitory control is expected to influence behavioural plasticity in animals, for example in the context of foraging, social interaction or responses to sudden changes in the environment. One widely used inhibitory control assay is the ‘detour task’ where subjects must avoid impulsively touching transparent barriers positioned in front of food, and instead access the food by an alternative but known route. However, because the detour task has been reported to measure factors unrelated to inhibitory control, including motivation, previous experience and persistence, the task may be unreliable for making cross-species comparisons, estimating individual differences and linking performance with socioecological traits. To address these concerns, we designed a variant of the detour task for wild great tits, Parus major, and deployed it at the nesting site across two spring seasons. We compared task performance of the same individuals in the wild across 2 years, and with their performance in captivity when tested using the classical cylinder detour task during the nonbreeding season. Potential confounds of motivation, previous experience, body size, sex, age and personality did not significantly predict performance, and temporal and contextual repeatability were low but significant. These results support the hypothesis that our assays captured intrinsic differences in inhibitory control. Instead of dismissing detour tasks and ‘throwing the baby out with the bathwater’, we suggest confounds are likely system and experimental-design specific, and that assays for this potentially fundamental but largely overlooked source of behavioural plasticity in animal populations, should be validated and refined for each study system