67 research outputs found
Reporting randomised clinical trials of analgesics after traumatic or orthopaedic surgery is inadequate: a systematic review
- Author
- AD Oxman
- Antoni Vallano
- AR Jadad
- AR Jadad
- C Gummesson
- C Hewit
- CL Hill
- Cristina Aguilera
- CY Ko
- D Moher
- D Moher
- D Moher
- D Moher
- D Moher
- DG Altman
- E Garfield
- E Kiter
- E Mills
- E Montané
- Eva Montané
- FJ Bath
- GFM Strippoli
- GS Doig
- HD Clark
- I Boutron
- JC Sánchez-Thorin
- JE Edwards
- Joan-Ramon Laporte
- K Huwiler-Müntener
- KF Schulz
- KP Lee
- KW Ah-See
- M Bhandari
- M Bhandari
- M Bhandari
- M Egger
- M Petticrew
- M Piggott
- N Latronico
- P Jüni
- R Montenegro
- VM Montori
- Xavier Vidal
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
Background Several randomised clinical trials (RCTs) of analgesics in postoperative pain after traumatic or orthopaedic surgery (TOS) have been published, but no studies have assessed the quality of these reports. We aimed to examine the quality of reporting RCTs on analgesics for postoperative pain after TOS. Methods Reports of RCTs assessing analgesics in postoperative pain after TOS were systematically searched from electronic databases. The quality of reports was assessed using the CONSORT checklist (scoring range from 0 to 22). The quality was considered poor when scoring was 12 or lesser. The publication year and the impact factor of journals were recorded. Results A total of 92 reports of RCTs were identified and 69 (75%) scored 12 or lesser in CONSORT checklist (range 5-17). The mean (SD) CONSORT score of all reports was 10.6 (2.7). Missing CONSORT items included primary and secondary outcome measures (11%), the specific objectives and hypothesis definition (12%), the sample size calculation (12%), the dates defining the periods of recruitment (12%), the discussion of external validity of findings (14%), the allocation sequence generation (24%), and the interpretation of potential bias or imprecision of results (25%). There was a little improvement in CONSORT scores over time (r = 0.62; p < 0.001) and with impact factor of journals (r = 0.30; p < 0.001). Conclusion Quality of reporting RCTs on analgesics after TOS is poor. Reporting of those RCTs should be improved according to methodological standard checklists in the next years
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- Author
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- Abdallah J
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- Teyssier D
- Thompson AS
- Thompson JC
- Thompson LF
- Thomson MA
- Tilquin A
- Timmermans C
- Timmermans J
- Ting SCC
- Ting SM
- Tittel K
- Tkatchev L
- Tobin M
- Todorovova S
- Tomalin IR
- Tome B
- Tonazzo A
- Tonwar SC
- Torrence E
- Tortosa P
- Toth J
- Toya D
- Trabelsi A
- Tran P
- Travnicek P
- Trefzger T
- Treille D
- Tricoli A
- Tricomi A
- Trigger I
- Tristram G
- Trochimczuk M
- Trocme B
- Trocsanyi Z
- Troncon C
- Tsur E
- Tuchming B
- Tully C
- Tung KL
- Turluer ML
- Turner-Watson MF
- Tyapkin IA
- Tyapkin P
- Tzamarias S
- Uchida Y
- Ueda I
- Ujvari B
- Ulbricht J
- Uvarov V
- Vachon B
- Valassi A
- Valente E
- Valenti G
- Vallage B
- van Dalen JA
- Van Dam P
- van de Walle RT
- van Dierendonck D
- Van Eldik J
- van Gulik R
- Van Lysebetten A
- van Remortel N
- Van Vulpen I
- Vannerem P
- Vayaki A
- Vegni G
- Veillet JJ
- Veloso F
- Venturi A
- Venus W
- Verbeure F
- Verdier P
- Verdini PG
- Verzi V
- Verzocchi M
- Veszpremi V
- Vesztergombi G
- Vetlitsky I
- Vicinanza D
- Videau H
- Videau I
- Viertel G
- Vilanova D
- Villa S
- Vitale L
- Vivargent M
- Vlachos S
- Vodopianov I
- Vogel H
- Vogt H
- Vollmer CF
- von Krogh J
- von Wimmersperg-Toeller JH
- Vorobiev I
- Vorobyov AA
- Voss H
- Vossebeld J
- Vrba V
- Waananen A
- Wachsmuth H
- Wadhwa M
- Wahlen H
- Waller D
- Wallraff W
- Wang M
- Wang T
- Wang XL
- Wang ZM
- Ward CP
- Ward DR
- Ward JJ
- Washbrook AJ
- Wasserbacch S
- Watkins PM
- Watson AT
- Watson NK
- Weber M
- Weiser C
- Well PS
- Wengler T
- Wermes N
- Werner S
- Wetterling D
- White R
- Wicke D
- Wickens J
- Wiedenmann W
- Wienemann P
- Wilkens H
- Wilkinson G
- Wilson GW
- Wilson JA
- Winter M
- Witek M
- Wolf G
- Wolf G
- Wu J
- Wu SL
- Wu SX
- Wu X
- Wunsch M
- Wyatt TR
- Wynhoff S
- Xia L
- Xie Y
- Xu R
- Xu ZZ
- Xue S
- Yamamoto J
- Yamashita S
- Yang BZ
- Yang CG
- Yang HJ
- Yang M
- Yeh SC
- Yuan C
- Yushchenko O
- Zachariadou K
- Zalewska A
- Zalewski P
- Zalite A
- Zalite Y
- Zavrtanik D
- Zeitnitz C
- Zer-Zion D
- Zhang J
- Zhang L
- Zhang ZP
- Zhao J
- Zhao W
- Zhu GY
- Zhu RY
- Zhuang HL
- Zhuravlov V
- Zichichi A
- Ziegler T
- Zilizi G
- Zimin NI
- Zimmermann B
- Zintchenko A
- Zito G
- Zivkovic L
- Zobernig G
- Zoller M
- Zupan M
- Publication venue
- ELSEVIER SCIENCE BV
- Publication date
- 17/07/2003
- Field of study
ERICA: prevalences of hypertension and obesity in Brazilian adolescents
- Author
- Ana Julia Pantoja Moraes
- Ana Luíza Borges
- Ana Mayra Andrade de Oliveira
- Andrade SSCA
- Barufaldi LA
- Beaglehole R
- Beatriz Schaan
- Bloch KV
- Bruno Mendes Tavares
- Carlos Henrique Klein
- Cecília Lacroix de Oliveira
- Chorin E
- Cristiane de Freitas Cunha
- Denise Tavares Giannini
- Dilson Rodrigues Belfort
- Eduardo Lima Santos
- Elisa Brosina de Leon
- Elizabete Regina Araújo Oliveira
- Elizabeth Fujimori
- Erika da Silva Magliano
- Francisco de Assis Guedes Vasconcelos
- Freedman DS
- Gabriela de Azevedo Abreu
- George Dantas Azevedo
- Gisela Soares Brunken
- Gloria Valeria da Veiga
- Guimarães ICB
- Isabel Cristina Britto Guimarães
- José Rocha Faria Neto
- Juliana Souza Oliveira
- Katia Vergetti Bloch
- Kenia Mara B. de Carvalho
- Lai CC
- Laura Augusta Barufaldi
- Li L
- Luis Gonzaga de Oliveira Gonçalves
- Magliano ES
- Maria Cristina C Kuschnir
- Maria Inês Monteiro
- Marize M. Santos
- May AL
- Moraes ACF
- Moraes ACF
- Moreira NF
- Moyses Szklo
- Olshansky SJ
- Onis M
- Paulo César B. Veiga Jardim
- Pedro Antônio Muniz Ferreira
- Raj M
- Renan Magalhães Montenegro Jr.
- Ribas SA
- Ricardo Queiroz Gurgel
- Rodrigo Pinheiro Vianna
- Rosner B
- Sandra Mary Vasconcelos
- Schmidt MI
- Schommer VA
- Stergiou GS
- Tamara Beres Lederer Goldberg
- Thiago Luiz Nogueira da Silva
- Vaněčková I
- Vasconcellos MTL
- Zhang YX
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2016
- Field of study
ERICA: prevalence of metabolic syndrome in Brazilian adolescents
- Author
- Alvarez MM
- Ana Júlia Pantoja de Moraes
- Ana Luíza Borges
- Ana Mayra Andrade de Oliveira
- Barter P
- Beatriz Schaan
- Bloch KV
- Bruno Mendes Tavares
- Buff CG
- Carlos Henrique Klein
- Castro IRR
- Cecília Lacroix de Oliveira
- Christofaro DGD
- Cook S
- Cristiane de Freitas Cunha
- Denise Tavares Giannini
- Dilson Rodrigues Belfort
- Eduardo Lima Santos
- Elisa Brosina de Leon
- Elizabete Regina Araújo Oliveira
- Elizabeth Fujimori
- Erika da Silva Magliano
- Fernández JR
- Ferranti SD
- Ford ES
- Francisco de Assis Guedes Vasconcelos
- Gabriela de Azevedo Abreu
- George Dantas Azevedo
- Giannini DT
- Gisela Soares Brunken
- Gloria Valeria da Veiga
- Isabel Cristina Britto Guimarães
- José Rocha Faria Neto
- Juliana Souza Oliveira
- Katia Vergetti Bloch
- Kenia Mara B de Carvalho
- Laura Augusta Barufaldi
- Laurson KR
- Luis Gonzaga de Oliveira Gonçalves
- Maria Cristina C Kuschnir
- Maria Inês Monteiro
- Marize M Santos
- Maurício T L de Vasconcellos
- Miller M
- Moyses Szklo
- Muoio DM
- Nasreddine L
- Onis M
- Onis M
- Pascoal Torres Muniz
- Paulo César B Veiga Jardim
- Pedro Antônio Muniz Ferreira
- Reaven GM
- Renan Magalhães Montenegro Jr
- Ricardo Queiroz Gurgel
- Rodrigo Pinheiro Vianna
- Sandra Mary Vasconcelos
- Stella Maris Seixas Martins
- Stergiou GS
- Tamara Beres Lederer Goldberg
- Tavares LF
- Thiago Luiz Nogueira da Silva
- Vasconcellos MTL
- Wang J
- Zimmet P
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2016
- Field of study
Treament and prevention of anemia with ferrous sulfate plus folic acid in children attending daycare centers in Goiânia, Goiás State, Brazil: a randomized controlled trial
- Author
- Allen LH
- Assis AMO
- Bailey LB
- Barbosa RMS
- Beaton GH
- Brunken GS
- Corrêa NBO
- Dallman PR
- DeMayer E
- DeMayer EM
- Dijkhuizen MA
- Dirce Maria Sigulem
- Escoteguy CC
- Geltman PL
- Hadler MCCM
- Hadler MCCM
- Hadler MCCM
- Liu X-N
- Lozoff B
- Maria Claret Costa Monteiro Hadler
- Maria de Fátima Costa Alves
- Monteiro CA
- Ribeiro LC
- Ribeiro LC
- Sankaranarayanan S
- Sazawal S
- Silva DG
- Spinelli MGN
- Stoltzfus RJ
- Tee E-S
- Tielsch JM
- Trowbridge F
- Vannucchi H
- Vinícius Montenegro Torres
- Walter T
- Whitehead RG
- Wieringa FT
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2008
- Field of study
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
- Colhoun H
- Collier D
- Collins R
- Coloma G
- Colquhoun D
- Colvin T
- Coman S
- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
- Cosgrove S
- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
- Cox R
- Craig W
- Crandall L
- Crawford G
- Crea F
- Crepps K
- Crocamo A
- Cromer M
- Cruz H
- Cruz H
- Cruz M
- Csala L
- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
- Damron M
- Danik J
- Davalos C
- Dave B
- Dave K
- Davidsson K
- Davies M
- Davies N
- Davis B
- Davis M
- Dawkins-Hughes S
- Dawood Sy
- Dayer M
- De Boer P
- De Caterina R
- De Jong C
- De Knijf K
- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
- Debnam S
- Decsi K
- Decsi Kl
- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
- Dhawan M
- Di Biase M
- Diago M
- Diaz M
- Dicken T
- Dickstein K
- Diederich C
- Diederich M
- Diehl R
- Diller P
- Dimattia M
- Dimitrov G
- Diodati J
- Dobariya H
- Dobilas V
- Dodds G
- Doesborg L
- Doggett J
- Dognini Gp
- Doi M
- Dokupilova A
- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
- Dudhatra N
- Duff J
- Duhan S
- Dunhurst F
- Dussan Ma
- Dutka C
- Dwenger E
- Dzupina A
- Dékány Jn
- E Eleuteri
- E Englmann
- Earl J
- East C
- Eaton C
- Eaves W
- Ebeling K
- Ebrahim I
- Eccleston D
- Echeverria L
- Eder F
- Edgerton L
- Edillo C
- Edwards J
- Edwards T
- Eichinger G
- Einhorn D
- Eki Y
- El Hachem M
- El Hafi S
- Ellenbroek D
- Ellis M
- Emil B
- Endo T
- Engelen W
- Erhard M
- Erickson B
- Ervin W
- Eskridge L
- Espinosa V
- Everett Bm
- F Fedele
- F Fonseca
- F Fucci
- Facello A
- Facello M
- Faghih M
- Fail P
- Falcon D
- Fang C
- Fang Cy
- Farias E
- Fattal P
- Fawson A
- Feitosa G
- Felario Junior Ga
- Felix L
- Feng Y
- Feng Z
- Ferdinand K
- Ferkl R
- Fernandez Aa
- Ferrari V
- Ferrario M
- Ferraz R
- Ferreira Dos Santos T
- Ferreira-Jardim A
- Fien E
- Filardi Pp
- Filho P
- Fintel D
- Firek C
- Fischer Sm
- Fisher J
- Fitilev S
- Fitz-Patrick D
- Fitzpatrick L
- Flaksa I
- Flather M
- Flezar M
- Fliesser-Goerzer E
- Flores E
- Flores E
- Flores Gs
- Flores H
- Floro T
- Foerster A
- Folkeringa Rj
- Fonseca A
- Fontaine S
- Forgon T
- Forgosh L
- Forker A
- Forster T
- Foster M
- Foucauld J
- Fowler V
- Fox B
- Franco M
- Francoeur L
- Frandsen B
- Frandsen B
- Frankenstein L
- Fratczak M
- Freitas E
- French J
- Frivold G
- Fruchter G
- Fu G
- Fucak E
- Fuchs R
- Fucili A
- Fukuike C
- Fullerton D
- Fulop P
- Fulop T
- Fulwani M
- Furch G
- Furuseth B
- G Gacioch
- G Gosselin
- Gabito A
- Gabor M
- Gabriel J
- Gabrielli D
- Gaeb-Strasas B
- Gamba C
- Ganau A
- Gapon L
- Garas S
- Garcia Duran R
- Garcia Pinna J
- Garcia Rinaldi R
- Garcia F
- Garcia N
- Garcia-Fragoso V
- Garcia-Portela M
- Garner K
- Gazizianova V
- Gelb R
- Genest J
- Genova D
- George F
- Germann H
- Gersh B
- Gervais B
- Ghali J
- Ghondale N
- Ghosh N
- Ghosh S
- Giese C
- Gilbert J
- Gilley J
- Gits F
- Glancy R
- Glenny J
- Glover J
- Glynn Rj
- Godoy Sanchez M
- Goette A
- Goff R
- Goffinet C
- Gohel P
- Goldberg N
- Gomez Sanchez J
- Gonsorcik J
- Gonzales D
- Gonzales V
- Gonzalez E
- Gordeev I
- Gorges R
- Gospodinov K
- Gotcheva N
- Goudev A
- Gould R
- Govindaraj D
- Goyal B
- Goyal S
- Grabeau R
- Grable M
- Graham J
- Graham Ja
- Graif J
- Gralow J
- Gravellone M
- Gravenhorst-Muenter U
- Green E
- Greener R
- Greenway F
- Grieshaber V
- Griffin S
- Grigaraviciene I
- Grigorova V
- Gros C
- Grosse A
- Grover A
- Grundtvig M
- Gudipati Rvc
- Guerrero A
- Guillinta P
- Gundala Ak
- Gupta A
- Gupta A
- Gupta M
- Gupta V
- Gutmann J
- Guzman I
- Guzman P
- Gwyn M
- Gyorgyova E
- H Haldane
- H Hansen
- H Haught
- H Hill
- Haase F
- Haege R
- Haenel T
- Hage F
- Hageman T
- Hagemann D
- Hagenow A
- Hagiwara Y
- Haidar A
- Haider K
- Hakas J
- Haldis T
- Hall C
- Hall L
- Hall S
- Halliwell Tc
- Halpern S
- Hamer Bjb
- Hamud-Socoro A
- Han B
- Han S
- Hanak P
- Hanefeld M
- Hangyal T
- Hansson A
- Hanustiakova A
- Hao Y
- Hardas S
- Hardee L
- Harrell W
- Harrington A
- Harris B
- Hartleib M
- Hartwell J
- Hasan F
- Hasbani E
- Hasegawa K
- Hattler B
- Haughton G
- Haynes E
- Haywood A
- He Y
- He Z
- Heaney L
- Hecht J
- Heeren G
- Hegedus V
- Heider J
- Heisters J
- Henley L
- Hennig D
- Henriksson A
- Hermans K
- Hernandez E
- Hernandez I
- Hernandez M
- Hernández N
- Herrman Jp
- Herzog W
- Hess E
- Hettwer Magedanz E
- Hickey L
- Hiden C
- Hielscher S
- Higuchi T
- Higuchi Y
- Hilkert R
- Hilton T
- Himpel-Boenninghoff A
- Hinderaker P
- Hioki M
- Hirayama A
- Hiroma J
- Ho Cj
- Hodnett P
- Hoffman M
- Hofsoey K
- Hogan C
- Hollanders G
- Holmes Z
- Holoubek D
- Holscher A
- Hominal M
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- Hong T
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- Hoogslag Pam
- Horackova K
- Horak A
- Hornig M
- Horvat P
- Hosokawa S
- Hotchkiss D
- Houra M
- Hristova K
- Hsieh Ic
- Huang A
- Huang P
- Huang Ph
- Humbert J
- Hurtig U
- Hutchens E
- Huynh T
- Hwang Jj
- Hwang Jj
- Hyun K
- Härstedt N
- Høivik Ho
- I Ilic
- I Ivanov
- Iachini K
- Iannopollo G
- Ibarra J
- Ibarra M
- Ibañez J
- Iby M
- Ichisawa M
- Igbokidi O
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- Woelcke J
- Wohnlich T
- Wolf S
- Woodall S
- Woods A
- Woyczak D
- Wrage P
- Wright J
- Wu J
- Wu J
- Wujkowski M
- Wyss F
- Xavier Jp
- Xu H
- Xu Zj
- Yakovova S
- Yakushin S
- Yamada T
- Yamaguchi E
- Yamamoto H
- Yamamoto T
- Yamane M
- Yan J
- Yanase T
- Yanev T
- Yang Cc
- Yang K
- Yang P
- Yao Z
- Yaoqing H
- Yarows S
- Yasuoka S
- Yasutake M
- Yigit Z
- Yilmaz Mb
- Yim Kh
- Yim S
- Yokoyama M
- Yong H
- Yoshida M
- Yoshimoto E
- Yossen M
- Young A
- Younis L
- Youssef G
- Yuan Z
- Yunoki C
- Yupanqui H
- Z Zhai
- Z Zilahi
- Zadionchenko V
- Zadra R
- Zagozen P
- Zaidman C
- Zalazar L
- Zaman A
- Zangroniz P
- Zarate J
- Zareczky P
- Zarifis I
- Zdrenghea D
- Zebrack J
- Zena N
- Zhang J
- Zhang W
- Zhang Y
- Zhao R
- Zhou H
- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
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- Huddart S
- Hull AM
- Hung CY
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- Hung WT
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- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
- Ilan R
- Ilyina V
- Imanaka H
- Inaloo S
- Ince C
- Iotti GA
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- IPREA Study Group
- Irazabal JM
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- Ishimatsu S
- Itenov TS
- Iwamoto M
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- Jaber S
- Jacky A
- Jacobs FM
- Jacques T
- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
- Jeon YD
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- Jeong IY
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- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
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- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
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- Kang PL
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- Kao KC
- Kappler F
- Kara A
- Karachi F
- Karanjia N
- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
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- Katira BH
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- Kawamura N
- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
- Ke MW
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- Keep J
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- Keller E
- Kellner F
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- Kerhuel L
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- Kezyte G
- Khadjibaev A
- Khaliq W
- Khine H
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- King HS
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- Kirca H
- Kirman M
- Kirwan CJ
- Kittnar O
- Klapsing P
- Klaus DA
- Kleinpell R
- Kluge S
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- Ko JI
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- Kobayashi A
- Koco E
- Kodate A
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- Kokkini S
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- Komuro T
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- Kongpolprom N
- Kooner G
- Kostalas M
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- Kovacikova L
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- Kristof J
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- Ku NS
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- Kubik M
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- Kunze-Szikszay N
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- Kurtz P
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- Kwon HM
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- Kye YC
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- Labaune MA
- Labra C
- Lacerda P
- Laerkner E
- Lafaurie M
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- Lagonidis D
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- Lipcsey M
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- Lissonde F
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- Litchfield K
- Liu CP
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- Liu D
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- Lortat-Jacob B
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- Mackey G
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- Maekawa K
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- Maertens B
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- Mezidi M
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- Mistry M
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- Sadamoto Y
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- Saha T
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- Salgado DR
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- Savin I
- Savvidou S
- Sawamura A
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- Spazzadeschi A
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- Spronk PE
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- St George’s University of London
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- Stella A
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- Street H
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- Struijs A
- Stubbs C
- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
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- Timsit JF
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- Tokyo Womens Medical University
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- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adhyapak S
- Agarwal H
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- Ahremark U
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- Akhter F
- Ako J
- Akright L
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- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
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- Alonso Martin JJ
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- Batushkin V
- Bayat J
- Bayram Llamas EA
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- Benedicto A
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- Gremmler U
- Grewal JS
- Griffiths H
- Gring C
- Groenemeijer BE
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- Guardigli G
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- Guzman PN
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- Iqbal SMR
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- Istratoaie O
- Ito K
- Ivanov IG
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- Kamensky G
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- Kapin T
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- Velasquez JRD
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- Verdel GJE
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- Yao Z
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- Yerra SK
- Yin W-H
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- Yoon JH
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- Zaidman CJ
- Zainea M
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- Zhang W
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- Zong W
- Zrazhevsky K
- Zuniga JDH
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Aims The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
Aleitamento materno em crianças de 0 a 59 meses no Estado de Pernambuco, Brasil, segundo o peso ao nascer
- Author
- Agrasada GV
- Almeida H
- Alves JGB
- Berkowitz GS
- Bernardo Barbosa Sampaio
- Bittencourt LJ
- Boccolini CS
- Buccini GS
- Caminha MFC
- Caminha MFC
- De Morais AM
- Eriksson JG
- Fewtrell MS
- Geib LTC
- Hung KJ
- Kramer MS
- Lami FF
- Machado MMT
- Malaquias Batista Filho
- Marcela Patrícia Macêdo Belo
- Maria de Fátima Costa Caminha
- Marques ES
- Midodzi WK
- Miglioli TC
- Miglioli TC
- Mondini L
- Monteiro CA
- Moraes AB
- Morris SK
- Noronha GA
- Oliveira JS
- Oliveira O
- Pacheco STA
- Pedro Israel Cabral de Lira
- Pedro Tadeu Álvares Costa Caminha de Azevedo
- Puffer RR
- Pérez-Escamilla R
- Riechi TIJ
- Salgado CM
- Sanches MTC
- Van de Poel E
- Venâncio SI
- Viana KJ
- Victor Montenegro Cavalcanti de Acioly
- Victora CG
- Victora CG
- Xavier CC
- Xu X
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Assessment instruments of functioning in Brazilian elderly and the ICF: a systematic review
- Author
- Abrahin O
- Aguiar AF
- Al Haddad MA
- Andrade LP
- Andreotti RA
- Antes DL
- Araujo TB
- Arcoverde C
- Balasubramanian CK
- Barbosa BR
- Barbosa JMM
- Barduzzi GO
- Barry E
- Bastone AC
- Batista LH
- Bento PCB
- Berg KO
- Bottaro M
- Carvalho AR
- Carvalho GS
- Castro SS
- Chumbler NR
- Cieza A
- Cipriani NCS
- Deeks JJ
- Downs SH
- Farinatti PT
- Geraldes AAR
- Harada ND
- Karinkanta S
- Lawton MP
- Locks RR
- Lustosa LP
- Lustosa LP
- Lustosa LP
- Masala C
- Montenegro SMRS
- Moonem JE
- Moraes K
- Moraes WM
- Okochi J
- Pereira VV
- Perez AJ
- Pinto RS
- Podsiadlo D
- Raso V
- Rebok GW
- Rikli RE
- Rikli RE
- Sampaio RF
- Seemann T
- Silva AFG
- Simic M
- Simão AP
- van de Rest O
- Vellas BJ
- Wells KF
- Zamboni AB
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
- …